NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|30688739|ref|NP_850353|]
View 

P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

YlqF/YawG GTPase family protein( domain architecture ID 10111434)

YlqF/YawG GTPase family protein similar to human mitochondrial ribosome-associated GTPase 1 that plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 28-205 7.07e-70

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


:

Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 217.01  E-value: 7.07e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  28 WFPGHMAAATRAIRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNKWTRHFESSKQDCIA 107
Cdd:cd01856   1 WFPGHMAKALRQIKEKLKLVDVVIEVRDARIPLSSRNPDLDKILGNKPRLIVLNKADLADPAKTKKWLKYFKSQGEPVLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 108 INAHSRSSVMKLLDLVELKLKEVIAR------EPTLLVMVVGVPNVGKSALINSIHQIaaarfpvqerlKRATVGPLPGV 181
Cdd:cd01856  81 VNAKNGKGVKKLLKKAKKLLKENEKLkakgllPRPLRAMVVGIPNVGKSTLINRLRGK-----------KVAKVGNKPGV 149

                       170       180
                ....*....|....*....|....
gi 30688739 182 TQDIAGFKIAhrPSIYVLDSPGVL 205
Cdd:cd01856 150 TRGQQWIRIG--PNIELLDTPGIL 171
 
Name Accession Description Interval E-value
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 28-205 7.07e-70

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 217.01  E-value: 7.07e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  28 WFPGHMAAATRAIRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNKWTRHFESSKQDCIA 107
Cdd:cd01856   1 WFPGHMAKALRQIKEKLKLVDVVIEVRDARIPLSSRNPDLDKILGNKPRLIVLNKADLADPAKTKKWLKYFKSQGEPVLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 108 INAHSRSSVMKLLDLVELKLKEVIAR------EPTLLVMVVGVPNVGKSALINSIHQIaaarfpvqerlKRATVGPLPGV 181
Cdd:cd01856  81 VNAKNGKGVKKLLKKAKKLLKENEKLkakgllPRPLRAMVVGIPNVGKSTLINRLRGK-----------KVAKVGNKPGV 149

                       170       180
                ....*....|....*....|....
gi 30688739 182 TQDIAGFKIAhrPSIYVLDSPGVL 205
Cdd:cd01856 150 TRGQQWIRIG--PNIELLDTPGIL 171
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
26-242 1.25e-67

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 214.97  E-value: 1.25e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  26 INWFPGHMAAATRAIRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNKWTRHFESSKQDC 105
Cdd:COG1161   3 IQWFPGHMAKARRQIKEILKLVDLVIEVVDARIPLSSRNPMLDELVGNKPRLLVLNKADLADPSVTKQWLKYFEKQGVDA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 106 IAINAHSRSSVMKLLDLVELKLKEVIAREPTLLVMVVGVPNVGKSALINSIhqiaAARfpvqerlKRATVGPLPGVTQDI 185
Cdd:COG1161  83 LAISAKKGKGIKELIEAIRELAPEKGIKRRPIRVMIVGIPNVGKSTLINRL----AGK-------KVAKTGNKPGVTKGQ 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 30688739 186 AGFKIAhrPSIYVLDSPGVLVPSIPDIETGLKLALSGSVKDSVVGEERIAQYFLAIL 242
Cdd:COG1161 152 QWIKLD--DGLELLDTPGILWPKFEDPEVGYKLAATGAIKDEVLDLEEVALFLLGYL 206
GTPase_YlqF TIGR03596
ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding ...
 26-242 4.54e-67

ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding proteins involved in ribosome biogenesis, including the essential YlqF protein of Bacillus subtilis, which is an essential protein. They are related to Era, EngA, and other GTPases of ribosome biogenesis, but are circularly permuted. This family is not universal, and is not present in Escherichia coli, and so is not as well studied as some other GTPases. This model is built for bacterial members. [Protein synthesis, Other]


