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Conserved domains on  [gi|42570183|ref|NP_849567|]
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HECT ubiquitin protein ligase family protein KAK [Arabidopsis thaliana]

Protein Classification

HECTc domain-containing protein( domain architecture ID 13416457)

HECTc domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
1471-1883 8.54e-125

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 396.55  E-value: 8.54e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1471 QKVRVSRNRILDSAAKVMEMYSSQ--KAVLEVEYFGEVGTG-LGPTLEFYTLLSHDLQKASLGMWRSSSGDKVsmqigrd 1547
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSdlKKVLEVEFVGEEGIDaGGVTREFFTLVSKELFNPSYGLFRYTPDDSG------- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1548 eiedgkpsaanrdivlaplGLFPRPWPSTADiseggqfhKVIEYFRLLGRVMAKALQDGRLLDVPLSTAFYKLILGQELD 1627
Cdd:cd00078   74 -------------------LLYPNPSSFADE--------DHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLS 126
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1628 LHDIVLFDAELGKTLQELRvvvarkhylegvggDNSSTISDLCLRgcriEDLSLEFTLPGYP--EYILRSGDEIVDITNL 1705
Cdd:cd00078  127 LEDLEELDPELYKSLKELL--------------DNDGDEDDLELT----FTIELDSSFGGAVtvELKPGGRDIPVTNENK 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1706 EEYISLVVDATVKRGVTRQIEAFRSGFNQVFDITSLQIFTPSELDYLLCGRRElWEVETLAEHIKFDHGYNAKSPAIINL 1785
Cdd:cd00078  189 EEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSED-IDLEDLKKNTEYKGGYSSDSPTIQWF 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1786 LEIMGELTADQQRAFCQFVTGAPRLPPGGLAVLNPKLTIVRKHSStssaaangagasetaDDDLPSVMTCANYLKLPPYS 1865
Cdd:cd00078  268 WEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNPKFTIRRVGSP---------------DDRLPTAHTCFNLLKLPPYS 332
                        410
                 ....*....|....*...
gi 42570183 1866 TKEIMYKKLLYAINEGQG 1883
Cdd:cd00078  333 SKEILREKLLYAINEGAG 350
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
211-611 1.68e-04

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 46.42  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  211 QVEALTQLCEMLSIGTEDSLSTFSVDSFVPVLVGLLNHESNPDIMLLAARALTHLCDVLPSSCAAVVHYGAVSCLVARLL 290
Cdd:COG5064   88 QLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLS 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  291 TIEyMDLAEQSLQALKKISQEHPtAC----LRAGALMAVLSYLDFFSTGVQ--RVALSTAANMCK-KLPSDASDYVMEAV 363
Cdd:COG5064  168 STE-DDVREQAVWALGNIAGDSE-GCrdyvLQCGALEPLLGLLLSSAIHISmlRNATWTLSNLCRgKNPPPDWSNISQAL 245
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  364 PLLTNLLQYHDSKVLEYASICLTRIAEAFApypEKLDELCNHGLVTQAASLIStsnsgggqaSLSVSTYTGLIRLLSTCA 443
Cdd:COG5064  246 PILAKLIYSRDPEVLVDACWAISYLSDGPN---EKIQAVLDVGIPGRLVELLS---------HESAKIQTPALRSVGNIV 313
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  444 SGSPLgfrtllllgissiLKDILLGSGvsANASVSPALSRPADQI-----YEIVNLA------------NELLPPLpegV 506
Cdd:COG5064  314 TGSDD-------------QTQVIINCG--ALKAFRSLLSSPKENIrkeacWTISNITagnteqiqavidANLIPPL---I 375
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  507 ISLPTSTNALVKGSCQKKSSPSTSG-KQEDILK-------ISPREKLLGDQPELLQQFGLDLL----------------- 561
Cdd:COG5064  376 HLLSSAEYKIKKEACWAISNATSGGlNRPDIIRylvsqgfIKPLCDLLDVVDNKIIEVALDAIenilkvgeqdrlrygkn 455
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42570183  562 ----PVLVQIYG---------SSVNGTIRHKCLSVIGKlmYFSSSEMIQSLIGDTNISSFLAG 611
Cdd:COG5064  456 iniyAVYVEKAGgmdaihglqDSVNRTIYDKAYSIIEK--FFGEEDAVDELAPETAGNTFTFG 516
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
1471-1883 8.54e-125

