NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|254911090|ref|NP_780333|]
View 

leucine-rich repeat-containing protein 28 isoform 1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-221 5.00e-29

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.19  E-value: 5.00e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  62 QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGGLRALRHLRLANNQLQFLPPEVGDLKELQTLDI 141
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 142 SSNRLLALPERLHLCLSLQYLTVDRNRLCCVPRHLCQLPSLNELSMAGNHLASLPiDLGRSRELQYVYVDNNiQLKGLPS 221
Cdd:COG4886  190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN-QLTDLPP 267
PRK15387 super family cl33133
type III secretion system effector E3 ubiquitin transferase SspH2;
123-350 5.73e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


The actual alignment was detected with superfamily member PRK15387:

Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 48.23  E-value: 5.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 123 LQFLPPEvgdlkeLQTLDISSNRLLALPERLHLCLSLQYLTVDRNRLCCVPRHLCQL--------------PSLNELSMA 188
Cdd:PRK15387 237 LPALPPE------LRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLwifgnqltslpvlpPGLQELSVS 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 189 GNHLASLPidlGRSRELQYVYVDNN--IQLKGLPSYLYNKVIGCNG-CGIPIQLSEVRLLTFSSGQLTVF--LPAEVKTI 263
Cdd:PRK15387 311 DNQLASLP---ALPSELCKLWAYNNqlTSLPTLPSGLQELSVSDNQlASLPTLPSELYKLWAYNNRLTSLpaLPSGLKEL 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 264 GTEKDHV--LPLQELTMRSLYRTYHGLwkdlnfLSPISLPRSLL-------ELLHCPLGHCHLCSEpmfTFVYPKIFPLR 334
Cdd:PRK15387 388 IVSGNRLtsLPVLPSELKELMVSGNRL------TSLPMLPSGLLslsvyrnQLTRLPESLIHLSSE---TTVNLEGNPLS 458

                        250
                 ....*....|....*.
gi 254911090 335 ETPMAGLHQRRTSIGF 350
Cdd:PRK15387 459 ERTLQALREITSAPGY 474
LRR_8 pfam13855
Leucine rich repeat;
18-77 2.90e-05

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 2.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090   18 KNLFLNYRNLHHFPLELLKdeGLQHLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNI 77
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFK--GLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-221 5.00e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.19  E-value: 5.00e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  62 QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGGLRALRHLRLANNQLQFLPPEVGDLKELQTLDI 141
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 142 SSNRLLALPERLHLCLSLQYLTVDRNRLCCVPRHLCQLPSLNELSMAGNHLASLPiDLGRSRELQYVYVDNNiQLKGLPS 221
Cdd:COG4886  190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN-QLTDLPP 267
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
8-223 1.35e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 1.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090   8 TISVARLEKHKNLFLNYRNLHHFPlellkdEGLQ-HLERLYMKRNSLTTLPENlaqkLPNLVE-LYLHSNNIVVVPEAIG 85
Cdd:PRK15370 192 TIPACIPEQITTLILDNNELKSLP------ENLQgNIKTLYANSNQLTSIPAT----LPDTIQeMELSINRITELPERLP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  86 SlvKLQCLDLSDNALEIV---CPEigglrALRHLRLANNQLQFLPPEVGdlKELQTLDISSNRLLALPERLHlcLSLQYL 162
Cdd:PRK15370 262 S--ALQSLDLFHNKISCLpenLPE-----ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP--PGLKTL 330

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254911090 163 TVDRNRLCCVPRHLCqlPSLNELSMAGNHLASLPIDLGRSreLQYVYVDNNIqLKGLPSYL 223
Cdd:PRK15370 331 EAGENALTSLPASLP--PELQVLDVSKNQITVLPETLPPT--ITTLDVSRNA-LTNLPENL 386
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-195 6.05e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 6.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  46 LYMKRNSLTTLpENLAQkLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNALEivcpEIGGLRALRHLR---LANNQ 122
Cdd:cd21340    7 LYLNDKNITKI-DNLSL-CKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIE----KIENLENLVNLKklyLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 123 LQFLppE-VGDLKELQTLDISSNRlLALPERLH--------LCLSLQYLTVDRNRLCCVpRHLCQLPSLNELSMAGNHLA 193
Cdd:cd21340   80 ISVV--EgLENLTNLEELHIENQR-LPPGEKLTfdprslaaLSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155