Pssm-ID: 274669 [Multi-domain]  Cd Length: 276  Bit Score: 213.52  E-value: 4.54e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739    26 INWFPGHMAAATRAIRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNKWTRHFESSKQDC 105
Cdd:TIGR03596   1 IQWFPGHMAKARREIKENLKLVDVVIEVLDARIPLSSRNPMIDEIRGNKPRLIVLNKADLADPAVTKQWLKYFEEKGIKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739   106 IAINAHSRSSVMKLLDLVELKLKEVIARE-------PTLLVMVVGVPNVGKSALINsihqiaaarfpvqeRL---KRATV 175
Cdd:TIGR03596  81 LAVNAKKGAGVKKIIKAAKKLLKEKNEKLkakglknRPIRAMIVGIPNVGKSTLIN--------------RLagkKVAKV 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30688739   176 GPLPGVTQDIAGFKIAhrPSIYVLDSPGVLVPSIPDIETGLKLALSGSVKDSVVGEERIAQYFLAIL 242
Cdd:TIGR03596 147 GNRPGVTKGQQWIKLS--DNLELLDTPGILWPKFEDQEVGLKLAATGAIKDEALDLEDVALFLLEYL 211
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 139-205 5.30e-10

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 56.47  E-value: 5.30e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30688739   139 VMVVGVPNVGKSALINSIHQiaaarfpvqerlKRATVGPLPGVTQDIAGFKIAHR-PSIYVLDSPGVL 205
Cdd:pfam01926   2 VALVGRPNVGKSTLINALTG------------AKAIVSDYPGTTRDPNEGRLELKgKQIILVDTPGLI 57
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 15-184 2.90e-05

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 45.81  E-value: 2.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739   15 GGMSFAKDAgkinwFPGHMAA-ATRAIRNrlklSDLVIEVRDARIPLSSANEDLqSQM---SAKRRIIALNKKDlaNPNV 90
Cdd:PRK00093  57 GGIEPDDDG-----FEKQIREqAELAIEE----ADVILFVVDGRAGLTPADEEI-AKIlrkSNKPVILVVNKVD--GPDE 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739   91 LNkwtRHFESSK---QDCIAINAHSRSSVMKLLDLVELKLKEVIAREP---TLLVMVVGVPNVGKSALINSIhqiaaarf 164
Cdd:PRK00093 125 EA---DAYEFYSlglGEPYPISAEHGRGIGDLLDAILEELPEEEEEDEedePIKIAIIGRPNVGKSSLINAL-------- 193

                        170       180
                 ....*....|....*....|
gi 30688739  165 pVQErlKRATVGPLPGVTQD 184
Cdd:PRK00093 194 -LGE--ERVIVSDIAGTTRD 210
 
Name Accession Description Interval E-value
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 28-205 7.07e-70

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 217.01  E-value: 7.07e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  28 WFPGHMAAATRAIRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNKWTRHFESSKQDCIA 107
Cdd:cd01856   1 WFPGHMAKALRQIKEKLKLVDVVIEVRDARIPLSSRNPDLDKILGNKPRLIVLNKADLADPAKTKKWLKYFKSQGEPVLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 108 INAHSRSSVMKLLDLVELKLKEVIAR------EPTLLVMVVGVPNVGKSALINSIHQIaaarfpvqerlKRATVGPLPGV 181
Cdd:cd01856  81 VNAKNGKGVKKLLKKAKKLLKENEKLkakgllPRPLRAMVVGIPNVGKSTLINRLRGK-----------KVAKVGNKPGV 149

                       170       180
                ....*....|....*....|....
gi 30688739 182 TQDIAGFKIAhrPSIYVLDSPGVL 205
Cdd:cd01856 150 TRGQQWIRIG--PNIELLDTPGIL 171
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
26-242 1.25e-67

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 214.97  E-value: 1.25e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  26 INWFPGHMAAATRAIRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNKWTRHFESSKQDC 105
Cdd:COG1161   3 IQWFPGHMAKARRQIKEILKLVDLVIEVVDARIPLSSRNPMLDELVGNKPRLLVLNKADLADPSVTKQWLKYFEKQGVDA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 106 IAINAHSRSSVMKLLDLVELKLKEVIAREPTLLVMVVGVPNVGKSALINSIhqiaAARfpvqerlKRATVGPLPGVTQDI 185
Cdd:COG1161  83 LAISAKKGKGIKELIEAIRELAPEKGIKRRPIRVMIVGIPNVGKSTLINRL----AGK-------KVAKTGNKPGVTKGQ 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 30688739 186 AGFKIAhrPSIYVLDSPGVLVPSIPDIETGLKLALSGSVKDSVVGEERIAQYFLAIL 242
Cdd:COG1161 152 QWIKLD--DGLELLDTPGILWPKFEDPEVGYKLAATGAIKDEVLDLEEVALFLLGYL 206
GTPase_YlqF TIGR03596
ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding ...
 26-242 4.54e-67

ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding proteins involved in ribosome biogenesis, including the essential YlqF protein of Bacillus subtilis, which is an essential protein. They are related to Era, EngA, and other GTPases of ribosome biogenesis, but are circularly permuted. This family is not universal, and is not present in Escherichia coli, and so is not as well studied as some other GTPases. This model is built for bacterial members. [Protein synthesis, Other]


Pssm-ID: 274669 [Multi-domain]  Cd Length: 276  Bit Score: 213.52  E-value: 4.54e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739    26 INWFPGHMAAATRAIRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNKWTRHFESSKQDC 105
Cdd:TIGR03596   1 IQWFPGHMAKARREIKENLKLVDVVIEVLDARIPLSSRNPMIDEIRGNKPRLIVLNKADLADPAVTKQWLKYFEEKGIKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739   106 IAINAHSRSSVMKLLDLVELKLKEVIARE-------PTLLVMVVGVPNVGKSALINsihqiaaarfpvqeRL---KRATV 175
Cdd:TIGR03596  81 LAVNAKKGAGVKKIIKAAKKLLKEKNEKLkakglknRPIRAMIVGIPNVGKSTLIN--------------RLagkKVAKV 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30688739   176 GPLPGVTQDIAGFKIAhrPSIYVLDSPGVLVPSIPDIETGLKLALSGSVKDSVVGEERIAQYFLAIL 242
Cdd:TIGR03596 147 GNRPGVTKGQQWIKLS--DNLELLDTPGILWPKFEDQEVGLKLAATGAIKDEALDLEDVALFLLEYL 211
MJ1464 cd01859
An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents ...
 44-204 1.64e-29

An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents archaeal GTPase typified by the protein MJ1464 from Methanococcus jannaschii. The members of this family show a circular permutation of the GTPase signature motifs so that C-terminal strands 5, 6, and 7 (strands 6 contain the NKxD motif) are relocated to the N terminus.


Pssm-ID: 206752 [Multi-domain]  Cd Length: 157  Bit Score: 111.64  E-value: 1.64e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  44 LKLSDLVIEVRDARIPLSSANEDLQSQMSA--KRRIIALNKKDLANPNVLNKWTRHFESSKQDCIAINAHSRSSVMKLLD 121
Cdd:cd01859   9 IKEADVVLEVVDARDPELTRSRKLERMALElgKKLIIVLNKADLVPREVLEKWKEVFESEGLPVVYVSARERLGTRILRR 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 122 lvelKLKEVIAREPTLLVMVVGVPNVGKSALINSIhqiaaarfpvqERLKRATVGPLPGV---TQDIAGFKIAHRpsIYV 198
Cdd:cd01859  89 ----TIKELAIDGKPVIVGVVGYPKVGKSSIINAL-----------KGRHSASTSPIPGSpgyTKGIQLVRIDSK--IYL 151


                ....*.
gi 30688739 199 LDSPGV 204
Cdd:cd01859 152 IDTPGV 157
Nucleostemin_like cd04178
A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein ...
 48-204 1.67e-16

A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein that functions as a regulator of cell growth and proliferation in stem cells and in several types of cancer cells, but is not expressed in the differentiated cells of most mammalian adult tissues. NS shuttles between the nucleolus and nucleoplasm bidirectionally at a rate that is fast and independent of cell type. Lowering GTP levels decreases the nucleolar retention of NS, and expression of NS is abruptly down-regulated during differentiation prior to terminal cell division. Found only in eukaryotes, NS consists of an N-terminal basic domain, a coiled-coil domain, a GTP-binding domain, an intermediate domain, and a C-terminal acidic domain. Experimental evidence indicates that NS uses its GTP-binding property as a molecular switch to control the transition between the nucleolus and nucleoplasm, and this process involves interaction between the basic, GTP-binding, and intermediate domains of the protein.