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 396.55  E-value: 8.54e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1471 QKVRVSRNRILDSAAKVMEMYSSQ--KAVLEVEYFGEVGTG-LGPTLEFYTLLSHDLQKASLGMWRSSSGDKVsmqigrd 1547
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSdlKKVLEVEFVGEEGIDaGGVTREFFTLVSKELFNPSYGLFRYTPDDSG------- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1548 eiedgkpsaanrdivlaplGLFPRPWPSTADiseggqfhKVIEYFRLLGRVMAKALQDGRLLDVPLSTAFYKLILGQELD 1627
Cdd:cd00078   74 -------------------LLYPNPSSFADE--------DHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLS 126
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1628 LHDIVLFDAELGKTLQELRvvvarkhylegvggDNSSTISDLCLRgcriEDLSLEFTLPGYP--EYILRSGDEIVDITNL 1705
Cdd:cd00078  127 LEDLEELDPELYKSLKELL--------------DNDGDEDDLELT----FTIELDSSFGGAVtvELKPGGRDIPVTNENK 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1706 EEYISLVVDATVKRGVTRQIEAFRSGFNQVFDITSLQIFTPSELDYLLCGRRElWEVETLAEHIKFDHGYNAKSPAIINL 1785
Cdd:cd00078  189 EEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSED-IDLEDLKKNTEYKGGYSSDSPTIQWF 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1786 LEIMGELTADQQRAFCQFVTGAPRLPPGGLAVLNPKLTIVRKHSStssaaangagasetaDDDLPSVMTCANYLKLPPYS 1865
Cdd:cd00078  268 WEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNPKFTIRRVGSP---------------DDRLPTAHTCFNLLKLPPYS 332
                        410
                 ....*....|....*...
gi 42570183 1866 TKEIMYKKLLYAINEGQG 1883
Cdd:cd00078  333 SKEILREKLLYAINEGAG 350
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
1518-1888 1.93e-100

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 325.33  E-value: 1.93e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183   1518 TLLSHDLQKASLGMWRSSSGDKVSMQigrdeiedgkpsaanrdivlaplglfprPWPSTADISeggqFHKVIEYFRLLGR 1597
Cdd:pfam00632    1 TLLSKELFDPNYGLFEYETEDDRTYW----------------------------FNPSSSESP----DLELLDYFKFLGK 48
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183   1598 VMAKALQDGRLLDVPLSTAFYKLILGQELDLHDIVLFDAELGKTLQELRVVVARKHylegvggdnsstisdlclrgcriE 1677
Cdd:pfam00632   49 LLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPELYKSLKSLLNMDNDDD-----------------------E 105
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183   1678 DLSLEFTLP--GYPEYI--LRSGDEI-VDITNLEEYISLVVDATVKRGVTRQIEAFRSGFNQVFDITSLQIFTPSELDYL 1752
Cdd:pfam00632  106 DLGLTFTIPvfGESKTIelIPNGRNIpVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGFYSVIPKEALSLFTPEELELL 185
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183   1753 LCGRRElWEVETLAEHIKFDHGYNAKSPAIINLLEIMGELTADQQRAFCQFVTGAPRLPPGGLAVLnPKLTIVRKHSsts 1832
Cdd:pfam00632  186 ICGSPE-IDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVGGFKSL-PKFTIVRKGG--- 260
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 42570183   1833 saaangagaseTADDDLPSVMTCANYLKLPPYSTKEIMYKKLLYAINEGQGsFDLS 1888
Cdd:pfam00632  261 -----------DDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEG-FGLS 304
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
1494-1883 1.45e-93

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 306.47  E-value: 1.45e-93
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183    1494 QKAVLEVEYFGEVG-TGLGPTLEFYTLLSHDLQKASLGMWRSSSGDKvsmqigrdeiedgkpsaanrdivlaplGLFPRP 1572
Cdd:smart00119    3 KKRVLEIEFEGEEGlDGGGVTREFFFLLSKELFNPDYGLFRYSPNDY---------------------------LLYPNP 55
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183    1573 WPSTADiseggqfHKVIEYFRLLGRVMAKALQDGRLLDVPLSTAFYKLILGQELDLHDIVLFDAELGKTLQELRvvvark 1652
Cdd:smart00119   56 RSGFAN-------EEHLSYFRFIGRVLGKALYDNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLL------ 122
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183    1653 hyLEgvggDNSSTISDLClrgcriEDLSLEFTLPGYPEYILRSGDEIVDIT--NLEEYISLVVDATVKRGVTRQIEAFRS 1730
Cdd:smart00119  123 --LN----NDTSEELDLT------FSIVLTSEFGQVKVVELKPGGSNIPVTeeNKKEYVHLVIEYRLNKGIEKQLEAFRE 190
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183    1731 GFNQVFDITSLQIFTPSELDYLLCGRRElWEVETLAEHIKFDHGYNAKSPAIINLLEIMGELTADQQRAFCQFVTGAPRL 1810
Cdd:smart00119  191 GFSEVIPENLLKLFDPEELELLICGSPE-IDVDDLKSNTEYKGGYSANSQTIKWFWEVVESFTNEERRKLLQFVTGSSRL 269
                           330       340       350       360       370       380       390
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42570183    1811 PPGGLAVLNPKLTIVRKHSStssaaangagasetaDDDLPSVMTCANYLKLPPYSTKEIMYKKLLYAINEGQG 1883
Cdd:smart00119  270 PVGGFAALSPKFTIRKAGSD---------------DERLPTAHTCFNRLKLPPYSSKEILREKLLLAINEGKG 327
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
1384-1885 6.54e-75

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 269.33  E-value: 6.54e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1384 FVNSKLTPKLARQIQDALALCSGSLPSWCYQLTracPFLFPFQTRRQYFYSTAFGLSR-ALNRLQQQQGADGSGSTNERE 1462
Cdd:COG5021  413 TYEDLRREQLGRESDESFYVASNVQQQRASREG---PLLSGWKTRLNNLYRFYFVEHRkKTLTKNDSRLGSFISLNKLDI 489
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1463 MRIGRLQRQKVRVSRNRILDSAAKVMEMYSSQKAVLEV---EYFGEVGTGLGPTLEFYTLLSHDLQKASLGMWRsssgdk 1539
Cdd:COG5021  490 RRIKEDKRRKLFYSLKQKAKIFDPYLHIKVRRDRVFEDsyrEIMDESGDDLKKTLEIEFVGEEGIDAGGLTREW------ 563
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1540 vsMQIGRDEIEDGKPSAanrdIVLAPLGLFPRPWPSTADISEggqfhKVIEYFRLLGRVMAKALQDGRLLDVPLSTAFYK 1619
Cdd:COG5021  564 --LFLLSKEMFNPDYGL----FEYITEDLYTLPINPLSSINP-----EHLSYFKFLGRVIGKAIYDSRILDVQFSKAFYK 632
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1620 LILGQELDLHDIVLFDAELGKTLQELRvvvarkhylegvggDNSSTISDLCLRgCRIEDLSLEFTLPgyPEYILRSGDEI 1699
Cdd:COG5021  633 KLLGKPVSLVDLESLDPELYRSLVWLL--------------NNDIDETILDLT-FTVEDDSFGESRT--VELIPNGRNIS 695
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1700 VDITNLEEYISLVVDATVKRGVTRQIEAFRSGFNQVFDITSLQIFTPSELDYLLCGRRELWEVETLAEHIKfDHGYNAKS 1779
Cdd:COG5021  696 VTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGIPEDIDIDDWKSNTA-YHGYTEDS 774
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1780 PAIINLLEIMGELTADQQRAFCQFVTGAPRLPPGGLAVLNPKLTIVRKHSstssaaangaGASETADDDLPSVMTCANYL 1859
Cdd:COG5021  775 PIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQGSDGVRKFTI----------EKGGTDDDRLPSAHTCFNRL 844
                        490       500
                 ....*....|....*....|....*.
gi 42570183 1860 KLPPYSTKEIMYKKLLYAINEGQGSF 1885
Cdd:COG5021  845 KLPEYSSKEKLRSKLLTAINEGAGFG 870
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
211-611 1.68e-04

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 46.42  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  211 QVEALTQLCEMLSIGTEDSLSTFSVDSFVPVLVGLLNHESNPDIMLLAARALTHLCDVLPSSCAAVVHYGAVSCLVARLL 290
Cdd:COG5064   88 QLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLS 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  291 TIEyMDLAEQSLQALKKISQEHPtAC----LRAGALMAVLSYLDFFSTGVQ--RVALSTAANMCK-KLPSDASDYVMEAV 363
Cdd:COG5064  168 STE-DDVREQAVWALGNIAGDSE-GCrdyvLQCGALEPLLGLLLSSAIHISmlRNATWTLSNLCRgKNPPPDWSNISQAL 245
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  364 PLLTNLLQYHDSKVLEYASICLTRIAEAFApypEKLDELCNHGLVTQAASLIStsnsgggqaSLSVSTYTGLIRLLSTCA 443
Cdd:COG5064  246 PILAKLIYSRDPEVLVDACWAISYLSDGPN---EKIQAVLDVGIPGRLVELLS---------HESAKIQTPALRSVGNIV 313
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  444 SGSPLgfrtllllgissiLKDILLGSGvsANASVSPALSRPADQI-----YEIVNLA------------NELLPPLpegV 506
Cdd:COG5064  314 TGSDD-------------QTQVIINCG--ALKAFRSLLSSPKENIrkeacWTISNITagnteqiqavidANLIPPL---I 375
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  507 ISLPTSTNALVKGSCQKKSSPSTSG-KQEDILK-------ISPREKLLGDQPELLQQFGLDLL----------------- 561
Cdd:COG5064  376 HLLSSAEYKIKKEACWAISNATSGGlNRPDIIRylvsqgfIKPLCDLLDVVDNKIIEVALDAIenilkvgeqdrlrygkn 455
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42570183  562 ----PVLVQIYG---------SSVNGTIRHKCLSVIGKlmYFSSSEMIQSLIGDTNISSFLAG 611
Cdd:COG5064  456 iniyAVYVEKAGgmdaihglqDSVNRTIYDKAYSIIEK--FFGEEDAVDELAPETAGNTFTFG 516
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
336-388 1.80e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.12  E-value: 1.80e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 42570183    336 VQRVALSTAANMCKKLPSDASDYVMEAVPLLTNLLQYHDSKVLEYASICLTRI 388
Cdd:pfam13513    3 VREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
1471-1883 8.54e-125

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 396.55  E-value: 8.54e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1471 QKVRVSRNRILDSAAKVMEMYSSQ--KAVLEVEYFGEVGTG-LGPTLEFYTLLSHDLQKASLGMWRSSSGDKVsmqigrd 1547
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSdlKKVLEVEFVGEEGIDaGGVTREFFTLVSKELFNPSYGLFRYTPDDSG------- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1548 eiedgkpsaanrdivlaplGLFPRPWPSTADiseggqfhKVIEYFRLLGRVMAKALQDGRLLDVPLSTAFYKLILGQELD 1627
Cdd:cd00078   74 -------------------LLYPNPSSFADE--------DHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLS 126
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1628 LHDIVLFDAELGKTLQELRvvvarkhylegvggDNSSTISDLCLRgcriEDLSLEFTLPGYP--EYILRSGDEIVDITNL 1705
Cdd:cd00078  127 LEDLEELDPELYKSLKELL--------------DNDGDEDDLELT----FTIELDSSFGGAVtvELKPGGRDIPVTNENK 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1706 EEYISLVVDATVKRGVTRQIEAFRSGFNQVFDITSLQIFTPSELDYLLCGRRElWEVETLAEHIKFDHGYNAKSPAIINL 1785
Cdd:cd00078  189 EEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSED-IDLEDLKKNTEYKGGYSSDSPTIQWF 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1786 LEIMGELTADQQRAFCQFVTGAPRLPPGGLAVLNPKLTIVRKHSStssaaangagasetaDDDLPSVMTCANYLKLPPYS 1865
Cdd:cd00078  268 WEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNPKFTIRRVGSP---------------DDRLPTAHTCFNLLKLPPYS 332
                        410
                 ....*....|....*...
gi 42570183 1866 TKEIMYKKLLYAINEGQG 1883
Cdd:cd00078  333 SKEILREKLLYAINEGAG 350
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
1518-1888 1.93e-100

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 325.33  E-value: 1.93e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183   1518 TLLSHDLQKASLGMWRSSSGDKVSMQigrdeiedgkpsaanrdivlaplglfprPWPSTADISeggqFHKVIEYFRLLGR 1597
Cdd:pfam00632    1 TLLSKELFDPNYGLFEYETEDDRTYW----------------------------FNPSSSESP----DLELLDYFKFLGK 48
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183   1598 VMAKALQDGRLLDVPLSTAFYKLILGQELDLHDIVLFDAELGKTLQELRVVVARKHylegvggdnsstisdlclrgcriE 1677
Cdd:pfam00632   49 LLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPELYKSLKSLLNMDNDDD-----------------------E 105
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183   1678 DLSLEFTLP--GYPEYI--LRSGDEI-VDITNLEEYISLVVDATVKRGVTRQIEAFRSGFNQVFDITSLQIFTPSELDYL 1752
Cdd:pfam00632  106 DLGLTFTIPvfGESKTIelIPNGRNIpVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGFYSVIPKEALSLFTPEELELL 185
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183   1753 LCGRRElWEVETLAEHIKFDHGYNAKSPAIINLLEIMGELTADQQRAFCQFVTGAPRLPPGGLAVLnPKLTIVRKHSsts 1832
Cdd:pfam00632  186 ICGSPE-IDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVGGFKSL-PKFTIVRKGG--- 260
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 42570183   1833 saaangagaseTADDDLPSVMTCANYLKLPPYSTKEIMYKKLLYAINEGQGsFDLS 1888
Cdd:pfam00632  261 -----------DDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEG-FGLS 304
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
1494-1883 1.45e-93

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 306.47  E-value: 1.45e-93
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183    1494 QKAVLEVEYFGEVG-TGLGPTLEFYTLLSHDLQKASLGMWRSSSGDKvsmqigrdeiedgkpsaanrdivlaplGLFPRP 1572
Cdd:smart00119    3 KKRVLEIEFEGEEGlDGGGVTREFFFLLSKELFNPDYGLFRYSPNDY---------------------------LLYPNP 55
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183    1573 WPSTADiseggqfHKVIEYFRLLGRVMAKALQDGRLLDVPLSTAFYKLILGQELDLHDIVLFDAELGKTLQELRvvvark 1652
Cdd:smart00119   56 RSGFAN-------EEHLSYFRFIGRVLGKALYDNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLL------ 122
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183    1653 hyLEgvggDNSSTISDLClrgcriEDLSLEFTLPGYPEYILRSGDEIVDIT--NLEEYISLVVDATVKRGVTRQIEAFRS 1730
Cdd:smart00119  123 --LN----NDTSEELDLT------FSIVLTSEFGQVKVVELKPGGSNIPVTeeNKKEYVHLVIEYRLNKGIEKQLEAFRE 190
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183    1731 GFNQVFDITSLQIFTPSELDYLLCGRRElWEVETLAEHIKFDHGYNAKSPAIINLLEIMGELTADQQRAFCQFVTGAPRL 1810
Cdd:smart00119  191 GFSEVIPENLLKLFDPEELELLICGSPE-IDVDDLKSNTEYKGGYSANSQTIKWFWEVVESFTNEERRKLLQFVTGSSRL 269
                           330       340       350       360       370       380       390
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42570183    1811 PPGGLAVLNPKLTIVRKHSStssaaangagasetaDDDLPSVMTCANYLKLPPYSTKEIMYKKLLYAINEGQG 1883
Cdd:smart00119  270 PVGGFAALSPKFTIRKAGSD---------------DERLPTAHTCFNRLKLPPYSSKEILREKLLLAINEGKG 327
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
1384-1885 6.54e-75

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 269.33  E-value: 6.54e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1384 FVNSKLTPKLARQIQDALALCSGSLPSWCYQLTracPFLFPFQTRRQYFYSTAFGLSR-ALNRLQQQQGADGSGSTNERE 1462
Cdd:COG5021  413 TYEDLRREQLGRESDESFYVASNVQQQRASREG---PLLSGWKTRLNNLYRFYFVEHRkKTLTKNDSRLGSFISLNKLDI 489
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1463 MRIGRLQRQKVRVSRNRILDSAAKVMEMYSSQKAVLEV---EYFGEVGTGLGPTLEFYTLLSHDLQKASLGMWRsssgdk 1539
Cdd:COG5021  490 RRIKEDKRRKLFYSLKQKAKIFDPYLHIKVRRDRVFEDsyrEIMDESGDDLKKTLEIEFVGEEGIDAGGLTREW------ 563
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1540 vsMQIGRDEIEDGKPSAanrdIVLAPLGLFPRPWPSTADISEggqfhKVIEYFRLLGRVMAKALQDGRLLDVPLSTAFYK 1619
Cdd:COG5021  564 --LFLLSKEMFNPDYGL----FEYITEDLYTLPINPLSSINP-----EHLSYFKFLGRVIGKAIYDSRILDVQFSKAFYK 632
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1620 LILGQELDLHDIVLFDAELGKTLQELRvvvarkhylegvggDNSSTISDLCLRgCRIEDLSLEFTLPgyPEYILRSGDEI 1699
Cdd:COG5021  633 KLLGKPVSLVDLESLDPELYRSLVWLL--------------NNDIDETILDLT-FTVEDDSFGESRT--VELIPNGRNIS 695
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1700 VDITNLEEYISLVVDATVKRGVTRQIEAFRSGFNQVFDITSLQIFTPSELDYLLCGRRELWEVETLAEHIKfDHGYNAKS 1779
Cdd:COG5021  696 VTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGIPEDIDIDDWKSNTA-YHGYTEDS 774
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183 1780 PAIINLLEIMGELTADQQRAFCQFVTGAPRLPPGGLAVLNPKLTIVRKHSstssaaangaGASETADDDLPSVMTCANYL 1859
Cdd:COG5021  775 PIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQGSDGVRKFTI----------EKGGTDDDRLPSAHTCFNRL 844
                        490       500
                 ....*....|....*....|....*.
gi 42570183 1860 KLPPYSTKEIMYKKLLYAINEGQGSF 1885
Cdd:COG5021  845 KLPEYSSKEKLRSKLLTAINEGAGFG 870
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
211-611 1.68e-04

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 46.42  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  211 QVEALTQLCEMLSIGTEDSLSTFSVDSFVPVLVGLLNHESNPDIMLLAARALTHLCDVLPSSCAAVVHYGAVSCLVARLL 290
Cdd:COG5064   88 QLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLS 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  291 TIEyMDLAEQSLQALKKISQEHPtAC----LRAGALMAVLSYLDFFSTGVQ--RVALSTAANMCK-KLPSDASDYVMEAV 363
Cdd:COG5064  168 STE-DDVREQAVWALGNIAGDSE-GCrdyvLQCGALEPLLGLLLSSAIHISmlRNATWTLSNLCRgKNPPPDWSNISQAL 245
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  364 PLLTNLLQYHDSKVLEYASICLTRIAEAFApypEKLDELCNHGLVTQAASLIStsnsgggqaSLSVSTYTGLIRLLSTCA 443
Cdd:COG5064  246 PILAKLIYSRDPEVLVDACWAISYLSDGPN---EKIQAVLDVGIPGRLVELLS---------HESAKIQTPALRSVGNIV 313
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  444 SGSPLgfrtllllgissiLKDILLGSGvsANASVSPALSRPADQI-----YEIVNLA------------NELLPPLpegV 506
Cdd:COG5064  314 TGSDD-------------QTQVIINCG--ALKAFRSLLSSPKENIrkeacWTISNITagnteqiqavidANLIPPL---I 375
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570183  507 ISLPTSTNALVKGSCQKKSSPSTSG-KQEDILK-------ISPREKLLGDQPELLQQFGLDLL----------------- 561
Cdd:COG5064  376 HLLSSAEYKIKKEACWAISNATSGGlNRPDIIRylvsqgfIKPLCDLLDVVDNKIIEVALDAIenilkvgeqdrlrygkn 455
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42570183  562 ----PVLVQIYG---------SSVNGTIRHKCLSVIGKlmYFSSSEMIQSLIGDTNISSFLAG 611
Cdd:COG5064  456 iniyAVYVEKAGgmdaihglqDSVNRTIYDKAYSIIEK--FFGEEDAVDELAPETAGNTFTFG 516
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
336-388 1.80e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.12  E-value: 1.80e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 42570183    336 VQRVALSTAANMCKKLPSDASDYVMEAVPLLTNLLQYHDSKVLEYASICLTRI 388
Cdd:pfam13513    3 VREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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