                 ..
gi 254911090 194 SL 195
Cdd:cd21340  156 DL 157
LRR_8 pfam13855
Leucine rich repeat;
65-123 2.09e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.09e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254911090   65 PNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNALEIVCPE-IGGLRALRHLRLANNQL 123
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
123-350 5.73e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 48.23  E-value: 5.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 123 LQFLPPEvgdlkeLQTLDISSNRLLALPERLHLCLSLQYLTVDRNRLCCVPRHLCQL--------------PSLNELSMA 188
Cdd:PRK15387 237 LPALPPE------LRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLwifgnqltslpvlpPGLQELSVS 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 189 GNHLASLPidlGRSRELQYVYVDNN--IQLKGLPSYLYNKVIGCNG-CGIPIQLSEVRLLTFSSGQLTVF--LPAEVKTI 263
Cdd:PRK15387 311 DNQLASLP---ALPSELCKLWAYNNqlTSLPTLPSGLQELSVSDNQlASLPTLPSELYKLWAYNNRLTSLpaLPSGLKEL 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 264 GTEKDHV--LPLQELTMRSLYRTYHGLwkdlnfLSPISLPRSLL-------ELLHCPLGHCHLCSEpmfTFVYPKIFPLR 334
Cdd:PRK15387 388 IVSGNRLtsLPVLPSELKELMVSGNRL------TSLPMLPSGLLslsvyrnQLTRLPESLIHLSSE---TTVNLEGNPLS 458

                        250
                 ....*....|....*.
gi 254911090 335 ETPMAGLHQRRTSIGF 350
Cdd:PRK15387 459 ERTLQALREITSAPGY 474
LRR_8 pfam13855
Leucine rich repeat;
18-77 2.90e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 2.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090   18 KNLFLNYRNLHHFPLELLKdeGLQHLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNI 77
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFK--GLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-221 5.00e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.19  E-value: 5.00e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  62 QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGGLRALRHLRLANNQLQFLPPEVGDLKELQTLDI 141
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 142 SSNRLLALPERLHLCLSLQYLTVDRNRLCCVPRHLCQLPSLNELSMAGNHLASLPiDLGRSRELQYVYVDNNiQLKGLPS 221
Cdd:COG4886  190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN-QLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-169 2.79e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 2.79e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  10 SVARLEKHKNLFLNYRNLHHFPLELlkdEGLQHLERLYMKRNSLTTLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVK 89
Cdd:COG4886  131 ELANLTNLKELDLSNNQLTDLPEPL---GNLTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLPEPLGNLTN 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  90 LQCLDLSDNALEIVCPEIGGLRALRHLRLANNQLQFLpPEVGDLKELQTLDISSNRLLALPERLHLClSLQYLTVDRNRL 169
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPLANLT-NLKTLDLSNNQL 284
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
8-223 1.35e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 1.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090   8 TISVARLEKHKNLFLNYRNLHHFPlellkdEGLQ-HLERLYMKRNSLTTLPENlaqkLPNLVE-LYLHSNNIVVVPEAIG 85
Cdd:PRK15370 192 TIPACIPEQITTLILDNNELKSLP------ENLQgNIKTLYANSNQLTSIPAT----LPDTIQeMELSINRITELPERLP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  86 SlvKLQCLDLSDNALEIV---CPEigglrALRHLRLANNQLQFLPPEVGdlKELQTLDISSNRLLALPERLHlcLSLQYL 162
Cdd:PRK15370 262 S--ALQSLDLFHNKISCLpenLPE-----ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP--PGLKTL 330

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254911090 163 TVDRNRLCCVPRHLCqlPSLNELSMAGNHLASLPIDLGRSreLQYVYVDNNIqLKGLPSYL 223
Cdd:PRK15370 331 EAGENALTSLPASLP--PELQVLDVSKNQITVLPETLPPT--ITTLDVSRNA-LTNLPENL 386
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
45-350 3.83e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.88  E-value: 3.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  45 RLYMKRNSLTTLPENLAQKLPNLVelyLHSNNIVVVPEaigslvklqclDLSDNaleivcpeigglraLRHLRLANNQLQ 124
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTLI---LDNNELKSLPE-----------NLQGN--------------IKTLYANSNQLT 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 125 FLPPEVGDlkELQTLDISSNRLLALPErlHLCLSLQYLTVDRNRLCCVPRHLCQlpSLNELSMAGNHLASLPIDLGRSre 204
Cdd:PRK15370 234 SIPATLPD--TIQEMELSINRITELPE--RLPSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPSG-- 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 205 LQYVYVDNNiQLKGLPSYLynkvigcngcgiPIQLsevRLLTFSSGQLTVF---LPAEVKTIGTEKDHVLPLQEltmrSL 281
Cdd:PRK15370 306 ITHLNVQSN-SLTALPETL------------PPGL---KTLEAGENALTSLpasLPPELQVLDVSKNQITVLPE----TL 365

