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Conserved domains on  [gi|241982732|ref|NP_848478|]
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histone-lysine N-methyltransferase SETMAR isoform 1 [Mus musculus]

Protein Classification

histone-lysine N-methyltransferase SETMAR( domain architecture ID 14410657)

histone-lysine N-methyltransferase SETMAR methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation

EC:  2.1.1.357
Gene Symbol:  SETMAR
Gene Ontology:  GO:0005515|GO:1904047|GO:0016279
PubMed:  20620605|12372294|17013555

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 50-304 1.46e-154

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


:

Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 432.49  E-value: 1.46e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  50 KPFQYTPDHVAGPGADIDPTQITFPGCACIETPCVPGTCSCLRHE-NNYDDNLCLRDVgsEGKYAKPVFECNVLCQCGMR 128
Cdd:cd10544    1 PDFQYTPENVPGPGADTDPNEITFPGCDCKTSSCEPETCSCLRKYgPNYDDDGCLLDF--DGKYSGPVFECNSMCKCSES 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 129 CRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVREHIYSGQIME 208
Cdd:cd10544   79 CQNRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYIIVLREHLSSGKVLE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 209 TFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDILPGEELSYDYSGRFLNQVSSKDKEKIDCSPPRKPC 288
Cdd:cd10544  159 TFVDPTYIGNIGRFLNHSCEPNLFMVPVRVDSMVPKLALFAARDIVAGEELSFDYSGEFSNSVESVTLARQDESKSRKPC 238

                        250
                 ....*....|....*.
gi 241982732 289 YCGAQSCTTFLPYDSS 304
Cdd:cd10544  239 LCGAENCRGFLPFDES 254
 
Name Accession Description Interval E-value
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 50-304 1.46e-154

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 432.49  E-value: 1.46e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  50 KPFQYTPDHVAGPGADIDPTQITFPGCACIETPCVPGTCSCLRHE-NNYDDNLCLRDVgsEGKYAKPVFECNVLCQCGMR 128
Cdd:cd10544    1 PDFQYTPENVPGPGADTDPNEITFPGCDCKTSSCEPETCSCLRKYgPNYDDDGCLLDF--DGKYSGPVFECNSMCKCSES 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 129 CRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVREHIYSGQIME 208
Cdd:cd10544   79 CQNRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYIIVLREHLSSGKVLE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 209 TFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDILPGEELSYDYSGRFLNQVSSKDKEKIDCSPPRKPC 288
Cdd:cd10544  159 TFVDPTYIGNIGRFLNHSCEPNLFMVPVRVDSMVPKLALFAARDIVAGEELSFDYSGEFSNSVESVTLARQDESKSRKPC 238

                        250
                 ....*....|....*.
gi 241982732 289 YCGAQSCTTFLPYDSS 304
Cdd:cd10544  239 LCGAENCRGFLPFDES 254
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 142-269 6.91e-37

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 128.22  E-value: 6.91e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732   142 LQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRihlqtshDSNYIIAVREHIYSGQI-METFVDPTYIGNIG 220
Cdd:smart00317   3 LEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEER-------PKAYDTDGAKAFYLFDIdSDLCIDARRKGNLA 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 241982732   221 RFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDYSGRFLN 269
Cdd:smart00317  76 RFINHSCEPNCELLFVEVNGD-DRIVIFALRDIKPGEELTIDYGSDYAN 123
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 151-263 1.30e-26

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 101.06  E-value: 1.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  151 GWGLRTLEFIPKGRFVCEYAGEVLgFSEVQRRIHLQTSHDSNYIIAVREHIYS-GQIMETFVDPT--YIGNIGRFLNHSC 227
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLL-ITKEEADKRELLYYDKLELRLWGPYLFTlDEDSEYCIDARalYYGNWARFINHSC 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 241982732  228 EPNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDY 263
Cdd:pfam00856  80 DPNCEVRVVYVNGG-PRIVIFALRDIKPGEELTIDY 114
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
138-290 1.20e-23

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 93.87  E-value: 1.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 138 LHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDsNYIIAVREhiysgqimETFVDPTYIG 217
Cdd:COG2940    4 LHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPLH-TYLFELDD--------DGVIDGALGG 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 241982732 218 NIGRFLNHSCEPNLLMIPVRidsmvPKLALFAAKDILPGEELSYDYSGrflnqvsskdkekiDCSPPRKPCYC 290
Cdd:COG2940   75 NPARFINHSCDPNCEADEED-----GRIFIVALRDIAAGEELTYDYGL--------------DYDEEEYPCRC 128
 
Name Accession Description Interval E-value
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 50-304 1.46e-154

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 432.49  E-value: 1.46e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  50 KPFQYTPDHVAGPGADIDPTQITFPGCACIETPCVPGTCSCLRHE-NNYDDNLCLRDVgsEGKYAKPVFECNVLCQCGMR 128
Cdd:cd10544    1 PDFQYTPENVPGPGADTDPNEITFPGCDCKTSSCEPETCSCLRKYgPNYDDDGCLLDF--DGKYSGPVFECNSMCKCSES 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 129 CRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVREHIYSGQIME 208
Cdd:cd10544   79 CQNRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYIIVLREHLSSGKVLE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 209 TFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDILPGEELSYDYSGRFLNQVSSKDKEKIDCSPPRKPC 288
Cdd:cd10544  159 TFVDPTYIGNIGRFLNHSCEPNLFMVPVRVDSMVPKLALFAARDIVAGEELSFDYSGEFSNSVESVTLARQDESKSRKPC 238

                        250
                 ....*....|....*.
gi 241982732 289 YCGAQSCTTFLPYDSS 304
Cdd:cd10544  239 LCGAENCRGFLPFDES 254
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 50-264 2.95e-94

