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Conserved domains on  [gi|33239423|ref|NP_778173|]
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uncharacterized protein LOC218921 [Mus musculus]

Protein Classification

Ras-GEF domain-containing protein( domain architecture ID 10153433)

Ras guanine nucleotide exchange factor (Ras-GEF) domain-containing protein activates Ras-like small GTPases by mediating the replacement of GDP with GTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
 77-189 1.78e-22

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


:

Pssm-ID: 100121  Cd Length: 122  Bit Score: 88.24  E-value: 1.78e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239423  77 KLVNNLVPSLQEGDHFFVSIFLSTYRSFVTPLQVLGLLFMRYPYFHP--------HSVEHRQVRSSLCNFLHTWMDKNPE 148
Cdd:cd06224   4 ALIEHLTSTFDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPenleyndwDKKKSKPIRLRVLNVLRTWVENYPY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 33239423 149 DFCDpsDMLPLTYLKAYLSVHMPHSELFIRVDRLLNELWEE 189
Cdd:cd06224  84 DFFD--DEELLELLEEFLNRLVQEGALLQELKKLLRKLLKL 122
 
Name Accession Description Interval E-value
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
 77-189 1.78e-22

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 88.24  E-value: 1.78e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239423  77 KLVNNLVPSLQEGDHFFVSIFLSTYRSFVTPLQVLGLLFMRYPYFHP--------HSVEHRQVRSSLCNFLHTWMDKNPE 148
Cdd:cd06224   4 ALIEHLTSTFDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPenleyndwDKKKSKPIRLRVLNVLRTWVENYPY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 33239423 149 DFCDpsDMLPLTYLKAYLSVHMPHSELFIRVDRLLNELWEE 189
Cdd:cd06224  84 DFFD--DEELLELLEEFLNRLVQEGALLQELKKLLRKLLKL 122
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
 75-177 6.90e-17

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 73.52  E-value: 6.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239423     75 VVKLVNNLVPSLQEGDHFFVSIFLSTYRSFVTPLQVLGLLFMRYPYFHPHS-----VEHRQVRSSLCNFLHTWMDKNPED 149
Cdd:smart00229  10 LEALIEHLTEAFDKADPSFVETFLLTYRSFITTQELLQLLLYRYNAIPPESwveekVNPRRVKNRVLNILRTWVENYWED 89

                           90       100       110
                   ....*....|....*....|....*....|
gi 33239423    150 FCDPSDMLP--LTYLKAYLSVHMPHSELFI 177
Cdd:smart00229  90 FEDDPKLISflLEFLELVDDEKYPGLVTSL 119
RasGEF_N pfam00618
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ...
 77-157 1.33e-15

RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.


Pssm-ID: 459873  Cd Length: 104  Bit Score: 69.64  E-value: 1.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239423    77 KLVNNLVPSLQEGDHFFVSIFLSTYRSFVTPLQVLGLLFMRYPYFHP-----------HSVEHRQVRssLCNFLHTWMDK 145
Cdd:pfam00618   9 KLVEYLTSTRIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPldlssdsywisKKTLPIRIR--VLSVLRHWVEN 86

                          90
                  ....*....|..
gi 33239423   146 NPEDFCDPSDML 157
Cdd:pfam00618  87 YFSDFNDDPVLL 98
 
Name Accession Description Interval E-value
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
 77-189 1.78e-22

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 88.24  E-value: 1.78e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239423  77 KLVNNLVPSLQEGDHFFVSIFLSTYRSFVTPLQVLGLLFMRYPYFHP--------HSVEHRQVRSSLCNFLHTWMDKNPE 148
Cdd:cd06224   4 ALIEHLTSTFDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPenleyndwDKKKSKPIRLRVLNVLRTWVENYPY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 33239423 149 DFCDpsDMLPLTYLKAYLSVHMPHSELFIRVDRLLNELWEE 189
Cdd:cd06224  84 DFFD--DEELLELLEEFLNRLVQEGALLQELKKLLRKLLKL 122
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
 75-177 6.90e-17

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 73.52  E-value: 6.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239423     75 VVKLVNNLVPSLQEGDHFFVSIFLSTYRSFVTPLQVLGLLFMRYPYFHPHS-----VEHRQVRSSLCNFLHTWMDKNPED 149
Cdd:smart00229  10 LEALIEHLTEAFDKADPSFVETFLLTYRSFITTQELLQLLLYRYNAIPPESwveekVNPRRVKNRVLNILRTWVENYWED 89

                           90       100       110
                   ....*....|....*....|....*....|
gi 33239423    150 FCDPSDMLP--LTYLKAYLSVHMPHSELFI 177
Cdd:smart00229  90 FEDDPKLISflLEFLELVDDEKYPGLVTSL 119
RasGEF_N pfam00618
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ...
 77-157 1.33e-15

RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.


Pssm-ID: 459873  Cd Length: 104  Bit Score: 69.64  E-value: 1.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239423    77 KLVNNLVPSLQEGDHFFVSIFLSTYRSFVTPLQVLGLLFMRYPYFHP-----------HSVEHRQVRssLCNFLHTWMDK 145
Cdd:pfam00618   9 KLVEYLTSTRIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPldlssdsywisKKTLPIRIR--VLSVLRHWVEN 86

                          90
                  ....*....|..
gi 33239423   146 NPEDFCDPSDML 157
Cdd:pfam00618  87 YFSDFNDDPVLL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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