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254911090 282 YRTYHGLWKDLNFLS--PISLPRSLL-------ELLHCPLGHCHLCSE-PMFTFVYPKIFPLRETPMAGLHQRRTSIGF 350
Cdd:PRK15370 366 PPTITTLDVSRNALTnlPENLPAALQimqasrnNLVRLPESLPHFRGEgPQPTRIIVEYNPFSERTIQNMQRLMSSVGY 444
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-225 1.06e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.41  E-value: 1.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  39 GLQHLERLYMKRNSLT-TLPENLAQKLPNLVELYLhSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCP-EIGGLRALRHL 116
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNL-SNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPnDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 117 RLANNQLQ-FLPPEVGDLKELQTLDISSNRLLA-LPERLHLCLSLQYLTVDRNRLCC-VPRHLCQLPSLNELSMAGNHLA 193
Cdd:PLN00113 170 DLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYNNLSGeIPYEIGGLTSLNHLDLVYNNLT 249

                        170       180       190
                 ....*....|....*....|....*....|...
gi 254911090 194 -SLPIDLGRSRELQYVYVDNNIQLKGLPSYLYN 225
Cdd:PLN00113 250 gPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS 282
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 12-221 4.97e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 4.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  12 ARLEKHKNL---FLNYRNLH-HFPLELLKDEGLQHLERLYmkrNSLT-TLPENLAQkLPNLVELYLHSNNIV-VVPEAIG 85
Cdd:PLN00113 206 RELGQMKSLkwiYLGYNNLSgEIPYEIGGLTSLNHLDLVY---NNLTgPIPSSLGN-LKNLQYLFLYQNKLSgPIPPSIF 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  86 SLVKLQCLDLSDNALEIVCPE-IGGLRALRHLRL-ANNQLQFLPPEVGDLKELQTLDISSNRLLA-LPERLHLCLSLQYL 162
Cdd:PLN00113 282 SLQKLISLDLSDNSLSGEIPElVIQLQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGeIPKNLGKHNNLTVL 361

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254911090 163 TVDRNRLCC-VPRHLCQLPSLNELSMAGNHLAS-LPIDLGRSRELQYVYVDNNIQLKGLPS 221
Cdd:PLN00113 362 DLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSGELPS 422
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-195 6.05e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 6.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  46 LYMKRNSLTTLpENLAQkLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNALEivcpEIGGLRALRHLR---LANNQ 122
Cdd:cd21340    7 LYLNDKNITKI-DNLSL-CKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIE----KIENLENLVNLKklyLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 123 LQFLppE-VGDLKELQTLDISSNRlLALPERLH--------LCLSLQYLTVDRNRLCCVpRHLCQLPSLNELSMAGNHLA 193
Cdd:cd21340   80 ISVV--EgLENLTNLEELHIENQR-LPPGEKLTfdprslaaLSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155


                 ..
gi 254911090 194 SL 195
Cdd:cd21340  156 DL 157
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-196 6.77e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.26  E-value: 6.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  38 EGLQHLERLYMKRNSLTTLpENLaQKLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNAL---EIVCPEIGGLRA-- 112
Cdd:cd21340   43 EFLTNLTHLYLQNNQIEKI-ENL-ENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLppgEKLTFDPRSLAAls 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 113 --LRHLRLANNQLQFLPPeVGDLKELQTLDISSNRLLALPErlhlclslqyltvdrnrLCCVprhLCQLPSLNELSMAGN 190
Cdd:cd21340  120 nsLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEE-----------------LLDL---LSSWPSLRELDLTGN 178


                 ....*.
gi 254911090 191 HLASLP 196
Cdd:cd21340  179 PVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 20-247 1.67e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.48  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  20 LFLNYRNLHHFPLELLK------DEGLQHLERlYMKRNSLTTLPENLAQKLPNLVELYLHSNNIV-VVPEAIGSLVKLQC 92
Cdd:PLN00113  19 LFLNFSMLHAEELELLLsfkssiNDPLKYLSN-WNSSADVCLWQGITCNNSSRVVSIDLSGKNISgKISSAIFRLPYIQT 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  93 LDLSDNALEIVCPE--IGGLRALRHLRLANNQLQFLPPEvGDLKELQTLDISSNRLLA-LPERLHLCLSLQYLTVDRNRL 169
Cdd:PLN00113  98 INLSNNQLSGPIPDdiFTTSSSLRYLNLSNNNFTGSIPR-GSIPNLETLDLSNNMLSGeIPNDIGSFSSLKVLDLGGNVL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 170 CC-VPRHLCQLPSLNELSMAGNHL-ASLPIDLGRSRELQYVYVDNN-------IQLKGLPS-----YLYNKVIGcngcGI 235
Cdd:PLN00113 177 VGkIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNnlsgeipYEIGGLTSlnhldLVYNNLTG----PI 252

