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Conserved domains on  [gi|172072675|ref|NP_780664|]
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ankyrin repeat domain-containing protein 34B [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-140 4.99e-25

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 104.65  E-value: 4.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  33 GAYINESNDRGETPLMIACKTKHVDqqsvgrakMVKYLLENSADPNIQDKSGKSALMHAClERAGPEVVSLLLKSGADLS 112
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLE--------IVKLLLEAGADVNARDNDGETPLHLAA-ENGHLEIVKLLLEAGADVN 213

                         90       100
                 ....*....|....*....|....*...
gi 172072675 113 LQDHSGYSALVYAINAEDRDTLKVLLSA 140
Cdd:COG0666  214 AKDNDGKTALDLAAENGNLEIVKLLLEA 241
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-140 4.99e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 104.65  E-value: 4.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  33 GAYINESNDRGETPLMIACKTKHVDqqsvgrakMVKYLLENSADPNIQDKSGKSALMHAClERAGPEVVSLLLKSGADLS 112
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLE--------IVKLLLEAGADVNARDNDGETPLHLAA-ENGHLEIVKLLLEAGADVN 213

                         90       100
                 ....*....|....*....|....*...
gi 172072675 113 LQDHSGYSALVYAINAEDRDTLKVLLSA 140
Cdd:COG0666  214 AKDNDGKTALDLAAENGNLEIVKLLLEA 241
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-115 3.58e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 3.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675   31 EGGAYINESNDRGETPLMIACKTKHVDqqsvgrakMVKYLLENsADPNIQDKsGKSALMHACLERAgPEVVSLLLKSGAD 110
Cdd:pfam12796  18 ENGADANLQDKNGRTALHLAAKNGHLE--------IVKLLLEH-ADVNLKDN-GRTALHYAARSGH-LEIVKLLLEKGAD 86


                  ....*
gi 172072675  111 LSLQD 115
Cdd:pfam12796  87 INVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-138 4.32e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.52  E-value: 4.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  33 GAYINESNDRGETPLMIACKTKhvdqqsVGRAKMVKYLLENSADPNIQDKSGKSALmHACLERAGPEV------------ 100
Cdd:PHA03100  96 GANVNAPDNNGITPLLYAISKK------SNSYSIVEYLLDNGANVNIKNSDGENLL-HLYLESNKIDLkilkllidkgvd 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 172072675 101 ------VSLLLKSGADLSLQDHSGYSALVYAINAEDRDTLKVLL 138
Cdd:PHA03100 169 inaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLL 212
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 42-79 8.43e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 8.43e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 172072675    42 RGETPLMIACKTKHVDqqsvgrakMVKYLLENSADPNI 79
Cdd:smart00248   1 DGRTPLHLAAENGNLE--------VVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-140 4.99e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 104.65  E-value: 4.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  33 GAYINESNDRGETPLMIACKTKHVDqqsvgrakMVKYLLENSADPNIQDKSGKSALMHAClERAGPEVVSLLLKSGADLS 112
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLE--------IVKLLLEAGADVNARDNDGETPLHLAA-ENGHLEIVKLLLEAGADVN 213

                         90       100
                 ....*....|....*....|....*...
gi 172072675 113 LQDHSGYSALVYAINAEDRDTLKVLLSA 140
Cdd:COG0666  214 AKDNDGKTALDLAAENGNLEIVKLLLEA 241
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-154 5.85e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.24  E-value: 5.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  31 EGGAYINESNDRGETPLMIACKTKHVDqqsvgrakMVKYLLENSADPNIQDKSGKSALMHAClERAGPEVVSLLLKSGAD 110
Cdd:COG0666  174 EAGADVNARDNDGETPLHLAAENGHLE--------IVKLLLEAGADVNAKDNDGKTALDLAA-ENGNLEIVKLLLEAGAD 244

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 172072675 111 LSLQDHSGYSALVYAINAEDRDTLKVLLSACQAKGKEVIIITTA 154
Cdd:COG0666  245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-115 3.58e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 3.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675   31 EGGAYINESNDRGETPLMIACKTKHVDqqsvgrakMVKYLLENsADPNIQDKsGKSALMHACLERAgPEVVSLLLKSGAD 110
Cdd:pfam12796  18 ENGADANLQDKNGRTALHLAAKNGHLE--------IVKLLLEH-ADVNLKDN-GRTALHYAARSGH-LEIVKLLLEKGAD 86


                  ....*
gi 172072675  111 LSLQD 115
Cdd:pfam12796  87 INVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-139 1.49e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 1.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675   47 LMIACKTKHVDqqsvgrakMVKYLLENSADPNIQDKSGKSALMHACleRAG-PEVVSLLLKSgADLSLQDHsGYSALVYA 125
Cdd:pfam12796   1 LHLAAKNGNLE--------LVKLLLENGADANLQDKNGRTALHLAA--KNGhLEIVKLLLEH-ADVNLKDN-GRTALHYA 68

                          90
                  ....*....|....
gi 172072675  126 INAEDRDTLKVLLS 139
Cdd:pfam12796  69 ARSGHLEIVKLLLE 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
62-140 5.29e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.35  E-value: 5.29e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 172072675  62 GRAKMVKYLLENSADPNIQDKSGKSALMHAClERAGPEVVSLLLKSGADLSLQDHSGYSALVYAINAEDRDTLKVLLSA 140
Cdd:COG0666   65 GDLLVALLLLAAGADINAKDDGGNTLLHAAA-RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-138 4.32e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.52  E-value: 4.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  33 GAYINESNDRGETPLMIACKTKhvdqqsVGRAKMVKYLLENSADPNIQDKSGKSALmHACLERAGPEV------------ 100
Cdd:PHA03100  96 GANVNAPDNNGITPLLYAISKK------SNSYSIVEYLLDNGANVNIKNSDGENLL-HLYLESNKIDLkilkllidkgvd 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 172072675 101 ------VSLLLKSGADLSLQDHSGYSALVYAINAEDRDTLKVLL 138
Cdd:PHA03100 169 inaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLL 212
PHA03095 PHA03095
ankyrin-like protein; Provisional
 33-122 6.11e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.11  E-value: 6.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  33 GAYINESNDRGETPLMIACKTKHVDqqsvgrAKMVKYLLENSADPNIQDKSGKSALmHACLE--RAGPEVVSLLLKSGAD 110
Cdd:PHA03095 107 GADVNAKDKVGRTPLHVYLSGFNIN------PKVIRLLLRKGADVNALDLYGMTPL-AVLLKsrNANVELLRLLIDAGAD 179

                         90
                 ....*....|..
gi 172072675 111 LSLQDHSGYSAL 122
Cdd:PHA03095 180 VYAVDDRFRSLL 191
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-139 1.69e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.60  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  33 GAYINESNDRGETPLMIACKTKHVDQQ----------SVGRAKMVKYLLENSADPNIQDKSGKSALMHAClERAGPEVVS 102
Cdd:PHA03100 131 GANVNIKNSDGENLLHLYLESNKIDLKilkllidkgvDINAKNRVNYLLSYGVPINIKDVYGFTPLHYAV-YNNNPEFVK 209

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 172072675 103 LLLKSGADLSLQDHSGYSALVYAINAEDRDTLKVLLS 139
Cdd:PHA03100 210 YLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
Ank_5 pfam13857
Ankyrin repeats (many copies);
36-91 9.62e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.50  E-value: 9.62e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 172072675   36 INESNDRGETPLMIACKTKHVDqqsvgrakMVKYLLENSADPNIQDKSGKSALMHA 91
Cdd:pfam13857   9 LNRLDGEGYTPLHVAAKYGALE--------IVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 31-168 3.08e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 3.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  31 EGGAYINESNDRGETPLmiacktkHVDQQSVGRAKMVKYLLENSADPNIQDKSGKSALmHACL--ERAGPEVVSLLLKSG 108
Cdd:PHA03095  71 EAGADVNAPERCGFTPL-------HLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPL-HVYLsgFNINPKVIRLLLRKG 142

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 172072675 109 ADLSLQDHSGYSAL-VYAINAE-DRDTLKVLLSAcqakGKEViiitTAKSPSGRHTTQHHLN 168
Cdd:PHA03095 143 ADVNALDLYGMTPLaVLLKSRNaNVELLRLLIDA----GADV----YAVDDRFRSLLHHHLQ 196
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 33-140 4.15e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 52.30  E-value: 4.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  33 GAYINES-NDRGETPLMIACKTKHVDqqsvgrakMVKYLLENSADPNIQDkSGKSALMHACLERAGPEVVSLLLKSGADL 111
Cdd:PHA02875  91 GKFADDVfYKDGMTPLHLATILKKLD--------IMKLLIARGADPDIPN-TDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                         90       100
                 ....*....|....*....|....*....
gi 172072675 112 SLQDHSGYSALVYAINAEDRDTLKVLLSA 140
Cdd:PHA02875 162 DIEDCCGCTPLIIAMAKGDIAICKMLLDS 190
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-139 5.21e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.97  E-value: 5.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  33 GAYINESNDRGETPLMIACKTKHVDQQSVgraKMVKYLLENSADPNIQDKSGKSALMHA-CLERAGPEVVSLLLKSGADL 111
Cdd:PHA03100  58 GADINSSTKNNSTPLHYLSNIKYNLTDVK---EIVKLLLEYGANVNAPDNNGITPLLYAiSKKSNSYSIVEYLLDNGANV 134

                         90       100       110
                 ....*....|....*....|....*....|
gi 172072675 112 SLQDHSGYSALVYAI--NAEDRDTLKVLLS 139
Cdd:PHA03100 135 NIKNSDGENLLHLYLesNKIDLKILKLLID 164
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 42-82 1.23e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 44.97  E-value: 1.23e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 172072675   42 RGETPLMIACKtkhvdqqSVGRAKMVKYLLENSADPNIQDK 82
Cdd:pfam00023   1 DGNTPLHLAAG-------RRGNLEIVKLLLSKGADVNARDK 34
PHA03095 PHA03095
ankyrin-like protein; Provisional
 63-140 3.58e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.25  E-value: 3.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  63 RAKMVKYLLENSADPNIQDKSGKSALmHACLERAGP---EVVSLLLKSGADLSLQDHSGYSAL-VYAINAEDRDTLKVLL 138
Cdd:PHA03095  26 TVEEVRRLLAAGADVNFRGEYGKTPL-HLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLI 104


                 ..
gi 172072675 139 SA 140
Cdd:PHA03095 105 KA 106
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-138 4.90e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.81  E-value: 4.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  31 EGGAYINESNDRGETPLMIACKtkhvdqqsVGRAKMVKYLLENSADPNIQDKSGKSALMHACLERAgpEVVSLLLKSgAD 110
Cdd:PHA02874 178 EKGAYANVKDNNGESPLHNAAE--------YGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINN-AS 246

                         90       100
                 ....*....|....*....|....*....
gi 172072675 111 LSLQDHSGYSALVYAINAE-DRDTLKVLL 138
Cdd:PHA02874 247 INDQDIDGSTPLHHAINPPcDIDIIDILL 275
Ank_2 pfam12796
Ankyrin repeats (3 copies);
88-147 7.06e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 7.06e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675   88 LMHACLERAgPEVVSLLLKSGADLSLQDHSGYSALVYAINAEDRDTLKVLLSACQAKGKE 147
Cdd:pfam12796   1 LHLAAKNGN-LELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD 59
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 63-126 9.30e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.12  E-value: 9.30e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 172072675  63 RAKMVKYLLENSADPNIQDKSGKSALMHACLERA----GPEVVSLLLKSGADLSLQDHSGYSALVYAI 126
Cdd:PHA03100  47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdVKEIVKLLLEYGANVNAPDNNGITPLLYAI 114
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 62-142 1.19e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.97  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  62 GRAKMVKYLLENSADPNIQDKSGKSALMHACLeRAGPEVVSLLLKSGADLSLQDHSGYSALVYAINAEDRDTLKVLLSAC 141
Cdd:PTZ00322  93 GDAVGARILLTGGADPNCRDYDGRTPLHIACA-NGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHS 171


                 .
gi 172072675 142 Q 142
Cdd:PTZ00322 172 Q 172
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 35-138 1.34e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 46.35  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  35 YINESNDRGETPLMIACKTKHVDQQsvgrakMVKYLLENSADPNIQDKSGKSALMHACL---ERAGPEVVSLLLKSGADL 111
Cdd:PHA02859  43 FVNDCNDLYETPIFSCLEKDKVNVE------ILKFLIENGADVNFKTRDNNLSALHHYLsfnKNVEPEILKILIDSGSSI 116

                         90       100
                 ....*....|....*....|....*....
gi 172072675 112 SLQDHSGYSAL-VYAINAEDR-DTLKVLL 138
Cdd:PHA02859 117 TEEDEDGKNLLhMYMCNFNVRiNVIKLLI 145
Ank_4 pfam13637
Ankyrin repeats (many copies);
45-105 1.36e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 1.36e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 172072675   45 TPLMIACKTKHVDqqsvgrakMVKYLLENSADPNIQDKSGKSALMHACleRAG-PEVVSLLL 105
Cdd:pfam13637   3 TALHAAAASGHLE--------LLRLLLEKGADINAVDGNGETALHFAA--SNGnVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
70-125 2.53e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.95  E-value: 2.53e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 172072675   70 LLEN-SADPNIQDKSGKSALMHACLERAgPEVVSLLLKSGADLSLQDHSGYSALVYA 125
Cdd:pfam13857   1 LLEHgPIDLNRLDGEGYTPLHVAAKYGA-LEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 33-138 5.66e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 5.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  33 GAYINESNDRGETPLMIACKTKHVDqqsvgRAKMVKYLLENSADPNIQDKSGKSALmHACLERAG-PEVVSLLLKSGADL 111
Cdd:PHA03095  37 GADVNFRGEYGKTPLHLYLHYSSEK-----VKDIVRLLLEAGADVNAPERCGFTPL-HLYLYNATtLDVIKLLIKAGADV 110

                         90       100
                 ....*....|....*....|....*....
gi 172072675 112 SLQDHSGYSAL-VYAINAE-DRDTLKVLL 138
Cdd:PHA03095 111 NAKDKVGRTPLhVYLSGFNiNPKVIRLLL 139
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 43-141 7.16e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 7.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  43 GETPLMIACktkhvdqqSVGRAKMVKYLLENSADPNIQDKSGKSALMHACLERAGPEVVSLLLKSGADlslqdhsgySAL 122
Cdd:PHA02875 168 GCTPLIIAM--------AKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGAD---------CNI 230

                         90
                 ....*....|....*....
gi 172072675 123 VYAINAEDRDTLKVLLSAC 141
Cdd:PHA02875 231 MFMIEGEECTILDMICNMC 249
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 14-138 7.34e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.34  E-value: 7.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  14 LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKH-----------VDQQSVG----RAKMVKYLLENSADPN 78
Cdd:PHA02874  39 LIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAhdiikllidngVDTSILPipciEKDMIKTILDCGIDVN 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  79 IQDKSGKSALMHAcLERAGPEVVSLLLKSGADLSLQDHSGYSALVYAINAEDRDTLKVLL 138
Cdd:PHA02874 119 IKDAELKTFLHYA-IKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLL 177
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 42-79 8.43e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 8.43e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 172072675    42 RGETPLMIACKTKHVDqqsvgrakMVKYLLENSADPNI 79
Cdd:smart00248   1 DGRTPLHLAAENGNLE--------VVKLLLDKGADINA 30
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-139 8.81e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 8.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  31 EGGAYINESNDRGETPLMIACKTkhvdqqsvGRAKMVKYLLENSADPNIQDKSGKSALmHACLERAGPEVVSLLLKSGAD 110
Cdd:PHA02874 112 DCGIDVNIKDAELKTFLHYAIKK--------GDLESIKMLFEYGADVNIEDDNGCYPI-HIAIKHNFFDIIKLLLEKGAY 182

                         90       100
                 ....*....|....*....|....*....
gi 172072675 111 LSLQDHSGYSALVYAINAEDRDTLKVLLS 139
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGDYACIKLLID 211
Ank_4 pfam13637
Ankyrin repeats (many copies);
88-138 1.64e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.64e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 172072675   88 LMHACLERAGPEVVSLLLKSGADLSLQDHSGYSALVYAINAEDRDTLKVLL 138
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02917 PHA02917
ankyrin-like protein; Provisional
 31-138 1.76e-04

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 44.22  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  31 EGGAYINESNDrGETPLMIACKTKH------VDQQSVGRAKM---------VKYLLENSADPNIQDKSGKSaLMHACLER 95
Cdd:PHA02917 385 EGGDAVNHLDD-GEIPIGHLCKSNYgcynfyTYTYKKGLCDMsyacpilstINICLPYLKDINMIDKRGET-LLHKAVRY 462

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 172072675  96 AGPEVVSLLLKSGADLSLQDHSGYSALVYAIN-AEDRDTLKVLL 138
Cdd:PHA02917 463 NKQSLVSLLLESGSDVNIRSNNGYTCIAIAINeSRNIELLKMLL 506
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 31-106 2.64e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 2.64e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 172072675  31 EGGAYINESNDRGETPLMIACktkhvdqqSVGRAKMVKYLLENSADPNIQDKSGKSALMHAcLERAGPEVVSLLLK 106
Cdd:PTZ00322 103 TGGADPNCRDYDGRTPLHIAC--------ANGHVQVVRVLLEFGADPTLLDKDGKTPLELA-EENGFREVVQLLSR 169
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 84-116 3.54e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 3.54e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 172072675   84 GKSALMHACLERAGPEVVSLLLKSGADLSLQDH 116
Cdd:pfam00023   2 GNTPLHLAAGRRGNLEIVKLLLSKGADVNARDK 34
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 42-79 3.54e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 3.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 172072675   42 RGETPLMIACktkhvdqqSVGRAKMVKYLLENSADPNI 79
Cdd:pfam13606   1 DGNTPLHLAA--------RNGRLEIVKLLLENGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 65-138 4.02e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.13  E-value: 4.02e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 172072675  65 KMVKYLLENSADPNIQDKSGKSALmHACLERAGPEVVSLLLKSGADLSLQDHSGYSALVYAINAEDRDTLKVLL 138
Cdd:PHA02876 159 LIAEMLLEGGADVNAKDIYCITPI-HYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAII 231
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 9-115 1.22e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.40  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675   9 TDGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIacktkhvdqqSVGRAK---MVKYLLENSADPNIQDKSGK 85
Cdd:PHA02878 200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHI----------SVGYCKdydILKLLLEHGVDVNAKSYILG 269

                         90       100       110
                 ....*....|....*....|....*....|
gi 172072675  86 SALMHACLEraGPEVVSLLLKSGADLSLQD 115
Cdd:PHA02878 270 LTALHSSIK--SERKLKLLLEYGADINSLN 297
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 60-137 1.65e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.01  E-value: 1.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 172072675  60 SVGRAKMVKYLLENSADPNIQDKSGKSALmHACLERAGPEVVSLLLKSGADLSLQDHSGYSALVYAINAEDRDTLKVL 137
Cdd:PLN03192 534 STGNAALLEELLKAKLDPDIGDSKGRTPL-HIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 48-139 4.72e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.26  E-value: 4.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  48 MIACKTKHVDQqsvgRAKMVKYLLENSADPNIQDKSgKSALMHACLERAGPEVVSLLLKSGADLSLQDHSGYSALVYAIN 127
Cdd:PHA03100   3 SYIVLTKSRII----KVKNIKYIIMEDDLNDYSYKK-PVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSN 77

                         90
                 ....*....|....*..
gi 172072675 128 A-----EDRDTLKVLLS 139
Cdd:PHA03100  78 IkynltDVKEIVKLLLE 94
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 64-138 4.85e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.48  E-value: 4.85e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 172072675  64 AKMVKYLLENSADPNIQDKSGKSALMHACLERAGPEVVSLLLKSGADLSLQDHSGYSALVYAINAEDRDTLKVLL 138
Cdd:PHA02878 147 AEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILL 221
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-140 5.94e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 38.78  E-value: 5.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172072675  35 YINESNDRGETPLMIACKTKHVDQQSVGRAKMVKYLLENSADPNIQDKSGKSALMHACLERAGPEVVSLLLKSGADLSLQ 114
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                         90       100
                 ....*....|....*....|....*.
gi 172072675 115 DHSGYSALVYAINAEDRDTLKVLLSA 140
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLEA 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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