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 278.10  E-value: 2.95e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  50 KPFQYTPDHVAGPGADIDPTQITFPGCACIEtPCVPGTCSCLRH---ENNYDDNLCLRDvgseGKYAKPVFECNVLCQCG 126
Cdd:cd10538    1 PSFTYIKDNIVGKNVQPFSNIIDSVGCKCKD-DCLDSKCACAAEsdgIFAYTKNGLLRL----NNSPPPIFECNSKCSCD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 127 MRCRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVREHIYS-GQ 205
Cdd:cd10538   76 DDCKNRVVQRGLQARLQVFRTSKKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDSdGD 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 241982732 206 IMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRI---DSMVPKLALFAAKDILPGEELSYDYS 264
Cdd:cd10538  156 GEELCVDATFCGNVSRFINHSCDPNLFPFNVVIdhdDLRYPRIALFATRDILPGEELTFDYG 217
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 52-299 3.48e-56

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 182.11  E-value: 3.48e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  52 FQYTPDHVAGPGADIDPTQITfpGCACIEtPCVPGTCSCLRHENN----YDDNLCLR-DVGsegkyaKPVFECNVLCQCG 126
Cdd:cd10542    3 FQYINDYIPGDGVKIPEDFLV--GCECTE-DCHNNNPTCCPAESGvkfaYDKQGRLRlPPG------TPIYECNSRCKCG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 127 MRCRNRVVQNGLHFLLQVFQT-EKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVRehiYSGQ 205
Cdd:cd10542   74 PDCPNRVVQRGRKVPLCIFRTsNGRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRTYLFDLD---YNDD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 206 IMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRI---DSMVPKLALFAAKDILPGEELSYDY--SGRFLNQVSSKDKEKid 280
Cdd:cd10542  151 DCEYTVDAAYYGNISHFINHSCDPNLAVYAVWInhlDPRLPRIAFFAKRDIKAGEELTFDYlmTGTGGSSESTIPKPK-- 228

                        250
                 ....*....|....*....
gi 241982732 281 csPPRKPCYCGAQSCTTFL 299
Cdd:cd10542  229 --DVRVPCLCGSKNCRKYL 245
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 52-267 6.00e-53

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 173.29  E-value: 6.00e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  52 FQYTPDHVAGPGADIDPTQITFPGCACIETpCVPGTCSCLR--HENNYDDNLCLrdVGSEGKYAKPV-FECNVLCQCGMR 128
Cdd:cd10543    3 FLYVTENCETSPLNIDRNITSLQTCSCRDD-CSSDNCVCGRlsVRCWYDKEGRL--LPDFNKLDPPLiFECNRACSCWRN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 129 CRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRihlqtsHDSNYIIAV--REHiysgqi 206
Cdd:cd10543   80 CRNRVVQNGIRYRLQLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEADSR------EDDSYLFDLdnKDG------ 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 241982732 207 mETF-VDPTYIGNIGRFLNHSCEPNllMIPVRI-----DSMVPKLALFAAKDILPGEELSYDYSGRF 267
Cdd:cd10543  148 -ETYcIDARRYGNISRFINHLCEPN--LIPVRVfvehqDLRFPRIAFFASRDIKAGEELGFDYGEKF 211
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 75-263 3.10e-47

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 158.34  E-value: 3.10e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  75 GCACiETPCVPGTCSCLRHENNyddnlclrdvGSEGKY--------AKP-VFECNVLCQCGMRCRNRVVQNGLHFLLQVF 145
Cdd:cd10545   23 GCDC-KNRCTDGASDCACVKKN----------GGEIPYnfngrlirAKPaIYECGPLCKCPPSCYNRVTQKGLRYRLEVF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 146 QTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRihlqtSHDSNYIIAVREHiYSGQIM------------------ 207
Cdd:cd10545   92 KTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTR-----SGNDDYLFDIDNR-QTNRGWdggqrldvgmsdgerssa 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 241982732 208 ------ETFVDPTYIGNIGRFLNHSCEPNLLMIPVRI---DSMVPKLALFAAKDILPGEELSYDY 263
Cdd:cd10545  166 edeessEFTIDAGSFGNVARFINHSCSPNLFVQCVLYdhnDLRLPRVMLFAADNIPPLQELTYDY 230
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 28-296 5.87e-47

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 159.38  E-value: 5.87e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  28 DVACGLENLPVSLWPLGAEPRPKPFQYTPDHVAGPGADIDPTQITFPGCACIETPCVPGTCSClrHENNYDDNLCL---R 104
Cdd:cd10517    8 DISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKGVNINLDPDFLVGCDCTDGCRDKSKCAC--QQLTIEATAATpggQ 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 105 DVGSEG--------KYAKPVFECNVLCQCGMRCRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGF 176
Cdd:cd10517   86 INPSAGyqyrrlmeKLPTGVYECNSRCKCDKRCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQILTE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 177 SEVQRRihlQTSHDSNYI-----------------IAVREHIYSgqimetfVDPTYIGNIGRFLNHSCEPNLLMIPVRID 239
Cdd:cd10517  166 DEANEE---GLQYGDEYFaeldyievveklkegyeSDVEEHCYI-------IDAKSEGNLGRYLNHSCSPNLFVQNVFVD 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 240 SM---VPKLALFAAKDILPGEELSYDYsGRFLNQVSSKDKEkidcspprkpCYCGAQSCT 296
Cdd:cd10517  236 THdlrFPWVAFFASRYIRAGTELTWDY-NYEVGSVPGKVLY----------CYCGSSNCR 284
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 52-295 2.99e-42