                        250
                 ....*....|..
gi 254911090 236 PIQLSEVRLLTF 247
Cdd:PLN00113 253 PSSLGNLKNLQY 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-225 1.21e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 1.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  19 NLFLNYRNLHHFPLELLKDEGLQHLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDN 98
Cdd:COG4886    4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  99 ALEIVCPEIGGLRALRHLRLANNQlqflppEVGDLKELQTLDISSNRLLALPERLHlclslqyltvdrnrlccvprhlcQ 178
Cdd:COG4886   84 LLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA-----------------------N 134

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 254911090 179 LPSLNELSMAGNHLASLPIDLGRSRELQYVYVDNNiQLKGLPSYLYN 225
Cdd:COG4886  135 LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN-QLTDLPEELGN 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-207 1.16e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  10 SVARLEKHKNLFLNYRNLHHFPLELlkdEGLQHLERLYMKRNSLTTLPEnLAQkLPNLVELYLHSNNIVVVPEaIGSLVK 89
Cdd:COG4886  200 PLGNLTNLEELDLSGNQLTDLPEPL---ANLTNLETLDLSNNQLTDLPE-LGN-LTNLEELDLSNNQLTDLPP-LANLTN 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  90 LQCLDLSDNALEIVCPEIGGLRALRHLRLANNQLQFLPPEVGDLKELQTLDISSNRLLALPERLHLCLSLQYLTVDRNRL 169
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 254911090 170 CCVPRHLCQLPSLNELSMAGNHLASLPIDLGRSRELQY 207
Cdd:COG4886  354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
43-220 1.86e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.86  E-value: 1.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  43 LERLYMKRNSLTTLPenlaQKLPNLVELYLHSNNIVVVPEAIGSLVKL-----------------QCLDLSDNALEIVcP 105
Cdd:PRK15387 244 LRTLEVSGNQLTSLP----VLPPGLLELSIFSNPLTHLPALPSGLCKLwifgnqltslpvlppglQELSVSDNQLASL-P 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 106 EIGGlrALRHLRLANNQLQFLPPEVGDLKELQtldISSNRLLALPErlhLCLSLQYLTVDRNRLCCVPrhlcQLPS-LNE 184
Cdd:PRK15387 319 ALPS--ELCKLWAYNNQLTSLPTLPSGLQELS---VSDNQLASLPT---LPSELYKLWAYNNRLTSLP----ALPSgLKE 386

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 254911090 185 LSMAGNHLASLPIdlgRSRELQYVYVDNNiQLKGLP 220
Cdd:PRK15387 387 LIVSGNRLTSLPV---LPSELKELMVSGN-RLTSLP 418
LRR_8 pfam13855
Leucine rich repeat;
65-123 2.09e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.09e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254911090   65 PNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNALEIVCPE-IGGLRALRHLRLANNQL 123
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
43-193 1.49e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.16  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  43 LERLYMKRNSLTTLPenlaqKLPN-LVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVcPEigglrALRHLRLANN 121
Cdd:PRK15387 324 LCKLWAYNNQLTSLP-----TLPSgLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPAL-PS-----GLKELIVSGN 392

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254911090 122 QLQFLPPEVGDLKELQtldISSNRLLALPerlHLCLSLQYLTVDRNRLCCVPRHLCQLPSLNELSMAGNHLA 193
Cdd:PRK15387 393 RLTSLPVLPSELKELM---VSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLS 458
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
123-350 5.73e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 48.23  E-value: 5.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 123 LQFLPPEvgdlkeLQTLDISSNRLLALPERLHLCLSLQYLTVDRNRLCCVPRHLCQL--------------PSLNELSMA 188
Cdd:PRK15387 237 LPALPPE------LRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLwifgnqltslpvlpPGLQELSVS 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 189 GNHLASLPidlGRSRELQYVYVDNN--IQLKGLPSYLYNKVIGCNG-CGIPIQLSEVRLLTFSSGQLTVF--LPAEVKTI 263
Cdd:PRK15387 311 DNQLASLP---ALPSELCKLWAYNNqlTSLPTLPSGLQELSVSDNQlASLPTLPSELYKLWAYNNRLTSLpaLPSGLKEL 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 264 GTEKDHV--LPLQELTMRSLYRTYHGLwkdlnfLSPISLPRSLL-------ELLHCPLGHCHLCSEpmfTFVYPKIFPLR 334
Cdd:PRK15387 388 IVSGNRLtsLPVLPSELKELMVSGNRL------TSLPMLPSGLLslsvyrnQLTRLPESLIHLSSE---TTVNLEGNPLS 458

