NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|30697360|ref|NP_849850|]
View 

AAR2 protein family [Arabidopsis thaliana]

Protein Classification

AAR2 splicing factor family protein( domain architecture ID 12062569)

AAR2 splicing factor family protein similar to human protein AAR2 homolog, a component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing

Gene Ontology:  GO:0000244|GO:0005682

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
AAR2 pfam05282
AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein ...
12-364 2.41e-132

AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth.


:

Pssm-ID: 461609 [Multi-domain]  Cd Length: 356  Bit Score: 383.57  E-value: 2.41e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360    12 HGATLLFLDVPQYTLVGIDTQIFAVGPAFKGIKMIPPGIHFVFYSSSTRDGrEFSPTIGFFVDVAPSQVIVRKWNQQDEW 91
Cdd:pfam05282   1 EGATLLLLDLPPGTEFGIDLKSFTVGPRFKGIKMIPPGVHFVYYSSVSKTG-EFSPRSGFFFYFKPGEVLVKKWDKETED 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360    92 L--TKVSEEEEERYSQAVRSLEFDKNLGPYNLKQYGEWRHLSNYITKDVVEKFEPVGGEITVTYESAILKGGPKTAmeia 169
Cdd:pfam05282  80 LvdEDLSEEEIERYKANLGLGELDGFLGPYPYDASEDWKSLTSHITPELLERILPISGRITSTAELTSSEDEPCTD---- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360   170 ldtQMKKSKFTTSSTEQPKGNR------------------FYYTSIPRIIKHK-GMSGQELTSMNLDKTQLLESVLSKEY 230
Cdd:pfam05282 156 ---EDGRRRWSKSSPEETSGSSakvdedllpglkpkegteIRFTPIPLKRTWPpGATGRERTKHSLDKSWALEDLLRKHY 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360   231 KDSEDLLLGELQFSFVAFLMGQSLESFMQWKSIVSLLLGCTSApFQTRSQLFTKFIKVIYHQLKYglqkensGPETgiha 310
Cdd:pfam05282 233 GGDEDELLGELQFAFVCFLLGQNYSSFEQWKRLLSLLCTCEEA-IGERPDLFVKFLRVLRHQLKE-------LPED---- 300
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 30697360   311 LLDDsWLASDSFLHFLCKDFFALVEETSVVD---GDLLSWTRKFKELLENRLGWEFQ 364
Cdd:pfam05282 301 FFVD-IVSGDNFLRKLLRDFFRNLEESSGVDeelGDLKKEAEKLKDLLKKKFGWDLD 356
 
Name Accession Description Interval E-value
AAR2 pfam05282
AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein ...
12-364 2.41e-132

AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth.


Pssm-ID: 461609 [Multi-domain]  Cd Length: 356  Bit Score: 383.57  E-value: 2.41e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360    12 HGATLLFLDVPQYTLVGIDTQIFAVGPAFKGIKMIPPGIHFVFYSSSTRDGrEFSPTIGFFVDVAPSQVIVRKWNQQDEW 91
Cdd:pfam05282   1 EGATLLLLDLPPGTEFGIDLKSFTVGPRFKGIKMIPPGVHFVYYSSVSKTG-EFSPRSGFFFYFKPGEVLVKKWDKETED 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360    92 L--TKVSEEEEERYSQAVRSLEFDKNLGPYNLKQYGEWRHLSNYITKDVVEKFEPVGGEITVTYESAILKGGPKTAmeia 169
Cdd:pfam05282  80 LvdEDLSEEEIERYKANLGLGELDGFLGPYPYDASEDWKSLTSHITPELLERILPISGRITSTAELTSSEDEPCTD---- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360   170 ldtQMKKSKFTTSSTEQPKGNR------------------FYYTSIPRIIKHK-GMSGQELTSMNLDKTQLLESVLSKEY 230
Cdd:pfam05282 156 ---EDGRRRWSKSSPEETSGSSakvdedllpglkpkegteIRFTPIPLKRTWPpGATGRERTKHSLDKSWALEDLLRKHY 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360   231 KDSEDLLLGELQFSFVAFLMGQSLESFMQWKSIVSLLLGCTSApFQTRSQLFTKFIKVIYHQLKYglqkensGPETgiha 310
Cdd:pfam05282 233 GGDEDELLGELQFAFVCFLLGQNYSSFEQWKRLLSLLCTCEEA-IGERPDLFVKFLRVLRHQLKE-------LPED---- 300
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 30697360   311 LLDDsWLASDSFLHFLCKDFFALVEETSVVD---GDLLSWTRKFKELLENRLGWEFQ 364
Cdd:pfam05282 301 FFVD-IVSGDNFLRKLLRDFFRNLEESSGVDeelGDLKKEAEKLKDLLKKKFGWDLD 356
Aar2_C cd13778
C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This ...
191-359 5.51e-46

C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This family consists of the C-terminal domain of eukaryotic Aar2 and Aar2-like proteins. Aar2 is a U5 small nuclear ribonucleoprotein (snRNP) particle assembly factor and part of Prp8, which forms a large complex containing U5 snRNA, Snu114, and seven Sm proteins (B, D1, D2, D3, E, F and G). Upon import of the complex into the nucleus, Aar2 phosphorylation leads to its release from Prp8 and replacement by Brr2p, thus playing an important role in Brr2p regulation and possibly safeguarding against non-specific RNA binding to Prp8. Aar2p binds directly with the RNaseH-like domain in the C-terminal region of Prp8p. In yeast, Aar2 protein is involved in splicing pre-mRNA of the a1 cistron and other genes important for cell growth.


Pssm-ID: 260100  Cd Length: 155  Bit Score: 155.15  E-value: 5.51e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360 191 RFYYTSIPRIIKHKGMSGQELTSMNLDKTQLLESVLSKEYKDSEDLLLGELQFSFVAFLMGQSLESFMQWKSIVSLLLGC 270
Cdd:cd13778   1 ELRFTFIPLKRTWPGATGRERTRHSLDKSWYLEEVLLKSYNGDERELLGELQFAFLLFLLLGNYSSFEQWKNLLELLCSS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360 271 TSAPfQTRSQLFTKFIKVIYHQLKYglqkensgpetgIHALLDDSWLASDSFLHFLCKDFFALVEEtSVVDGDLLSWTRK 350
Cdd:cd13778  81 AEAL-KKRPSLFLKFLKTLHAQLKY------------LPEDFFVDLLLNDNFLKRLLSELLENLGD-SEVDTPLKKAVKR 146

                ....*....
gi 30697360 351 FKELLENRL 359
Cdd:cd13778 147 LKRLLEEKF 155
 
Name Accession Description Interval E-value
AAR2 pfam05282
AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein ...
12-364 2.41e-132

AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth.


Pssm-ID: 461609 [Multi-domain]  Cd Length: 356  Bit Score: 383.57  E-value: 2.41e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360    12 HGATLLFLDVPQYTLVGIDTQIFAVGPAFKGIKMIPPGIHFVFYSSSTRDGrEFSPTIGFFVDVAPSQVIVRKWNQQDEW 91
Cdd:pfam05282   1 EGATLLLLDLPPGTEFGIDLKSFTVGPRFKGIKMIPPGVHFVYYSSVSKTG-EFSPRSGFFFYFKPGEVLVKKWDKETED 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360    92 L--TKVSEEEEERYSQAVRSLEFDKNLGPYNLKQYGEWRHLSNYITKDVVEKFEPVGGEITVTYESAILKGGPKTAmeia 169
Cdd:pfam05282  80 LvdEDLSEEEIERYKANLGLGELDGFLGPYPYDASEDWKSLTSHITPELLERILPISGRITSTAELTSSEDEPCTD---- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360   170 ldtQMKKSKFTTSSTEQPKGNR------------------FYYTSIPRIIKHK-GMSGQELTSMNLDKTQLLESVLSKEY 230
Cdd:pfam05282 156 ---EDGRRRWSKSSPEETSGSSakvdedllpglkpkegteIRFTPIPLKRTWPpGATGRERTKHSLDKSWALEDLLRKHY 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360   231 KDSEDLLLGELQFSFVAFLMGQSLESFMQWKSIVSLLLGCTSApFQTRSQLFTKFIKVIYHQLKYglqkensGPETgiha 310
Cdd:pfam05282 233 GGDEDELLGELQFAFVCFLLGQNYSSFEQWKRLLSLLCTCEEA-IGERPDLFVKFLRVLRHQLKE-------LPED---- 300
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 30697360   311 LLDDsWLASDSFLHFLCKDFFALVEETSVVD---GDLLSWTRKFKELLENRLGWEFQ 364
Cdd:pfam05282 301 FFVD-IVSGDNFLRKLLRDFFRNLEESSGVDeelGDLKKEAEKLKDLLKKKFGWDLD 356
Aar2_C cd13778
C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This ...
191-359 5.51e-46