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 145.46  E-value: 2.99e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  52 FQYTPDHVAGPGADIDPTQITFPGCACIETpCVPGTCSC--LRHENNYDDNLCLRdvgSEGKYAKP--VFECNVLCQCGM 127
Cdd:cd10535    3 YKYVSQNCVTSPMNIDRNITHLQYCVCIDD-CSSSNCMCgqLSMRCWYDKDGRLL---PEFNMAEPplIFECNHACSCWR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 128 RCRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRihlqtsHDSNYIIAVREHiySGQIM 207
Cdd:cd10535   79 NCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVR------EEDSYLFDLDNK--DGEVY 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 208 etFVDPTYIGNIGRFLNHSCEPNLlmIPVRI-----DSMVPKLALFAAKDILPGEELSYDYSGRFLnqvsskdkekiDCS 282
Cdd:cd10535  151 --CIDARFYGNVSRFINHHCEPNL--VPVRVfmahqDLRFPRIAFFSTRLIEAGEQLGFDYGERFW-----------DIK 215

                        250
                 ....*....|...
gi 241982732 283 PPRKPCYCGAQSC 295
Cdd:cd10535  216 GKLFSCRCGSPKC 228
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 75-299 2.43e-41

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 144.25  E-value: 2.43e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  75 GCAC-IETPC---VPGTCSCLRHENN----YDDNLCLR-DVGSegkyakPVFECNVLCQCGMRCRNRVVQNGLHFLLQVF 145
Cdd:cd20073   25 GCSCsKLGGCdlnNPGSCQCLEDSNEksfaYDEYGRVRaNTGS------IIYECNENCDCGINCPNRVVQRGRKLPLEIF 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 146 QTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRihlQTSHDSNYIIAVRE-HIYSGQIMETF-VDPTYIGNIGRFL 223
Cdd:cd20073   99 KTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIR---GKKYDNVGVTYLFDlDLFEDQVDEYYtVDAQYCGDVTRFI 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 224 NHSCEPNLLMIPVRID---SMVPKLALFAAKDILPGEELSYDYSGR-FLNQVSSKDKEKID---CSPPRKPCYCGAQSCT 296
Cdd:cd20073  176 NHSCDPNLAIYSVLRDksdSKIYDLAFFAIKDIPALEELTFDYSGRnNFDQLGFIGNRSNSkyiNLKNKRPCYCGSANCR 255


                 ...
gi 241982732 297 TFL 299
Cdd:cd20073  256 GWL 258
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 52-299 2.98e-41

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 143.49  E-value: 2.98e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  52 FQYTPDHVAGPGADIDpTQITFpGCACIETP---CVPGTCSCLRHENNyDDNLCLrdvgsegKYAKPVFECNVLCQCGMR 128
Cdd:cd10532    3 FYYINEYKPAPGINLD-NEATV-GCDCSDCFfgkCCPAEAGVLFAYNE-HGQLKI-------PPGTPIYECNSRCKCGPD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 129 CRNRVVQNGLHFLLQVFQTEK-KGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVRehiYSGQim 207
Cdd:cd10532   73 CPNRVVQKGTQYSLCIFRTSNgRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGITYLFDLD---YESD-- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 208 ETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM---VPKLALFAAKDILPGEELSYDYSGRFLNQVSSkdkEKIDCSPP 284
Cdd:cd10532  148 EFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLdtrLPRIALFSTRTIKAGEELTFDYQMKGSGDLSS---DSIDNSPA 224

                        250
                 ....*....|....*....
gi 241982732 285 RKP----CYCGAQSCTTFL 299
Cdd:cd10532  225 KKRvrtvCKCGAVTCRGYL 243
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 52-295 1.53e-40

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 141.31  E-value: 1.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  52 FQYTPDHVAGPGADIDPTQITFPGCACIETpCVPGTCSC--LRHENNYD-DNLCLRDVGsegKYAKP-VFECNVLCQCGM 127
Cdd:cd10533    3 YKYISENCETSTMNIDRNITHLQHCTCVDD-CSSSNCLCgqLSIRCWYDkDGRLLQEFN---KIEPPlIFECNQACSCWR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 128 RCRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRihlqtsHDSNYIIAVREHiySGQIM 207
Cdd:cd10533   79 NCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR------EDDSYLFDLDNK--DGEVY 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 208 etFVDPTYIGNIGRFLNHSCEPNLlmIPVRI-----DSMVPKLALFAAKDILPGEELSYDYSGRFLnqvsskdkekiDCS 282
Cdd:cd10533  151 --CIDARYYGNISRFINHLCDPNI--IPVRVfmlhqDLRFPRIAFFSSRDIRTGEELGFDYGDRFW-----------DIK 215

                        250
                 ....*....|...
gi 241982732 283 PPRKPCYCGAQSC 295
Cdd:cd10533  216 SKYFTCQCGSEKC 228
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 50-299 3.09e-40

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 141.18  E-value: 3.09e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  50 KPFQYTPDHVAGPGADIDPTQItfpGCAC------IETPCVPGTcscLRHENNYDDNLCLRDvgsegKYAKPVFECNVLC 123
Cdd:cd10525    1 RDFVYINEYKVGEGVTLNQVAV---GCECqdclsqPVGGCCPGA---SKHRFAYNEQGQVKV-----RPGLPIYECNSRC 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 124 QCGMRCRNRVVQNGLHFLLQVFQTEK-KGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVR--EH 200
Cdd:cd10525   70 RCGPDCPNRVVQKGIQYDLCIFRTDNgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDyvED 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 201 IYSgqimetfVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM---VPKLALFAAKDILPGEELSYDYSgrflNQVSSKDKE 277
Cdd:cd10525  150 VYT-------VDAAYYGNISHFVNHSCDPNLQVYNVFIDNLderLPRIALFATRTIRAGEELTFDYN----MQVDPVDAE 218

