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isocitrate dehydrogenase [NADP], mitochondrial precursor [Mus musculus]
Protein Classification
NADP-dependent isocitrate dehydrogenase ( domain architecture ID 10015366 )
NADP-dependent isocitrate dehydrogenase catalyzes the conversion of isocitrate to 2-oxoglutarate in an NADP-dependent manner
List of domain hits
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
39-451
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 869.31
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 39 YAEKR IKV EK PVVE M DGDEMTRIIW QF IKEKLILP HV DV QL KY F DL GLP NRD Q T N D Q VT I D S A L A TQ K YS V AV KCATITP 118
Cdd:PTZ00435 1 NTGGK IKV KN PVVE L DGDEMTRIIW KM IKEKLILP YL DV PI KY Y DL SIE NRD K T D D K VT V D A A E A IK K HK V GI KCATITP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 119 DEARV E EF K LKKMWKSPNGTIRNIL G GTVFREPII C KNIPRLVPGW T KPI T IGRHA H GDQYKATDFVVD RA G TFK LVFTP 198
Cdd:PTZ00435 81 DEARV K EF N LKKMWKSPNGTIRNIL D GTVFREPII I KNIPRLVPGW K KPI V IGRHA F GDQYKATDFVVD GP G KLE LVFTP 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 199 K DGS SAKEWE V YN F PA GGV G MGMYNTDESI S GFA H SCFQY SIQK K W PLYLSTKNTILK A YDGRFKDIFQEI F D KH YK TD F 278
Cdd:PTZ00435 161 A DGS EPQRVD V FD F KG GGV A MGMYNTDESI E GFA R SCFQY ALDR K M PLYLSTKNTILK K YDGRFKDIFQEI Y D EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 279 D K NKI WYEHRLIDDMVAQ VL KS S GGFVWACKNYDGDVQSDI L AQG F GSLGLMTSVLVCPDGKT I EAEAAHGTVTRHYR E H 358
Cdd:PTZ00435 241 E K AGL WYEHRLIDDMVAQ AI KS E GGFVWACKNYDGDVQSDI V AQG Y GSLGLMTSVLVCPDGKT V EAEAAHGTVTRHYR Q H 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 359 QKG RP TSTN P IASIFAWTRGL E HR G KLD G NQ D L IR F A Q T LE KV C VQ T V E S G A MTKDLA G C I HG L S N V K l NEHF LNT TD F L 438
Cdd:PTZ00435 321 QKG KE TSTN S IASIFAWTRGL A HR A KLD N NQ E L VK F C Q A LE RS C IE T I E A G F MTKDLA I C V HG S S K V T - RSDY LNT EE F I 399
410
....*....|...
gi 225579033 439 D TIKSN L DRA LG K 451
Cdd:PTZ00435 400 D KVAEK L KKK LG A 412
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
39-451
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 869.31
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 39 YAEKR IKV EK PVVE M DGDEMTRIIW QF IKEKLILP HV DV QL KY F DL GLP NRD Q T N D Q VT I D S A L A TQ K YS V AV KCATITP 118
Cdd:PTZ00435 1 NTGGK IKV KN PVVE L DGDEMTRIIW KM IKEKLILP YL DV PI KY Y DL SIE NRD K T D D K VT V D A A E A IK K HK V GI KCATITP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 119 DEARV E EF K LKKMWKSPNGTIRNIL G GTVFREPII C KNIPRLVPGW T KPI T IGRHA H GDQYKATDFVVD RA G TFK LVFTP 198
Cdd:PTZ00435 81 DEARV K EF N LKKMWKSPNGTIRNIL D GTVFREPII I KNIPRLVPGW K KPI V IGRHA F GDQYKATDFVVD GP G KLE LVFTP 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 199 K DGS SAKEWE V YN F PA GGV G MGMYNTDESI S GFA H SCFQY SIQK K W PLYLSTKNTILK A YDGRFKDIFQEI F D KH YK TD F 278
Cdd:PTZ00435 161 A DGS EPQRVD V FD F KG GGV A MGMYNTDESI E GFA R SCFQY ALDR K M PLYLSTKNTILK K YDGRFKDIFQEI Y D EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 279 D K NKI WYEHRLIDDMVAQ VL KS S GGFVWACKNYDGDVQSDI L AQG F GSLGLMTSVLVCPDGKT I EAEAAHGTVTRHYR E H 358
Cdd:PTZ00435 241 E K AGL WYEHRLIDDMVAQ AI KS E GGFVWACKNYDGDVQSDI V AQG Y GSLGLMTSVLVCPDGKT V EAEAAHGTVTRHYR Q H 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 359 QKG RP TSTN P IASIFAWTRGL E HR G KLD G NQ D L IR F A Q T LE KV C VQ T V E S G A MTKDLA G C I HG L S N V K l NEHF LNT TD F L 438
Cdd:PTZ00435 321 QKG KE TSTN S IASIFAWTRGL A HR A KLD N NQ E L VK F C Q A LE RS C IE T I E A G F MTKDLA I C V HG S S K V T - RSDY LNT EE F I 399
410
....*....|...
gi 225579033 439 D TIKSN L DRA LG K 451
Cdd:PTZ00435 400 D KVAEK L KKK LG A 412
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
42-449
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 709.33
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 42 KR IKV EK PVVEMDGDEMTRIIW QF IK E KLILP H V DVQ LKY F DLG LPN RD Q TNDQVT I D S A L A TQ KY S V A VKCATITPDEA 121
Cdd:TIGR00127 1 SK IKV AN PVVEMDGDEMTRIIW EL IK D KLILP Y V ELD LKY Y DLG VEY RD A TNDQVT V D A A E A IK KY N V G VKCATITPDEA 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 122 RVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW T KPI T IGRHA H GDQY K ATDFVV DRA G TFK LV FT PKDG 201
Cdd:TIGR00127 81 RVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW E KPI I IGRHA F GDQY R ATDFVV PGP G KLE LV YK PKDG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 202 SSAKEWE VY N F P - A GGV G M G MYNTDESI S GFAHS C FQ YSIQ KKWPLYLSTKNTILK A YDGRFKDIFQE IFDKH YK TD F DK 280
Cdd:TIGR00127 161 TQKVTLK VY D F E e G GGV A M A MYNTDESI E GFAHS S FQ LALE KKWPLYLSTKNTILK K YDGRFKDIFQE VYEAQ YK SK F EA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 281 NK IWYEHRLIDDMVAQ V LKS S GGF V WACKNYDGDVQSDI L AQGFGSLGLMTSVL V CPDGKT I EAEAAHGTVTRHYR EH QK 360
Cdd:TIGR00127 241 LG IWYEHRLIDDMVAQ A LKS E GGF I WACKNYDGDVQSDI V AQGFGSLGLMTSVL I CPDGKT F EAEAAHGTVTRHYR MY QK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 361 G RP TSTN P IASIFAW T RGL E HR G KLD G N QD L IR FA QT LE KV C VQ TVE S G A MTKDLA GCIH G LSNVK ln EHF LNT TD F L D T 440
Cdd:TIGR00127 321 G QE TSTN S IASIFAW S RGL A HR A KLD N N PE L SK FA NI LE SA C IN TVE A G I MTKDLA LILG G SPVER -- SAY LNT EE F I D A 398
....*....