Pssm-ID: 206753 [Multi-domain]  Cd Length: 171  Bit Score: 76.46  E-value: 1.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  48 DLVIEVRDARIPLSSANEDLQSQMSA----KRRIIALNKKDLANPNVLNKWTRH---------FESSKQDCIAINAHSRS 114
Cdd:cd04178   1 DVILEVLDARDPLGCRCPQVERAVLVlgpnKKLVLVLNKIDLVPKENVEKWLKYlrnefptvaFKASTQQQKKNLSRKSK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 115 SVMKLLDLVE----------LKLKEVIAREP----TLLVMVVGVPNVGKSALINSihqiaaarfpvqerLKR---ATVGP 177
Cdd:cd04178  81 KVKASDDLLSssaclgadalLKLLKNYARNKgiktSITVGVVGYPNVGKSSVINS--------------LKRsraCNVGA 146

                       170       180
                ....*....|....*....|....*..
gi 30688739 178 LPGVTQDIAGFKIahRPSIYVLDSPGV 204
Cdd:cd04178 147 TPGVTKSMQEVHL--DKHVKLLDSPGV 171
YqeH cd01855
Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH ...
 62-204 5.28e-16

Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically present in bacteria with probable acquisition by plants from chloroplasts. Proteins of the YqeH family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases.


Pssm-ID: 206748 [Multi-domain]  Cd Length: 191  Bit Score: 75.76  E-value: 5.28e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  62 SANEDLQSQMSAKRRIIALNKKDL----ANPNVLNKWTR----HFESSKQDCIAINAHSRSSVMKLLDLVELKLKEVIAr 133
Cdd:cd01855  49 SLIPGLAELIGAKPVILVGNKIDLlpkdVKPNRLKQWVKkrlkIGGLKIKDVILVSAKKGWGVEELIEEIKKLAKYRGD- 127

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30688739 134 eptllVMVVGVPNVGKSALINSIHQIAAARFPVQERLKRATVGPLPGVTQDIAGFKIAHRPSIYvlDSPGV 204
Cdd:cd01855 128 -----VYVVGATNVGKSTLINALLKSNGGKVQAQALVQRLTVSPIPGTTLGLIKIPLGEGKKLY--DTPGI 191
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
 48-204 6.67e-16

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 73.96  E-value: 6.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  48 DLVIEVRDARIPLSSANEDLQ--SQMSAKRRIIALNKKDLANPNVLNKWTR-HFESSKQDCIAINAhsrSSVMKLLDLVE 124
Cdd:cd01849   1 DVVVEVVDARDPLSSRNPDIEvlINEKNKKLIMVLNKADLVPKEVLRKWVAeLSELYGTKTFFISA---TNGQGILKLKA 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 125 LKLKEVIAREPT--LLVMVVGVPNVGKSALINSIHQIAAARfpvqerlkratVGPLPGVTQDIAGFKIAHRpsIYVLDSP 202
Cdd:cd01849  78 EITKQKLKLKYKkgIRVGVVGLPNVGKSSFINALLNKFKLK-----------VGSIPGTTKLQQDVKLDKE--IYLYDTP 144


                ..
gi 30688739 203 GV 204
Cdd:cd01849 145 GI 146
NGP_1 cd01858
A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases; ...
 47-204 1.91e-11

A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases; Autoantigen NGP-1 (Nucleolar G-protein gene 1) has been shown to localize in the nucleolus and nucleolar organizers in all cell types analyzed, which is indicative of a function in ribosomal assembly. NGP-1 and its homologs show a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with NKXD motif) are relocated to the N terminus.


