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Conserved domains on  [gi|28178853|ref|NP_775302|]
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homeobox protein TGIF1 isoform d [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10531334)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 34-72 5.06e-20

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 80.25  E-value: 5.06e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 28178853    34 LYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRR 72
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 34-72 5.06e-20

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 80.25  E-value: 5.06e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 28178853    34 LYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRR 72
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 15-72 4.83e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 64.96  E-value: 4.83e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 28178853     15 KRRRRGNLPKESVQILRDWLYEhryNAYPSEQEKALLSQQTHLSTLQVCNWFINARRR 72
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQK---NPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 16-73 9.18e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 64.19  E-value: 9.18e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 28178853  16 RRRRGNLPKESVQILRDWLYEhryNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRL 73
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEK---NPYPSREEREELAKELGLTERQVKIWFQNRRAKL 55
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 34-72 5.06e-20

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 80.25  E-value: 5.06e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 28178853    34 LYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRR 72
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 15-72 4.83e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 64.96  E-value: 4.83e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 28178853     15 KRRRRGNLPKESVQILRDWLYEhryNAYPSEQEKALLSQQTHLSTLQVCNWFINARRR 72
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQK---NPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 16-73 9.18e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 64.19  E-value: 9.18e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 28178853  16 RRRRGNLPKESVQILRDWLYEhryNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRL 73
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEK---NPYPSREEREELAKELGLTERQVKIWFQNRRAKL 55
Homeodomain pfam00046
Homeodomain;
16-72 1.47e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 44.41  E-value: 1.47e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 28178853    16 RRRRGNLPKESVQILrdwlyEHRY--NAYPSEQEKALLSQQTHLSTLQVCNWFINARRR 72
Cdd:pfam00046   1 RRKRTTFTPEQLEEL-----EKEFqeNPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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