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 241982732 278 K-----------IDCSPPRK---PCYCGAQSCTTFL 299
Cdd:cd10525  219 StkmdsnfglagLPGSPKKRvriECKCGVRSCRKYL 254
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 62-299 2.07e-39

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 139.37  E-value: 2.07e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  62 PGADIDPTQITF-PGCACIETP-CVPGTCSCL------------RHENNY----DDNLCLRDVGSEGKYakPVFECNVLC 123
Cdd:cd19473   11 LGEGVELADEEFrSGCECTDDEdCMYSGCLCLqdvdpdddrdpgKKKNAYhssgAKKGCLRGHMLNSRL--PIYECHEGC 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 124 QCGMRCRNRVVQNGLHFLLQVFQTE-KKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHlqtshdsNYIIAVREHIY 202
Cdd:cd19473   89 ACSDDCPNRVVERGRKVPLQIFRTSdGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRD-------AATIAQRKDVY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 203 -----------------SGQIMEtfVDPTYIGNIGRFLNHSCEPNLlmipvRI--------DSMVPKLALFAAKDILPGE 257
Cdd:cd19473  162 lfaldkfsdpdsldprlRGDPYE--IDGEFMSGPTRFINHSCDPNL-----RIfarvgdhaDKHIHDLAFFAIKDIPRGT 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 241982732 258 ELSYDYsgrflnqVSSKDKEKIDCSPPRK-----PCYCGAQSCTTFL 299
Cdd:cd19473  235 ELTFDY-------VDGVTGLDDDAGDEEKekemtKCLCGSPKCRGYL 274
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 76-295 1.53e-38

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 136.89  E-value: 1.53e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  76 CACIETPCVPGTCSCLR--HENNYDDNLCLRDVGSEGKYAK---PV----FECNVLCQCG-MRCRNRVVQNGLHFLLQVF 145
Cdd:cd10523   34 CDCTDGCIDILKCACLQltARAFSKSESSPSKGGRGYKYKRlqePIpsglYECNVSCKCNrMLCQNRVVQHGLQVRLQVF 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 146 QTEKKGWGLRTLEFIPKGRFVCEYAGEVLgfsevqRRIHLQTSHDSNYIIAVREHIYSGQIMET-------------FVD 212
Cdd:cd10523  114 KTEKKGWGVRCLDDIDKGTFVCIYAGRVL------SRARSPTEPLPPKLELPSENEVEVVTSWLilskkrklrenvcFLD 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 213 PTYIGNIGRFLNHSCEPNLLMIPVRIDSM---VPKLALFAAKDILPGEELSYDYSgrfLNQVSSKDKEkidcspprKPCY 289
Cdd:cd10523  188 ASKEGNVGRFLNHSCCPNLFVQNVFVDTHdknFPWVAFFTNRVVKAGTELTWDYS---YDAGTSPEQE--------IPCL 256


                 ....*.
gi 241982732 290 CGAQSC 295
Cdd:cd10523  257 CGVNKC 262
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 142-269 6.91e-37

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 128.22  E-value: 6.91e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732   142 LQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRihlqtshDSNYIIAVREHIYSGQI-METFVDPTYIGNIG 220
Cdd:smart00317   3 LEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEER-------PKAYDTDGAKAFYLFDIdSDLCIDARRKGNLA 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 241982732   221 RFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDYSGRFLN 269
Cdd:smart00317  76 RFINHSCEPNCELLFVEVNGD-DRIVIFALRDIKPGEELTIDYGSDYAN 123
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 142-296 2.08e-35

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 124.67  E-value: 2.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 142 LQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSN--YIIAVREhiysgqimETFVDPTYIGNI 219
Cdd:cd10531    2 LELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEELGKSnfYILSLSD--------DVVIDATRKGNL 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 241982732 220 GRFLNHSCEPNLLMIPVRIDSmVPKLALFAAKDILPGEELSYDYSGRFLNQVSSKdkekidcspprkpCYCGAQSCT 296
Cdd:cd10531   74 SRFINHSCEPNCETQKWIVNG-EYRIGIFALRDIPAGEELTFDYNFVNYNEAKQV-------------CLCGAQNCR 136
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 142-299 6.34e-34

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 120.86  E-value: 6.34e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 142 LQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAvreHIYSGQImetfVDPTYIGNIGR 221
Cdd:cd19174    2 LERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQYHNHSHHYCL---NLDSGMV----IDGYRMGNEAR 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 241982732 222 FLNHSCEPNLLMIPVRIDSmVPKLALFAAKDILPGEELSYDYsgrflNQVSSKDKEKidcspprKPCYCGAQSCTTFL 299
Cdd:cd19174   75 FVNHSCDPNCEMQKWSVNG-VYRIGLFALKDIPAGEELTYDY-----NFHSFNVEKQ-------QPCKCGSPNCRGVI 139
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 116-296 4.23e-33

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 121.88  E-value: 4.23e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 116 VFECNVLCQCGMR-CRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRrihlQTSHDSNYI 194
Cdd:cd10541   67 VYECNKLCKCDPNmCQNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKILTDDFADK----EGLEMGDEY 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 195 IAVREHIYSGQIMetfVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM---VPKLALFAAKDILPGEELSYDYSgrflNQV 271
Cdd:cd10541  143 FANLDHIEESCYI---IDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHdlrFPWVAFFASKRIKAGTELTWDYN----YEV 215

                        170       180
                 ....*....|....*....|....*
gi 241982732 272 SSKDKEKIDCSpprkpcyCGAQSCT 296
Cdd:cd10541  216 GSVEGKELLCC-------CGSNECR 233
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 144-299 1.91e-32

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 117.30  E-value: 1.91e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 144 VFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLqtshdsnYIIAVREHIY-----SGQImetfVDPTYIGN 218
Cdd:cd19172    6 VFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKE-------YAREGNRHYYfmalkSDEI----IDATKKGN 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 219 IGRFLNHSCEPNLLMIPVRIDSMVpKLALFAAKDILPGEELSYDYsgrflnQVSSKDKEKidcspprKPCYCGAQSCTTF 298
Cdd:cd19172   75 LSRFINHSCEPNCETQKWTVNGEL-RVGFFAKRDIPAGEELTFDY------QFERYGKEA-------QKCYCGSPNCRGY 140


                 .
gi 241982732 299 L 299
Cdd:cd19172  141 I 141
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 142-299 3.54e-28

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 105.86  E-value: 3.54e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 142 LQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRI-HLQTSHDSNY--IIAVREHIysgqimetfVDPTYIGN 218
Cdd:cd19173    4 TEPFKTGDRGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLkKAHENNITNFymLTLDKDRI---------IDAGPKGN 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 219 IGRFLNHSCEPNL--LMIPVRIDsmvPKLALFAAKDILPGEELSYDYSGRFLNQVsskdkekidcsppRKPCYCGAQSCT 296
Cdd:cd19173   75 LSRFMNHSCQPNCetQKWTVNGD---TRVGLFAVRDIPAGEELTFNYNLDCLGNE-------------KKVCRCGAPNCS 138


                 ...
gi 241982732 297 TFL 299
Cdd:cd19173  139 GFL 141
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 151-295 4.90e-28

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 105.76  E-value: 4.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 151 GWGLRTLEFIPKGRFVCEYAGEVLGfSEV----QRRIHLQTSHDSnYIIAVREHIYsgqimetfVDPTYIGNIGRFLNHS 226
Cdd:cd10518   25 GWGLFAKRPIAAGEMVIEYVGEVIR-PIVadkrEKRYDEEGGGGT-YMFRIDEDLV--------IDATKKGNIARFINHS 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 241982732 227 CEPNLLMIPVRIDSmVPKLALFAAKDILPGEELSYDYsgrflnQVSSKDKEKIdcspprkPCYCGAQSC 295
Cdd:cd10518   95 CDPNCYAKIITVDG-EKHIVIFAKRDIAPGEELTYDY------KFPIEDEEKI-------PCLCGAPNC 149
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 151-263 1.30e-26

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 101.06  E-value: 1.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732  151 GWGLRTLEFIPKGRFVCEYAGEVLgFSEVQRRIHLQTSHDSNYIIAVREHIYS-GQIMETFVDPT--YIGNIGRFLNHSC 227
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLL-ITKEEADKRELLYYDKLELRLWGPYLFTlDEDSEYCIDARalYYGNWARFINHSC 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 241982732  228 EPNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDY 263
Cdd:pfam00856  80 DPNCEVRVVYVNGG-PRIVIFALRDIKPGEELTIDY 114
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 142-299 2.07e-26

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 101.34  E-value: 2.07e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 142 LQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRI-HLQTSHDSNYiiavrehiYSGQIMETFV-DPTYIGNI 219
Cdd:cd19175    2 MKLVKTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEERLwDMKHKGEKNF--------YMCEIDKDMViDATFKGNL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 220 GRFLNHSCEPNLLMIPVRIDSMVpKLALFAAKDILPGEELSYDYsgRFLnQVSSKDKekidcspprkpCYCGAQSCTTFL 299
Cdd:cd19175   74 SRFINHSCDPNCELQKWQVDGET-RIGVFAIRDIKKGEELTYDY--QFV-QFGADQD-----------CHCGSKNCRGKL 138
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
138-290 1.20e-23

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 93.87  E-value: 1.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 138 LHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDsNYIIAVREhiysgqimETFVDPTYIG 217
Cdd:COG2940    4 LHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPLH-TYLFELDD--------DGVIDGALGG 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 241982732 218 NIGRFLNHSCEPNLLMIPVRidsmvPKLALFAAKDILPGEELSYDYSGrflnqvsskdkekiDCSPPRKPCYC 290
Cdd:COG2940   75 NPARFINHSCDPNCEADEED-----GRIFIVALRDIAAGEELTYDYGL--------------DYDEEEYPCRC 128
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 143-299 1.83e-22

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 91.14  E-value: 1.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 143 QVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRI-HLQTSHDSN-YIIAVREhiysgqimETFVDPTYIGNIG 220
Cdd:cd19212    5 EIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIkRAHENSVTNfYMLTVTK--------DRIIDAGPKGNYS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 221 RFLNHSCEPNLLMIPVRIDSMVpKLALFAAKDILPGEELSYDYSgrflnqvsskdkekIDC-SPPRKPCYCGAQSCTTFL 299
Cdd:cd19212   77 RFMNHSCNPNCETQKWTVNGDV-RVGLFALCDIPAGMELTFNYN--------------LDClGNGRTECHCGADNCSGFL 141
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 143-299 3.00e-21

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 87.74  E-value: 3.00e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 143 QVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNyiiavreHIYSGQI-METFVDPTYIGNIGR 221
Cdd:cd19211    5 KIIKTEGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDIT-------HFYMLTIdKDRIIDAGPKGNYSR 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 241982732 222 FLNHSCEPNLLMIPVRIDSMVpKLALFAAKDILPGEELSYDYSgrflnqvsskdkekIDCSPPRKP-CYCGAQSCTTFL 299
Cdd:cd19211   78 FMNHSCQPNCETQKWTVNGDT-RVGLFAVCDIPAGTELTFNYN--------------LDCLGNEKTvCRCGAPNCSGFL 141
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 152-295 7.46e-21

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 86.71  E-value: 7.46e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 152 WGLRTLEFIPKGRFVCEYAGEVL--GFSEVQRRIHLQTSHDSNYIIAVREhiysgqimETFVDPTYIGNIGRFLNHSCEP 229
Cdd:cd20072   25 WGLYAMENISAKDMVIEYVGEVIrqQVADEREKRYLRQGIGSSYLFRIDD--------DTVVDATKKGNIARFINHCCDP 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 241982732 230 NLLMIPVRIDSMvPKLALFAAKDILPGEELSYDYsgRFlnqvsSKDKEKIdcspprkPCYCGAQSC 295
Cdd:cd20072   97 NCTAKIIKVEGE-KRIVIYAKRDIAAGEELTYDY--KF-----PREEDKI-------PCLCGAPNC 147
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 132-266 2.17e-20

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 85.32  E-value: 2.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 132 RVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRR--IHLQTSHDSNYIIAVRehiYSGQIMet 209
Cdd:cd10528    9 ELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKReaLYAKDPSTGCYMYYFQ---YKGKTY-- 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 241982732 210 FVDPTYI-GNIGRFLNHSC-EPNLLMIPVRIDSmVPKLALFAAKDILPGEELSYDYSGR 266
Cdd:cd10528   84 CVDATKEsGRLGRLINHSKkKPNLKTKLLVIDG-VPHLILVAKRDIKPGEELLYDYGDR 141
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 151-295 9.03e-20

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 83.93  E-value: 9.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 151 GWGLRTLEFIPKGRFVCEYAGEVL--GFSEVQRRIHLQTSHDSNYIIAVREhiysgqimETFVDPTYIGNIGRFLNHSCE 228
Cdd:cd19169   24 DWGLFALEPIAADEMVIEYVGQVIrqSVADEREKRYEAIGIGSSYLFRVDD--------DTIIDATKCGNLARFINHSCN 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 241982732 229 PNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDYsgRFlnqvsSKDKEKIdcspprkPCYCGAQSC 295
Cdd:cd19169   96 PNCYAKIITVESQ-KKIVIYSKRPIAVNEEITYDY--KF-----PIEDEKI-------PCLCGAPQC 147
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 127-299 1.17e-19

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 83.60  E-value: 1.17e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 127 MRCRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLgfsevqRRIhlqtshdsnyIIAVREHIYSGQI 206
Cdd:cd19170    1 MAMRFRHLRKTAKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGEVI------RSV----------LTDKREKYYESKG 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 207 M---------ETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSmVPKLALFAAKDILPGEELSYDYsgRFlnqvsSKDKE 277
Cdd:cd19170   65 IgcymfriddDEVVDATMHGNAARFINHSCEPNCYSRVVNIDG-KKHIVIFALRRILRGEELTYDY--KF-----PIEDV 136

                        170       180
                 ....*....|....*....|..
gi 241982732 278 KIdcspprkPCYCGAQSCTTFL 299
Cdd:cd19170  137 KI-------PCTCGSKKCRKYL 151
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 142-299 5.04e-19

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 81.90  E-value: 5.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 142 LQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHD-SNYIIAVREHiysgqimETFVDPTYIGNIG 220
Cdd:cd19210    4 VEIFRTLGRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDiTNFYMLTLDK-------DRIIDAGPKGNYA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 221 RFLNHSCEPNLLMIPVRIDSMVpKLALFAAKDILPGEELSYDYSgrflnqvsskdkekIDCSPPRKP-CYCGAQSCTTFL 299
Cdd:cd19210   77 RFMNHCCQPNCETQKWTVNGDT-RVGLFALCDIKAGTELTFNYN--------------LECLGNGKTvCKCGAPNCSGFL 141
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 151-264 9.11e-19

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 80.37  E-value: 9.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 151 GWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVREhiysgqimETFVDPTYIGNIGRFLNHSCEPN 230
Cdd:cd10519   12 GWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYNSSYLFNLND--------QFVVDATRKGNKIRFANHSSNPN 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 241982732 231 LLmipVRIdSMVP---KLALFAAKDILPGEELSYDYS 264
Cdd:cd10519   84 CY---AKV-MMVNgdhRIGIFAKRDIEAGEELFFDYG 116
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 150-295 2.38e-17

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 77.47  E-value: 2.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 150 KGWGLRTLEFIPKGRFVCEYAGEVLGfSEVQRRihlqtshdsnyiiavREHIYSGQ----IM-----ETFVDPTYIGNIG 220
Cdd:cd19171   24 QGLGLYAARDIEKHTMVIEYIGEIIR-NEVANR---------------REKIYESQnrgiYMfridnDWVIDATMTGGPA 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 241982732 221 RFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDYSGRFlnqvsSKDKEKIdcspprkPCYCGAQSC 295
Cdd:cd19171   88 RYINHSCNPNCVAEVVTFDKE-KKIIIISNRRIAKGEELTYDYKFDF-----EDDQHKI-------PCLCGAPNC 149
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 144-299 3.29e-16

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 74.29  E-value: 3.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 144 VFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRihlQTSHDSNYIIAVREHIYSGQImetfVDPTYIGNIGRFL 223
Cdd:cd19206   18 VYRSPIHGRGLFCKRNIDAGEMVIEYSGNVIRSILTDKR---EKYYDSKGIGCYMFRIDDSEV----VDATMHGNAARFI 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 241982732 224 NHSCEPNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDYsgrflnqvsskdKEKIDCSPPRKPCYCGAQSCTTFL 299
Cdd:cd19206   91 NHSCEPNCYSRVINIDGQ-KHIVIFAMRKIYRGEELTYDY------------KFPIEDASNKLPCNCGAKKCRKFL 153
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 150-263 3.58e-16

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 73.53  E-value: 3.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 150 KGWGLRTLEFIPKGRFVCEYAGEVLgfSEVQRRIHLQTSHDSNYIIAVREHIYsgqimetFVDPTYIGNIGRFLNHSCEP 229
Cdd:cd10522   13 NGLGLFAAETIAKGEFVGEYTGEVL--DRWEEDRDSVYHYDPLYPFDLNGDIL-------VIDAGKKGNLTRFINHSDQP 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 241982732 230 NLLMIpVRIDSMVPKLALFAAKDILPGEELSYDY 263
Cdd:cd10522   84 NLELI-VRTLKGEQHIGFVAIRDIKPGEELFISY 116
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 26-124 5.12e-16

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 72.06  E-value: 5.12e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732    26 QQDVACGLENLPVSLW-PLGAEPRPKPFQYTPDHVAGPGADIDPTQITFPGCACIEtPCVPGT-CSCLRHENNYDDNlcL 103
Cdd:smart00468   1 CLDISNGKENVPVPLVnEVDEDPPPPDFEYISEYIYGQGVPIDRSPSPLVGCSCSG-DCSSSNkCECARKNGGEFAY--E 77

                           90       100
                   ....*....|....*....|.
gi 241982732   104 RDVGSEGKYAKPVFECNVLCQ 124
Cdd:smart00468  78 LNGGLRLKRKPLIYECNSRCS 98
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 29-132 6.77e-16

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 72.07  E-value: 6.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732   29 VACGLENLPVSLW-PLGAEPRPKPFQYTPDHVAGPGadidPTQITFPGCACieTPCVPGTCSCLR-----HENNYDDNLC 102
Cdd:pfam05033   1 ISKGKENVPIPVVnEVDDEPPPPDFTYITSYIYPKE----FLLIIPQGCDC--GDCSSEKCSCAQlnggeFRFPYDKDGL 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 241982732  103 LRDvgsegKYAKPVFECNVLCQCGMRCRNR 132
Cdd:pfam05033  75 LVP-----ESKPPIYECNPLCGCPPSCPNR 99
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 138-263 1.89e-15

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 71.54  E-value: 1.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 138 LHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQtSHDSNYIIAvrehiYSGQIMETF-VDPTYI 216
Cdd:cd10529    3 LTSRTVEKVVGKNRKGLVATEDISPGEPILEYKGEVSLRSEFKEDNGFF-KRPSPFVFF-----YDGFEGLPLcVDARKY 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 241982732 217 GNIGRFLNHSCEPNllmipVRIDSMV-----PKLALFAAKDILPGEE--LSYDY 263
Cdd:cd10529   77 GNEARFIRRSCRPN-----AELRHVVvsngeLRLFIFALKDIRKGTEitIPFDY 125
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 151-267 2.53e-14

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 68.37  E-value: 2.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 151 GWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVREHIYsgqimetfVDPTYIGNIGRFLNHS---- 226
Cdd:cd19168   13 GLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRRGDVSYLYLFEEQEGIW--------VDAAIYGNLSRYINHAtdkv 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 241982732 227 ----CEPNLLMIPVRIdsmvpKLALFAAKDILPGEELSYDYSGRF 267
Cdd:cd19168   85 ktgnCMPKIMYVNHEW-----RIKFTAIKDIKIGEELFFNYGDNF 124
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 214-263 6.97e-14

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 65.35  E-value: 6.97e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 241982732 214 TYIGnIGRFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDY 263
Cdd:cd08161   24 EVIG-LARFINHSCEPNCEFEEVYVGGK-PRVFIVALRDIKAGEELTVDY 71
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 152-295 4.19e-13

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 65.82  E-value: 4.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 152 WGLRTLEFIPKGRFVCEYAGEVLG--FSEVQRRIHLQTSHDSNYIIAVREhiysgqimETFVDPTYIGNIGRFLNHSCEP 229
Cdd:cd19204   26 WGLFAMEPIAADEMVIEYVGQNIRqvVADMREKRYVQEGIGSSYLFRVDH--------DTIIDATKCGNLARFINHCCTP 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 241982732 230 NLLMIPVRIDSMvPKLALFAAKDILPGEELSYDYsgrflnqvsskdkeKIDCSPPRKPCYCGAQSC 295
Cdd:cd19204   98 NCYAKVITIESQ-KKIVIYSKQPIGVNEEITYDY--------------KFPIEDNKIPCLCGTENC 148
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 144-299 4.45e-13

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 65.82  E-value: 4.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 144 VFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLgfsevqrrihlqtshdSNYIIAVREHIYSGQ-------IMETF--VDPT 214
Cdd:cd19207   18 VYRSAIHGRGLFCKRNIDAGEMVIEYSGIVI----------------RSVLTDKREKFYDSKgigcymfRIDDFdvVDAT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 215 YIGNIGRFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDYsgrflnqvsskdKEKIDCSPPRKPCYCGAQS 294
Cdd:cd19207   82 MHGNAARFINHSCEPNCYSRVIHVEGQ-KHIVIFALRKIYRGEELTYDY------------KFPIEDASNKLPCNCGAKR 148


                 ....*
gi 241982732 295 CTTFL 299
Cdd:cd19207  149 CRRFL 153
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 152-295 1.78e-11

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 61.22  E-value: 1.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 152 WGLRTLEFIPKGRFVCEYAGEVLG--FSEVQRRIHLQTSHDSNYIIAVrEHiysgqimETFVDPTYIGNIGRFLNHSCEP 229
Cdd:cd19205   26 WGLFAMEPIAADEMVIEYVGQNIRqvIADMREKRYEDEGIGSSYMFRV-DH-------DTIIDATKCGNFARFINHSCNP 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 241982732 230 NLLMIPVRIDSMvPKLALFAAKDILPGEELSYDYsgrflnqvsskdkeKIDCSPPRKPCYCGAQSC 295
Cdd:cd19205   98 NCYAKVITVESQ-KKIVIYSKQHINVNEEITYDY--------------KFPIEDVKIPCLCGSENC 148
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 135-263 2.05e-11

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 60.85  E-value: 2.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 135 QNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVREhiysgqimETFVDPT 214
Cdd:cd19217    1 QRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNN--------DFVVDAT 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 241982732 215 YIGNIGRFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDY 263
Cdd:cd19217   73 RKGNKIRFANHSVNPNCYAKVVMVNGD-HRIGIFAKRAIQQGEELFFDY 120
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 150-299 8.09e-11

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 59.32  E-value: 8.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 150 KGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNyiiavrehIYSGQIM-ETFVDPTYIGNIGRFLNHSCE 228
Cdd:cd19209   26 QGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRG--------IYMFRINnEHVIDATLTGGPARYINHSCA 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 241982732 229 PNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDYSGRFlnqvsSKDKEKIdcspprkPCYCGAQSCTTFL 299
Cdd:cd19209   98 PNCVAEVVTFDKE-DKIIIISSRRIPKGEELTYDYQFDF-----EDDQHKI-------PCHCGAWNCRKWM 155
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 137-264 1.78e-10

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 57.62  E-value: 1.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 137 GLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVREhiysgqimETFVDPTYI 216
Cdd:cd19218    1 GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN--------DFVVDATRK 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 241982732 217 GNIGRFLNHSCEPNLL--MIPVRIDSmvpKLALFAAKDILPGEELSYDYS 264
Cdd:cd19218   73 GNKIRFANHSVNPNCYakVMMVNGDH---RIGIFAKRAIQTGEELFFDYR 119
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 153-263 2.80e-10

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 58.18  E-value: 2.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 153 GLRTLEFIPKGRFVCEYAGEVlgfsEVQRRIHLQTSHDSNYIIAVREHIYsgqimetFVD--PTYI-----GNIGRFLNH 225
Cdd:cd19183   15 GLFADRPIPAGDPIQELLGEI----GLQSEYIADPENQYQILGAPKPHVF-------FHPqsPLYIdtrrsGSVARFIRR 83

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 241982732 226 SCEPNLLMIPVRIDS-MVPKLALFAAKDILPGEELSYDY 263
Cdd:cd19183   84 SCRPNAELVTVASDSgSVLKFVLYASRDISPGEEITIGW 122
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 150-299 1.19e-09

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 56.17  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 150 KGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNyiiavrehIYSGQIMETFV-DPTYIGNIGRFLNHSCE 228
Cdd:cd19208   25 QGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRG--------VYMFRIDNDHViDATLTGGPARYINHSCA 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 241982732 229 PNLLMIPVRIDSMvPKLALFAAKDILPGEELSYDYSGRFlnqvsSKDKEKIdcspprkPCYCGAQSCTTFL 299
Cdd:cd19208   97 PNCVAEVVTFEKG-HKIIISSSRRIQKGEELCYDYKFDF-----EDDQHKI-------PCHCGAVNCRKWM 154
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 141-265 2.09e-07

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 49.33  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 141 LLQVFQTeKKGWGLRTLEFIPKGRFVCEYAGEVLGFSevqrrihlQTSHDSNYIIAvrEHIYSGQIMETFVD-PTYIGNI 219
Cdd:cd10539    6 LLVVFDP-REGFTVEADGFIKDLTIIAEYTGDVDYIR--------NREFDDNDSIM--TLLLAGDPSKSLVIcPDKRGNI 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 241982732 220 GRFL----NHSCE----PNLLMIPVRIDSMVPKLaLFAAKDILPGEELSYDYSG 265
Cdd:cd10539   75 ARFIsginNHTKDgkkkQNCKCVRYSINGEARVL-LVATRDIAKGERLYYDYNG 127
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 222-268 1.62e-05

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 43.52  E-value: 1.62e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 241982732 222 FLNHSCEPNLlmipVRIDSMVPKLALFAAKDILPGEELSYDYSGRFL 268
Cdd:cd20071   58 LLNHSCDPNA----VVVFDGNGTLRVRALRDIKAGEELTISYIDPLL 100
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 142-267 3.69e-05

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 42.24  E-value: 3.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 142 LQVFQTEKKGWGLRTLEFIPKGRFVcEYAGeVLGFSEvQRRIHLQTSHDSNYIIAVREHIYS---Gqimetfvdptyign 218
Cdd:cd10540    2 LEVKPSTLKGRGVFATRPIKKGEVI-EEAP-VIVLPK-EEYQHLCKTVLDHYVFSWGDGCLAlalG-------------- 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 241982732 219 IGRFLNHSCEPNLLmipVRIDSMVPKLALFAAKDILPGEELSYDYSGRF 267
Cdd:cd10540   65 YGSMFNHSYTPNAE---YEIDFENQTIVFYALRDIEAGEELTINYGDDL 110
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 221-264 9.69e-05

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 41.50  E-value: 9.69e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 241982732 221 RFLNHSCEPNLLMIPVRIDSMVPKlalfAAKDILPGEELSYDYS 264
Cdd:cd10524   78 AFINHDCRPNCKFVPTGKSTACVK----VLRDIEPGEEITVYYG 117
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 207-295 6.74e-04

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 39.61  E-value: 6.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982732 207 METFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVpKLALFAAKDILPGEELS----YDYsgrflnqvsSKDKEKIDCS 282
Cdd:cd19181   69 VEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMI-HLCIYAVAAIAKDAEVTiafdYEY---------SNCNYKVDCA 138

                         90
                 ....*....|...
gi 241982732 283 pprkpCYCGAQSC 295
Cdd:cd19181  139 -----CHKGNRNC 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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