Pssm-ID: 206751 [Multi-domain]  Cd Length: 157  Bit Score: 61.93  E-value: 1.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  47 SDLVIEVRDARIPLSSANEDLQSQMSAKRR----IIALNKKDLANPNVLNKWTRHFeSSKQDCIAI-----NAHSRSSVM 117
Cdd:cd01858   9 SDVIIQVLDARDPMGTRCKHVEKYLRKEKPhkhlIFVLNKCDLVPTWVTKRWVKVL-SKEYPTLAFhasitNPFGKGALI 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 118 KLLDlvelKLKEVIAREPTLLVMVVGVPNVGKSALINSIhqiaaarfpvqeRLKRA-TVGPLPGVT---QDIAGFKiahr 193
Cdd:cd01858  88 NLLR----QFAKLHSDKKQISVGFIGYPNVGKSSVINTL------------RSKKVcKVAPIPGETkvwQYITLMK---- 147

                       170
                ....*....|.
gi 30688739 194 pSIYVLDSPGV 204
Cdd:cd01858 148 -RIYLIDCPGV 157
HSR1_MMR1 cd01857
A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC ...
 47-207 4.46e-11

A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse. These proteins represent a new subfamily of GTP-binding proteins that has only eukaryote members. This subfamily shows a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with sequence NKXD) are relocated to the N-terminus.


Pssm-ID: 206750 [Multi-domain]  Cd Length: 140  Bit Score: 60.32  E-value: 4.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  47 SDLVIEVRDARIPLSSANEDL----QSQMSAKRRIIALNKKDLANPNVLNKWTRHFESskqdciaiNAHSrssvmklldl 122
Cdd:cd01857  12 SDVVVQIVDARNPLFFRCPDLekyvKEVDPSKENVLLLNKADLVTEEQRKAWARYFKK--------EGIV---------- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 123 velKLKEVIAREPTllVMVVGVPNVGKSALINSIHQIaaarfpvqerlKRATVGPLPGVTQDIAGFKIAhrPSIYVLDSP 202
Cdd:cd01857  74 ---VLFFSALNEAT--IGLVGYPNVGKSSLINALVGS-----------KKVSVSSTPGKTKHFQTIFLE--PGITLCDCP 135


                ....*
gi 30688739 203 GVLVP 207
Cdd:cd01857 136 GLVFP 140
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 139-205 5.30e-10

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 56.47  E-value: 5.30e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30688739   139 VMVVGVPNVGKSALINSIHQiaaarfpvqerlKRATVGPLPGVTQDIAGFKIAHR-PSIYVLDSPGVL 205
Cdd:pfam01926   2 VALVGRPNVGKSTLINALTG------------AKAIVSDYPGTTRDPNEGRLELKgKQIILVDTPGLI 57
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
15-184 2.29e-07

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 52.33  E-value: 2.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  15 GGMSFAKDAGkinwFPGHMAA-ATRAIrnrlKLSDLVIEVRDARIPLSSANEDLqSQM---SAKRRIIALNKKDlaNPNv 90
Cdd:COG1160  58 GGIEPDDDDG----LEAEIREqAELAI----EEADVILFVVDGRAGLTPLDEEI-AKLlrrSGKPVILVVNKVD--GPK- 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  91 lnKWTRHFESSK---QDCIAINAHSRSSVMKLLDLVELKLKEVIAREPTLLVM---VVGVPNVGKSALINSIhqiaaarf 164
Cdd:COG1160 126 --READAAEFYSlglGEPIPISAEHGRGVGDLLDAVLELLPEEEEEEEEDDPIkiaIVGRPNVGKSSLINAL-------- 195

                       170       180
                ....*....|....*....|
gi 30688739 165 pVQErlKRATVGPLPGVTQD 184
Cdd:COG1160 196 -LGE--ERVIVSDIAGTTRD 212
GTPase_YqeH TIGR03597
ribosome biogenesis GTPase YqeH; This family describes YqeH, a member of a larger family of ...
 65-205 3.59e-07

ribosome biogenesis GTPase YqeH; This family describes YqeH, a member of a larger family of GTPases involved in ribosome biogenesis. Like YqlF, it shows a cyclical permutation relative to GTPases EngA (in which the GTPase domain is duplicated), Era, and others. Members of this protein family are found in a relatively small number of bacterial species, including Bacillus subtilis but not Escherichia coli. [Protein synthesis, Other]


Pssm-ID: 213834 [Multi-domain]  Cd Length: 360  Bit Score: 51.47  E-value: 3.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739    65 EDLQSQMSAKRRIIALNKKDL----ANPNVLNKWTRHFESSK----QDCIAINAHSRSSVMKLLDLVElklkevIAREPT 136
Cdd:TIGR03597  82 PELKRFVGGNPVLLVGNKIDLlpksVNLSKIKEWMKKRAKELglkpVDIILVSAKKGNGIDELLDKIK------KARNKK 155

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30688739   137 LlVMVVGVPNVGKSALINSIHQIAaarfpvQERLKRATVGPLPGVTQDIagFKIAHRPSIYVLDSPGVL 205
Cdd:TIGR03597 156 D-VYVVGVTNVGKSSLINKLLKQN------NGDKDVITTSPFPGTTLDL--IEIPLDDGHSLYDTPGII 215
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 141-205 1.60e-05

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 44.54  E-value: 1.60e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30688739 141 VVGVPNVGKSALINSIHqiaaarfpvqeRLKRATVGPLPGVTQDIAGFKIAHRP--SIYVLDSPGVL 205
Cdd:cd00880   2 IFGRPNVGKSSLLNALL-----------GQNVGIVSPIPGTTRDPVRKEWELLPlgPVVLIDTPGLD 57
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 15-184 2.90e-05

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 45.81  E-value: 2.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739   15 GGMSFAKDAgkinwFPGHMAA-ATRAIRNrlklSDLVIEVRDARIPLSSANEDLqSQM---SAKRRIIALNKKDlaNPNV 90
Cdd:PRK00093  57 GGIEPDDDG-----FEKQIREqAELAIEE----ADVILFVVDGRAGLTPADEEI-AKIlrkSNKPVILVVNKVD--GPDE 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739   91 LNkwtRHFESSK---QDCIAINAHSRSSVMKLLDLVELKLKEVIAREP---TLLVMVVGVPNVGKSALINSIhqiaaarf 164
Cdd:PRK00093 125 EA---DAYEFYSlglGEPYPISAEHGRGIGDLLDAILEELPEEEEEDEedePIKIAIIGRPNVGKSSLINAL-------- 193

                        170       180
                 ....*....|....*....|
gi 30688739  165 pVQErlKRATVGPLPGVTQD 184
Cdd:PRK00093 194 -LGE--ERVIVSDIAGTTRD 210
trmE cd04164
trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in ...
 38-121 5.19e-05

trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase domain that forms a canonical Ras-like fold. It functions a molecular switch GTPase, and apparently uses a conformational change associated with GTP hydrolysis to promote the tRNA modification reaction, in which the conserved cysteine in the C-terminal domain is thought to function as a catalytic residue. In bacteria that are able to survive in extremely low pH conditions, TrmE regulates glutamate-dependent acid resistance.


Pssm-ID: 206727 [Multi-domain]  Cd Length: 159  Bit Score: 43.25  E-value: 5.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  38 RAiRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNKwtrhfESSKQDCIAINAHSRSSVM 117
Cdd:cd04164  75 RA-REAIEEADLVLLVVDASEGLDEEDLEILELPAKKPVIVVLNKSDLLSDAEGIS-----ELNGKPIIAISAKTGEGID 148


                ....
gi 30688739 118 KLLD 121
Cdd:cd04164 149 ELKE 152
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
 77-156 1.62e-04

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 42.39  E-value: 1.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  77 IIALNKKDLANPNVLNKWTRHFESSKQDCIAINAHSRSSVMKLLDLVELKlkeviareptlLVMVVGVPNVGKSALINSI 156
Cdd:cd01854  37 VIVLNKADLVDDEELEELLEIYEKLGYPVLAVSAKTGEGLDELRELLKGK-----------TSVLVGQSGVGKSTLLNAL 105
PRK03003 PRK03003
GTP-binding protein Der; Reviewed
 120-184 3.22e-04

GTP-binding protein Der; Reviewed


Pssm-ID: 179525 [Multi-domain]  Cd Length: 472  Bit Score: 42.65  E-value: 3.22e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30688739  120 LDLVELKLKEVIAREPTLLVMVVGVPNVGKSALINSIhqiaaarfpvqerLKR--ATVGPLPGVTQD 184
Cdd:PRK03003  22 LDDEDLAELEAAEGGPLPVVAVVGRPNVGKSTLVNRI-------------LGRreAVVEDVPGVTRD 75
HflX cd01878
HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment ...
 47-127 4.30e-04

HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual biological functions of these GTPases remain unclear. HflX is widespread, but not universally represented in all three superkingdoms.


Pssm-ID: 206666 [Multi-domain]  Cd Length: 204  Bit Score: 40.91  E-value: 4.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  47 SDLVIEVRDAriplssANEDLQSQMSA------------KRRIIALNKKDLANPNVLNKWtrhFESSKQDCIAINAHSRS 114
Cdd:cd01878 121 ADLLLHVVDA------SDPDREEQIETveevlkelgaddIPIILVLNKIDLLDDEELEER---LRAGRPDAVFISAKTGE 191

                        90
                ....*....|...
gi 30688739 115 SVMKLLDLVELKL 127
Cdd:cd01878 192 GLDLLKEAIEELL 204
RsgA COG1162
Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];
77-156 8.61e-04

Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440776 [Multi-domain]  Cd Length: 300  Bit Score: 40.87  E-value: 8.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739  77 IIALNKKDLANPNVLNKWTRHFESSKQDCIAINAHSRSSVMKLLDLVELKLkeviareptllVMVVGVPNVGKSALINSI 156
Cdd:COG1162 118 VIVLNKADLADDEELEELLAIYEALGYPVLAVSAKTGEGLDELRELLKGKT-----------SVLVGQSGVGKSTLINAL 186
MnmE_helical pfam12631
MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An ...
 38-139 1.15e-03

MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An N-terminal domain, a helical domain and a GTPase domain which is nested within the helical domain. This family represents the helical domain.


Pssm-ID: 463649 [Multi-domain]  Cd Length: 326  Bit Score: 40.54  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739    38 RAiRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIA-LNKKDLANPNVLNKwtrhfESSKQDCIAINAHSRSSV 116
Cdd:pfam12631 166 RA-REAIEEADLVLLVLDASRPLDEEDLEILELLKDKKPIIVvLNKSDLLGEIDELE-----ELKGKPVLAISAKTGEGL 239

                          90       100
                  ....*....|....*....|....
gi 30688739   117 MKLLD-LVELKLKEVIAREPTLLV 139
Cdd:pfam12631 240 DELEEaIKELFLAGEIASDGPIIT 263
MnmE COG0486
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal ...
 38-88 1.51e-03

tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440253 [Multi-domain]  Cd Length: 448  Bit Score: 40.43  E-value: 1.51e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 30688739  38 RAiRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANP 88
Cdd:COG0486 285 RA-REAIEEADLVLLLLDASEPLTEEDEEILEKLKDKPVIVVLNKIDLPSE 334
EngA2 cd01895
EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second ...
 141-184 2.01e-03

EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206682 [Multi-domain]  Cd Length: 174  Bit Score: 38.57  E-value: 2.01e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 30688739 141 VVGVPNVGKSALINSIhqiaaarfpVQErlKRATVGPLPGVTQD 184
Cdd:cd01895   7 IIGRPNVGKSSLLNAL---------LGE--ERVIVSDIAGTTRD 39
Nog1 COG1084
GTP-binding protein, GTP1/Obg family [General function prediction only];
126-205 2.60e-03

GTP-binding protein, GTP1/Obg family [General function prediction only];


Pssm-ID: 440701 [Multi-domain]  Cd Length: 330  Bit Score: 39.43  E-value: 2.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 126 KLKEVIAREPTllVMVVGVPNVGKSALINsihqiaaarfpvqeRLKRAT--VGPLPGVTQDI-AGFKIAHRPSIYVLDSP 202
Cdd:COG1084 152 KLPDIDPDLPT--IVVAGYPNVGKSSLVS--------------KVTSAKpeIASYPFTTKGIiVGHFERGHGRYQVIDTP 215


                ...
gi 30688739 203 GVL 205
Cdd:COG1084 216 GLL 218
EngA1 cd01894
EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first ...
 142-185 2.92e-03

EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206681 [Multi-domain]  Cd Length: 157  Bit Score: 37.80  E-value: 2.92e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 30688739 142 VGVPNVGKSALINSIhqiaaarfpVQERlkRATVGPLPGVTQDI 185
Cdd:cd01894   3 VGRPNVGKSTLFNRL---------TGRR--DAIVSDTPGVTRDR 35
era TIGR00436
GTP-binding protein Era; Era is an essential GTPase in Escherichia coli and many other ...
 139-203 3.28e-03

GTP-binding protein Era; Era is an essential GTPase in Escherichia coli and many other bacteria. It plays a role in ribosome biogenesis. Few bacteria lack this protein. [Protein synthesis, Other]


Pssm-ID: 129528 [Multi-domain]  Cd Length: 270  Bit Score: 38.91  E-value: 3.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30688739   139 VMVVGVPNVGKSALINSIHqiaaarfpvqeRLKRATVGPLPGVTQD-IAGFKIAHRPSIYVLDSPG 203
Cdd:TIGR00436   3 VAILGRPNVGKSTLLNQLH-----------GQKISITSPKAQTTRNrISGIHTTGASQIIFIDTPG 57
FeoB cd01879
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ...
 141-244 3.99e-03

Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 206667 [Multi-domain]  Cd Length: 159  Bit Score: 37.44  E-value: 3.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 141 VVGVPNVGKSALINsihqiaaarfpvqeRL--KRATVGPLPGVTQDIA-GFKIAHRPSIYVLDSPGV--LVPSIPDietg 215
Cdd:cd01879   2 LVGNPNVGKTTLFN--------------ALtgARQKVGNWPGVTVEKKeGEFKLGGKEIEIVDLPGTysLTPYSED---- 63

                        90       100       110
                ....*....|....*....|....*....|....*
gi 30688739 216 lklalsgsvkdsvvgeERIAQYFL------AILNI 244
Cdd:cd01879  64 ----------------EKVARDFLlgeepdLIVNV 82
YeeP COG3596
Predicted GTPase [General function prediction only];
119-204 4.02e-03

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 38.98  E-value: 4.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739 119 LLDLVELKLKEVIAREPTLLVMVVGVPNVGKSALINSIhqiaaarFpvqeRLKRATVGPLPGVTQDIAGFKI--AHRPSI 196
Cdd:COG3596  22 LRELLAEALERLLVELPPPVIALVGKTGAGKSSLINAL-------F----GAEVAEVGVGRPCTREIQRYRLesDGLPGL 90


                ....*...
gi 30688739 197 YVLDSPGV 204
Cdd:COG3596  91 VLLDTPGL 98
PRK09518 PRK09518
bifunctional cytidylate kinase/GTPase Der; Reviewed
 133-184 5.56e-03

bifunctional cytidylate kinase/GTPase Der; Reviewed


Pssm-ID: 236546 [Multi-domain]  Cd Length: 712  Bit Score: 39.01  E-value: 5.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 30688739  133 REPTLLVMVVGVPNVGKSALINSIhqiaaarfpvqerLKR--ATVGPLPGVTQD 184
Cdd:PRK09518 272 PKAVGVVAIVGRPNVGKSTLVNRI-------------LGRreAVVEDTPGVTRD 312
FeoB_N pfam02421
Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) ...
 139-244 8.38e-03

Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 460552 [Multi-domain]  Cd Length: 156  Bit Score: 36.66  E-value: 8.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688739   139 VMVVGVPNVGKSALINsihQIAAArfpvqerlkRATVGPLPGVTQDIA-GFKIAHRPSIYVLDSPGV--LVPSIPDietg 215
Cdd:pfam02421   3 IALVGNPNVGKTTLFN---ALTGA---------NQHVGNWPGVTVEKKeGKFKYKGYEIEIVDLPGIysLSPYSEE---- 66

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 30688739   216 lklalsgsvkdsvvgeERIAQYFL------AILNI 244
Cdd:pfam02421  67 ----------------ERVARDYLlnekpdVIVNV 85
trmE PRK05291
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;
38-110 8.58e-03

tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;


Pssm-ID: 235392 [Multi-domain]  Cd Length: 449  Bit Score: 38.17  E-value: 8.58e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30688739   38 RAiRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNkwtrhfESSKQDCIAINA 110
Cdd:PRK05291 287 RS-REAIEEADLVLLVLDASEPLTEEDDEILEELKDKPVIVVLNKADLTGEIDLE------EENGKPVIRISA 352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH