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Conserved domains on  [gi|226437674|ref|NP_780367|]
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small subunit processome component 20 homolog [Mus musculus]

Protein Classification

UTP20 family protein( domain architecture ID 10540292)

UTP20 (U three protein 20) family protein similar to Saccharomyces cerevisiae U3 small nucleolar RNA-associated protein 20, also called UTP20, that is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
DRIM pfam07539
Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In ...
 911-1534 0e+00

Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In Metastasis), which is differentially expressed in metastatic and non-metastatic human breast carcinoma cells. It is believed to be involved in processing of non-coding RNA.


:

Pssm-ID: 462198  Cd Length: 609  Bit Score: 582.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674   911 AAAKQLIAHLQVFSKFSNPRALYLESKLYELYLQLLLHQDQAVQKITLDCIMTYRHPHILPYRENLQRLLDDRSFKEEIV 990
Cdd:pfam07539    1 WSRKDLKALLKLFAKFKNPKALYKSDELYEALLDLLSNGDAEVQKLALDCLLTWKDPAVVPYKENLKNLLDDTRFRDELT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674   991 HFNISEDNTVVKAAHRADLFPILMRILYGRMKNKTGSKTQGKSASGTRMAIVLRFLAGTQPEEIQLFLDLLSEPVKHFKD 1070
Cdd:pfam07539   81 VFLQSDEDSVIEPEHRPELMPVLLRILYGRMISKKGSRSSGKAGQQARRKAVLRFLAGLSEEELGLFLDLALGPLKYVSV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1071 GDCCSAVIQAVEDLDVSkVLPVGRQHGVLNSLEVVLKNISHLISTYLPKILQILLCMTATVSHILDQR---EKIQLRFIN 1147
Cdd:pfam07539  161 VDESVEFFENGDELLSE-VLPLRRQLGFLNLLEDVLKVLGSKLAPYLPKLLNPLLYCLVAAQRRLDQEdeeEEEEGILLK 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1148 PLKNLRRLGIKMVTDIFLDWESYQFKaEEIDAVFHGTVWPQICRLGSESQYSPTPLLKLISIWSRNARYFPLLAKqkpgh 1227
Cdd:pfam07539  240 LLRNIRQLGLKCLVDLFQNFGDFDWT-PYIDAIFEEVISPRLEKLAVENLQSPSALLKLFHTWSKNPRYAPFLVK----- 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1228 PEYDILTNVFAVLSAKNLSEATASIIMDIVDDLLNLPDFQPTEAVPSLpvtgcvyadvaedtepvTVGGRLVLPHVPAIL 1307
Cdd:pfam07539  314 YDSAVLPAVIELLSNPKAKPSVVLFVLDIVENLLTLADEEDEEEEDSE-----------------DIGSELLLPHVSSLL 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1308 QYLSKTTisaeKVKKKKNRAQVSKELGILSKISKFMKDREQCSLLITLLLPFLLRGN--VAQDTELDILVTVQNLLQHC- 1384
Cdd:pfam07539  377 QHLPALL----ERSKTPSKELLSRELSILSRLAPYVTDSEQASSLLDLLLPLLRKPSrrVSPKTKVDLLKILSNLLPLYd 452

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1385 -----LHPAHFLRPLAKLFSVIKNKLSRQLLCTVFQSLSDFESRLKYITDIV-KLNAFDKRHLDDINFDVRFSAFQTITS 1458
Cdd:pfam07539  453 cswddILPEKLYKTLSSLFSTFKDRESREALCKVFKALAKKDPELEEVADLVaDLNAYSTRRLDEPDFDRRLSAFKKINE 532

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226437674  1459 niKAMQTVDADYLIAVMHNCFYNM-EIGDMSLSDNASICLTSIIKRLAALNVTE--KEYKEIIHRTLLEKLRKGLKSQT 1534
Cdd:pfam07539  533 --ELYKSLTARQWLPLLYNCLFFIrDEEELAIRSNASHCLKRFIDAAASKSSEEekEEFEDLLKDVLLPALRRGLRSKS 609
DUF6700 pfam20416
Domain of unknown function (DUF6700); This putative domain is found in the UTP20 protein which ...
 1815-2031 5.39e-93

Domain of unknown function (DUF6700); This putative domain is found in the UTP20 protein which associated with the U3 snRNA.


