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Conserved domains on  [gi|30684518|ref|NP_849672|]
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Transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

LisH and CTLH domain-containing protein( domain architecture ID 13922873)

protein containing domains LisH, CTLH, and WD40

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 359-667 1.92e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 136.70  E-value: 1.92e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  359 MSMDFHPIKQTLLlvgtnvgdiglweVGSRerlvQKTFKVWDLSKCSMPLQaalVKEPVVSVNRVIWSPDGSLFGVAYSR 438
Cdd:cd00200   13 TCVAFSPDGKLLA-------------TGSG----DGTIKVWDLETGELLRT---LKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  439 HIVQLYSYHGGEDMRqhlEIDAHVGGVNDISFStPNKQLcVITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVCPHykE 518
Cdd:cd00200   73 KTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--P 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  519 NIQFIFSTALDGKIKAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLFSCGTskDGESFIveWNESEGAVKRTYQGfHKR 598
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-HEN 220

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  599 SLGVVQFDTTKNRYLAAGDDFSIKFWDMDAVQLLTAIDG-DGGLQAsprIRFNKEGSLLAVSGNENVIKI 667
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTS---LAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
453-950 3.02e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 3.02e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  453 RQHLEIDAHVGGVNDISFSTPNKQLcvITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVcpHYKENIQFIFSTALDGKI 532
Cdd:COG2319   27 ALLLLLLGLAAAVASLAASPDGARL--AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV--AFSPDGRLLASASADGTV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  533 KAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLFScgTSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRY 612
Cdd:COG2319  103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS--GSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  613 LAAGDDFSIKFWDMDAVQLLTAIDGDGGLQASprIRFNKEGSLLAVSGNENVIKImANSDGLRLLHTFEnissesskpai 692
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPDGKLLASGSADGTVRL-WDLATGKLLRTLT----------- 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  693 nsiaaaaaaaatsaGHADRsanvvsiqgmngdsrnmvdvkpviteesndkskiwkltevsepsqcrslrlpenlrvakIS 772
Cdd:COG2319  244 --------------GHSGS-----------------------------------------------------------VR 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  773 RLIFTNSGNaILALAS--NAIHLlwkWQRnernATGKATASLppqqwqpasgilmtndvaeTNPEEAVPCFALSKNDSYV 850
Cdd:COG2319  251 SVAFSPDGR-LLASGSadGTVRL---WDL----ATGELLRTL-------------------TGHSGGVNSVAFSPDGKLL 303

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  851 MSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSN 929
Cdd:COG2319  304 ASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                        490       500
                 ....*....|....*....|.
gi 30684518  930 VLNVLVSSGADAQLCVWNTDG 950
Cdd:COG2319  383 DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
817-1094 7.33e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.27  E-value: 7.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  817 WQPASGILMTNDVAETNPeeaVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIG 895
Cdd:COG2319  105 WDLATGLLLRTLTGHTGA---VRSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASG 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  896 MDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQRskVLPLPQGRPNSapsdtrV 975
Cdd:COG2319  181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR--TLTGHSGSVRS------V 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  976 QFHQDQAHFLVVHETQ-LAIYETTKLECMKQWAVRESlaPITHATFSCDSQLVYASFMDATVCVFSSANLRLRcrvnpsa 1054
Cdd:COG2319  253 AFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL------- 323

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 30684518 1055 ylpASLSNSNVHPLVIAAHPQEpNMFAVGLSDGGVHIFEP 1094
Cdd:COG2319  324 ---RTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDL 359
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 1.44e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 71.83  E-value: 1.44e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 30684518      34 FFFNMKYFEDEVHNGNWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDKHDRPK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.33e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


:

Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.33e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 30684518       4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 206-300 3.14e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518   206 PPNGARAPSPVNNPLLGGIPKAGGFPPLGAHGPfQPTASPVPTPLAGWMSSPSS---VPHPAVSAGAIALGGPSIPAALK 282
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASP-ALPAAPAPPAVPAGPATPGGparPARPPTTAGPPAPAPPAAPAAGP 2779

                          90
                  ....*....|....*...
gi 30684518   283 HPRTPPTNASLDYPSADS 300
Cdd:PHA03247 2780 PRRLTRPAVASLSESRES 2797
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 359-667 1.92e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.70  E-value: 1.92e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  359 MSMDFHPIKQTLLlvgtnvgdiglweVGSRerlvQKTFKVWDLSKCSMPLQaalVKEPVVSVNRVIWSPDGSLFGVAYSR 438
Cdd:cd00200   13 TCVAFSPDGKLLA-------------TGSG----DGTIKVWDLETGELLRT---LKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  439 HIVQLYSYHGGEDMRqhlEIDAHVGGVNDISFStPNKQLcVITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVCPHykE 518
Cdd:cd00200   73 KTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--P 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  519 NIQFIFSTALDGKIKAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLFSCGTskDGESFIveWNESEGAVKRTYQGfHKR 598
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-HEN 220

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  599 SLGVVQFDTTKNRYLAAGDDFSIKFWDMDAVQLLTAIDG-DGGLQAsprIRFNKEGSLLAVSGNENVIKI 667
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTS---LAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
340-667 8.18e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 8.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  340 APDDLPKTVARTLSQGSSPMSMDFHPIKQTLLLVGTNvGDIGLWEVGSRERLVQ-------------------------- 393
Cdd:COG2319   63 LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD-GTVRLWDLATGLLLRTltghtgavrsvafspdgktlasgsad 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  394 KTFKVWDLSKcsmPLQAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRqhlEIDAHVGGVNDISFStP 473
Cdd:COG2319  142 GTVRLWDLAT---GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---TLTGHTGAVRSVAFS-P 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  474 NKQLcVITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYDAPGR 551
Cdd:COG2319  215 DGKL-LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfsP----DGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  552 WCTTMAYSADGTRLFScgTSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRYLAAGDDFSIKFWDMDAVQL 631
Cdd:COG2319  290 GVNSVAFSPDGKLLAS--GSDDGT--VRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 30684518  632 LTAIDG-DGGLQAsprIRFNKEGSLLAVSGNENVIKI 667
Cdd:COG2319  365 LRTLTGhTGAVTS---VAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
453-950 3.02e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 3.02e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  453 RQHLEIDAHVGGVNDISFSTPNKQLcvITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVcpHYKENIQFIFSTALDGKI 532
Cdd:COG2319   27 ALLLLLLGLAAAVASLAASPDGARL--AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV--AFSPDGRLLASASADGTV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  533 KAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLFScgTSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRY 612
Cdd:COG2319  103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS--GSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  613 LAAGDDFSIKFWDMDAVQLLTAIDGDGGLQASprIRFNKEGSLLAVSGNENVIKImANSDGLRLLHTFEnissesskpai 692
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPDGKLLASGSADGTVRL-WDLATGKLLRTLT----------- 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  693 nsiaaaaaaaatsaGHADRsanvvsiqgmngdsrnmvdvkpviteesndkskiwkltevsepsqcrslrlpenlrvakIS 772
Cdd:COG2319  244 --------------GHSGS-----------------------------------------------------------VR 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  773 RLIFTNSGNaILALAS--NAIHLlwkWQRnernATGKATASLppqqwqpasgilmtndvaeTNPEEAVPCFALSKNDSYV 850
Cdd:COG2319  251 SVAFSPDGR-LLASGSadGTVRL---WDL----ATGELLRTL-------------------TGHSGGVNSVAFSPDGKLL 303

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  851 MSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSN 929
Cdd:COG2319  304 ASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                        490       500
                 ....*....|....*....|.
gi 30684518  930 VLNVLVSSGADAQLCVWNTDG 950
Cdd:COG2319  383 DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
817-1094 7.33e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.27  E-value: 7.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  817 WQPASGILMTNDVAETNPeeaVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIG 895
Cdd:COG2319  105 WDLATGLLLRTLTGHTGA---VRSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASG 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  896 MDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQRskVLPLPQGRPNSapsdtrV 975
Cdd:COG2319  181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR--TLTGHSGSVRS------V 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  976 QFHQDQAHFLVVHETQ-LAIYETTKLECMKQWAVRESlaPITHATFSCDSQLVYASFMDATVCVFSSANLRLRcrvnpsa 1054
Cdd:COG2319  253 AFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL------- 323

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 30684518 1055 ylpASLSNSNVHPLVIAAHPQEpNMFAVGLSDGGVHIFEP 1094
Cdd:COG2319  324 ---RTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDL 359
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 1.44e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 71.83  E-value: 1.44e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 30684518      34 FFFNMKYFEDEVHNGNWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDKHDRPK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 838-1040 3.92e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 3.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  838 VPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLK 916
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGECVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  917 GHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDgwEKQRSKVLPLPQGRPNSapsdtrVQFHQDQaHFLVV--HETQLAI 994
Cdd:cd00200   91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNS------VAFSPDG-TFVASssQDGTIKL 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 30684518  995 YETTKLECMKQWAVRESlaPITHATFSCDSQLVYASFMDATVCVFS 1040
Cdd:cd00200  162 WDLRTGKCVATLTGHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 880-1101 1.60e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 1.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  880 TFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQRskVL 959
Cdd:cd00200   13 TCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR--TL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  960 PLPQGRPNSapsdtrVQFHQDQaHFLVV--HETQLAIYETTKLECMKqwAVRESLAPITHATFSCDSQLVYASFMDATVC 1037
Cdd:cd00200   90 TGHTSYVSS------VAFSPDG-RILSSssRDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30684518 1038 VFSSANLRLRcrvnpsaylpASLS--NSNVHplVIAAHPQEPNMFAVGlSDGGVHIFEPleSEGKW 1101
Cdd:cd00200  161 LWDLRTGKCV----------ATLTghTGEVN--SVAFSPDGEKLLSSS-SDGTIKLWDL--STGKC 211
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.33e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.33e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 30684518       4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 910-947 2.55e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 2.55e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 30684518     910 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 947
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PHA03247 PHA03247
large tegument protein UL36; Provisional
 206-300 3.14e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518   206 PPNGARAPSPVNNPLLGGIPKAGGFPPLGAHGPfQPTASPVPTPLAGWMSSPSS---VPHPAVSAGAIALGGPSIPAALK 282
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASP-ALPAAPAPPAVPAGPATPGGparPARPPTTAGPPAPAPPAAPAAGP 2779

                          90
                  ....*....|....*...
gi 30684518   283 HPRTPPTNASLDYPSADS 300
Cdd:PHA03247 2780 PRRLTRPAVASLSESRES 2797
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 451-492 3.63e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 3.63e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 30684518     451 DMRQHLEIDAHVGGVNDISFSTPNKQLcvITCGDDKTIKVWD 492
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYL--ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
457-492 9.35e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 9.35e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 30684518    457 EIDAHVGGVNDISFStPNKQLcVITCGDDKTIKVWD 492
Cdd:pfam00400    6 TLEGHTGSVTSLAFS-PDGKL-LASGSDDGTVKVWD 39
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 5-33 2.56e-04

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 39.30  E-value: 2.56e-04
                           10        20
                   ....*....|....*....|....*....
gi 30684518      5 SRELVFLILQFLDEEKFKETVHKLEQESG 33
Cdd:pfam17814    1 SQDVVRLILQFLKENGLHRTLQALQTESG 29
WD40 pfam00400
WD domain, G-beta repeat;
910-947 3.01e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 30684518    910 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 947
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 882-960 7.09e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 7.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518   882 LAFHPQDNNIIAIGMDDSTIQIYNVR-----VDEVKSK---LKGHSKRITGLAFsNVLN--VLVSSGADAQLCVWNTDGW 951
Cdd:PTZ00420   80 LQFNPCFSEILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDW-NPMNyyIMCSSGFDSFVNIWDIENE 158


                  ....*....
gi 30684518   952 EKQRSKVLP 960
Cdd:PTZ00420  159 KRAFQINMP 167
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 359-667 1.92e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.70  E-value: 1.92e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  359 MSMDFHPIKQTLLlvgtnvgdiglweVGSRerlvQKTFKVWDLSKCSMPLQaalVKEPVVSVNRVIWSPDGSLFGVAYSR 438
Cdd:cd00200   13 TCVAFSPDGKLLA-------------TGSG----DGTIKVWDLETGELLRT---LKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  439 HIVQLYSYHGGEDMRqhlEIDAHVGGVNDISFStPNKQLcVITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVCPHykE 518
Cdd:cd00200   73 KTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--P 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  519 NIQFIFSTALDGKIKAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLFSCGTskDGESFIveWNESEGAVKRTYQGfHKR 598
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-HEN 220

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  599 SLGVVQFDTTKNRYLAAGDDFSIKFWDMDAVQLLTAIDG-DGGLQAsprIRFNKEGSLLAVSGNENVIKI 667
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTS---LAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
340-667 8.18e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 8.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  340 APDDLPKTVARTLSQGSSPMSMDFHPIKQTLLLVGTNvGDIGLWEVGSRERLVQ-------------------------- 393
Cdd:COG2319   63 LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD-GTVRLWDLATGLLLRTltghtgavrsvafspdgktlasgsad 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  394 KTFKVWDLSKcsmPLQAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRqhlEIDAHVGGVNDISFStP 473
Cdd:COG2319  142 GTVRLWDLAT---GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---TLTGHTGAVRSVAFS-P 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  474 NKQLcVITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYDAPGR 551
Cdd:COG2319  215 DGKL-LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfsP----DGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  552 WCTTMAYSADGTRLFScgTSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRYLAAGDDFSIKFWDMDAVQL 631
Cdd:COG2319  290 GVNSVAFSPDGKLLAS--GSDDGT--VRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 30684518  632 LTAIDG-DGGLQAsprIRFNKEGSLLAVSGNENVIKI 667
Cdd:COG2319  365 LRTLTGhTGAVTS---VAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 419-667 3.82e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.29  E-value: 3.82e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  419 SVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRQhLEidAHVGGVNDISFSTPNKQLcvITCGDDKTIKVWDAATGVK 498
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LK--GHTGPVRDVAASADGTYL--ASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  499 RHTFEGHEAPVYSVcpHYKENIQFIFSTALDGKIKAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLFSCgtSKDGESFI 578
Cdd:cd00200   86 VRTLTGHTSYVSSV--AFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS--SQDGTIKL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  579 veWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRYLAAGDDFSIKFWDMDAVQLLTAIDGDggLQASPRIRFNKEGSLLAV 658
Cdd:cd00200  162 --WDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVAFSPDGYLLAS 236


                 ....*....
gi 30684518  659 SGNENVIKI 667
Cdd:cd00200  237 GSEDGTIRV 245
WD40 COG2319
WD40 repeat [General function prediction only];
409-681 5.48e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 5.48e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  409 QAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRQhleIDAHVGGVNDISFStPNKQLcVITCGDDKTI 488
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT---LTGHTGAVRSVAFS-PDGKT-LASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  489 KVWDAATGVKRHTFEGHEAPVYSVC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLF 566
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTSVAfsP----DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  567 SCgtSKDGEsfIVEWNESEGAVKRTYQGFHKRSLGVVqFdTTKNRYLA-AGDDFSIKFWDMDAVQLLTAIDGDGGLQASp 645
Cdd:COG2319  221 SG--SADGT--VRLWDLATGKLLRTLTGHSGSVRSVA-F-SPDGRLLAsGSADGTVRLWDLATGELLRTLTGHSGGVNS- 293

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 30684518  646 rIRFNKEGSLLAVSGNENVIKIMANSDGlRLLHTFE 681
Cdd:COG2319  294 -VAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
345-627 8.17e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.32  E-value: 8.17e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  345 PKTVARTLSQGSSPMSMDFHPiKQTLLLVGTNVGDIGLWEVGSRERLVQ--------------------------KTFKV 398
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTltghsgavtsvafspdgkllasgsddGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  399 WDLSkcSMPLQAALvKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRqhlEIDAHVGGVNDISFStPNKQLc 478
Cdd:COG2319  189 WDLA--TGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFS-PDGRL- 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  479 VITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYDAPGRWCTTM 556
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAfsP----DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30684518  557 AYSADGTRLFSCgtSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRYLAAGDDFSIKFWDMD 627
Cdd:COG2319  337 AFSPDGKTLASG--SDDGT--VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
453-950 3.02e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 3.02e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  453 RQHLEIDAHVGGVNDISFSTPNKQLcvITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVcpHYKENIQFIFSTALDGKI 532
Cdd:COG2319   27 ALLLLLLGLAAAVASLAASPDGARL--AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV--AFSPDGRLLASASADGTV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  533 KAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLFScgTSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRY 612
Cdd:COG2319  103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS--GSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  613 LAAGDDFSIKFWDMDAVQLLTAIDGDGGLQASprIRFNKEGSLLAVSGNENVIKImANSDGLRLLHTFEnissesskpai 692
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPDGKLLASGSADGTVRL-WDLATGKLLRTLT----------- 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  693 nsiaaaaaaaatsaGHADRsanvvsiqgmngdsrnmvdvkpviteesndkskiwkltevsepsqcrslrlpenlrvakIS 772
Cdd:COG2319  244 --------------GHSGS-----------------------------------------------------------VR 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  773 RLIFTNSGNaILALAS--NAIHLlwkWQRnernATGKATASLppqqwqpasgilmtndvaeTNPEEAVPCFALSKNDSYV 850
Cdd:COG2319  251 SVAFSPDGR-LLASGSadGTVRL---WDL----ATGELLRTL-------------------TGHSGGVNSVAFSPDGKLL 303

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  851 MSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSN 929
Cdd:COG2319  304 ASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                        490       500
                 ....*....|....*....|.
gi 30684518  930 VLNVLVSSGADAQLCVWNTDG 950
Cdd:COG2319  383 DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 455-715 3.89e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.87  E-value: 3.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  455 HLEIDAHVGGVNDISFSTPNKQLCviTCGDDKTIKVWDAATGVKRHTFEGHEAPVYSV--CPHYkeniQFIFSTALDGKI 532
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLA--TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaaSADG----TYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  533 KAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLFSCGTSKDgesfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRY 612
Cdd:cd00200   76 RLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT----IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  613 LAAGDDFSIKFWDMDAVQLLTAIDG-DGGLQAsprIRFNKEGSLLAVSGNENVIKIMaNSDGLRLLHTFenissESSKPA 691
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGhTGEVNS---VAFSPDGEKLLSSSSDGTIKLW-DLSTGKCLGTL-----RGHENG 221

                        250       260
                 ....*....|....*....|....
gi 30684518  692 INSIAAAAAAAATSAGHADRSANV 715
Cdd:cd00200  222 VNSVAFSPDGYLLASGSEDGTIRV 245
WD40 COG2319
WD40 repeat [General function prediction only];
407-952 4.26e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 4.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  407 PLQAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRQHLeidAHVGGVNDISFSTPNKQLcvITCGDDK 486
Cdd:COG2319   26 GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL---GHTAAVLSVAFSPDGRLL--ASASADG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  487 TIKVWDAATGVKRHTFEGHEAPVYSVcphykeniqfifstaldgkikawlydnmgsrvdydapgrwcttmAYSADGTRLF 566
Cdd:COG2319  101 TVRLWDLATGLLLRTLTGHTGAVRSV--------------------------------------------AFSPDGKTLA 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  567 ScgTSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRYLAAGDDFSIKFWDMDAVQLLTAIDGDGGLQASpr 646
Cdd:COG2319  137 S--GSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS-- 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  647 IRFNKEGSLLAVSGNENVIKImansdglrllhtfenissesskpainsiaaaaaaaatsaghadrsanvvsiqgmngdsr 726
Cdd:COG2319  210 VAFSPDGKLLASGSADGTVRL----------------------------------------------------------- 230

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  727 nmvdvkpviteesndkskiWKLtevsepsqcrslrlpenlrvakisrliftnsgnailalasnaihllwkwqrnernATG 806
Cdd:COG2319  231 -------------------WDL-------------------------------------------------------ATG 236

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  807 KATASLPPQQWqpasgilmtndvaetnpeeAVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFH 885
Cdd:COG2319  237 KLLRTLTGHSG-------------------SVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30684518  886 PqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWE 952
Cdd:COG2319  298 P-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 499-947 5.51e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 5.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  499 RHTFEGHEAPVYSVCPHYKENiqFIFSTALDGKIKAWLYDNMG---SRVDYDAPGRWCttmAYSADGTRLFSCGTSKdge 575
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLETGEllrTLKGHTGPVRDV---AASADGTYLASGSSDK--- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  576 sFIVEWNESEGAVKRTYQGfHKRSLGVVQFdTTKNRYLAA-GDDFSIKFWDMDAVQLLTAIDG-DGGLQAsprIRFNKEG 653
Cdd:cd00200   74 -TIRLWDLETGECVRTLTG-HTSYVSSVAF-SPDGRILSSsSRDKTIKVWDVETGKCLTTLRGhTDWVNS---VAFSPDG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  654 SLLAVSGNENVIKImANSDGLRLLHTFEnissesskpainsiaaaaaaaatsaGHADRsanvvsiqgmngdsrnmvdvkp 733
Cdd:cd00200  148 TFVASSSQDGTIKL-WDLRTGKCVATLT-------------------------GHTGE---------------------- 179

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  734 viteesndkskiwkltevsepsqcrslrlpenlrvakISRLIFTNSGNAILAlasnaihllwkwqrnernatgkataslp 813
Cdd:cd00200  180 -------------------------------------VNSVAFSPDGEKLLS---------------------------- 194

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  814 pqqwqpasgilmtndvaetnpeeavpcfalskndsyvmSASGGKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIA 893
Cdd:cd00200  195 --------------------------------------SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLA 235

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 30684518  894 IGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 947
Cdd:cd00200  236 SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
817-1094 7.33e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.27  E-value: 7.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  817 WQPASGILMTNDVAETNPeeaVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIG 895
Cdd:COG2319  105 WDLATGLLLRTLTGHTGA---VRSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASG 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  896 MDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQRskVLPLPQGRPNSapsdtrV 975
Cdd:COG2319  181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR--TLTGHSGSVRS------V 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  976 QFHQDQAHFLVVHETQ-LAIYETTKLECMKQWAVRESlaPITHATFSCDSQLVYASFMDATVCVFSSANLRLRcrvnpsa 1054
Cdd:COG2319  253 AFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL------- 323

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 30684518 1055 ylpASLSNSNVHPLVIAAHPQEpNMFAVGLSDGGVHIFEP 1094
Cdd:COG2319  324 ---RTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
834-1046 2.03e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 2.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  834 PEEAVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVK 912
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  913 SKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQRskVLPLPQGRPNSapsdtrVQFHQDQAHFLVVHETQ- 991
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR--TLTGHSGGVNS------VAFSPDGKLLASGSDDGt 311

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 30684518  992 LAIYETTKLECMKQWavRESLAPITHATFSCDSQLVYASFMDATVCVFSSANLRL 1046
Cdd:COG2319  312 VRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 COG2319
WD40 repeat [General function prediction only];
521-1038 1.28e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 1.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  521 QFIFSTALDGKIKAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLFSCGTSKDgesfIVEWNESEGAVKRTYQGfHKRSL 600
Cdd:COG2319    7 AALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLT----LLLLDAAAGALLATLLG-HTAAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  601 GVVQFDTTKNRYLAAGDDFSIKFWDMDAVQLLTAIDGDGGlqASPRIRFNKEGSLLAVSGNENVIKIMANSDGlRLLHTF 680
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG--AVRSVAFSPDGKTLASGSADGTVRLWDLATG-KLLRTL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  681 EnissesskpainsiaaaaaaaatsaGHADRsanvvsiqgmngdsrnmvdvkpviteesndkskiwkltevsepsqcrsl 760
Cdd:COG2319  159 T-------------------------GHSGA------------------------------------------------- 164

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  761 rlpenlrvakISRLIFTNSGNaILALAS--NAIHLlWKWqrnernATGKATASLppqqwqpasgilmtndvaeTNPEEAV 838
Cdd:COG2319  165 ----------VTSVAFSPDGK-LLASGSddGTVRL-WDL------ATGKLLRTL-------------------TGHTGAV 207

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  839 PCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKG 917
Cdd:COG2319  208 RSVAFSPDGKLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  918 HSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQRSkvLPLPQGRPNSapsdtrVQFHQDQAHFLVVHETQ-LAIYE 996
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT--LTGHTGAVRS------VAFSPDGKTLASGSDDGtVRLWD 358

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 30684518  997 TTKLECMKQWAVREslAPITHATFSCDSQLVYASFMDATVCV 1038
Cdd:COG2319  359 LATGELLRTLTGHT--GAVTSVAFSPDGRTLASGSADGTVRL 398
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 1.44e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 71.83  E-value: 1.44e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 30684518      34 FFFNMKYFEDEVHNGNWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDKHDRPK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 838-1040 3.92e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 3.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  838 VPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLK 916
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGECVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  917 GHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDgwEKQRSKVLPLPQGRPNSapsdtrVQFHQDQaHFLVV--HETQLAI 994
Cdd:cd00200   91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNS------VAFSPDG-TFVASssQDGTIKL 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 30684518  995 YETTKLECMKQWAVRESlaPITHATFSCDSQLVYASFMDATVCVFS 1040
Cdd:cd00200  162 WDLRTGKCVATLTGHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 769-1040 7.36e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 7.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  769 AKISRLIFTNSGNAILALASNAIHLLWKWQRNERNATGK------ATASLPPQQWQPASG---------ILMTNDVAET- 832
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghtgpvRDVAASADGTYLASGssdktirlwDLETGECVRTl 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  833 -NPEEAVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDE 910
Cdd:cd00200   90 tGHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  911 VKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKqrSKVLPLPQGRPNSapsdtrVQFHQDQAHFLVVHET 990
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC--LGTLRGHENGVNS------VAFSPDGYLLASGSED 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 30684518  991 Q-LAIYETTKLECMKQwaVRESLAPITHATFSCDSQLVYASFMDATVCVFS 1040
Cdd:cd00200  241 GtIRVWDLRTGECVQT--LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 880-1101 1.60e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 1.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  880 TFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQRskVL 959
Cdd:cd00200   13 TCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR--TL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  960 PLPQGRPNSapsdtrVQFHQDQaHFLVV--HETQLAIYETTKLECMKqwAVRESLAPITHATFSCDSQLVYASFMDATVC 1037
Cdd:cd00200   90 TGHTSYVSS------VAFSPDG-RILSSssRDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30684518 1038 VFSSANLRLRcrvnpsaylpASLS--NSNVHplVIAAHPQEPNMFAVGlSDGGVHIFEPleSEGKW 1101
Cdd:cd00200  161 LWDLRTGKCV----------ATLTghTGEVN--SVAFSPDGEKLLSSS-SDGTIKLWDL--STGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
784-1094 9.55e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 9.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  784 LALASNAIHLLWKWQRNERNATGKATASLPPQQWQPASGILMTNDVAETNPEEAVPCFALSKNDSYVMSASG-GKISLFN 862
Cdd:COG2319   27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAdGTVRLWD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  863 MMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQ 942
Cdd:COG2319  107 LATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  943 LCVWNTDGWEKQRskVLPLPQGRPNSapsdtrVQFHQDQaHFLVV--HETQLAIYETTKLECMKQWAVRESlaPITHATF 1020
Cdd:COG2319  186 VRLWDLATGKLLR--TLTGHTGAVRS------VAFSPDG-KLLASgsADGTVRLWDLATGKLLRTLTGHSG--SVRSVAF 254

