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Conserved domains on  [gi|161016797|ref|NP_835214|]
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condensin-2 complex subunit D3 isoform 1 [Mus musculus]

Protein Classification

CTD kinase subunit gamma family protein( domain architecture ID 10914501)

CTD kinase subunit gamma is a component of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
 951-1127 2.59e-17

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


:

Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 80.58  E-value: 2.59e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797   951 AVRNNVIIVICdlCIRYTVMVDNYIPNISVCLKDSDPFIRKQTLVLLTNLLQEEYVKWKGsLFFRFVSTLVDSHPDIASL 1030
Cdd:pfam12717    1 LIRALAIRTMG--CIRFPNLVEYLTEPLYRRLKDEDPYVRKTAAMCVAKLILPDMVKVKG-FISELAKLLEDPNPMVVAN 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797  1031 gefCLAHL--LLKRNPTMFFQHFIECIFHFNSyekhgqynkfsqsergkqlflLKGKTNKEKRMRIYKFLLEHFTDEQR- 1107
Cdd:pfam12717   78 ---ALAALteISEKDPNAIYNLLPDIISKLSD---------------------ALNECSEWGQIYILDFLASYIPKDKQe 133

                          170       180
                   ....*....|....*....|.
gi 161016797  1108 -FNVTSKICLNILACFTDGIL 1127
Cdd:pfam12717  134 aESLVEKLCPRLQHANSAVVL 154
VHS_ENTH_ANTH super family cl02544
VHS, ENTH and ANTH domain superfamily; This superfamily is composed of proteins containing a ...
 538-603 4.58e-04

VHS, ENTH and ANTH domain superfamily; This superfamily is composed of proteins containing a VHS, CID, ENTH, or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal Transducing Adaptor Molecule). It is located at the N-termini of proteins involved in intracellular membrane trafficking. The CTD-Interacting Domain (CID) is present in several RNA-processing factors and binds tightly to the carboxy-terminal domain (CTD) of RNA polymerase II (RNAP II or Pol II). The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet unique module referred to as an AP180 N-Terminal Homology (ANTH) domain. VHS, ENTH, and ANTH domains are structurally similar and are composed of a superhelix of eight alpha helices. ENTH and ANTH (E/ANTH) domains bind both inositol phospholipids and proteins and contribute to the nucleation and formation of clathrin coats on membranes. ENTH domains also function in the development of membrane curvature through lipid remodeling during the formation of clathrin-coated vesicles. E/ANTH domain-bearing proteins have recently been shown to function with adaptor protein-1 and GGA adaptors at the Trans-Golgi Network, which suggests that E/ANTH domains are universal components of the machinery for clathrin-mediated membrane budding.


The actual alignment was detected with superfamily member pfam01417:

Pssm-ID: 470608  Cd Length: 124  Bit Score: 41.39  E-value: 4.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797   538 MTMLRKRIKDEKINVR---KsALQVLMSILK------------HCDILSMEQDLLILQDHCRDPAISVRKQAlQSLTELV 602
Cdd:pfam01417   41 MKMLWKRLNDKGKNWRhiyK-ALTLLEYLLKngservvddlreNIYIIRTLTDFHYIDENGKDQGINVRKKA-KEILNLL 118


                   .
gi 161016797   603 M 603
Cdd:pfam01417  119 E 119
 
Name Accession Description Interval E-value
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
 951-1127 2.59e-17

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 80.58  E-value: 2.59e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797   951 AVRNNVIIVICdlCIRYTVMVDNYIPNISVCLKDSDPFIRKQTLVLLTNLLQEEYVKWKGsLFFRFVSTLVDSHPDIASL 1030
Cdd:pfam12717    1 LIRALAIRTMG--CIRFPNLVEYLTEPLYRRLKDEDPYVRKTAAMCVAKLILPDMVKVKG-FISELAKLLEDPNPMVVAN 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797  1031 gefCLAHL--LLKRNPTMFFQHFIECIFHFNSyekhgqynkfsqsergkqlflLKGKTNKEKRMRIYKFLLEHFTDEQR- 1107
Cdd:pfam12717   78 ---ALAALteISEKDPNAIYNLLPDIISKLSD---------------------ALNECSEWGQIYILDFLASYIPKDKQe 133

                          170       180
                   ....*....|....*....|.
gi 161016797  1108 -FNVTSKICLNILACFTDGIL 1127
Cdd:pfam12717  134 aESLVEKLCPRLQHANSAVVL 154
COG5098 COG5098
Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell ...
 903-1043 1.80e-05

Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning];


Pssm-ID: 227429 [Multi-domain]  Cd Length: 1128  Bit Score: 49.59  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797  903 FQPRSSAMPSVIRAhAIITLGKL-CLQHEdLAKKSIPALVRELEVSEDVAVRNNVIIVICDLCIRYTVMVDNYIPNISVC 981
Cdd:COG5098   902 SNSSRFSDEELQVA-AYLSLYKLmCLSFE-FCSEHLPLLITSMEKHPIPRIRANAVVGLGDFLVCFNTTADEHTHYLYRR 979

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161016797  982 LKDSDPFIRKQTLVLLTNLLQEEYVKWKGSLfFRFVSTLVDSHPDIASLGEFCLAHLLLKRN 1043
Cdd:COG5098   980 LGDEDADVRRTCLMTIHFLILAGQLKVKGQL-GKMALLLTDEDAEISDMARHFFTQIAKKDN 1040
ENTH pfam01417
ENTH domain; The ENTH (Epsin N-terminal homology) domain is found in proteins involved in ...
 538-603 4.58e-04

ENTH domain; The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery. The function of the ENTH domain is unknown.


Pssm-ID: 426255  Cd Length: 124  Bit Score: 41.39  E-value: 4.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797   538 MTMLRKRIKDEKINVR---KsALQVLMSILK------------HCDILSMEQDLLILQDHCRDPAISVRKQAlQSLTELV 602
Cdd:pfam01417   41 MKMLWKRLNDKGKNWRhiyK-ALTLLEYLLKngservvddlreNIYIIRTLTDFHYIDENGKDQGINVRKKA-KEILNLL 118


                   .
gi 161016797   603 M 603
Cdd:pfam01417  119 E 119
 
Name Accession Description Interval E-value
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
 951-1127 2.59e-17

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 80.58  E-value: 2.59e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797   951 AVRNNVIIVICdlCIRYTVMVDNYIPNISVCLKDSDPFIRKQTLVLLTNLLQEEYVKWKGsLFFRFVSTLVDSHPDIASL 1030
Cdd:pfam12717    1 LIRALAIRTMG--CIRFPNLVEYLTEPLYRRLKDEDPYVRKTAAMCVAKLILPDMVKVKG-FISELAKLLEDPNPMVVAN 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797  1031 gefCLAHL--LLKRNPTMFFQHFIECIFHFNSyekhgqynkfsqsergkqlflLKGKTNKEKRMRIYKFLLEHFTDEQR- 1107
Cdd:pfam12717   78 ---ALAALteISEKDPNAIYNLLPDIISKLSD---------------------ALNECSEWGQIYILDFLASYIPKDKQe 133

                          170       180
                   ....*....|....*....|.
gi 161016797  1108 -FNVTSKICLNILACFTDGIL 1127
Cdd:pfam12717  134 aESLVEKLCPRLQHANSAVVL 154
COG5098 COG5098
Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell ...
 903-1043 1.80e-05

Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning];


Pssm-ID: 227429 [Multi-domain]  Cd Length: 1128  Bit Score: 49.59  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797  903 FQPRSSAMPSVIRAhAIITLGKL-CLQHEdLAKKSIPALVRELEVSEDVAVRNNVIIVICDLCIRYTVMVDNYIPNISVC 981
Cdd:COG5098   902 SNSSRFSDEELQVA-AYLSLYKLmCLSFE-FCSEHLPLLITSMEKHPIPRIRANAVVGLGDFLVCFNTTADEHTHYLYRR 979

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161016797  982 LKDSDPFIRKQTLVLLTNLLQEEYVKWKGSLfFRFVSTLVDSHPDIASLGEFCLAHLLLKRN 1043
Cdd:COG5098   980 LGDEDADVRRTCLMTIHFLILAGQLKVKGQL-GKMALLLTDEDAEISDMARHFFTQIAKKDN 1040
ENTH pfam01417
ENTH domain; The ENTH (Epsin N-terminal homology) domain is found in proteins involved in ...
 538-603 4.58e-04

ENTH domain; The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery. The function of the ENTH domain is unknown.


Pssm-ID: 426255  Cd Length: 124  Bit Score: 41.39  E-value: 4.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797   538 MTMLRKRIKDEKINVR---KsALQVLMSILK------------HCDILSMEQDLLILQDHCRDPAISVRKQAlQSLTELV 602
Cdd:pfam01417   41 MKMLWKRLNDKGKNWRhiyK-ALTLLEYLLKngservvddlreNIYIIRTLTDFHYIDENGKDQGINVRKKA-KEILNLL 118


                   .
gi 161016797   603 M 603
Cdd:pfam01417  119 E 119
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 911-1104 3.45e-03

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 41.84  E-value: 3.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797   911 PSVIRAHAIITLGKLClqhedlAKKSIPALVREL--EVSE--DVAVRNNVIIVICDLCIRYTVMVDNYIPNISVCLKDSD 986
Cdd:pfam01602  314 DISIRLRALDLLYALV------NESNVKEIVKELlkYVHEiaDPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAG 387

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016797   987 PFIRKQTLVLLTNLLQEeyvkwKGSLFFRFVSTLVDSHPDIAS----------LGEFCLaHLLLKRNPTMFFQHFIEcIF 1056
Cdd:pfam01602  388 SYVVDEIVEVIRDIIQN-----VPELREYILEHLCELLEDIESpealaaalwiLGEYGE-LIPNGSSPPDLLRSILE-VF 460

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 161016797  1057 HFNSYEKHGQYNKFSQsergkQLFLLKGKTNKEKRMRIYKFLLEHFTD 1104
Cdd:pfam01602  461 VLESAKVRAAALTALA-----KLGLTSPEETTQNLIIQLLLTLATQDS 503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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