:

Pssm-ID: 466565  Cd Length: 221  Bit Score: 300.99  E-value: 5.39e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1815 NDEEVVRVPLAFAMVKLMRSLPREVMEANLPSILLKVCVLLKNRAQEIRDIARSTLSKIIEDLGVHFLQYVLKELQTTLV 1894
Cdd:pfam20416    5 EDEDVLRVPVALAIVKLLQLLPEKSLEVNLPGLLLKLCQFLRSRSQEVRDLARETLVKILETLGPKYLPFILKELKSALT 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1895 RGYQVHVLTFTVYTLLQGLSSKLQVGDLDSCLHIMTEIFNHELFGALAEEKEVKQILSKVMEARRSKSYDSYEILGKFVG 1974
Cdd:pfam20416   85 RGYQLHVLSYTVHSLLVALEPTLEPGDLDSCLEDILDIIMDDIFGEVAEEKEVEEITSKMKEAKSSKSYDTFEILAQFIS 164

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 226437674  1975 KQQVTKLILPLKEILQNTTSLKLARKVHETLRRIIAGLIVNPDMTADALLLLSYGLV 2031
Cdd:pfam20416  165 FNALHDLLLPLKEILHETESAKTLRKVEELLRRIALGLSANPSLSSEDLLIFCYGLI 221
 
Name Accession Description Interval E-value
DRIM pfam07539
Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In ...
 911-1534 0e+00

Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In Metastasis), which is differentially expressed in metastatic and non-metastatic human breast carcinoma cells. It is believed to be involved in processing of non-coding RNA.


Pssm-ID: 462198  Cd Length: 609  Bit Score: 582.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674   911 AAAKQLIAHLQVFSKFSNPRALYLESKLYELYLQLLLHQDQAVQKITLDCIMTYRHPHILPYRENLQRLLDDRSFKEEIV 990
Cdd:pfam07539    1 WSRKDLKALLKLFAKFKNPKALYKSDELYEALLDLLSNGDAEVQKLALDCLLTWKDPAVVPYKENLKNLLDDTRFRDELT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674   991 HFNISEDNTVVKAAHRADLFPILMRILYGRMKNKTGSKTQGKSASGTRMAIVLRFLAGTQPEEIQLFLDLLSEPVKHFKD 1070
Cdd:pfam07539   81 VFLQSDEDSVIEPEHRPELMPVLLRILYGRMISKKGSRSSGKAGQQARRKAVLRFLAGLSEEELGLFLDLALGPLKYVSV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1071 GDCCSAVIQAVEDLDVSkVLPVGRQHGVLNSLEVVLKNISHLISTYLPKILQILLCMTATVSHILDQR---EKIQLRFIN 1147
Cdd:pfam07539  161 VDESVEFFENGDELLSE-VLPLRRQLGFLNLLEDVLKVLGSKLAPYLPKLLNPLLYCLVAAQRRLDQEdeeEEEEGILLK 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1148 PLKNLRRLGIKMVTDIFLDWESYQFKaEEIDAVFHGTVWPQICRLGSESQYSPTPLLKLISIWSRNARYFPLLAKqkpgh 1227
Cdd:pfam07539  240 LLRNIRQLGLKCLVDLFQNFGDFDWT-PYIDAIFEEVISPRLEKLAVENLQSPSALLKLFHTWSKNPRYAPFLVK----- 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1228 PEYDILTNVFAVLSAKNLSEATASIIMDIVDDLLNLPDFQPTEAVPSLpvtgcvyadvaedtepvTVGGRLVLPHVPAIL 1307
Cdd:pfam07539  314 YDSAVLPAVIELLSNPKAKPSVVLFVLDIVENLLTLADEEDEEEEDSE-----------------DIGSELLLPHVSSLL 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1308 QYLSKTTisaeKVKKKKNRAQVSKELGILSKISKFMKDREQCSLLITLLLPFLLRGN--VAQDTELDILVTVQNLLQHC- 1384
Cdd:pfam07539  377 QHLPALL----ERSKTPSKELLSRELSILSRLAPYVTDSEQASSLLDLLLPLLRKPSrrVSPKTKVDLLKILSNLLPLYd 452

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1385 -----LHPAHFLRPLAKLFSVIKNKLSRQLLCTVFQSLSDFESRLKYITDIV-KLNAFDKRHLDDINFDVRFSAFQTITS 1458
Cdd:pfam07539  453 cswddILPEKLYKTLSSLFSTFKDRESREALCKVFKALAKKDPELEEVADLVaDLNAYSTRRLDEPDFDRRLSAFKKINE 532

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226437674  1459 niKAMQTVDADYLIAVMHNCFYNM-EIGDMSLSDNASICLTSIIKRLAALNVTE--KEYKEIIHRTLLEKLRKGLKSQT 1534
Cdd:pfam07539  533 --ELYKSLTARQWLPLLYNCLFFIrDEEELAIRSNASHCLKRFIDAAASKSSEEekEEFEDLLKDVLLPALRRGLRSKS 609
DUF6700 pfam20416
Domain of unknown function (DUF6700); This putative domain is found in the UTP20 protein which ...
 1815-2031 5.39e-93

Domain of unknown function (DUF6700); This putative domain is found in the UTP20 protein which associated with the U3 snRNA.


Pssm-ID: 466565  Cd Length: 221  Bit Score: 300.99  E-value: 5.39e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1815 NDEEVVRVPLAFAMVKLMRSLPREVMEANLPSILLKVCVLLKNRAQEIRDIARSTLSKIIEDLGVHFLQYVLKELQTTLV 1894
Cdd:pfam20416    5 EDEDVLRVPVALAIVKLLQLLPEKSLEVNLPGLLLKLCQFLRSRSQEVRDLARETLVKILETLGPKYLPFILKELKSALT 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1895 RGYQVHVLTFTVYTLLQGLSSKLQVGDLDSCLHIMTEIFNHELFGALAEEKEVKQILSKVMEARRSKSYDSYEILGKFVG 1974
Cdd:pfam20416   85 RGYQLHVLSYTVHSLLVALEPTLEPGDLDSCLEDILDIIMDDIFGEVAEEKEVEEITSKMKEAKSSKSYDTFEILAQFIS 164

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 226437674  1975 KQQVTKLILPLKEILQNTTSLKLARKVHETLRRIIAGLIVNPDMTADALLLLSYGLV 2031
Cdd:pfam20416  165 FNALHDLLLPLKEILHETESAKTLRKVEELLRRIALGLSANPSLSSEDLLIFCYGLI 221
 
Name Accession Description Interval E-value
DRIM pfam07539
Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In ...
 911-1534 0e+00

Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In Metastasis), which is differentially expressed in metastatic and non-metastatic human breast carcinoma cells. It is believed to be involved in processing of non-coding RNA.


Pssm-ID: 462198  Cd Length: 609  Bit Score: 582.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674   911 AAAKQLIAHLQVFSKFSNPRALYLESKLYELYLQLLLHQDQAVQKITLDCIMTYRHPHILPYRENLQRLLDDRSFKEEIV 990
Cdd:pfam07539    1 WSRKDLKALLKLFAKFKNPKALYKSDELYEALLDLLSNGDAEVQKLALDCLLTWKDPAVVPYKENLKNLLDDTRFRDELT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674   991 HFNISEDNTVVKAAHRADLFPILMRILYGRMKNKTGSKTQGKSASGTRMAIVLRFLAGTQPEEIQLFLDLLSEPVKHFKD 1070
Cdd:pfam07539   81 VFLQSDEDSVIEPEHRPELMPVLLRILYGRMISKKGSRSSGKAGQQARRKAVLRFLAGLSEEELGLFLDLALGPLKYVSV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1071 GDCCSAVIQAVEDLDVSkVLPVGRQHGVLNSLEVVLKNISHLISTYLPKILQILLCMTATVSHILDQR---EKIQLRFIN 1147
Cdd:pfam07539  161 VDESVEFFENGDELLSE-VLPLRRQLGFLNLLEDVLKVLGSKLAPYLPKLLNPLLYCLVAAQRRLDQEdeeEEEEGILLK 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1148 PLKNLRRLGIKMVTDIFLDWESYQFKaEEIDAVFHGTVWPQICRLGSESQYSPTPLLKLISIWSRNARYFPLLAKqkpgh 1227
Cdd:pfam07539  240 LLRNIRQLGLKCLVDLFQNFGDFDWT-PYIDAIFEEVISPRLEKLAVENLQSPSALLKLFHTWSKNPRYAPFLVK----- 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1228 PEYDILTNVFAVLSAKNLSEATASIIMDIVDDLLNLPDFQPTEAVPSLpvtgcvyadvaedtepvTVGGRLVLPHVPAIL 1307
Cdd:pfam07539  314 YDSAVLPAVIELLSNPKAKPSVVLFVLDIVENLLTLADEEDEEEEDSE-----------------DIGSELLLPHVSSLL 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1308 QYLSKTTisaeKVKKKKNRAQVSKELGILSKISKFMKDREQCSLLITLLLPFLLRGN--VAQDTELDILVTVQNLLQHC- 1384
Cdd:pfam07539  377 QHLPALL----ERSKTPSKELLSRELSILSRLAPYVTDSEQASSLLDLLLPLLRKPSrrVSPKTKVDLLKILSNLLPLYd 452

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1385 -----LHPAHFLRPLAKLFSVIKNKLSRQLLCTVFQSLSDFESRLKYITDIV-KLNAFDKRHLDDINFDVRFSAFQTITS 1458
Cdd:pfam07539  453 cswddILPEKLYKTLSSLFSTFKDRESREALCKVFKALAKKDPELEEVADLVaDLNAYSTRRLDEPDFDRRLSAFKKINE 532

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226437674  1459 niKAMQTVDADYLIAVMHNCFYNM-EIGDMSLSDNASICLTSIIKRLAALNVTE--KEYKEIIHRTLLEKLRKGLKSQT 1534
Cdd:pfam07539  533 --ELYKSLTARQWLPLLYNCLFFIrDEEELAIRSNASHCLKRFIDAAASKSSEEekEEFEDLLKDVLLPALRRGLRSKS 609
DUF6700 pfam20416
Domain of unknown function (DUF6700); This putative domain is found in the UTP20 protein which ...
 1815-2031 5.39e-93

Domain of unknown function (DUF6700); This putative domain is found in the UTP20 protein which associated with the U3 snRNA.


Pssm-ID: 466565  Cd Length: 221  Bit Score: 300.99  E-value: 5.39e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1815 NDEEVVRVPLAFAMVKLMRSLPREVMEANLPSILLKVCVLLKNRAQEIRDIARSTLSKIIEDLGVHFLQYVLKELQTTLV 1894
Cdd:pfam20416    5 EDEDVLRVPVALAIVKLLQLLPEKSLEVNLPGLLLKLCQFLRSRSQEVRDLARETLVKILETLGPKYLPFILKELKSALT 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437674  1895 RGYQVHVLTFTVYTLLQGLSSKLQVGDLDSCLHIMTEIFNHELFGALAEEKEVKQILSKVMEARRSKSYDSYEILGKFVG 1974
Cdd:pfam20416   85 RGYQLHVLSYTVHSLLVALEPTLEPGDLDSCLEDILDIIMDDIFGEVAEEKEVEEITSKMKEAKSSKSYDTFEILAQFIS 164

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 226437674  1975 KQQVTKLILPLKEILQNTTSLKLARKVHETLRRIIAGLIVNPDMTADALLLLSYGLV 2031
Cdd:pfam20416  165 FNALHDLLLPLKEILHETESAKTLRKVEELLRRIALGLSANPSLSSEDLLIFCYGLI 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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