                        250
                 ....*....|....*.
gi 254911090 335 ETPMAGLHQRRTSIGF 350
Cdd:PRK15387 459 ERTLQALREITSAPGY 474
LRR_8 pfam13855
Leucine rich repeat;
41-100 1.20e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254911090   41 QHLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNAL 100
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
18-77 2.90e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 2.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090   18 KNLFLNYRNLHHFPLELLKdeGLQHLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNI 77
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFK--GLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
89-146 5.83e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 5.83e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090   89 KLQCLDLSDNALEIVCPEI-GGLRALRHLRLANNQLQFLPPEV-GDLKELQTLDISSNRL 146
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-146 1.09e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  39 GLQHLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNIV-VVPEAIGSLVKLQCLDLSDNALEIVCP-EIGGLRALRHL 116
Cdd:PLN00113 473 GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPaSFSEMPVLSQL 552

                         90       100       110
                 ....*....|....*....|....*....|.
gi 254911090 117 RLANNQLQF-LPPEVGDLKELQTLDISSNRL 146
Cdd:PLN00113 553 DLSQNQLSGeIPKNLGNVESLVQVNISHNHL 583
PLN03150 PLN03150
hypothetical protein; Provisional
 116-200 2.13e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090 116 LRLANNQLQ-FLPPEVGDLKELQTLDISSNRLL-ALPERLHLCLSLQYLTVDRNRLC-CVPRHLCQLPSLNELSMAGNHL 192
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                 ....*....
gi 254911090 193 AS-LPIDLG 200
Cdd:PLN03150 503 SGrVPAALG 511
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-196 2.28e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 2.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  43 LERLYMKRNSLT-TLPENLAQKlpNLVELYLHSNNIV-VVPEAIGSLVKLQCLDLSDNALEIVCP-EIGGLRALRHLRLA 119
Cdd:PLN00113 454 LQMLSLARNKFFgGLPDSFGSK--RLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEIPdELSSCKKLVSLDLS 531

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254911090 120 NNQLQ-FLPPEVGDLKELQTLDISSNRLLALperlhlclslqyltvdrnrlccVPRHLCQLPSLNELSMAGNHL-ASLP 196
Cdd:PLN00113 532 HNQLSgQIPASFSEMPVLSQLDLSQNQLSGE----------------------IPKNLGNVESLVQVNISHNHLhGSLP 588
PLN03150 PLN03150
hypothetical protein; Provisional
 93-169 2.63e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  93 LDLSDNALEIVCP-EIGGLRALRHLRLANNQLQ-FLPPEVGDLKELQTLDISSNRLL-ALPERLHLCLSLQYLTVDRNRL 169
Cdd:PLN03150 423 LGLDNQGLRGFIPnDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PLN03150 PLN03150
hypothetical protein; Provisional
 79-146 3.48e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 3.48e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  79 VVPEAIGSLVKLQCLDLSDNALE-IVCPEIGGLRALRHLRLANNQLQFLPPE-VGDLKELQTLDISSNRL 146
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPEsLGQLTSLRILNLNGNSL 502
LRR_8 pfam13855
Leucine rich repeat;
111-192 1.07e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254911090  111 RALRHLRLANNQLQFLPPEV-GDLKELQTLDISSNRLLALPerlhlclslqyltvdrnrlccvPRHLCQLPSLNELSMAG 189
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLS----------------------PGAFSGLPSLRYLDLSG 58


                  ...
gi 254911090  190 NHL 192
Cdd:pfam13855  59 NRL 61
LRR_9 pfam14580
Leucine-rich repeat;
33-98 2.44e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.59  E-value: 2.44e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254911090   33 ELLKDEGLQHLER---LYMKRNSLTTLPENLAQKLPNLVELYLHSNNI--VVVPEAIGSLVKLQCLDLSDN 98
Cdd:pfam14580  53 EIRKLDGFPLLRRlktLLLNNNRICRIGEGLGEALPNLTELILTNNNLqeLGDLDPLASLKKLTFLSLLRN 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH