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Conserved domains on  [gi|27734126|ref|NP_775605|]
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zinc finger protein 775 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
305-353 7.53e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.53e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 27734126 305 RPYACPECGRCFSQKPNLTRHLRNHTGERPHPCSHCGRSFRQ------KQHLLKH 353
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTH 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-215 1.62e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 130 KPYLCGKCGKSFSQKPNLVRHQR--HHTGE--RPFCCPE--CTRRFSQKQHLLKHQKTHSRPATHTCPECERCFRHQVGL 203
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                        90
                ....*....|....
gi 27734126 204 RI--HQRAHARNRL 215
Cdd:COG5048 368 NNepPQSLQQYKDL 381
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
472-529 7.26e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.26e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27734126 472 RPYACPDCGRCFSQKPNLTRHRRNHTGERPYLCTACGRGFRQ------KQHLLKHQRVHRGTQA 529
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTHHNNPSDLNS 95
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
305-353 7.53e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.53e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 27734126 305 RPYACPECGRCFSQKPNLTRHLRNHTGERPHPCSHCGRSFRQ------KQHLLKH 353
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTH 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-215 1.62e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 130 KPYLCGKCGKSFSQKPNLVRHQR--HHTGE--RPFCCPE--CTRRFSQKQHLLKHQKTHSRPATHTCPECERCFRHQVGL 203
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                        90
                ....*....|....
gi 27734126 204 RI--HQRAHARNRL 215
Cdd:COG5048 368 NNepPQSLQQYKDL 381
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 1.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 27734126   321 NLTRHLRNHTGERPHPCSHCGRSFRQ 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-171 1.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 27734126   146 NLVRHQRHHTGERPFCCPECTRRFSQ 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
472-529 7.26e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.26e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27734126 472 RPYACPDCGRCFSQKPNLTRHRRNHTGERPYLCTACGRGFRQ------KQHLLKHQRVHRGTQA 529
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-485 1.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 27734126   460 ALTIHQRIHTGERPYACPDCGRCFSQ 485
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
305-353 7.53e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.53e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 27734126 305 RPYACPECGRCFSQKPNLTRHLRNHTGERPHPCSHCGRSFRQ------KQHLLKH 353
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTH 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-215 1.62e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 130 KPYLCGKCGKSFSQKPNLVRHQR--HHTGE--RPFCCPE--CTRRFSQKQHLLKHQKTHSRPATHTCPECERCFRHQVGL 203
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                        90
                ....*....|....
gi 27734126 204 RI--HQRAHARNRL 215
Cdd:COG5048 368 NNepPQSLQQYKDL 381
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 1.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 27734126   321 NLTRHLRNHTGERPHPCSHCGRSFRQ 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-171 1.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 27734126   146 NLVRHQRHHTGERPFCCPECTRRFSQ 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-515 1.31e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 158 RPFCCPECTRRFSQKQHLLKHQKTHSRPATHTCPECER--------CFRHQVgLRIHQRAHARNRLGARVNLHEMFRYAA 229
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksfsrplELSRHL-RTHHNNPSDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 230 ARRWSCRLRPGSPRGHPewvwlglcrswWGQHGVRTTAHSRLGPSeqrQFICNDCGKSFTWWSSLNIHQRIHTgerPYAC 309
Cdd:COG5048 111 SSSSSNSNDNNLLSSHS-----------LPPSSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSLHP---PLPA 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 310 PECGRCFSQKPNLTRHLRNHTGERPHPCSHCGRSFRQKQHLL-KHLRTHLPGAQAARCTSCGQSCPSRAALRAHQRVHTA 388
Cdd:COG5048 174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSsDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS 253

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 389 AELLRSQSAVRDGVPGSeSQAEIAQSVVVKPQGPQgakevlcgqecetlavpseqRQFICNECGKSFSWWSALTIHQR-- 466
Cdd:COG5048 254 SSSASESPRSSLPTASS-QSSSPNESDSSSEKGFS--------------------LPIKSKQCNISFSRSSPLTRHLRsv 312

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 27734126 467 IHTGE--RPYACP--DCGRCFSQKPNLTRHRRNHTGERPYLCTACGRGFRQKQ 515
Cdd:COG5048 313 NHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSP 365
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
273-526 1.91e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 273 PSEQRQFICNDCGKSFTWWSSLNIHQRIHTGERPYACPECGRCFSQKP--NLTRHLRNHTGERPHPCSHCGRSFRQK--- 347
Cdd:COG5048  28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKass 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 348 -----------------QHLLKH-----------LRTHLPGAQAARCTSCGQSCPSRAALRA------------------ 381
Cdd:COG5048 108 sslsssssnsndnnllsSHSLPPssrdpqlpdllSISNLRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpssnlsll 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 382 -HQRVHTAA------ELLRSQSAVRDGVPG-----SESQAEIAQSVVVKPQGPQGAKEVlcgQECETLAVPSEQRQFICN 449
Cdd:COG5048 188 iSSNVSTSIpsssenSPLSSSYSIPSSSSDqnlenSSSSLPLTTNSQLSPKSLLSQSPS---SLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 450 ECGKSFSWWSALTIHQRIHTGER-PYACPDCGRCFSQKPNLTRHRR--NHTGE--RPYLCTA--CGRGFRQKQHLLKHQR 522
Cdd:COG5048 265 LPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344


                ....
gi 27734126 523 VHRG 526
Cdd:COG5048 345 LHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-143 2.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.25e-04
                          10        20
                  ....*....|....*....|....*.
gi 27734126   118 SLKIHQRTHTGEKPYLCGKCGKSFSQ 143
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-318 3.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 27734126   293 SLNIHQRIHTGERPYACPECGRCFSQ 318
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
472-529 7.26e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.26e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27734126 472 RPYACPDCGRCFSQKPNLTRHRRNHTGERPYLCTACGRGFRQ------KQHLLKHQRVHRGTQA 529
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-485 1.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 27734126   460 ALTIHQRIHTGERPYACPDCGRCFSQ 485
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 335-357 1.12e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|...
gi 27734126   335 HPCSHCGRSFRQKQHLLKHLRTH 357
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
104-185 1.24e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734126 104 FVCVDCGKRFSWWSSLKIHQRT--HTGE--KPYLCGK--CGKSFSQKPNLVRHQRHHTGERPFCCP--ECTRRFSQKQHL 175
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNN 369

                        90
                ....*....|
gi 27734126 176 LKHQKTHSRP 185
Cdd:COG5048 370 EPPQSLQQYK 379
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 474-496 1.45e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.45e-03
                          10        20
                  ....*....|....*....|...
gi 27734126   474 YACPDCGRCFSQKPNLTRHRRNH 496
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 307-329 1.50e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|...
gi 27734126   307 YACPECGRCFSQKPNLTRHLRNH 329
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
438-509 1.56e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.56e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27734126 438 AVPSEQRQFICNECGKSFSWWSALTIHQRIHTGERPYACPDCGRCFSQKP--NLTRHRRNHTGERPYLCTACGR 509
Cdd:COG5048  26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLP 99
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 160-182 9.07e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.07e-03
                          10        20
                  ....*....|....*....|...
gi 27734126   160 FCCPECTRRFSQKQHLLKHQKTH 182
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 132-154 9.81e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.81e-03
                          10        20
                  ....*....|....*....|...
gi 27734126   132 YLCGKCGKSFSQKPNLVRHQRHH 154
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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