gi 225579033 441 IKSN L DRAL 449
Cdd:TIGR00127 399 VEER L KKKI 407
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
42-447
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 530.07
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 42 KR IKVE K ----- P ---- VVEMD GD ---- E M TR I IW QF I KEKLILPH --- V D VQL K YF D L G LPN RD Q T N D QVTIDS A L A TQ 105
Cdd:COG0538 4 EK IKVE D gklkv P dnpi IPFIE GD gigp E I TR A IW KV I DAAVEKAY ggk R D IEW K EV D A G EKA RD E T G D WLPDET A E A IK 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 106 K Y S V AV K CATI TP DEA rveefklkk M W K S P N G TIR N IL GGT V F R E P I - IC K NI P RL V PGW - TKP I T I G R HAHG D Q Y KATD 183
Cdd:COG0538 84 E Y G V GI K GPLT TP VGG --------- G W R S L N V TIR Q IL DLY V C R R P V r YF K GV P SP V KHP e KVD I V I F R ENTE D I Y AGIE 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 184 FVVDRAGTF KL V F TPK D GS sak EWE V YN FP AG - G V G MGMYN t DE SISGFAHSCF QY SIQ - K KWPLY L ST K NT I L K AYD G R 261
Cdd:COG0538 155 WKAGSPEAL KL I F FLE D EM --- GVT V IR FP ED s G I G IKPVS - DE GTERLVRAAI QY ALD n K RKSVT L VH K GN I M K FTE G A 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 262 FKD IFQ E IFDKHYKTD F ------------- DKN KI W Y EH R LI DDM VA Q V L KSS G G - F V W A C KN YD GD VQ SD I LA QGF G S L 327
Cdd:COG0538 231 FKD WGY E VAEEEFGDK F itegpwekykgpk PAG KI V Y KD R IA DDM LQ Q I L LRP G E y D V I A T KN LN GD YI SD A LA AQV G G L 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 328 G LMTSVLVCP DG K t I E A EA A HGT VTRH yrehqk GRPT STNP IAS I FAW T RG L E HRG K L DG nqdlirf A QTL EK VCVQ T V E 407
Cdd:COG0538 311 G IAPGANIGD DG G - A E F EA T HGT APKY ------ AGKD STNP GSL I LSG T MM L R HRG W L EA ------- A DLI EK AVEK T I E 376
410 420 430 440
....*....|....*....|....*....|....*....|
gi 225579033 408 SG AM T K DLA GCIH G lsnvkln EHF L N T TD F L D T I KS NLD R 447
Cdd:COG0538 377 SG KV T Y DLA RLME G ------- ATE L S T SE F G D A I IE NLD K 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
45-441
1.16e-88
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 273.79
E-value: 1.16e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 45 K VEKPVVEMD G D E MTRIIWQFI K EK L ILPHVDVQLKYF D L G LPNR D Q T NDQVTIDSAL A TQ K YSVAVKC A TIT P D ---- E 120
Cdd:pfam00180 1 K IAVLPGDGI G P E VMAAALKVL K AA L EKAPLEFEFEER D V G GAAI D E T GEPLPDETLE A CK K ADAVLLG A VGG P K wdpa G 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 121 A R V E EF k L KKMW K SP n G TIR N ILGGT VF R e P IICKNIPRLVPGWTK p I T I G R HAH G DQ Y KATDFVVDRA G T fklvftpkd 200
Cdd:pfam00180 81 V R P E NG - L LALR K EL - G LFA N LRPAK VF P - P LGDASPLKNEVEGVD - I V I V R ELT G GI Y FGIEKGIKGS G N --------- 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 201 gssakewevynfp AGG V GMGM Y NT DE s I SGF A HSC F QYSIQK - KWPLYLST K NTI LK AY D g RFKD I FQ E IFDKH Y K tdfd 279
Cdd:pfam00180 148 ------------- EVA V DTKL Y SR DE - I ERI A RVA F ELARKR g RKKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ---- 208
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 280 kn KIWY EH R L I D DMVA Q VL K SSGG F - V WACK N YD GD VQ SD ILAQGF GSLGL MT S VLVCPD G k TIEA E AA HG TVTRHYREH 358
Cdd:pfam00180 209 -- DVEL EH Q L V D NAAM Q LV K NPSQ F d V IVTP N LF GD IL SD EASMLT GSLGL LP S ASLGAN G - FGIF E PV HG SAPDIAGKG 285
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 359 Q kgrpts T NPIA S I FAWTRG L EHRGK L DGNQ D L I rfaqtl E KVCVQTV ESG AM T K DLAG cihglsnvkl NEHFLN T TD F L 438
Cdd:pfam00180 286 I ------ A NPIA T I LSAAMM L RYSLG L EDAA D K I ------ E AAVLKVL ESG IR T G DLAG ---------- SATYVS T SE F G 343
...
gi 225579033 439 DTI 441
Cdd:pfam00180 344 EAV 346
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
39-451
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 869.31
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 39 YAEKR IKV EK PVVE M DGDEMTRIIW QF IKEKLILP HV DV QL KY F DL GLP NRD Q T N D Q VT I D S A L A TQ K YS V AV KCATITP 118
Cdd:PTZ00435 1 NTGGK IKV KN PVVE L DGDEMTRIIW KM IKEKLILP YL DV PI KY Y DL SIE NRD K T D D K VT V D A A E A IK K HK V GI KCATITP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 119 DEARV E EF K LKKMWKSPNGTIRNIL G GTVFREPII C KNIPRLVPGW T KPI T IGRHA H GDQYKATDFVVD RA G TFK LVFTP 198
Cdd:PTZ00435 81 DEARV K EF N LKKMWKSPNGTIRNIL D GTVFREPII I KNIPRLVPGW K KPI V IGRHA F GDQYKATDFVVD GP G KLE LVFTP 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 199 K DGS SAKEWE V YN F PA GGV G MGMYNTDESI S GFA H SCFQY SIQK K W PLYLSTKNTILK A YDGRFKDIFQEI F D KH YK TD F 278
Cdd:PTZ00435 161 A DGS EPQRVD V FD F KG GGV A MGMYNTDESI E GFA R SCFQY ALDR K M PLYLSTKNTILK K YDGRFKDIFQEI Y D EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 279 D K NKI WYEHRLIDDMVAQ VL KS S GGFVWACKNYDGDVQSDI L AQG F GSLGLMTSVLVCPDGKT I EAEAAHGTVTRHYR E H 358
Cdd:PTZ00435 241 E K AGL WYEHRLIDDMVAQ AI KS E GGFVWACKNYDGDVQSDI V AQG Y GSLGLMTSVLVCPDGKT V EAEAAHGTVTRHYR Q H 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 359 QKG RP TSTN P IASIFAWTRGL E HR G KLD G NQ D L IR F A Q T LE KV C VQ T V E S G A MTKDLA G C I HG L S N V K l NEHF LNT TD F L 438
Cdd:PTZ00435 321 QKG KE TSTN S IASIFAWTRGL A HR A KLD N NQ E L VK F C Q A LE RS C IE T I E A G F MTKDLA I C V HG S S K V T - RSDY LNT EE F I 399
410
....*....|...
gi 225579033 439 D TIKSN L DRA LG K 451
Cdd:PTZ00435 400 D KVAEK L KKK LG A 412
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
42-449
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 847.60
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 42 KR IKV EK PVVE M DGDEMTRIIW Q FIK E KLILP HV D VQ L K Y F DLG LP NRD Q T N DQVTID S A L A TQ KY S V A VKCATITPDEA 121
Cdd:PRK08299 2 AK IKV KN PVVE L DGDEMTRIIW K FIK D KLILP YL D ID L E Y Y DLG IE NRD A T D DQVTID A A N A IK KY G V G VKCATITPDEA 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 122 RV E EF K LKKMWKSPNGTIRNILGGTVFREPIICKN I PRLVPGWTKPI T IGRHA H GDQY K ATDF V V DRA G TFK LVFT PK DG 201
Cdd:PRK08299 82 RV K EF N LKKMWKSPNGTIRNILGGTVFREPIICKN V PRLVPGWTKPI V IGRHA Y GDQY R ATDF K V PGK G KLT LVFT GE DG 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 202 S s AK E W EV YN FP AG GV G MGMYN T DESI SG FA HSC F Q Y SIQK K W P L YLSTKNTILKAYDGRFKDIFQE IFDKHY K TD F DKN 281
Cdd:PRK08299 162 E - PI E H EV HD FP GA GV A MGMYN L DESI RD FA RAS F N Y GLDR K Y P V YLSTKNTILKAYDGRFKDIFQE VYEAEF K EK F EAA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 282 K I W YEHRLIDDMVA QV LK SS GG F VWACKNYDGDVQSD IL AQGFGSLGLMTSVL VC PDGKT I EAEAAHGTVTRHYR E HQKG 361
Cdd:PRK08299 241 G I T YEHRLIDDMVA SA LK WE GG Y VWACKNYDGDVQSD TV AQGFGSLGLMTSVL MT PDGKT V EAEAAHGTVTRHYR Q HQKG 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 362 RP TSTNPIASIFAWTRGL E HRGKLDGN QD L IR FA Q TLEKVC VQ TVESG A MTKDLA GCIHG lsnvkl NEHF L N T TD FLD T I 441
Cdd:PRK08299 321 EE TSTNPIASIFAWTRGL A HRGKLDGN PE L VK FA D TLEKVC IE TVESG F MTKDLA LLVGP ------ DQKW L T T EE FLD A I 394
....*...
gi 225579033 442 KS NL DR AL 449
Cdd:PRK08299 395 DE NL EK AL 402
PLN03065
PLN03065 isocitrate dehydrogenase (NADP+); Provisional
4-450
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 178617 [Multi-domain]
Cd Length: 483
Bit Score: 752.48
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 4 YL RA VSSLCRASG S A R TW A P AA ltvpswpeqprrhy A EK RIKV EK P V VEMDGDEMTR I IWQ F IK E KLI L P HV D VQL KYFD 83
Cdd:PLN03065 48 NR RA FHVQFHRAS S V R CF A S AA -------------- A AD RIKV QN P I VEMDGDEMTR V IWQ M IK D KLI F P YL D LDI KYFD 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 84 LG LP NRD Q T N D Q VT ID SA L AT Q KY S VA V KCATITPDEARV E EF K LK K MW K SPNGTIRNIL G GTVFREPI I CKNIPRLVPG 163
Cdd:PLN03065 114 LG IL NRD A T D D K VT VE SA E AT L KY N VA I KCATITPDEARV K EF G LK S MW R SPNGTIRNIL N GTVFREPI L CKNIPRLVPG 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 164 W T KPI T IGRHA H GDQY K ATD F V VDRA G TF K L VF T P K DG SSAK E WE VY N F PAG GV GMG MYN T DESI SG FA H S CFQYSI QKK 243
Cdd:PLN03065 194 W K KPI C IGRHA F GDQY R ATD T V IKGP G KL K M VF V P E DG NAPV E LD VY D F KGP GV ALA MYN V DESI RA FA E S SMAMAL QKK 273
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 244 WPLYLSTKNTILK A YDGRFKDIFQE IFDKHY K TD F DKNK IWYEHRLIDDMVA QVL KS S GG F VWACKNYDGDVQSD I LAQG 323
Cdd:PLN03065 274 WPLYLSTKNTILK K YDGRFKDIFQE VYEEQW K QK F EEHS IWYEHRLIDDMVA YAV KS E GG Y VWACKNYDGDVQSD L LAQG 353
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 324 FGSLGLMTSVL VCP DGKT I EAEAAHGTVTRH Y R E HQKG RP TSTN P IASIFAWTRGLEHR G KLD G N QD L IR F AQT LE KV C V 403
Cdd:PLN03065 354 FGSLGLMTSVL LSS DGKT L EAEAAHGTVTRH F R L HQKG QE TSTN S IASIFAWTRGLEHR A KLD K N EE L LD F VHK LE SA C I 433
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 225579033 404 Q TVESG A MTKDLA GC IHG LSNVK ln E HF LNT TD F L D TIKSN L DRAL G 450
Cdd:PLN03065 434 E TVESG K MTKDLA IL IHG PKVSR -- E FY LNT EE F I D AVAQT L ATKR G 478
PLN00103
PLN00103 isocitrate dehydrogenase (NADP+); Provisional
40-449
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177720
Cd Length: 410
Bit Score: 718.92
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 40 A EKR IKV EK P V VEMDGDEMTR I IW QF IK E KLI L P HV D VQL KYFDLGLPNRD Q T N D Q VT ID SA L AT Q KY S VA V KCATITPD 119
Cdd:PLN00103 2 A FEK IKV AN P I VEMDGDEMTR V IW KS IK D KLI F P FL D LDI KYFDLGLPNRD A T D D K VT VE SA E AT L KY N VA I KCATITPD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 120 EARV E EF K LK K MWKSPNGTIRNIL G GTVFREPIICKNIPRLVPGWTKPI T IGRHA H GDQY K ATD F V VDRA G TF KLVF T P K 199
Cdd:PLN00103 82 EARV K EF G LK Q MWKSPNGTIRNIL N GTVFREPIICKNIPRLVPGWTKPI C IGRHA F GDQY R ATD A V IKGP G KL KLVF V P E 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 200 DGSSAK E W EVYNF P - AGGV GMG MYNTDESI SG FA HSCFQYSI QKKWPLYLSTKNTILK A YDGRFKDIFQE IFDKHY K TD F 278
Cdd:PLN00103 162 GKDEKT E L EVYNF T g AGGV ALS MYNTDESI RA FA EASMNTAY QKKWPLYLSTKNTILK K YDGRFKDIFQE VYEAQW K SK F 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 279 DKNK IWYEHRLIDDMVA QV LKS S GG F VWACKNYDGDVQSD I LAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYR E H 358
Cdd:PLN00103 242 EAAG IWYEHRLIDDMVA YA LKS E GG Y VWACKNYDGDVQSD F LAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYR V H 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 359 QKG RP TSTN P IASIFAW T RGL E HR G KLDGN QD L IR F AQT LE KV CV Q TVESG A MTKDLA GC IHG l SN V K l NEHF LNT TD F L 438
Cdd:PLN00103 322 QKG GE TSTN S IASIFAW S RGL A HR A KLDGN AR L LD F TEK LE AA CV G TVESG K MTKDLA LL IHG - PK V S - RDQY LNT EE F I 399
410
....*....|.
gi 225579033 439 D TIKSN L DRA L 449
Cdd:PLN00103 400 D AVAEE L KAR L 410
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
42-449
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 709.33
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 42 KR IKV EK PVVEMDGDEMTRIIW QF IK E KLILP H V DVQ LKY F DLG LPN RD Q TNDQVT I D S A L A TQ KY S V A VKCATITPDEA 121
Cdd:TIGR00127 1 SK IKV AN PVVEMDGDEMTRIIW EL IK D KLILP Y V ELD LKY Y DLG VEY RD A TNDQVT V D A A E A IK KY N V G VKCATITPDEA 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 122 RVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW T KPI T IGRHA H GDQY K ATDFVV DRA G TFK LV FT PKDG 201
Cdd:TIGR00127 81 RVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW E KPI I IGRHA F GDQY R ATDFVV PGP G KLE LV YK PKDG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 202 SSAKEWE VY N F P - A GGV G M G MYNTDESI S GFAHS C FQ YSIQ KKWPLYLSTKNTILK A YDGRFKDIFQE IFDKH YK TD F DK 280
Cdd:TIGR00127 161 TQKVTLK VY D F E e G GGV A M A MYNTDESI E GFAHS S FQ LALE KKWPLYLSTKNTILK K YDGRFKDIFQE VYEAQ YK SK F EA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 281 NK IWYEHRLIDDMVAQ V LKS S GGF V WACKNYDGDVQSDI L AQGFGSLGLMTSVL V CPDGKT I EAEAAHGTVTRHYR EH QK 360
Cdd:TIGR00127 241 LG IWYEHRLIDDMVAQ A LKS E GGF I WACKNYDGDVQSDI V AQGFGSLGLMTSVL I CPDGKT F EAEAAHGTVTRHYR MY QK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 361 G RP TSTN P IASIFAW T RGL E HR G KLD G N QD L IR FA QT LE KV C VQ TVE S G A MTKDLA GCIH G LSNVK ln EHF LNT TD F L D T 440
Cdd:TIGR00127 321 G QE TSTN S IASIFAW S RGL A HR A KLD N N PE L SK FA NI LE SA C IN TVE A G I MTKDLA LILG G SPVER -- SAY LNT EE F I D A 398
....*....
gi 225579033 441 IKSN L DRAL 449
Cdd:TIGR00127 399 VEER L KKKI 407
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
42-447
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 530.07
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 42 KR IKVE K ----- P ---- VVEMD GD ---- E M TR I IW QF I KEKLILPH --- V D VQL K YF D L G LPN RD Q T N D QVTIDS A L A TQ 105
Cdd:COG0538 4 EK IKVE D gklkv P dnpi IPFIE GD gigp E I TR A IW KV I DAAVEKAY ggk R D IEW K EV D A G EKA RD E T G D WLPDET A E A IK 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 106 K Y S V AV K CATI TP DEA rveefklkk M W K S P N G TIR N IL GGT V F R E P I - IC K NI P RL V PGW - TKP I T I G R HAHG D Q Y KATD 183
Cdd:COG0538 84 E Y G V GI K GPLT TP VGG --------- G W R S L N V TIR Q IL DLY V C R R P V r YF K GV P SP V KHP e KVD I V I F R ENTE D I Y AGIE 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 184 FVVDRAGTF KL V F TPK D GS sak EWE V YN FP AG - G V G MGMYN t DE SISGFAHSCF QY SIQ - K KWPLY L ST K NT I L K AYD G R 261
Cdd:COG0538 155 WKAGSPEAL KL I F FLE D EM --- GVT V IR FP ED s G I G IKPVS - DE GTERLVRAAI QY ALD n K RKSVT L VH K GN I M K FTE G A 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 262 FKD IFQ E IFDKHYKTD F ------------- DKN KI W Y EH R LI DDM VA Q V L KSS G G - F V W A C KN YD GD VQ SD I LA QGF G S L 327
Cdd:COG0538 231 FKD WGY E VAEEEFGDK F itegpwekykgpk PAG KI V Y KD R IA DDM LQ Q I L LRP G E y D V I A T KN LN GD YI SD A LA AQV G G L 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 328 G LMTSVLVCP DG K t I E A EA A HGT VTRH yrehqk GRPT STNP IAS I FAW T RG L E HRG K L DG nqdlirf A QTL EK VCVQ T V E 407
Cdd:COG0538 311 G IAPGANIGD DG G - A E F EA T HGT APKY ------ AGKD STNP GSL I LSG T MM L R HRG W L EA ------- A DLI EK AVEK T I E 376
410 420 430 440
....*....|....*....|....*....|....*....|
gi 225579033 408 SG AM T K DLA GCIH G lsnvkln EHF L N T TD F L D T I KS NLD R 447
Cdd:COG0538 377 SG KV T Y DLA RLME G ------- ATE L S T SE F G D A I IE NLD K 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
45-441
1.16e-88
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 273.79
E-value: 1.16e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 45 K VEKPVVEMD G D E MTRIIWQFI K EK L ILPHVDVQLKYF D L G LPNR D Q T NDQVTIDSAL A TQ K YSVAVKC A TIT P D ---- E 120
Cdd:pfam00180 1 K IAVLPGDGI G P E VMAAALKVL K AA L EKAPLEFEFEER D V G GAAI D E T GEPLPDETLE A CK K ADAVLLG A VGG P K wdpa G 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 121 A R V E EF k L KKMW K SP n G TIR N ILGGT VF R e P IICKNIPRLVPGWTK p I T I G R HAH G DQ Y KATDFVVDRA G T fklvftpkd 200
Cdd:pfam00180 81 V R P E NG - L LALR K EL - G LFA N LRPAK VF P - P LGDASPLKNEVEGVD - I V I V R ELT G GI Y FGIEKGIKGS G N --------- 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 201 gssakewevynfp AGG V GMGM Y NT DE s I SGF A HSC F QYSIQK - KWPLYLST K NTI LK AY D g RFKD I FQ E IFDKH Y K tdfd 279
Cdd:pfam00180 148 ------------- EVA V DTKL Y SR DE - I ERI A RVA F ELARKR g RKKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ---- 208
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 280 kn KIWY EH R L I D DMVA Q VL K SSGG F - V WACK N YD GD VQ SD ILAQGF GSLGL MT S VLVCPD G k TIEA E AA HG TVTRHYREH 358
Cdd:pfam00180 209 -- DVEL EH Q L V D NAAM Q LV K NPSQ F d V IVTP N LF GD IL SD EASMLT GSLGL LP S ASLGAN G - FGIF E PV HG SAPDIAGKG 285
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 359 Q kgrpts T NPIA S I FAWTRG L EHRGK L DGNQ D L I rfaqtl E KVCVQTV ESG AM T K DLAG cihglsnvkl NEHFLN T TD F L 438
Cdd:pfam00180 286 I ------ A NPIA T I LSAAMM L RYSLG L EDAA D K I ------ E AAVLKVL ESG IR T G DLAG ---------- SATYVS T SE F G 343
...
gi 225579033 439 DTI 441
Cdd:pfam00180 344 EAV 346
PLN00096
PLN00096 isocitrate dehydrogenase (NADP+); Provisional
50-445
2.96e-49
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177715
Cd Length: 393
Bit Score: 172.52
E-value: 2.96e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 50 V V EMD G D EMTR IIWQF I KE K L I L PHVD V - QLKY FDL GLP NRD Q T N DQV TI D SAL A TQKYSVAV K CA TITP DEAR V EEFK L 128
Cdd:PLN00096 1 M V YVA G E EMTR YTMDL I LA K W I E PHVD T s AWEF FDL RAK NRD D T E DQV LR D VIE A GARLKAIF K EP TITP TADQ V KRLG L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 129 KK M W K SPNG TI R NILG G - T VF R EP I ick N I PRLVP G WT KP ITIG RHA H G DQ Y K A TDFV V DR a GT FKLV F T P KD G SSAKEW 207
Cdd:PLN00096 81 KK A W G SPNG AM R RGWN G i T IS R DT I --- H I DGVEL G YK KP VFFE RHA V G GE Y S A GYKI V GK - GT LVTT F V P EE G GKPIVV 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 208 EVYNFPAGGVGMGM Y - N TDESISGF A HSC F QYSIQKKWPL Y LS TK N T IL K a YDGR F KD I FQEI FD KHY K TD F DKNKIWYE 286
Cdd:PLN00096 157 DDRTITDDLNAVVT Y h N PLDNVHHL A RIF F GRCLDAGIVP Y VV TK K T VF K - WQEP F WE I MKKV FD EEF K SK F VDKGVMKS 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 287 ----- H R L I D DMVAQ - V LKSS GGF VW A CK NYDGDV QS D I LAQ GFG S L G LM TS V LV CP D -- G KT I - E A EA A HGTVT RHYRE 357
Cdd:PLN00096 236 gdelv H L L S D AATMK l V VWTD GGF GM A AH NYDGDV LT D E LAQ VHK S P G FI TS N LV GV D en G TL I k E F EA S HGTVT DMDEA 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 358 HQK G RP TS T NP IASIFAWTRGLE H RGKLD G NQDLIR - F AQT L EK V CVQTVES G AM T K DL A G C i H GL S nvklnehfln T TD 436
Cdd:PLN00096 316 RLR G EE TS L NP LGMVEGLIGAMN H AADVH G GKERVH p F TAK L RA V IHKLFRE G RG T R DL C G A - G GL T ---------- T EQ 384
....*....
gi 225579033 437 F L D TIKSN L 445
Cdd:PLN00096 385 F I D AVAEE L 393
PLN00118
PLN00118 isocitrate dehydrogenase (NAD+)
251-445
1.18e-04
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062
Cd Length: 372
Bit Score: 44.10
E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 251 K NT I L K AY DG R F KDIFQ E IFD K H yktdfdk NK I W YE HRL ID DMVAQVL K SSGG F - V WACK N YD GD VQ SD IL A QGF G S LGL 329
Cdd:PLN00118 210 K AN I M K KT DG L F LKCCR E VAE K Y ------- PE I V YE EVI ID NCCMMLV K NPAL F d V LVMP N LY GD II SD LC A GLI G G LGL 282
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579033 330 MT S VLVCPD G KTI e AEA A HG TVT rhyreh QKGRPTST NP I A SIFAWTRG L E H rgk L DG N QD lirf A QTLEKVCVQ T VES G 409
Cdd:PLN00118 283 TP S CNIGEN G LAL - AEA V HG SAP ------ DIAGKNLA NP T A LLLSAVMM L R H --- L KL N EQ ---- A EQIHNAILN T IAE G 348
170 180 190
....*....|....*....|....*....|....*..
gi 225579033 410 A - M T K DL A G CI hglsnvklnehfl N TTDF LDT I KSN L 445
Cdd:PLN00118 349 K y R T A DL G G SS ------------- T TTDF TKA I CDH L 372
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
