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Conserved domains on  [gi|124249073|ref|NP_780389|]
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WD repeat-containing protein 44 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 512-859 1.05e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 1.05e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 512 HMGAVWTMKFSHCGRLLASAGQDNIVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDMGVCSGTdedpd 591
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------------------------------------DLETGELLRT----- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 592 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPrDDRYFLSGS 669
Cdd:cd00200   47 -------------LKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSS 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 670 LDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNKVgrkITG 749
Cdd:cd00200  113 RDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLTGHTGE---VNS 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 750 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTS 826
Cdd:cd00200  183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS-----VAFSPDGYLLASGSEDGTIRVW----DLRTGEC 253

                        330       340       350
                 ....*....|....*....|....*....|...
gi 124249073 827 VRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 859
Cdd:cd00200  254 VQT--------LSGHTNSVTSLAWSPDGKRLAS 278
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 512-859 1.05e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 1.05e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 512 HMGAVWTMKFSHCGRLLASAGQDNIVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDMGVCSGTdedpd 591
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------------------------------------DLETGELLRT----- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 592 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPrDDRYFLSGS 669
Cdd:cd00200   47 -------------LKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSS 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 670 LDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNKVgrkITG 749
Cdd:cd00200  113 RDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLTGHTGE---VNS 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 750 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTS 826
Cdd:cd00200  183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS-----VAFSPDGYLLASGSEDGTIRVW----DLRTGEC 253

                        330       340       350
                 ....*....|....*....|....*....|...
gi 124249073 827 VRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 859
Cdd:cd00200  254 VQT--------LSGHTNSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
497-817 1.42e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 1.42e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 497 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNIVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 576
Cdd:COG2319  147 WDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 577 DTDMGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 654
Cdd:COG2319  190 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRS 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 655 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 734
Cdd:COG2319  252 VAFSP-DGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLL 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 735 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKY 811
Cdd:COG2319  324 RTLTGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgAVTS-----VAFSPDGRTLASGSADGT 395


                 ....*.
gi 124249073 812 VYIWST 817
Cdd:COG2319  396 VRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 640-678 1.36e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 124249073   640 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 678
Cdd:smart00320   2 GELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
640-678 6.96e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 6.96e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 124249073  640 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 678
Cdd:pfam00400   1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 598-686 2.39e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 598 RQRPFCKYKGHTADLLDLSWSKNY--FLLSSSMDKTVRLWHISR--------RECLCCFQ-HIDFVTAIAFHPRDDRYFL 666
Cdd:PTZ00420  63 RKPPVIKLKGHTSSILDLQFNPCFseILASGSEDLTIRVWEIPHndesvkeiKDPQCILKgHKKKISIIDWNPMNYYIMC 142

                         90       100
                 ....*....|....*....|
gi 124249073 667 SGSLDGKLRLWNIPDKKVAL 686
Cdd:PTZ00420 143 SSGFDSFVNIWDIENEKRAF 162
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 512-859 1.05e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 1.05e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 512 HMGAVWTMKFSHCGRLLASAGQDNIVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDMGVCSGTdedpd 591
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------------------------------------DLETGELLRT----- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 592 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPrDDRYFLSGS 669
Cdd:cd00200   47 -------------LKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSS 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 670 LDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNKVgrkITG 749
Cdd:cd00200  113 RDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLTGHTGE---VNS 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 750 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTS 826
Cdd:cd00200  183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS-----VAFSPDGYLLASGSEDGTIRVW----DLRTGEC 253

                        330       340       350
                 ....*....|....*....|....*....|...
gi 124249073 827 VRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 859
Cdd:cd00200  254 VQT--------LSGHTNSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
497-817 1.42e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 1.42e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 497 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNIVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 576
Cdd:COG2319  147 WDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 577 DTDMGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 654
Cdd:COG2319  190 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRS 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 655 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 734
Cdd:COG2319  252 VAFSP-DGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLL 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 735 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKY 811
Cdd:COG2319  324 RTLTGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgAVTS-----VAFSPDGRTLASGSADGT 395


                 ....*.
gi 124249073 812 VYIWST 817
Cdd:COG2319  396 VRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
497-859 2.21e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 2.21e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 497 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNIVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 576
Cdd:COG2319  105 WDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVRLW------------------------------------ 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 577 DTDMGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 654
Cdd:COG2319  148 DLATGKLLRT------------------LTGHSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRS 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 655 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 734
Cdd:COG2319  210 VAFSP-DGKLLASGSADGTVRLWDLATGKLLR--TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-----TGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 735 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYI 814
Cdd:COG2319  282 RTLTGHS---GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRL 356

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 124249073 815 WstyhDLSKFTSVRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 859
Cdd:COG2319  357 W----DLATGELLRT--------LTGHTGAVTSVAFSPDGRTLAS 389
WD40 COG2319
WD40 repeat [General function prediction only];
512-859 3.20e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 3.20e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 512 HMGAVWTMKFSHCGRLLASAGQDNIVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDMGVCSGTdedpd 591
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASADGTVRLW------------------------------------DLATGLLLRT----- 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 592 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGS 669
Cdd:COG2319  116 -------------LTGHTGAVRSVAFSPDgKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSP-DGKLLASGS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 670 LDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRnkvGRKITG 749
Cdd:COG2319  182 DDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA-----TGKLLRTLTGH---SGSVRS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 750 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRr 829
Cdd:COG2319  252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLW----DLATGKLLR- 324

                        330       340       350
                 ....*....|....*....|....*....|
gi 124249073 830 drndfweGIKAHNAVVTSAIFAPNPSLMLS 859
Cdd:COG2319  325 -------TLTGHTGAVRSVAFSPDGKTLAS 347
WD40 COG2319
WD40 repeat [General function prediction only];
497-775 1.14e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 1.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 497 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNIVRIWALKNafdyfnnmrmkyntegrvspspsqeslsssks 576
Cdd:COG2319  189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-------------------------------- 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 577 dtdmgvcsgtdedpddknapfrQRPFCKYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 654
Cdd:COG2319  236 ----------------------GKLLRTLTGHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNS 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 655 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKVAlwNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 734
Cdd:COG2319  294 VAFSP-DGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA-----TGELL 365

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 124249073 735 RSTRGRnkvGRKITGIEPLPGENKILVTSNDSRIRLYDLRD 775
Cdd:COG2319  366 RTLTGH---TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
607-859 1.35e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 1.35e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 607 GHTADLLDLSWSKNY-FLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWNIPDKKv 684
Cdd:COG2319   76 GHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGK- 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 685 aLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKyhtqiHVRSTRGRNKVgrkITGIEPLPGENKILVTSN 764
Cdd:COG2319  154 -LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----LLRTLTGHTGA---VRSVAFSPDGKLLASGSA 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 765 DSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAV 844
Cdd:COG2319  225 DGTVRLWDLATGKLLRTLTGHSGSVRSV--AFSPDGRLLASGSADGTVRLW----DLATGELLRT--------LTGHSGG 290

                        250
                 ....*....|....*
gi 124249073 845 VTSAIFAPNPSLMLS 859
Cdd:COG2319  291 VNSVAFSPDGKLLAS 305
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 605-907 3.00e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.95  E-value: 3.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 605 YKGHTADLLDLSWSKNY-FLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWNIPDK 682
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 683 KVAlwNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYhtqihVRSTRGRNkvgrkitgieplpgenkilvt 762
Cdd:cd00200   84 ECV--RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC-----LTTLRGHT--------------------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 763 sndsrirlydlrdlslsmkykGYVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHN 842
Cdd:cd00200  136 ---------------------DWVNS-----VAFSPDGTFVASSSQDGTIKLW----DLRTGKCVAT--------LTGHT 177

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124249073 843 AVVTSAIFAPNPSLMLS---------LDVQSEKLEGIDKYEDAEVldstsTGIVKTDNTEVLLSADFTGAIKVF 907
Cdd:cd00200  178 GEVNSVAFSPDGEKLLSsssdgtiklWDLSTGKCLGTLRGHENGV-----NSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 689-856 7.83e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 7.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 689 EVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYHTQIHVRStrgrnkvgRKITGIEPLPGENKILVTSNDSRI 768
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT--------GPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 769 RLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAVV 845
Cdd:cd00200   76 RLWDLETGECVRTLTGhtsYVSS-----VAFSPDGRILSSSSRDKTIKVW----DVETGKCLTT--------LRGHTDWV 138

                        170
                 ....*....|.
gi 124249073 846 TSAIFAPNPSL 856
Cdd:cd00200  139 NSVAFSPDGTF 149
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 640-678 1.36e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 124249073   640 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 678
Cdd:smart00320   2 GELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 503-540 2.95e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.95e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 124249073   503 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNIVRIW 540
Cdd:smart00320   3 ELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
640-678 6.96e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 6.96e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 124249073  640 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 678
Cdd:pfam00400   1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 598-686 2.39e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 598 RQRPFCKYKGHTADLLDLSWSKNY--FLLSSSMDKTVRLWHISR--------RECLCCFQ-HIDFVTAIAFHPRDDRYFL 666
Cdd:PTZ00420  63 RKPPVIKLKGHTSSILDLQFNPCFseILASGSEDLTIRVWEIPHndesvkeiKDPQCILKgHKKKISIIDWNPMNYYIMC 142

                         90       100
                 ....*....|....*....|
gi 124249073 667 SGSLDGKLRLWNIPDKKVAL 686
Cdd:PTZ00420 143 SSGFDSFVNIWDIENEKRAF 162
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 625-907 3.51e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 3.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 625 SSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIpDKKVALwnevdGQTKliTAANFC 703
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMkEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-NQGVSI-----GTIK--TKANIC 621

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 704 ------QNGKYAVIGTYDGRCIFYDTEHLKyhtqIHVRSTRGRNKVGRKITGIEplpgENKILVTSNDSRIRLYDLrDLS 777
Cdd:PLN00181 622 cvqfpsESGRSLAFGSADHKVYYYDLRNPK----LPLCTMIGHSKTVSYVRFVD----SSTLVSSSTDNTLKLWDL-SMS 692

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 778 LS-------MKYKGYVNSSSQIKASFSHDftYLVSGSEDKYVYIWstyhdlskftsvrrdrndfwegikaHNAVvtsaif 850
Cdd:PLN00181 693 ISginetplHSFMGHTNVKNFVGLSVSDG--YIATGSETNEVFVY-------------------------HKAF------ 739

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 124249073 851 aPNPslmlsldVQSEKLEGIDKYEDAEVLDSTS--TGIVKTDNTEVLLSADFTGAIKVF 907
Cdd:PLN00181 740 -PMP-------VLSYKFKTIDPVSGLEVDDASQfiSSVCWRGQSSTLVAANSTGNIKIL 790
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 600-636 3.94e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 3.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 124249073   600 RPFCKYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWH 636
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
503-540 4.03e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 4.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 124249073  503 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNIVRIW 540
Cdd:pfam00400   2 KLLKTLEG-HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
604-635 1.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.22e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 124249073  604 KYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLW 635
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 497-541 3.34e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 3.34e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 124249073 497 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNIVRIWA 541
Cdd:cd00200  246 WDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 661-817 4.27e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 40.29  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 661 DDRYFLSGsldGK---LRLWNIPDKKVALW-------NEVDGQTKL-ITAANFcqngkyavIGTYDGRCIFYDTEHlkyH 729
Cdd:cd22857  137 NENYFAFG---GKeveLNVWDLEEKPGKIWraknvpnDSLGLRVPVwVTDLTF--------LSKDDHRKIVTGTGY---H 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249073 730 tQIHVRSTR-GR----NKVGRK--ITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYvnSSSQIKASFSH-DFT 801
Cdd:cd22857  203 -QVRLYDTRaQRrpvvSVDFGEtpIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGK--CGGSIRSIARHpELP 279

                        170
                 ....*....|....*.
gi 124249073 802 YLVSGSEDKYVYIWST 817
Cdd:cd22857  280 LIASCGLDRYLRIWDT 295
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 783-816 4.84e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 4.84e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 124249073   783 KGYVNSssqikASFSHDFTYLVSGSEDKYVYIWS 816
Cdd:smart00320  12 TGPVTS-----VAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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