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Conserved domains on  [gi|28882043|ref|NP_795361|]
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nuclear receptor 2C2-associated protein isoform 2 [Homo sapiens]

Protein Classification

discoidin/SUN/FTP domain-containing protein( domain architecture ID 581195)

discoidin/SUN/FTP domain-containing protein that may have beta sandwich domain(s) that adopt a jelly roll topology, such as discoidin (also known as F5/8 type C) domains and SUN domains and FTP (eel-fucolectin fachylectin-4 pentaxrin-1) domains; may bind carbohydrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sad1_UNC super family cl23730
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 38-138 2.21e-03

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


The actual alignment was detected with superfamily member pfam07738:

Pssm-ID: 474037  Cd Length: 130  Bit Score: 35.73  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28882043    38 CWnSDQGPSQWVTLEFPQLIRVSQLQIQ-FQG-GFSSR------RGCLEGSQGTQALhkIVDF-YPEDNNSLQTFPipaa 108
Cdd:pfam07738  21 CW-SFKGSRGFVVIELSEFIIVEAITLEhVEKsVFSSApkdfevSGSDRYPTTKWVL--LGEFsYDLDGKTIQTFQ---- 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 28882043   109 evdrlkvtFEDATDFFGRVV---------------IYHLRVLGEK 138
Cdd:pfam07738  94 --------LENPPDIWVKYVklrilsnygnehytcLYRFRVHGTV 130
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 38-138 2.21e-03

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 35.73  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28882043    38 CWnSDQGPSQWVTLEFPQLIRVSQLQIQ-FQG-GFSSR------RGCLEGSQGTQALhkIVDF-YPEDNNSLQTFPipaa 108
Cdd:pfam07738  21 CW-SFKGSRGFVVIELSEFIIVEAITLEhVEKsVFSSApkdfevSGSDRYPTTKWVL--LGEFsYDLDGKTIQTFQ---- 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 28882043   109 evdrlkvtFEDATDFFGRVV---------------IYHLRVLGEK 138
Cdd:pfam07738  94 --------LENPPDIWVKYVklrilsnygnehytcLYRFRVHGTV 130
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 38-138 2.21e-03

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 35.73  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28882043    38 CWnSDQGPSQWVTLEFPQLIRVSQLQIQ-FQG-GFSSR------RGCLEGSQGTQALhkIVDF-YPEDNNSLQTFPipaa 108
Cdd:pfam07738  21 CW-SFKGSRGFVVIELSEFIIVEAITLEhVEKsVFSSApkdfevSGSDRYPTTKWVL--LGEFsYDLDGKTIQTFQ---- 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 28882043   109 evdrlkvtFEDATDFFGRVV---------------IYHLRVLGEK 138
Cdd:pfam07738  94 --------LENPPDIWVKYVklrilsnygnehytcLYRFRVHGTV 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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