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Conserved domains on  [gi|334186700|ref|NP_849409|]
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VPS54 [Arabidopsis thaliana]

Protein Classification

vacuolar protein sorting-associated protein 54( domain architecture ID 10546179)

vacuolar protein sorting-associated protein 54 is a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network

Gene Ontology:  GO:0000938|GO:0006896|GO:0019905|GO:0006886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vps54 pfam07928
Vps54-like protein; This family contains various proteins that are homologs of the yeast Vps54 ...
 772-901 3.60e-49

Vps54-like protein; This family contains various proteins that are homologs of the yeast Vps54 protein, such as the rat homolog, the human homolog, and the mouse homolog. In yeast, Vps54 associates with Vps52 and Vps53 proteins to form a trimolecular complex that is involved in protein transport between Golgi, endosomal, and vacuolar compartments. All Vps54 homologs contain a coiled coil region (not found in the region featured in this family) and multiple dileucine motifs.


:

Pssm-ID: 462318  Cd Length: 131  Bit Score: 170.39  E-value: 3.60e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186700   772 YHMVNCGLILLKMLSEYIDMNNSLPALSSEIVLRVVEVLRFFNTRTCQLVLGAGAMQVSGLKSIKAKHLALASQVIDFTY 851
Cdd:pfam07928    3 FIVVNSALLLLKMLSDYLHLAANFPSLASDILSRLLELLKLFNSRTCQLILGAGATRTAGLKNITAKHLALASQALSFVI 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 334186700   852 TIIPETRRIlFSKVPETRKPLLSVEIDKVAQDFRIHRDEIYTKLVQIMRE 901
Cdd:pfam07928   83 ALIPYIREF-FRRHLGPKQALLLSEFDKVKRDYQEHQSEIHSKLVSIMSD 131
EnvC super family cl34844
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 206-303 5.15e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG4942:

Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 5.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186700  206 EAQGQLQDLNVKIVEGCSRIRELKETIRLLDRNLVDSARQIQELSSTRINMLELQRKLRLILYVNQALSALKLLVASADC 285
Cdd:COG4942    52 ALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDF 131

                          90
                  ....*....|....*...
gi 334186700  286 AGALDITDDLQNLLAGDE 303
Cdd:COG4942   132 LDAVRRLQYLKYLAPARR 149
 
Name Accession Description Interval E-value
Vps54 pfam07928
Vps54-like protein; This family contains various proteins that are homologs of the yeast Vps54 ...
 772-901 3.60e-49

Vps54-like protein; This family contains various proteins that are homologs of the yeast Vps54 protein, such as the rat homolog, the human homolog, and the mouse homolog. In yeast, Vps54 associates with Vps52 and Vps53 proteins to form a trimolecular complex that is involved in protein transport between Golgi, endosomal, and vacuolar compartments. All Vps54 homologs contain a coiled coil region (not found in the region featured in this family) and multiple dileucine motifs.


Pssm-ID: 462318  Cd Length: 131  Bit Score: 170.39  E-value: 3.60e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186700   772 YHMVNCGLILLKMLSEYIDMNNSLPALSSEIVLRVVEVLRFFNTRTCQLVLGAGAMQVSGLKSIKAKHLALASQVIDFTY 851
Cdd:pfam07928    3 FIVVNSALLLLKMLSDYLHLAANFPSLASDILSRLLELLKLFNSRTCQLILGAGATRTAGLKNITAKHLALASQALSFVI 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 334186700   852 TIIPETRRIlFSKVPETRKPLLSVEIDKVAQDFRIHRDEIYTKLVQIMRE 901
Cdd:pfam07928   83 ALIPYIREF-FRRHLGPKQALLLSEFDKVKRDYQEHQSEIHSKLVSIMSD 131
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 206-303 5.15e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 5.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186700  206 EAQGQLQDLNVKIVEGCSRIRELKETIRLLDRNLVDSARQIQELSSTRINMLELQRKLRLILYVNQALSALKLLVASADC 285
Cdd:COG4942    52 ALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDF 131

                          90
                  ....*....|....*...
gi 334186700  286 AGALDITDDLQNLLAGDE 303
Cdd:COG4942   132 LDAVRRLQYLKYLAPARR 149
 
Name Accession Description Interval E-value
Vps54 pfam07928
Vps54-like protein; This family contains various proteins that are homologs of the yeast Vps54 ...
 772-901 3.60e-49

Vps54-like protein; This family contains various proteins that are homologs of the yeast Vps54 protein, such as the rat homolog, the human homolog, and the mouse homolog. In yeast, Vps54 associates with Vps52 and Vps53 proteins to form a trimolecular complex that is involved in protein transport between Golgi, endosomal, and vacuolar compartments. All Vps54 homologs contain a coiled coil region (not found in the region featured in this family) and multiple dileucine motifs.


Pssm-ID: 462318  Cd Length: 131  Bit Score: 170.39  E-value: 3.60e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186700   772 YHMVNCGLILLKMLSEYIDMNNSLPALSSEIVLRVVEVLRFFNTRTCQLVLGAGAMQVSGLKSIKAKHLALASQVIDFTY 851
Cdd:pfam07928    3 FIVVNSALLLLKMLSDYLHLAANFPSLASDILSRLLELLKLFNSRTCQLILGAGATRTAGLKNITAKHLALASQALSFVI 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 334186700   852 TIIPETRRIlFSKVPETRKPLLSVEIDKVAQDFRIHRDEIYTKLVQIMRE 901
Cdd:pfam07928   83 ALIPYIREF-FRRHLGPKQALLLSEFDKVKRDYQEHQSEIHSKLVSIMSD 131
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 206-303 5.15e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 5.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186700  206 EAQGQLQDLNVKIVEGCSRIRELKETIRLLDRNLVDSARQIQELSSTRINMLELQRKLRLILYVNQALSALKLLVASADC 285
Cdd:COG4942    52 ALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDF 131

                          90
                  ....*....|....*...
gi 334186700  286 AGALDITDDLQNLLAGDE 303
Cdd:COG4942   132 LDAVRRLQYLKYLAPARR 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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