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30684518 1021 SCDSQLVYASFMDATVCVFSSANLRLRcrvnpsaylpASLSNSNVHPLVIAAHPQEpNMFAVGLSDGGVHIFEP 1094
Cdd:COG2319  255 SPDGRLLASGSADGTVRLWDLATGELL----------RTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 915-1040 1.37e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518  915 LKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQRSKVLPlpqgrpnsAPSDTRVQFHQDQAHFLVVHE-TQLA 993
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH--------TGPVRDVAASADGTYLASGSSdKTIR 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 30684518  994 IYETTKLECMKQWAVRESlaPITHATFSCDSQLVYASFMDATVCVFS 1040
Cdd:cd00200   77 LWDLETGECVRTLTGHTS--YVSSVAFSPDGRILSSSSRDKTIKVWD 121
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.33e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.33e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 30684518       4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 910-947 2.55e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 2.55e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 30684518     910 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 947
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PHA03247 PHA03247
large tegument protein UL36; Provisional
 206-300 3.14e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518   206 PPNGARAPSPVNNPLLGGIPKAGGFPPLGAHGPfQPTASPVPTPLAGWMSSPSS---VPHPAVSAGAIALGGPSIPAALK 282
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASP-ALPAAPAPPAVPAGPATPGGparPARPPTTAGPPAPAPPAAPAAGP 2779

                          90
                  ....*....|....*...
gi 30684518   283 HPRTPPTNASLDYPSADS 300
Cdd:PHA03247 2780 PRRLTRPAVASLSESRES 2797
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 451-492 3.63e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 3.63e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 30684518     451 DMRQHLEIDAHVGGVNDISFSTPNKQLcvITCGDDKTIKVWD 492
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYL--ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
457-492 9.35e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 9.35e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 30684518    457 EIDAHVGGVNDISFStPNKQLcVITCGDDKTIKVWD 492
Cdd:pfam00400    6 TLEGHTGSVTSLAFS-PDGKL-LASGSDDGTVKVWD 39
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 5-33 2.56e-04

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 39.30  E-value: 2.56e-04
                           10        20
                   ....*....|....*....|....*....
gi 30684518      5 SRELVFLILQFLDEEKFKETVHKLEQESG 33
Cdd:pfam17814    1 SQDVVRLILQFLKENGLHRTLQALQTESG 29
WD40 pfam00400
WD domain, G-beta repeat;
910-947 3.01e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 30684518    910 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 947
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 882-960 7.09e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 7.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684518   882 LAFHPQDNNIIAIGMDDSTIQIYNVR-----VDEVKSK---LKGHSKRITGLAFsNVLN--VLVSSGADAQLCVWNTDGW 951
Cdd:PTZ00420   80 LQFNPCFSEILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDW-NPMNyyIMCSSGFDSFVNIWDIENE 158


                  ....*....
gi 30684518   952 EKQRSKVLP 960
Cdd:PTZ00420  159 KRAFQINMP 167
WD40 pfam00400
WD domain, G-beta repeat;
496-535 1.48e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.48e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30684518    496 GVKRHTFEGHEAPVYSVCPHYKENiqFIFSTALDGKIKAW 535
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 495-535 1.85e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.85e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 30684518     495 TGVKRHTFEGHEAPVYSVCPHykENIQFIFSTALDGKIKAW 535
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFS--PDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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