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Conserved domains on  [gi|28574300|ref|NP_788084|]
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Tif-IA [Drosophila melanogaster]

Protein Classification

RNA polymerase I-specific transcription initiation factor RRN3 family protein( domain architecture ID 10526375)

RNA polymerase I-specific transcription initiation factor RRN3 family protein similar to human RRN3 that is required for efficient transcription initiation by RNA polymerase I, and for the formation of the competent preinitiation complex (PIC).

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 39-556 7.69e-164

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


:

Pssm-ID: 461623  Cd Length: 548  Bit Score: 479.03  E-value: 7.69e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300    39 KEKGLAESVRVALEER---NFHLVKEFTYFLREA-----ELSDDEVVIIIKDAKRIVHNLTPEFVTVVEALLSLNWKKRS 110
Cdd:pfam05327   4 SDKMYREFVRRALEEHekgDSEQYDELKEQFSPDpespdAPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   111 SEIIEAYTEFCIELMVTHNRYLPIGVSKLIVHWIPGDMDESdWVHGCPSEHVRNELKPIHKVLDRILTAVPMAFDIIIDA 190
Cdd:pfam05327  84 ESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPESSG-RLPGYPPVTRREVYERVHEALKYILRLIPTAPSVLLPI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   191 ISAKFPYFKKPYHVTAGYLYNVLWLLEYKPIFEELVFQLVLQKLLLLDVnapkdEIELEMNDEEEKVEADTL-------- 262
Cdd:pfam05327 163 LSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIQVELEDLDDDEDEELLeqldeddd 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   263 ------FEIDDVCAE---------NVPKSEKSVsHPVGKTLDVCLFLLYKFFDGKCRlNENSSEEQRRTANRLFKMLLYL 327
Cdd:pfam05327 238 ddddddSDDDSDSSDdgldddeedDEVQRIKKI-KELVEKLDAILDLLFEHLDSKFS-SGSPEELNEGEGVEVFNTLLSL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   328 FDEVLLPSHNTHHVQFILFYATSLRSVYSEAFLDSLWTKVQNPNVSAVIRHAAVGYMASFLSRARFLPLSTVTFYLKELT 407
Cdd:pfam05327 316 FKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLC 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   408 RWAHTYIDDSDAYKQNCSLKANLVFYSVCQAVFYLIAFRAKDLTASSKDLLFLQSL-------QLSRLAMCHLNPLRYCL 480
Cdd:pfam05327 396 DWLNRYVDEREEECRGPDLKRHGVFYAVCQALLYIFCFRWRDLTDADDDEEGGDLEwlpgldeFLQRAIYSKLNPLKVCS 475

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574300   481 APVATAFAGVTRTYQLAYCHTVLERNARRKLAtvyGHEKCMPDETLESFFPFDPYVLKLSKKYIETNYMVYQSNDT 556
Cdd:pfam05327 476 PNVVTEFARIAHHLQFAYCFSIIESNKREETA---GTATGQEFEQLDAYFPFDPYLLPRSKRWIEPDYVEWSEVAG 548
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 39-556 7.69e-164

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 479.03  E-value: 7.69e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300    39 KEKGLAESVRVALEER---NFHLVKEFTYFLREA-----ELSDDEVVIIIKDAKRIVHNLTPEFVTVVEALLSLNWKKRS 110
Cdd:pfam05327   4 SDKMYREFVRRALEEHekgDSEQYDELKEQFSPDpespdAPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   111 SEIIEAYTEFCIELMVTHNRYLPIGVSKLIVHWIPGDMDESdWVHGCPSEHVRNELKPIHKVLDRILTAVPMAFDIIIDA 190
Cdd:pfam05327  84 ESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPESSG-RLPGYPPVTRREVYERVHEALKYILRLIPTAPSVLLPI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   191 ISAKFPYFKKPYHVTAGYLYNVLWLLEYKPIFEELVFQLVLQKLLLLDVnapkdEIELEMNDEEEKVEADTL-------- 262
Cdd:pfam05327 163 LSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIQVELEDLDDDEDEELLeqldeddd 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   263 ------FEIDDVCAE---------NVPKSEKSVsHPVGKTLDVCLFLLYKFFDGKCRlNENSSEEQRRTANRLFKMLLYL 327
Cdd:pfam05327 238 ddddddSDDDSDSSDdgldddeedDEVQRIKKI-KELVEKLDAILDLLFEHLDSKFS-SGSPEELNEGEGVEVFNTLLSL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   328 FDEVLLPSHNTHHVQFILFYATSLRSVYSEAFLDSLWTKVQNPNVSAVIRHAAVGYMASFLSRARFLPLSTVTFYLKELT 407
Cdd:pfam05327 316 FKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLC 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   408 RWAHTYIDDSDAYKQNCSLKANLVFYSVCQAVFYLIAFRAKDLTASSKDLLFLQSL-------QLSRLAMCHLNPLRYCL 480
Cdd:pfam05327 396 DWLNRYVDEREEECRGPDLKRHGVFYAVCQALLYIFCFRWRDLTDADDDEEGGDLEwlpgldeFLQRAIYSKLNPLKVCS 475

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574300   481 APVATAFAGVTRTYQLAYCHTVLERNARRKLAtvyGHEKCMPDETLESFFPFDPYVLKLSKKYIETNYMVYQSNDT 556
Cdd:pfam05327 476 PNVVTEFARIAHHLQFAYCFSIIESNKREETA---GTATGQEFEQLDAYFPFDPYLLPRSKRWIEPDYVEWSEVAG 548
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 39-556 7.69e-164

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 479.03  E-value: 7.69e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300    39 KEKGLAESVRVALEER---NFHLVKEFTYFLREA-----ELSDDEVVIIIKDAKRIVHNLTPEFVTVVEALLSLNWKKRS 110
Cdd:pfam05327   4 SDKMYREFVRRALEEHekgDSEQYDELKEQFSPDpespdAPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   111 SEIIEAYTEFCIELMVTHNRYLPIGVSKLIVHWIPGDMDESdWVHGCPSEHVRNELKPIHKVLDRILTAVPMAFDIIIDA 190
Cdd:pfam05327  84 ESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPESSG-RLPGYPPVTRREVYERVHEALKYILRLIPTAPSVLLPI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   191 ISAKFPYFKKPYHVTAGYLYNVLWLLEYKPIFEELVFQLVLQKLLLLDVnapkdEIELEMNDEEEKVEADTL-------- 262
Cdd:pfam05327 163 LSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIQVELEDLDDDEDEELLeqldeddd 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   263 ------FEIDDVCAE---------NVPKSEKSVsHPVGKTLDVCLFLLYKFFDGKCRlNENSSEEQRRTANRLFKMLLYL 327
Cdd:pfam05327 238 ddddddSDDDSDSSDdgldddeedDEVQRIKKI-KELVEKLDAILDLLFEHLDSKFS-SGSPEELNEGEGVEVFNTLLSL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   328 FDEVLLPSHNTHHVQFILFYATSLRSVYSEAFLDSLWTKVQNPNVSAVIRHAAVGYMASFLSRARFLPLSTVTFYLKELT 407
Cdd:pfam05327 316 FKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLC 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574300   408 RWAHTYIDDSDAYKQNCSLKANLVFYSVCQAVFYLIAFRAKDLTASSKDLLFLQSL-------QLSRLAMCHLNPLRYCL 480
Cdd:pfam05327 396 DWLNRYVDEREEECRGPDLKRHGVFYAVCQALLYIFCFRWRDLTDADDDEEGGDLEwlpgldeFLQRAIYSKLNPLKVCS 475

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574300   481 APVATAFAGVTRTYQLAYCHTVLERNARRKLAtvyGHEKCMPDETLESFFPFDPYVLKLSKKYIETNYMVYQSNDT 556
Cdd:pfam05327 476 PNVVTEFARIAHHLQFAYCFSIIESNKREETA---GTATGQEFEQLDAYFPFDPYLLPRSKRWIEPDYVEWSEVAG 548
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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