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Conserved domains on  [gi|30697680|ref|NP_851248|]
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myb domain protein 96 [Arabidopsis thaliana]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 1000535)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein may be involved in the regulation of gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03212 super family cl31985
Transcription repressor MYB5; Provisional
 5-115 2.37e-50

Transcription repressor MYB5; Provisional


The actual alignment was detected with superfamily member PLN03212:

Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 168.33  E-value: 2.37e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697680    5 PCCEKIGVKKGPWTPEEDIILVSYIQEHGPGNWRSVPTHTGL-RCSKSCRLRWTNYLRPGIKRGNFTEHEEKTIVHLQAL 83
Cdd:PLN03212  16 PCCTKMGMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRL 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 30697680   84 LGNRWAAIASYLPERTDNDIKNYWNTHLKKKL 115
Cdd:PLN03212  96 LGNRWSLIAGRIPGRTDNEIKNYWNTHLRKKL 127
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 5-115 2.37e-50

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 168.33  E-value: 2.37e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697680    5 PCCEKIGVKKGPWTPEEDIILVSYIQEHGPGNWRSVPTHTGL-RCSKSCRLRWTNYLRPGIKRGNFTEHEEKTIVHLQAL 83
Cdd:PLN03212  16 PCCTKMGMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRL 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 30697680   84 LGNRWAAIASYLPERTDNDIKNYWNTHLKKKL 115
Cdd:PLN03212  96 LGNRWSLIAGRIPGRTDNEIKNYWNTHLRKKL 127
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 12-126 2.41e-21

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 94.85  E-value: 2.41e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697680  12 VKKGPWTPEEDIILVSYIQEHGPGNWRSVPTHTGLRCSKSCRLRWTNYLRPGIKRGNFTEHEEKTIVHLQALLGNRWAAI 91
Cdd:COG5147  18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWSTI 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 30697680  92 ASYLPERTDNDIKNYWNTHLK-------KKLKKINESGEEDN 126
Cdd:COG5147  98 ADYKDRRTAQQCVERYVNTLEdlssthdSKLQRRNEFDKIDP 139
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 14-60 6.66e-15

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 67.91  E-value: 6.66e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 30697680    14 KGPWTPEEDIILVSYIQEHGpGNWRSVPTHTGLRCSKSCRLRWTNYL 60
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
14-62 1.54e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 64.17  E-value: 1.54e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 30697680     14 KGPWTPEEDIILVSYIQEHGPGNWRSVPTHTGLRCSKSCRLRWTNYLRP 62
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 16-60 4.90e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 62.59  E-value: 4.90e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 30697680  16 PWTPEEDIILVSYIQEHGPGNWRSVPTHTGLRCSKSCRLRWTNYL 60
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 5-115 2.37e-50

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 168.33  E-value: 2.37e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697680    5 PCCEKIGVKKGPWTPEEDIILVSYIQEHGPGNWRSVPTHTGL-RCSKSCRLRWTNYLRPGIKRGNFTEHEEKTIVHLQAL 83
Cdd:PLN03212  16 PCCTKMGMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRL 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 30697680   84 LGNRWAAIASYLPERTDNDIKNYWNTHLKKKL 115
Cdd:PLN03212  96 LGNRWSLIAGRIPGRTDNEIKNYWNTHLRKKL 127
PLN03091 PLN03091
hypothetical protein; Provisional
 1-117 7.94e-48

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 167.46  E-value: 7.94e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697680    1 MGRPPCCEKIGVKKGPWTPEEDIILVSYIQEHGPGNWRSVPTHTGL-RCSKSCRLRWTNYLRPGIKRGNFTEHEEKTIVH 79
Cdd:PLN03091   1 MGRHSCCYKQKLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIE 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 30697680   80 LQALLGNRWAAIASYLPERTDNDIKNYWNTHLKKKLKK 117
Cdd:PLN03091  81 LHAVLGNRWSQIAAQLPGRTDNEIKNLWNSCLKKKLRQ 118
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 12-126 2.41e-21

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 94.85  E-value: 2.41e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697680  12 VKKGPWTPEEDIILVSYIQEHGPGNWRSVPTHTGLRCSKSCRLRWTNYLRPGIKRGNFTEHEEKTIVHLQALLGNRWAAI 91
Cdd:COG5147  18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWSTI 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 30697680  92 ASYLPERTDNDIKNYWNTHLK-------KKLKKINESGEEDN 126
Cdd:COG5147  98 ADYKDRRTAQQCVERYVNTLEdlssthdSKLQRRNEFDKIDP 139
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 14-60 6.66e-15

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 67.91  E-value: 6.66e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 30697680    14 KGPWTPEEDIILVSYIQEHGpGNWRSVPTHTGLRCSKSCRLRWTNYL 60
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
14-62 1.54e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 64.17  E-value: 1.54e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 30697680     14 KGPWTPEEDIILVSYIQEHGPGNWRSVPTHTGLRCSKSCRLRWTNYLRP 62
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 66-111 1.88e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 64.06  E-value: 1.88e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 30697680    66 RGNFTEHEEKTIVHLQALLGNRWAAIASYLPERTDNDIKNYWNTHL 111
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 16-60 4.90e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 62.59  E-value: 4.90e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 30697680  16 PWTPEEDIILVSYIQEHGPGNWRSVPTHTGLRCSKSCRLRWTNYL 60
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
66-113 3.10e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 57.62  E-value: 3.10e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 30697680     66 RGNFTEHEEKTIVHLQALLG-NRWAAIASYLPERTDNDIKNYWNTHLKK 113
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 17-74 5.42e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 57.32  E-value: 5.42e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 30697680    17 WTPEEDIILVSYIQEHGpGNWRSVPTHTGLRCSKSCRLRWTNYLRPGIKRGNFTEHEE 74
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEED 57
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 68-111 1.45e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 55.66  E-value: 1.45e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 30697680  68 NFTEHEEKTIVHLQALLG-NRWAAIASYLPERTDNDIKNYWNTHL 111
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 69-125 1.17e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 45.38  E-value: 1.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 30697680    69 FTEHEEKTIVHLQALLGNRWAAIASYLPERTDNDIKNYWNTHLKKKLKKINESGEED 125
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEED 57
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 16-38 1.33e-03

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 36.39  E-value: 1.33e-03
                        10        20
                ....*....|....*....|...
gi 30697680  16 PWTPEEDIILVSYIQEHGPGNWR 38
Cdd:cd11660   2 KWTDEEDEALVEGVEKYGVGNWA 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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