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Conserved domains on  [gi|28575002|ref|NP_788451|]
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stem cell tumor, isoform A [Drosophila melanogaster]

Protein Classification

rhomboid family protein( domain architecture ID 10483871)

rhomboid family protein may be an intramembrane serine protease that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchors, or an inactive rhomboid protein that lacks the conserved active sites and has no peptidase activity

CATH:  1.20.1540.10
Gene Ontology:  GO:0016020
MEROPS:  S54
SCOP:  4000471

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
107-273 4.91e-37

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


:

Pssm-ID: 426384  Cd Length: 147  Bit Score: 129.65  E-value: 4.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002   107 PDKRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDPD-VFLVGASGGVYA 185
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002   186 LLAAHLANVLLNYHQMRYGVIKLLHILVFVSFDFGFAIYARYagdelqlgssseflaidqaetagAVSYVAHLAGAIAGL 265
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGN-----------------------GVSNLAHLGGLLVGL 137

                  ....*...
gi 28575002   266 TIGLLVLK 273
Cdd:pfam01694 138 LLGFILLR 145
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
107-273 4.91e-37

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 129.65  E-value: 4.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002   107 PDKRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDPD-VFLVGASGGVYA 185
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002   186 LLAAHLANVLLNYHQMRYGVIKLLHILVFVSFDFGFAIYARYagdelqlgssseflaidqaetagAVSYVAHLAGAIAGL 265
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGN-----------------------GVSNLAHLGGLLVGL 137

                  ....*...
gi 28575002   266 TIGLLVLK 273
Cdd:pfam01694 138 LLGFILLR 145
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
102-273 5.62e-21

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 88.76  E-value: 5.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002 102 MFIYRPDKRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDP--DVFLVGA 179
Cdd:COG0705  32 ALVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPgsGYPLVGA 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002 180 SGGVYALLAAHLANVLLNYHQMRYGVIKLLH-ILVFVSFDFGFAIYaryagdelqlgssseflaidqaeTAGAVSYVAHL 258
Cdd:COG0705 112 SGAIFGLLGALLVLGPRRRVLLLFIPIPALLfLLVWLLLGLLFGLL-----------------------GGGGIAWEAHL 168
                       170
                ....*....|....*
gi 28575002 259 AGAIAGLTIGLLVLK 273
Cdd:COG0705 169 GGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
69-301 4.18e-13

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 68.34  E-value: 4.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002   69 FIILVTLVELGFFVYhSVVTGEAAPRgpIPSDSMFI-----YRPD-KRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLP 142
Cdd:PTZ00101  55 FIMAISIIQIIVFII-SVSIKPADFL--TPSDSLLVtlganVASRiKQGEIHRLILPIFLHANIFHTFFNVFFQLRMGFT 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002  143 LEMVHGSTRIACIYFSGVLAGSLGTSIFDPDVFLVGASGGVYALLAAHLANVLLNYHQMRYGVIKLLHILVFVSFDFGFa 222
Cdd:PTZ00101 132 LEKNYGIVKIIILYFLTGIYGNILSSSVTYCPIKVGASTSGMGLLGIVTSELILLWHVIRHRERVVFNIIFFSLISFFY- 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002  223 iYARYAGdelqlgssseflaidqaetaGAVSYVAHLAGAIAGLTIGLLvlksFEQKLHEQLLW--WIALGTYLALVVFAI 300
Cdd:PTZ00101 211 -YFTFNG--------------------SNIDHVGHLGGLLSGISMGIL----YNSQMENKPSWydHMKMASYACLALLAI 265

                 .
gi 28575002  301 A 301
Cdd:PTZ00101 266 V 266
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
112-269 5.35e-09

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 54.50  E-value: 5.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002   112 EIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDPDV-FLVGASGGVYALLAAH 190
Cdd:TIGR03902  15 EWWRLLTGHFVHLNWWHLLMNLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLqWYVGLSGVLHGLFAWG 94
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28575002   191 LanvllnYHQMRYGviKLLHILVFVsfdfgfAIYARYAGDELQLGSSSEflaidQAETAGAVSYVAHLAGAIAGLTIGL 269
Cdd:TIGR03902  95 A------LRDIRYG--RRSGWLLLL------GVIAKLAWEQLFGASAFT-----AALIGAPVATEAHLAGAISGLLIAL 154
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
107-273 4.91e-37

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 129.65  E-value: 4.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002   107 PDKRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDPD-VFLVGASGGVYA 185
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002   186 LLAAHLANVLLNYHQMRYGVIKLLHILVFVSFDFGFAIYARYagdelqlgssseflaidqaetagAVSYVAHLAGAIAGL 265
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGN-----------------------GVSNLAHLGGLLVGL 137

                  ....*...
gi 28575002   266 TIGLLVLK 273
Cdd:pfam01694 138 LLGFILLR 145
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
102-273 5.62e-21

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 88.76  E-value: 5.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002 102 MFIYRPDKRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDP--DVFLVGA 179
Cdd:COG0705  32 ALVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPgsGYPLVGA 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002 180 SGGVYALLAAHLANVLLNYHQMRYGVIKLLH-ILVFVSFDFGFAIYaryagdelqlgssseflaidqaeTAGAVSYVAHL 258
Cdd:COG0705 112 SGAIFGLLGALLVLGPRRRVLLLFIPIPALLfLLVWLLLGLLFGLL-----------------------GGGGIAWEAHL 168
                       170
                ....*....|....*
gi 28575002 259 AGAIAGLTIGLLVLK 273
Cdd:COG0705 169 GGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
69-301 4.18e-13

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 68.34  E-value: 4.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002   69 FIILVTLVELGFFVYhSVVTGEAAPRgpIPSDSMFI-----YRPD-KRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLP 142
Cdd:PTZ00101  55 FIMAISIIQIIVFII-SVSIKPADFL--TPSDSLLVtlganVASRiKQGEIHRLILPIFLHANIFHTFFNVFFQLRMGFT 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002  143 LEMVHGSTRIACIYFSGVLAGSLGTSIFDPDVFLVGASGGVYALLAAHLANVLLNYHQMRYGVIKLLHILVFVSFDFGFa 222
Cdd:PTZ00101 132 LEKNYGIVKIIILYFLTGIYGNILSSSVTYCPIKVGASTSGMGLLGIVTSELILLWHVIRHRERVVFNIIFFSLISFFY- 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002  223 iYARYAGdelqlgssseflaidqaetaGAVSYVAHLAGAIAGLTIGLLvlksFEQKLHEQLLW--WIALGTYLALVVFAI 300
Cdd:PTZ00101 211 -YFTFNG--------------------SNIDHVGHLGGLLSGISMGIL----YNSQMENKPSWydHMKMASYACLALLAI 265

                 .
gi 28575002  301 A 301
Cdd:PTZ00101 266 V 266
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
112-269 5.35e-09

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 54.50  E-value: 5.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002   112 EIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDPDV-FLVGASGGVYALLAAH 190
Cdd:TIGR03902  15 EWWRLLTGHFVHLNWWHLLMNLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLqWYVGLSGVLHGLFAWG 94
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28575002   191 LanvllnYHQMRYGviKLLHILVFVsfdfgfAIYARYAGDELQLGSSSEflaidQAETAGAVSYVAHLAGAIAGLTIGL 269
Cdd:TIGR03902  95 A------LRDIRYG--RRSGWLLLL------GVIAKLAWEQLFGASAFT-----AALIGAPVATEAHLAGAISGLLIAL 154
PRK10907 PRK10907
intramembrane serine protease GlpG; Provisional
105-187 4.21e-03

intramembrane serine protease GlpG; Provisional


Pssm-ID: 182828 [Multi-domain]  Cd Length: 276  Bit Score: 38.45  E-value: 4.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28575002  105 YRPDKRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDpDVFLVGASGGVY 184
Cdd:PRK10907 127 FDPSLKFELWRYFTHALLHFSLLHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGWVQSKFS-GPWFGGLSGVVY 205

                 ...
gi 28575002  185 ALL 187
Cdd:PRK10907 206 ALM 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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