C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This family consists of the C-terminal domain of eukaryotic Aar2 and Aar2-like proteins. Aar2 is a U5 small nuclear ribonucleoprotein (snRNP) particle assembly factor and part of Prp8, which forms a large complex containing U5 snRNA, Snu114, and seven Sm proteins (B, D1, D2, D3, E, F and G). Upon import of the complex into the nucleus, Aar2 phosphorylation leads to its release from Prp8 and replacement by Brr2p, thus playing an important role in Brr2p regulation and possibly safeguarding against non-specific RNA binding to Prp8. Aar2p binds directly with the RNaseH-like domain in the C-terminal region of Prp8p. In yeast, Aar2 protein is involved in splicing pre-mRNA of the a1 cistron and other genes important for cell growth.


Pssm-ID: 260100  Cd Length: 155  Bit Score: 155.15  E-value: 5.51e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360 191 RFYYTSIPRIIKHKGMSGQELTSMNLDKTQLLESVLSKEYKDSEDLLLGELQFSFVAFLMGQSLESFMQWKSIVSLLLGC 270
Cdd:cd13778   1 ELRFTFIPLKRTWPGATGRERTRHSLDKSWYLEEVLLKSYNGDERELLGELQFAFLLFLLLGNYSSFEQWKNLLELLCSS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360 271 TSAPfQTRSQLFTKFIKVIYHQLKYglqkensgpetgIHALLDDSWLASDSFLHFLCKDFFALVEEtSVVDGDLLSWTRK 350
Cdd:cd13778  81 AEAL-KKRPSLFLKFLKTLHAQLKY------------LPEDFFVDLLLNDNFLKRLLSELLENLGD-SEVDTPLKKAVKR 146

                ....*....
gi 30697360 351 FKELLENRL 359
Cdd:cd13778 147 LKRLLEEKF 155
Aar2_N cd13777
N-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This ...
14-142 1.12e-42

N-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This family consists of the N-terminal domain of eukaryotic Aar2 and Aar2-like proteins. Aar2 is a U5 small nuclear ribonucleoprotein (snRNP) particle assembly factor and part of Prp8, which forms a large complex containing U5 snRNA, Snu114, and seven Sm proteins (B, D1, D2, D3, E, F and G). Upon import of the complex into the nucleus, Aar2 phosphorylation leads to its release from Prp8 and replacement by Brr2p, thus playing an important role in Brr2p regulation and possibly safeguarding against non-specific RNA binding to Prp8. Aar2p binds directly with the RNaseH-like domain in the C-terminal region of Prp8p. In yeast, Aar2 protein is involved in splicing pre-mRNA of the a1 cistron and other genes important for cell growth.


Pssm-ID: 260099  Cd Length: 126  Bit Score: 145.51  E-value: 1.12e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30697360  14 ATLLFLDVPQYTLVGIDTQIFAVGPAFKGIKMIPPGIHFVFYSSStrDGREFSPTIGFFVDVAPSQVIVRKWNQQDEWLt 93
Cdd:cd13777   1 ATLLLLDLPEGTEFGIDLQSFTVGPRFKGIKMIPPGIHFIHYSSD--SSEGSSPRYGFFFNFKPGEVIVRKWDPEFEDL- 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 30697360  94 kVSEEEEERYSQAVRSLEF-DKNLGPYNLKQYGEWRHLSNYITKDVVEKF 142
Cdd:cd13777  78 -VEEPDSDEELERLRANLKeDQYLGPYPYEDSKDWKSLTSYITEEVLSRL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure