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Conserved domains on  [gi|29789445|ref|NP_817123|]
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desmoglein-4 isoform 2 preproprotein [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 11254343)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-265 2.14e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 2.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445  161 VYTASIEENSDANTLVVKLCATDADEENhlNSKIAYKIVSQEPSGapMFILNRYTGEVCTMSSfLDREQHSMYNLVVRGS 240
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 29789445  241 DRDGaaDGLSSECDCRIKVLDVNDN 265
Cdd:cd11304   76 DGGG--PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-379 7.01e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 7.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445  273 SYSASIEENC-LSSELIRLQAIDLDEEgtDNWLAQYLILSGNDGNWFDIqtDPQTneGILKVVKMLDYEQAPNIQLSIGV 351
Cdd:cd11304    1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*...
gi 29789445  352 KNQADFHYSVasqfqmhPTPVRIQVVDV 379
Cdd:cd11304   75 TDGGGPPLSS-------TATVTITVLDV 95
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 75-155 4.29e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 4.29e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445      75 SDCESNQKITYRISGvgidRPPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNA 154
Cdd:smart00112    5 ADSGENGKVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 29789445     155 P 155
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 392-492 4.04e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 4.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445  392 FSVREgikgSSLLNYVLGTYTAIDLDTGNPATdVRY-IIGHDAGSWLKIDSRTGEIQFSREFDKKSKyiinGIYTAEILA 470
Cdd:cd11304    4 VSVPE----NAPPGTVVLTVSATDPDSGENGE-VTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTA 74

                         90       100
                 ....*....|....*....|...
gi 29789445  471 IDDGS-GKTATGTICIEVPDIND 492
Cdd:cd11304   75 TDGGGpPLSSTATVTITVLDVND 97
CADH_Y-type_LIR super family cl03079
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 791-847 2.22e-07

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


The actual alignment was detected with superfamily member pfam01049:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 48.69  E-value: 2.22e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 29789445    791 ADEDEGRPANDCLLIYDHEGVGSPVGSIGC-CSWIVD-DLDESCMETLDPKFRTLAEIC 847
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSlESSTSDsDQDYDYLSDWGPRFKKLAELY 59
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-265 2.14e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 2.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445  161 VYTASIEENSDANTLVVKLCATDADEENhlNSKIAYKIVSQEPSGapMFILNRYTGEVCTMSSfLDREQHSMYNLVVRGS 240
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 29789445  241 DRDGaaDGLSSECDCRIKVLDVNDN 265
Cdd:cd11304   76 DGGG--PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
162-260 2.36e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 2.36e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445    162 YTASIEENSDANTLVVKLCATDADEEnhLNSKIAYKIVSQEPSGapMFILNRYTGEVCTMSSfLDREQHSMYNLVVRGSD 241
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDISTTKP-LDRESIGEYELTVEATD 75

                           90
                   ....*....|....*....
gi 29789445    242 RDGaaDGLSSECDCRIKVL 260
Cdd:pfam00028   76 SGG--PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-267 2.27e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 2.27e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445     181 ATDADEENhlNSKIAYKIVSQEPSGapMFILNRYTGEVCTMSSfLDREQHSMYNLVVRGSDRDGaaDGLSSECDCRIKVL 260
Cdd:smart00112    2 ATDADSGE--NGKVTYSILSGNDDG--LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGG--PPLSSTATVTITVL 74


                    ....*..
gi 29789445     261 DVNDNFP 267
Cdd:smart00112   75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-379 7.01e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 7.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445  273 SYSASIEENC-LSSELIRLQAIDLDEEgtDNWLAQYLILSGNDGNWFDIqtDPQTneGILKVVKMLDYEQAPNIQLSIGV 351
Cdd:cd11304    1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*...
gi 29789445  352 KNQADFHYSVasqfqmhPTPVRIQVVDV 379
Cdd:cd11304   75 TDGGGPPLSS-------TATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
274-376 1.27e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 1.27e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445    274 YSASIEENCLS-SELIRLQAIDLDEegTDNWLAQYLILSGNDGNWFDIQTDPqtneGILKVVKMLDYEQAPNIQLSIGVK 352
Cdd:pfam00028    1 YSASVPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                           90       100
                   ....*....|....*....|....
gi 29789445    353 NQadfhySVASQFQmhPTPVRIQV 376
Cdd:pfam00028   75 DS-----GGPPLSS--TATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 75-155 4.29e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 4.29e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445      75 SDCESNQKITYRISGvgidRPPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNA 154
Cdd:smart00112    5 ADSGENGKVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 29789445     155 P 155
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-153 7.49e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.11  E-value: 7.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445   62 EDNSKRNPIAKIR---SDCESNQKITYRISGVGIDrppyGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLE 138
Cdd:cd11304    8 ENAPPGTVVLTVSatdPDSGENGEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 29789445  139 RPLELRVKVMDINDN 153
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
54-147 3.10e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 3.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445     54 FAAACREGE-DNSKRNPIAKIRSDCESNQKITYRISGVGidrpPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNS 132
Cdd:pfam00028    1 YSASVPENApVGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 29789445    133 RGEDLERPLELRVKV 147
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 392-492 4.04e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 4.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445  392 FSVREgikgSSLLNYVLGTYTAIDLDTGNPATdVRY-IIGHDAGSWLKIDSRTGEIQFSREFDKKSKyiinGIYTAEILA 470
Cdd:cd11304    4 VSVPE----NAPPGTVVLTVSATDPDSGENGE-VTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTA 74

                         90       100
                 ....*....|....*....|...
gi 29789445  471 IDDGS-GKTATGTICIEVPDIND 492
Cdd:cd11304   75 TDGGGpPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 412-495 3.97e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 3.97e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445     412 TAIDLDTGNPATdVRY-IIGHDAGSWLKIDSRTGEIQFSREFDkkskYIINGIYTAEILAIDDGS-GKTATGTICIEVPD 489
Cdd:smart00112    1 SATDADSGENGK-VTYsILSGNDDGLFSIDPETGEITTTKPLD----REEQPEYTLTVEATDGGGpPLSSTATVTITVLD 75


                    ....*.
gi 29789445     490 INDYCP 495
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
392-487 2.93e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 2.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445    392 FSVREGikgsSLLNYVLGTYTAIDLDTGnPATDVRY-IIGHDAGSWLKIDSRTGEIQFSREFDKKSkyiiNGIYTAEILA 470
Cdd:pfam00028    3 ASVPEN----APVGTEVLTVTATDPDLG-PNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEA 73

                           90
                   ....*....|....*...
gi 29789445    471 IDDGS-GKTATGTICIEV 487
Cdd:pfam00028   74 TDSGGpPLSSTATVTITV 91
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 791-847 2.22e-07

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 48.69  E-value: 2.22e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 29789445    791 ADEDEGRPANDCLLIYDHEGVGSPVGSIGC-CSWIVD-DLDESCMETLDPKFRTLAEIC 847
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSlESSTSDsDQDYDYLSDWGPRFKKLAELY 59
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-265 2.14e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 2.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445  161 VYTASIEENSDANTLVVKLCATDADEENhlNSKIAYKIVSQEPSGapMFILNRYTGEVCTMSSfLDREQHSMYNLVVRGS 240
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 29789445  241 DRDGaaDGLSSECDCRIKVLDVNDN 265
Cdd:cd11304   76 DGGG--PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
162-260 2.36e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 2.36e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445    162 YTASIEENSDANTLVVKLCATDADEEnhLNSKIAYKIVSQEPSGapMFILNRYTGEVCTMSSfLDREQHSMYNLVVRGSD 241
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDISTTKP-LDRESIGEYELTVEATD 75

                           90
                   ....*....|....*....
gi 29789445    242 RDGaaDGLSSECDCRIKVL 260
Cdd:pfam00028   76 SGG--PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-267 2.27e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 2.27e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445     181 ATDADEENhlNSKIAYKIVSQEPSGapMFILNRYTGEVCTMSSfLDREQHSMYNLVVRGSDRDGaaDGLSSECDCRIKVL 260
Cdd:smart00112    2 ATDADSGE--NGKVTYSILSGNDDG--LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGG--PPLSSTATVTITVL 74


                    ....*..
gi 29789445     261 DVNDNFP 267
Cdd:smart00112   75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-379 7.01e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 7.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445  273 SYSASIEENC-LSSELIRLQAIDLDEEgtDNWLAQYLILSGNDGNWFDIqtDPQTneGILKVVKMLDYEQAPNIQLSIGV 351
Cdd:cd11304    1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*...
gi 29789445  352 KNQADFHYSVasqfqmhPTPVRIQVVDV 379
Cdd:cd11304   75 TDGGGPPLSS-------TATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
274-376 1.27e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 1.27e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445    274 YSASIEENCLS-SELIRLQAIDLDEegTDNWLAQYLILSGNDGNWFDIQTDPqtneGILKVVKMLDYEQAPNIQLSIGVK 352
Cdd:pfam00028    1 YSASVPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                           90       100
                   ....*....|....*....|....
gi 29789445    353 NQadfhySVASQFQmhPTPVRIQV 376
Cdd:pfam00028   75 DS-----GGPPLSS--TATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 75-155 4.29e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 4.29e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445      75 SDCESNQKITYRISGvgidRPPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNA 154
Cdd:smart00112    5 ADSGENGKVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 29789445     155 P 155
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-153 7.49e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.11  E-value: 7.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445   62 EDNSKRNPIAKIR---SDCESNQKITYRISGVGIDrppyGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLE 138
Cdd:cd11304    8 ENAPPGTVVLTVSatdPDSGENGEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 29789445  139 RPLELRVKVMDINDN 153
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
54-147 3.10e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 3.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445     54 FAAACREGE-DNSKRNPIAKIRSDCESNQKITYRISGVGidrpPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNS 132
Cdd:pfam00028    1 YSASVPENApVGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 29789445    133 RGEDLERPLELRVKV 147
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 392-492 4.04e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 4.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445  392 FSVREgikgSSLLNYVLGTYTAIDLDTGNPATdVRY-IIGHDAGSWLKIDSRTGEIQFSREFDKKSKyiinGIYTAEILA 470
Cdd:cd11304    4 VSVPE----NAPPGTVVLTVSATDPDSGENGE-VTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTA 74

                         90       100
                 ....*....|....*....|...
gi 29789445  471 IDDGS-GKTATGTICIEVPDIND 492
Cdd:cd11304   75 TDGGGpPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 412-495 3.97e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 3.97e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445     412 TAIDLDTGNPATdVRY-IIGHDAGSWLKIDSRTGEIQFSREFDkkskYIINGIYTAEILAIDDGS-GKTATGTICIEVPD 489
Cdd:smart00112    1 SATDADSGENGK-VTYsILSGNDDGLFSIDPETGEITTTKPLD----REEQPEYTLTVEATDGGGpPLSSTATVTITVLD 75


                    ....*.
gi 29789445     490 INDYCP 495
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
392-487 2.93e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 2.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445    392 FSVREGikgsSLLNYVLGTYTAIDLDTGnPATDVRY-IIGHDAGSWLKIDSRTGEIQFSREFDKKSkyiiNGIYTAEILA 470
Cdd:pfam00028    3 ASVPEN----APVGTEVLTVTATDPDLG-PNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEA 73

                           90
                   ....*....|....*...
gi 29789445    471 IDDGS-GKTATGTICIEV 487
Cdd:pfam00028   74 TDSGGpPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 57-153 5.93e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 51.58  E-value: 5.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789445   57 ACREGEDNSKRnpIAKIRSDCESNQKITYRISGVGIDRPPyGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGED 136
Cdd:cd00031    5 SAVEGRSRGSF--RVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                         90
                 ....*....|....*..
gi 29789445  137 LERPLELRVKVMDINDN 153
Cdd:cd00031   82 PQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 791-847 2.22e-07

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 48.69  E-value: 2.22e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 29789445    791 ADEDEGRPANDCLLIYDHEGVGSPVGSIGC-CSWIVD-DLDESCMETLDPKFRTLAEIC 847
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSlESSTSDsDQDYDYLSDWGPRFKKLAELY 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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