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Conserved domains on  [gi|115292450|ref|NP_848728|]
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GSK3B-interacting protein [Mus musculus]

Protein Classification

GSK3-beta interaction protein( domain architecture ID 10526340)

GSK3-beta interaction protein (GSKIP) is a DUF727 domain-containing protein which acts as a kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GSKIP_dom pfam05303
GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to ...
 38-138 4.82e-48

GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to GSK3beta. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria.


:

Pssm-ID: 398795  Cd Length: 103  Bit Score: 150.04  E-value: 4.82e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115292450   38 MQLEAEAVVNDVLFAVNHMFVSKSMPCADDVAYINVETKERNRYCLELTEAGLRVVGYAFDQV--EDHLQTPYHETVYSL 115
Cdd:pfam05303   1 FRLEAEAAVNDVAFGVKDISVSEKLPSTNGVAYINVTTLEGNRYCIELSAAGFRIVGYRYDCVdgESEDHTKYYETLYAL 80

                          90       100
                  ....*....|....*....|...
gi 115292450  116 LDTLSPAYREAFGNALLQRLEAL 138
Cdd:pfam05303  81 LDYISPLYRESFGEALLEKLSKL 103
 
Name Accession Description Interval E-value
GSKIP_dom pfam05303
GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to ...
 38-138 4.82e-48

GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to GSK3beta. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria.


Pssm-ID: 398795  Cd Length: 103  Bit Score: 150.04  E-value: 4.82e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115292450   38 MQLEAEAVVNDVLFAVNHMFVSKSMPCADDVAYINVETKERNRYCLELTEAGLRVVGYAFDQV--EDHLQTPYHETVYSL 115
Cdd:pfam05303   1 FRLEAEAAVNDVAFGVKDISVSEKLPSTNGVAYINVTTLEGNRYCIELSAAGFRIVGYRYDCVdgESEDHTKYYETLYAL 80

                          90       100
                  ....*....|....*....|...
gi 115292450  116 LDTLSPAYREAFGNALLQRLEAL 138
Cdd:pfam05303  81 LDYISPLYRESFGEALLEKLSKL 103
 
Name Accession Description Interval E-value
GSKIP_dom pfam05303
GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to ...
 38-138 4.82e-48

GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to GSK3beta. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria.


Pssm-ID: 398795  Cd Length: 103  Bit Score: 150.04  E-value: 4.82e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115292450   38 MQLEAEAVVNDVLFAVNHMFVSKSMPCADDVAYINVETKERNRYCLELTEAGLRVVGYAFDQV--EDHLQTPYHETVYSL 115
Cdd:pfam05303   1 FRLEAEAAVNDVAFGVKDISVSEKLPSTNGVAYINVTTLEGNRYCIELSAAGFRIVGYRYDCVdgESEDHTKYYETLYAL 80

                          90       100
                  ....*....|....*....|...
gi 115292450  116 LDTLSPAYREAFGNALLQRLEAL 138
Cdd:pfam05303  81 LDYISPLYRESFGEALLEKLSKL 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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