NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27806751|ref|NP_776409|]
View 

alpha-2-HS-glycoprotein precursor [Bos taurus]

Protein Classification

CY domain-containing protein( domain architecture ID 11249404)

CY domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-237 6.67e-20

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 83.15  E-value: 6.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751   149 CPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVS-VSVEFAVAATDCIaKEVVDPTKCNLLAEKQY 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTnYFIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80

                          90
                  ....*....|
gi 27806751   228 GFCKGSVIQK 237
Cdd:pfam00031  81 GLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-133 1.47e-14

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 68.99  E-value: 1.47e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751     24 VAGYKEPACDDPDTEQAALAAVDYINKHlpRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPlANCSVR 103
Cdd:smart00043   3 LGGPSDVPPNDPEVQEAADFAVAEYNKK--SNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 27806751    104 QQTQhaveGDCDIHVLKQDGQ--FSVLFTKCD 133
Cdd:smart00043  80 DQGE----KFCTAKVWEKPWEnkIKLVEFKCT 107
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-237 6.67e-20

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 83.15  E-value: 6.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751   149 CPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVS-VSVEFAVAATDCIaKEVVDPTKCNLLAEKQY 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTnYFIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80

                          90
                  ....*....|
gi 27806751   228 GFCKGSVIQK 237
Cdd:pfam00031  81 GLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 145-249 8.33e-18

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 77.85  E-value: 8.33e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751    145 LCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSY-LQLVEISRA-QFVPLPVSVSVEFAVAATDCIaKEVVDPTKCNLL 222
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYeLRVIKVVSAkSQVVAGTNYYLKVEVGETNCK-KLSVDLENCPFL 79

                           90       100
                   ....*....|....*....|....*....
gi 27806751    223 AEKQyGFCKGSVIQKALG--GEDVRVTCT 249
Cdd:smart00043  80 DQGE-KFCTAKVWEKPWEnkIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 148-248 3.59e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 70.58  E-value: 3.59e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751 148 DCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRA--QFVPlpvSVSVEFAVAATDCIAKEVV---DPTKCNLL 222
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAksQVVA---GTNYYITVEAGDTNCKKSSvplDCPDCKLL 77

                        90       100
                ....*....|....*....|....*...
gi 27806751 223 AEKQYGFCKGSVIQKA--LGGEDVRVTC 248
Cdd:cd00042  78 EEGKKKFCTAKVWEKPweNFKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-133 1.47e-14

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 68.99  E-value: 1.47e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751     24 VAGYKEPACDDPDTEQAALAAVDYINKHlpRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPlANCSVR 103
Cdd:smart00043   3 LGGPSDVPPNDPEVQEAADFAVAEYNKK--SNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 27806751    104 QQTQhaveGDCDIHVLKQDGQ--FSVLFTKCD 133
Cdd:smart00043  80 DQGE----KFCTAKVWEKPWEnkIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-132 4.98e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 56.33  E-value: 4.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751  26 GYKEPACDDPDTEQAALAAVDYINKHLPRGYkHTLNQIDSVK--VWPrrptGEVYDIEIDTLETTCHVLDPTPLanCSVR 103
Cdd:cd00042   2 GPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKsqVVA----GTNYYITVEAGDTNCKKSSVPLD--CPDC 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 27806751 104 QQTQHAVEGDCDIHVLKQD--GQFSVLFTKC 132
Cdd:cd00042  75 KLLEEGKKKFCTAKVWEKPweNFKELLSFKC 105
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-237 6.67e-20

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 83.15  E-value: 6.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751   149 CPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVS-VSVEFAVAATDCIaKEVVDPTKCNLLAEKQY 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTnYFIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80

                          90
                  ....*....|
gi 27806751   228 GFCKGSVIQK 237
Cdd:pfam00031  81 GLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 145-249 8.33e-18

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 77.85  E-value: 8.33e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751    145 LCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSY-LQLVEISRA-QFVPLPVSVSVEFAVAATDCIaKEVVDPTKCNLL 222
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYeLRVIKVVSAkSQVVAGTNYYLKVEVGETNCK-KLSVDLENCPFL 79

                           90       100
                   ....*....|....*....|....*....
gi 27806751    223 AEKQyGFCKGSVIQKALG--GEDVRVTCT 249
Cdd:smart00043  80 DQGE-KFCTAKVWEKPWEnkIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 148-248 3.59e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 70.58  E-value: 3.59e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751 148 DCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRA--QFVPlpvSVSVEFAVAATDCIAKEVV---DPTKCNLL 222
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAksQVVA---GTNYYITVEAGDTNCKKSSvplDCPDCKLL 77

                        90       100
                ....*....|....*....|....*...
gi 27806751 223 AEKQYGFCKGSVIQKA--LGGEDVRVTC 248
Cdd:cd00042  78 EEGKKKFCTAKVWEKPweNFKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-133 1.47e-14

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 68.99  E-value: 1.47e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751     24 VAGYKEPACDDPDTEQAALAAVDYINKHlpRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPlANCSVR 103
Cdd:smart00043   3 LGGPSDVPPNDPEVQEAADFAVAEYNKK--SNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 27806751    104 QQTQhaveGDCDIHVLKQDGQ--FSVLFTKCD 133
Cdd:smart00043  80 DQGE----KFCTAKVWEKPWEnkIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-132 4.98e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 56.33  E-value: 4.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806751  26 GYKEPACDDPDTEQAALAAVDYINKHLPRGYkHTLNQIDSVK--VWPrrptGEVYDIEIDTLETTCHVLDPTPLanCSVR 103
Cdd:cd00042   2 GPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKsqVVA----GTNYYITVEAGDTNCKKSSVPLD--CPDC 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 27806751 104 QQTQHAVEGDCDIHVLKQD--GQFSVLFTKC 132
Cdd:cd00042  75 KLLEEGKKKFCTAKVWEKPweNFKELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH