NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|42570377|ref|NP_850282|]
View 

Cystatin/monellin superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Atha_cystat_rel super family cl11766
Arabidopsis thaliana cystatin-related protein; This model represents a family similar in ...
 82-171 7.57e-10

Arabidopsis thaliana cystatin-related protein; This model represents a family similar in sequence and probably homologous to a large family of cysteine proteinase inhibitors, or cystatins, as described by pfam00031. Cystatins may help plants resist attack by insects.


The actual alignment was detected with superfamily member TIGR01638:

Pssm-ID: 130699  Cd Length: 92  Bit Score: 53.28  E-value: 7.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570377    82 DNELALEPETTREFMDRLCRKSLEHFNEIHSTKYEFVRFIKANHHVSAGMMYFITFEGKLLSNDDDSKQFQAKLCYCGGT 161
Cdd:TIGR01638   1 DWEAIRPIETNRDLLERLSYVASKKYNDTKFLNLELVEVVRANYRGGAKSKSYITFEARDKPDGPLGEYQQAAVVYLHRH 80

                          90
                  ....*....|
gi 42570377   162 PEIISCELKP 171
Cdd:TIGR01638  81 PIVCRPTPKP 90
 
Name Accession Description Interval E-value
Atha_cystat_rel TIGR01638
Arabidopsis thaliana cystatin-related protein; This model represents a family similar in ...
 82-171 7.57e-10

Arabidopsis thaliana cystatin-related protein; This model represents a family similar in sequence and probably homologous to a large family of cysteine proteinase inhibitors, or cystatins, as described by pfam00031. Cystatins may help plants resist attack by insects.


Pssm-ID: 130699  Cd Length: 92  Bit Score: 53.28  E-value: 7.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570377    82 DNELALEPETTREFMDRLCRKSLEHFNEIHSTKYEFVRFIKANHHVSAGMMYFITFEGKLLSNDDDSKQFQAKLCYCGGT 161
Cdd:TIGR01638   1 DWEAIRPIETNRDLLERLSYVASKKYNDTKFLNLELVEVVRANYRGGAKSKSYITFEARDKPDGPLGEYQQAAVVYLHRH 80

                          90
                  ....*....|
gi 42570377   162 PEIISCELKP 171
Cdd:TIGR01638  81 PIVCRPTPKP 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 70-138 4.90e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 40.49  E-value: 4.90e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42570377     70 RCVFNYRPVDLDDNELalepettrefmDRLCRKSLEHFNEIHSTKYEFVRF--IKANHHVSAGMMYFITFE 138
Cdd:smart00043   1 LCLGGPSDVPPNDPEV-----------QEAADFAVAEYNKKSNDKYELRVIkvVSAKSQVVAGTNYYLKVE 60
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 76-170 2.74e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 38.61  E-value: 2.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570377  76 RPVDLDDNELalepettrefmDRLCRKSLEHFNEIHS-TKYEFVRFIKANHHVSAGMMYFITFEGKLLSNDDDSKQFQAK 154
Cdd:cd00042   4 SDIPANDPEV-----------QELADFAVAEYNKKSNdKYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCP 72

                        90
                ....*....|....*.
gi 42570377 155 LCYCGGTPEIISCELK 170
Cdd:cd00042  73 DCKLLEEGKKKFCTAK 88
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 77-138 4.07e-04

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 37.70  E-value: 4.07e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42570377    77 PVDLDDNELALEpettrefmdRLCRKSLEHFNE-IHSTKYEFVRFIKANHHVSAGMMYFITFE 138
Cdd:pfam00031   3 LSPIPDNSPELQ---------EALDFALAEYNAkTDNYYFELVEVKRAKSQVVAGTNYFIKVE 56
 
Name Accession Description Interval E-value
Atha_cystat_rel TIGR01638
Arabidopsis thaliana cystatin-related protein; This model represents a family similar in ...
 82-171 7.57e-10

Arabidopsis thaliana cystatin-related protein; This model represents a family similar in sequence and probably homologous to a large family of cysteine proteinase inhibitors, or cystatins, as described by pfam00031. Cystatins may help plants resist attack by insects.


Pssm-ID: 130699  Cd Length: 92  Bit Score: 53.28  E-value: 7.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570377    82 DNELALEPETTREFMDRLCRKSLEHFNEIHSTKYEFVRFIKANHHVSAGMMYFITFEGKLLSNDDDSKQFQAKLCYCGGT 161
Cdd:TIGR01638   1 DWEAIRPIETNRDLLERLSYVASKKYNDTKFLNLELVEVVRANYRGGAKSKSYITFEARDKPDGPLGEYQQAAVVYLHRH 80

                          90
                  ....*....|
gi 42570377   162 PEIISCELKP 171
Cdd:TIGR01638  81 PIVCRPTPKP 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 70-138 4.90e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 40.49  E-value: 4.90e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42570377     70 RCVFNYRPVDLDDNELalepettrefmDRLCRKSLEHFNEIHSTKYEFVRF--IKANHHVSAGMMYFITFE 138
Cdd:smart00043   1 LCLGGPSDVPPNDPEV-----------QEAADFAVAEYNKKSNDKYELRVIkvVSAKSQVVAGTNYYLKVE 60
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 76-170 2.74e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 38.61  E-value: 2.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570377  76 RPVDLDDNELalepettrefmDRLCRKSLEHFNEIHS-TKYEFVRFIKANHHVSAGMMYFITFEGKLLSNDDDSKQFQAK 154
Cdd:cd00042   4 SDIPANDPEV-----------QELADFAVAEYNKKSNdKYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCP 72

                        90
                ....*....|....*.
gi 42570377 155 LCYCGGTPEIISCELK 170
Cdd:cd00042  73 DCKLLEEGKKKFCTAK 88
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 77-138 4.07e-04

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 37.70  E-value: 4.07e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42570377    77 PVDLDDNELALEpettrefmdRLCRKSLEHFNE-IHSTKYEFVRFIKANHHVSAGMMYFITFE 138
Cdd:pfam00031   3 LSPIPDNSPELQ---------EALDFALAEYNAkTDNYYFELVEVKRAKSQVVAGTNYFIKVE 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH