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Conserved domains on  [gi|124486714|ref|NP_766513|]
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kelch-like protein 31 [Mus musculus]

Protein Classification

kelch-like protein; BTB/POZ domain-containing protein 9( domain architecture ID 13033207)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases| BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein 9 (BTBD9) is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-174 8.37e-76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 237.40  E-value: 8.37e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLNDIAPLGLATVIAYAYTGKLT 134
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQRVELNDISPLGLATVITYAYTGKLT 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMY 174
Cdd:cd18260   81 LSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCMY 120
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
167-264 3.18e-64

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18470:

Pssm-ID: 475122  Cd Length: 98  Bit Score: 206.26  E-value: 3.18e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK 246
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQK 80
                         90
                 ....*....|....*...
gi 124486714 247 RVKHAADLLSNIRFGTIS 264
Cdd:cd18470   81 RVKYAADLLSNIRFGTIS 98
PHA03098 super family cl33709
kelch-like protein; Provisional
73-601 2.74e-59

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 207.31  E-value: 2.74e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  73 CD--LVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLN-DIAPLglATVIAYAYTGKLTLSLYTIGSIISAAVY 149
Cdd:PHA03098  10 CDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNiDYDSF--NEVIKYIYTGKINITSNNVKDILSIANY 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 150 LQIHTLVKMCSDFLIREISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPS 229
Cdd:PHA03098  88 LIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 230 ELVAFQIAMKWLEF-DQKRVKHAADLLSNIRFGTISaqdlvnyvqtvPRMMQDAdchKLLVDAMNYHLLPYHQNTLQSRR 308
Cdd:PHA03098 168 EDVVLEIIIKWLTSkKNNKYKDICLILKVLRITFLS-----------EEGIKKL---KRWKLRIKKKKIVFNKRCIKIIY 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 309 TRIRGGCRVLITVG--GRPGLTE----KSLSRDILYRDPENGWSKLTEMPAKsFNQCVAVMDGFLYVAGGedqndaRNQA 382
Cdd:PHA03098 234 SKKYNLNKILPRSStfGSIIYIHitmsIFTYNYITNYSPLSEINTIIDIHYV-YCFGSVVLNNVIYFIGG------MNKN 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 383 KHAVSNFCRYDPRFNTWIHLGSMNQKRTHFSLSVFNGLLYAVGGRNSEGSLASLECYVPSTNQWQPKAPLEVARCCHASA 462
Cdd:PHA03098 307 NLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVV 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 463 VADGRVIVTGG-YIGSAYSRSVCAYDPALDAWQELPQLSTPRGWHCAVALGDRLYVMGGSQLGPRGERVDVltVESFSPA 541
Cdd:PHA03098 387 NVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNI--VESYNPV 464
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 542 ARQWSFVAPLPVGVSTAGVSALHGRAYLLGGWNegEKKYKKCIQCFNPELNEWTEDDELP 601
Cdd:PHA03098 465 TNKWTELSSLNFPRINASLCIFNNKIYVVGGDK--YEYYINEIEVYDDKTNTWTLFCKFP 522
 
Name Accession Description Interval E-value
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-174 8.37e-76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 237.40  E-value: 8.37e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLNDIAPLGLATVIAYAYTGKLT 134
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQRVELNDISPLGLATVITYAYTGKLT 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMY 174
Cdd:cd18260   81 LSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCMY 120
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
167-264 3.18e-64

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 206.26  E-value: 3.18e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK 246
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQK 80
                         90
                 ....*....|....*...
gi 124486714 247 RVKHAADLLSNIRFGTIS 264
Cdd:cd18470   81 RVKYAADLLSNIRFGTIS 98
PHA03098 PHA03098
kelch-like protein; Provisional
73-601 2.74e-59

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 207.31  E-value: 2.74e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  73 CD--LVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLN-DIAPLglATVIAYAYTGKLTLSLYTIGSIISAAVY 149
Cdd:PHA03098  10 CDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNiDYDSF--NEVIKYIYTGKINITSNNVKDILSIANY 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 150 LQIHTLVKMCSDFLIREISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPS 229
Cdd:PHA03098  88 LIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 230 ELVAFQIAMKWLEF-DQKRVKHAADLLSNIRFGTISaqdlvnyvqtvPRMMQDAdchKLLVDAMNYHLLPYHQNTLQSRR 308
Cdd:PHA03098 168 EDVVLEIIIKWLTSkKNNKYKDICLILKVLRITFLS-----------EEGIKKL---KRWKLRIKKKKIVFNKRCIKIIY 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 309 TRIRGGCRVLITVG--GRPGLTE----KSLSRDILYRDPENGWSKLTEMPAKsFNQCVAVMDGFLYVAGGedqndaRNQA 382
Cdd:PHA03098 234 SKKYNLNKILPRSStfGSIIYIHitmsIFTYNYITNYSPLSEINTIIDIHYV-YCFGSVVLNNVIYFIGG------MNKN 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 383 KHAVSNFCRYDPRFNTWIHLGSMNQKRTHFSLSVFNGLLYAVGGRNSEGSLASLECYVPSTNQWQPKAPLEVARCCHASA 462
Cdd:PHA03098 307 NLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVV 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 463 VADGRVIVTGG-YIGSAYSRSVCAYDPALDAWQELPQLSTPRGWHCAVALGDRLYVMGGSQLGPRGERVDVltVESFSPA 541
Cdd:PHA03098 387 NVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNI--VESYNPV 464
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 542 ARQWSFVAPLPVGVSTAGVSALHGRAYLLGGWNegEKKYKKCIQCFNPELNEWTEDDELP 601
Cdd:PHA03098 465 TNKWTELSSLNFPRINASLCIFNNKIYVVGGDK--YEYYINEIEVYDDKTNTWTLFCKFP 522
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
345-612 3.74e-51

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 178.04  E-value: 3.74e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 345 WSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQakhavsnFCRYDPRFNTWIHLGSMNQK-RTHFSLSVFNGLLYA 423
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNS-------FEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 424 VGGRN----SEGSLASLECYVPSTNQWQPKAPLEVARCCHASAVADGRVIVTGGYIGSAYSRSVCAYDPALDAWQELPQL 499
Cdd:COG3055   76 FGGFTganpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 500 STPRGWHCAVALGD-RLYVMGGSqlgprgervdvltveSFSPAARQWSFVAPLPVGVSTAGVSALHGRAYLLGgwneGEK 578
Cdd:COG3055  156 PTPRDHLAAAVLPDgKILVIGGR---------------NGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFG----GES 216
                        250       260       270
                 ....*....|....*....|....*....|....
gi 124486714 579 KYKKCIQCFNPELNEWTEDDELPEATVGVSCCTL 612
Cdd:COG3055  217 GFSDEVEAYDPATNTWTALGELPTPRHGHAAVLT 250
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
172-273 2.39e-32

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 120.34  E-value: 2.39e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  172 CMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK-RVKH 250
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVErRKKH 80
                          90       100
                  ....*....|....*....|...
gi 124486714  251 AADLLSNIRFGTISAQDLVNYVQ 273
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
172-271 9.17e-27

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 104.35  E-value: 9.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714   172 CMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVKH 250
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDpEKRREH 80
                           90       100
                   ....*....|....*....|.
gi 124486714   251 AADLLSNIRFGTISAQDLVNY 271
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
63-164 9.64e-21

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 87.70  E-value: 9.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714   63 LSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTK---RVDLNDIAPLGLATVIAYAYTGKLtLSLYT 139
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESsvsEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79
                          90       100
                  ....*....|....*....|....*
gi 124486714  140 IGSIISAAVYLQIHTLVKMCSDFLI 164
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLI 104
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
74-167 3.09e-16

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 74.26  E-value: 3.09e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714    74 DLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPS---TKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYL 150
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesdKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80
                           90
                   ....*....|....*..
gi 124486714   151 QIHTLVKMCSDFLIREI 167
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
Kelch smart00612
Kelch domain;
420-466 1.40e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.49  E-value: 1.40e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 124486714   420 LLYAVGGRNSEGSLASLECYVPSTNQWQPKAPLEVARCCHASAVADG 466
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
409-452 2.32e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 53.00  E-value: 2.32e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 124486714  409 RTHFSLSVFNGLLYAVGGRNSEGSLASLECYVPSTNQWQPKAPL 452
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
340-618 5.40e-06

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 48.86  E-value: 5.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  340 DPENGWSKLTEMPAKSFNQCVA-VMDGFLYVAGGEDQNDARNQAKhAVSNFCRYDPRFNTWIHLgsmnQKRT------HF 412
Cdd:TIGR03547  38 KPSKGWQKIADFPGGPRNQAVAaAIDGKLYVFGGIGKANSEGSPQ-VFDDVYRYDPKKNSWQKL----DTRSpvgllgAS 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  413 SLSVFNGLLYAVGGRNSE---GSLASLECYVPSTNQWQpkaplEVARCCHASAVADGRvivtggyigsaYSRSVCAYDPA 489
Cdd:TIGR03547 113 GFSLHNGQAYFTGGVNKNifdGYFADLSAADKDSEPKD-----KLIAAYFSQPPEDYF-----------WNKNVLSYDPS 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  490 LDAWQ---ELPQLSTprgwhCAVAL---GDRLYVMGGsQLGPrGERVDVLTVESFSPAARQWSFVAPLPV-------GVS 556
Cdd:TIGR03547 177 TNQWRnlgENPFLGT-----AGSAIvhkGNKLLLING-EIKP-GLRTAEVKQYLFTGGKLEWNKLPPLPPpksssqeGLA 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  557 TA------GVSALHGRAYLLGGW---NEGE--------KKYKKCIQCFNPelNEWTEDDELPEA-TVGVScctLAMPNSV 618
Cdd:TIGR03547 250 GAfagisnGVLLVAGGANFPGAQenyKNGKlyahegliKAWSSEVYALDN--GKWSKVGKLPQGlAYGVS---VSWNNGV 324
 
Name Accession Description Interval E-value
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-174 8.37e-76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 237.40  E-value: 8.37e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLNDIAPLGLATVIAYAYTGKLT 134
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQRVELNDISPLGLATVITYAYTGKLT 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMY 174
Cdd:cd18260   81 LSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCMY 120
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
167-264 3.18e-64

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 206.26  E-value: 3.18e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK 246
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQK 80
                         90
                 ....*....|....*...
gi 124486714 247 RVKHAADLLSNIRFGTIS 264
Cdd:cd18470   81 RVKYAADLLSNIRFGTIS 98
PHA03098 PHA03098
kelch-like protein; Provisional
73-601 2.74e-59

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 207.31  E-value: 2.74e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  73 CD--LVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLN-DIAPLglATVIAYAYTGKLTLSLYTIGSIISAAVY 149
Cdd:PHA03098  10 CDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNiDYDSF--NEVIKYIYTGKINITSNNVKDILSIANY 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 150 LQIHTLVKMCSDFLIREISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPS 229
Cdd:PHA03098  88 LIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 230 ELVAFQIAMKWLEF-DQKRVKHAADLLSNIRFGTISaqdlvnyvqtvPRMMQDAdchKLLVDAMNYHLLPYHQNTLQSRR 308
Cdd:PHA03098 168 EDVVLEIIIKWLTSkKNNKYKDICLILKVLRITFLS-----------EEGIKKL---KRWKLRIKKKKIVFNKRCIKIIY 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 309 TRIRGGCRVLITVG--GRPGLTE----KSLSRDILYRDPENGWSKLTEMPAKsFNQCVAVMDGFLYVAGGedqndaRNQA 382
Cdd:PHA03098 234 SKKYNLNKILPRSStfGSIIYIHitmsIFTYNYITNYSPLSEINTIIDIHYV-YCFGSVVLNNVIYFIGG------MNKN 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 383 KHAVSNFCRYDPRFNTWIHLGSMNQKRTHFSLSVFNGLLYAVGGRNSEGSLASLECYVPSTNQWQPKAPLEVARCCHASA 462
Cdd:PHA03098 307 NLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVV 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 463 VADGRVIVTGG-YIGSAYSRSVCAYDPALDAWQELPQLSTPRGWHCAVALGDRLYVMGGSQLGPRGERVDVltVESFSPA 541
Cdd:PHA03098 387 NVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNI--VESYNPV 464
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 542 ARQWSFVAPLPVGVSTAGVSALHGRAYLLGGWNegEKKYKKCIQCFNPELNEWTEDDELP 601
Cdd:PHA03098 465 TNKWTELSSLNFPRINASLCIFNNKIYVVGGDK--YEYYINEIEVYDDKTNTWTLFCKFP 522
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
345-612 3.74e-51

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 178.04  E-value: 3.74e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 345 WSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQakhavsnFCRYDPRFNTWIHLGSMNQK-RTHFSLSVFNGLLYA 423
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNS-------FEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 424 VGGRN----SEGSLASLECYVPSTNQWQPKAPLEVARCCHASAVADGRVIVTGGYIGSAYSRSVCAYDPALDAWQELPQL 499
Cdd:COG3055   76 FGGFTganpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 500 STPRGWHCAVALGD-RLYVMGGSqlgprgervdvltveSFSPAARQWSFVAPLPVGVSTAGVSALHGRAYLLGgwneGEK 578
Cdd:COG3055  156 PTPRDHLAAAVLPDgKILVIGGR---------------NGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFG----GES 216
                        250       260       270
                 ....*....|....*....|....*....|....
gi 124486714 579 KYKKCIQCFNPELNEWTEDDELPEATVGVSCCTL 612
Cdd:COG3055  217 GFSDEVEAYDPATNTWTALGELPTPRHGHAAVLT 250
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
319-539 4.39e-40

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 148.00  E-value: 4.39e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 319 ITVGGrpGLTEKSLSRDI-LYrDPE-NGWSKLTEMPAKSFNQCVAVM-DGFLYVAGGEDQNDARNQAkhaVSNFCRYDPR 395
Cdd:COG3055   25 VYVAG--GLSGGSASNSFeVY-DPAtNTWSELAPLPGPPRHHAAAVAqDGKLYVFGGFTGANPSSTP---LNDVYVYDPA 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 396 FNTWIHLGSMNQKRTHFSLSVFNGLLYAVGGRNSEGSLASLECYVPSTNQWQPKAPLEVARCCHASAVA-DGRVIVTGGY 474
Cdd:COG3055   99 TNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGR 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 475 IGS-----------------------------------AYSRSVCAYDPALDAWQELPQLSTPRGWHCAVALGDRLYVMG 519
Cdd:COG3055  179 NGSgfsntwttlaplptaraghaaavlggkilvfggesGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIG 258
                        250       260
                 ....*....|....*....|.
gi 124486714 520 GSqlGPRGERV-DVLTVESFS 539
Cdd:COG3055  259 GE--TKPGVRTpLVTSAEVYD 277
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
398-612 3.50e-38

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 142.60  E-value: 3.50e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 398 TWIHLGSMNQKRTHFSLSVFNGLLYAVGGRNSEGSLASLECYVPSTNQWQPKAPLEVARCCHASAVA-DGRVIVTGGYIG 476
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGGFTG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 477 ----SAYSRSVCAYDPALDAWQELPQLSTPRGWHCAVALGDRLYVMGGSQLGprgerVDVLTVESFSPAARQWSFVAPLP 552
Cdd:COG3055   82 anpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDG-----GNVAWVEVYDPATGTWTQLAPLP 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124486714 553 VGVST-AGVSALHGRAYLLGGWNegekkykkciqcFNPELNEWTEDDELPEATVGVSCCTL 612
Cdd:COG3055  157 TPRDHlAAAVLPDGKILVIGGRN------------GSGFSNTWTTLAPLPTARAGHAAAVL 205
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
172-273 2.39e-32

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 120.34  E-value: 2.39e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  172 CMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK-RVKH 250
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVErRKKH 80
                          90       100
                  ....*....|....*....|...
gi 124486714  251 AADLLSNIRFGTISAQDLVNYVQ 273
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
172-271 9.17e-27

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 104.35  E-value: 9.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714   172 CMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVKH 250
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDpEKRREH 80
                           90       100
                   ....*....|....*....|.
gi 124486714   251 AADLLSNIRFGTISAQDLVNY 271
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-172 1.57e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 101.70  E-value: 1.57e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKN---DPSTKRVDLNDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18255    5 LLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGgmrESSQDEIELKGVSAKGLKHILDFAYTSELTL 84
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENC 172
Cdd:cd18255   85 DLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
51-172 1.31e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 90.63  E-value: 1.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  51 TDTSYGPNLLEGLSKMRQESFLCD--LVIGTKTKSFDVHKSVMASCSEYFYNILK---NDPSTKRVDLNDIAPLGLATVI 125
Cdd:cd18239    2 TSNTHSSVVLQGFDQLRGEGLLCDvtLVPGDGDETFPVHRAMMASASDYFKAMFTggmKEQELMCIKLHGVSKIGLKNII 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 124486714 126 AYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENC 172
Cdd:cd18239   82 DFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-163 3.31e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 89.53  E-value: 3.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRV----------DLNDIAPLGLAT 123
Cdd:cd18228    1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVlvspagkcvlDLHHVTVTGFAP 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 124486714 124 VIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18228   81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
63-164 9.64e-21

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 87.70  E-value: 9.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714   63 LSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTK---RVDLNDIAPLGLATVIAYAYTGKLtLSLYT 139
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESsvsEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79
                          90       100
                  ....*....|....*....|....*
gi 124486714  140 IGSIISAAVYLQIHTLVKMCSDFLI 164
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLI 104
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-177 1.82e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 87.93  E-value: 1.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKN---DPSTKRVDLNDIAPLGLATVIAYAYT 130
Cdd:cd18264   10 SHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDytqESKARVIHLPVVSAAGLQRVLDFIYT 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 124486714 131 GKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYVVN 177
Cdd:cd18264   90 SWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCCFSAN 136
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
52-173 1.22e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 85.44  E-value: 1.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  52 DTSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR---VDLNDIAPLGLATVIAYA 128
Cdd:cd18270    6 NTEYAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKqthVHLRNVDAATLQIIITYA 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 124486714 129 YTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18270   86 YTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
167-260 7.34e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 81.70  E-value: 7.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK 246
Cdd:cd18449    1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDD 80
                         90
                 ....*....|....
gi 124486714 247 RVKHAADLLSNIRF 260
Cdd:cd18449   81 RMQFAAKLMENIRF 94
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-173 8.37e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 82.69  E-value: 8.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDP---STKRVDLNDIAPLGLATVIAYAYTGKLT 134
Cdd:cd18306    4 SVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSdgeSILTVKLDGLDPDAVEVLVNYAYTSRLE 83
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18306   84 VPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCI 122
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
167-268 9.96e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 81.70  E-value: 9.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQ----FMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLE 242
Cdd:cd18473    1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDAddagLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80
                         90       100
                 ....*....|....*....|....*.
gi 124486714 243 FDQKRVKHAADLLSNIRFGTISAQDL 268
Cdd:cd18473   81 QDESRLAYANALLSRIRYGLVPVEEL 106
PHA02790 PHA02790
Kelch-like protein; Provisional
86-519 2.77e-18

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 88.18  E-value: 2.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  86 VHKSVMASCSEYFYNIL-----KNDPSTKRVDLnDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCS 160
Cdd:PHA02790  35 VNSTILKKLSPYFRTHLrqkytKNKDPVTRVCL-DLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCI 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 161 DFLIREISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFaESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKW 240
Cdd:PHA02790 114 NFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLEL-EDDIIDNFDYLSMKLILESDELNVPDEDYVVDFVIKW 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 241 LEFDQKRVKHAADLLSNIRFGTISAQDLVNYVQTVPRMMQDADCHKLLVDAMNYHLLPYHQNTLQsrrtrirggcrvLIT 320
Cdd:PHA02790 193 YMKRRNRLGNLLLLIKNVIRSNYLSPRGINNVKWILDCTKIFHCDKQPRKSYKYPFIEYPMNMDQ------------IID 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 321 VggrpgltekslsrdilyrdpengwskltempaksFNQCVAVMDG-FLYVAGGEDQNDARNqakHAVSNFCRYdprfNTW 399
Cdd:PHA02790 261 I----------------------------------FHMCTSTHVGeVVYLIGGWMNNEIHN---NAIAVNYIS----NNW 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 400 IHLGSMNQKRTHFSLSVFNGLLYAVGGRNSEgslASLECYVPSTNQWQPKAPLEVARCCHASAVADGRVIVTGGYigSAY 479
Cdd:PHA02790 300 IPIPPMNSPRLYASGVPANNKLYVVGGLPNP---TSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGH--SET 374
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 124486714 480 SRSVCAYDPALDAWQELPQLSTPRGWHCAVALGDRLYVMG 519
Cdd:PHA02790 375 DTTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG 414
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-163 3.49e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 80.66  E-value: 3.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTK---RVDLNDIAPLGLATVIAYAYTG 131
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKensEVEFQCIDETALQAIVEYAYTG 80
                         90       100       110
                 ....*....|....*....|....*....|..
gi 124486714 132 KLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18257   81 TVFISQATVESLLPAANLLQIKLVLKECCDFL 112
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
66-172 1.25e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 79.29  E-value: 1.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  66 MRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILK---NDPSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGS 142
Cdd:cd18240   11 LRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTngwNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEE 90
                         90       100       110
                 ....*....|....*....|....*....|
gi 124486714 143 IISAAVYLQIHTLVKMCSDFLIREISVENC 172
Cdd:cd18240   91 LLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-171 1.54e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 79.24  E-value: 1.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYF---YNILKNDPSTKRVDLNDIAPLGLATVIAYAYT 130
Cdd:cd18261   10 SHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFramFSLCMVESEADEVNLHGVTSLGLKQALDFAYT 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 124486714 131 GKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVEN 171
Cdd:cd18261   90 GQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
171-272 1.88e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 78.12  E-value: 1.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18457    5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDrENREE 84
                         90       100
                 ....*....|....*....|...
gi 124486714 250 HAADLLSNIRFGTISAQDLVNYV 272
Cdd:cd18457   85 YLPELLSKVRLPLLRPQFLTDRV 107
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-173 1.96e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 79.10  E-value: 1.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND---PSTKRVDLNDIAPLGLATVIAYAYT 130
Cdd:cd18259   14 SHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDfveSISARVEIKDVDPAVMESLIDFAYT 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 124486714 131 GKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18259   94 GKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-173 3.91e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 77.91  E-value: 3.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND---PSTKRVDLNDIAPLGLATVIAYAYTGKLT 134
Cdd:cd18237    7 DFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNmteSKSSEVELKDAEPDIIELLVEFAYTARIS 86
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18237   87 VNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
PHA02713 PHA02713
hypothetical protein; Provisional
49-518 3.98e-17

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 85.06  E-value: 3.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  49 ELTDTSYGPNLLEGLSKMRQESFLCDLVIGTKT-KSFDVHKSVMASCSEYFYNILKNDPSTK----RVDLNDIAPLGLAT 123
Cdd:PHA02713   2 DIDDIKHNRRVVSNISNLLDDDILCDVIITIGDgEEIKAHKTILAAGSKYFRTLFTTPMIIRdlvtRVNLQMFDKDAVKN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 124 VIAYAYTGKLTlSLYTIgSIISAAVYLQIHTLVKMCSDFLIREISVENCMYVVN-IAETYSLKNAKATAQKFIRdNFIEF 202
Cdd:PHA02713  82 IVQYLYNRHIS-SMNVI-DVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHrLYEMSHIPIVKYIKRMLMS-NIPTL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 203 AESEQFMKLTFEQINELL-VDDDLQLPSELVAFQIAMKWLEFDQKRVKHAADLLSNIRFGTISAQD-LVNYVQTVPRMMq 280
Cdd:PHA02713 159 ITTDAFKKTVFEILFDIIsTNDNVYLYREGYKVTILLKWLEYNYITEEQLLCILSCIDIQNLDKKSrLLLYSNKTINMY- 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 281 dADCHKLLVD-AMNYHLLPyHQNTLQSRRTRIrGGCRVLITVggrpgltekslsrdilYRDPENGWSKLTEMPAKSFNQC 359
Cdd:PHA02713 238 -PSCIQFLLDnKQNRNIIP-RQLCLVCHDTKY-NVCNPCILV----------------YNINTMEYSVISTIPNHIINYA 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 360 VAVMDGFLYVAGGEDQNDArnqakhAVSNFCRYDPRFNTWIHLGSMNQKRTHFSLSVFNGLLYAVGGRNSEGSLASLECY 439
Cdd:PHA02713 299 SAIVDNEIIIAGGYNFNNP------SLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECY 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 440 VPSTNQWQPKAPLEVARCCHASAVADGRVIVTGGY------------------IGSAYSRSVCAYDPALDAWQELPQLST 501
Cdd:PHA02713 373 TMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRtehidytsvhhmnsidmeEDTHSSNKVIRYDTVNNIWETLPNFWT 452
                        490
                 ....*....|....*..
gi 124486714 502 PRGWHCAVALGDRLYVM 518
Cdd:PHA02713 453 GTIRPGVVSHKDDIYVV 469
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
72-150 4.00e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 76.44  E-value: 4.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  72 LCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND---PSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAV 148
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmkeSSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                 ..
gi 124486714 149 YL 150
Cdd:cd18186   81 KL 82
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
171-298 1.32e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 76.67  E-value: 1.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQ-KRVK 249
Cdd:cd18452    5 NCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKeERED 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 124486714 250 HAADLLSNIRFGTISAQDLVNYVQTVPRMMQDADCHKLLVDAMNYHLLP 298
Cdd:cd18452   85 YLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRP 133
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
63-167 1.58e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 76.61  E-value: 1.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  63 LSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR---VDLNDIAPLGLATVIAYAYTGKLTLSLYT 139
Cdd:cd18246   30 MNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRqthVTLHDIDPQALEQLVQYAYTAEIVVGEGN 109
                         90       100
                 ....*....|....*....|....*...
gi 124486714 140 IGSIISAAVYLQIHTLVKMCSDFLIREI 167
Cdd:cd18246  110 VQTLLPAASLLQLNGVRDACCKFLLSQL 137
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
74-167 3.09e-16

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 74.26  E-value: 3.09e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714    74 DLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPS---TKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYL 150
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesdKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80
                           90
                   ....*....|....*..
gi 124486714   151 QIHTLVKMCSDFLIREI 167
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
52-173 3.97e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 75.21  E-value: 3.97e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  52 DTSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKN---DPSTKRVDLNDIAPLGLATVIAYA 128
Cdd:cd18268    3 DQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNnfrESSQAKVDLKGIDSDVLDQIVDYV 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 124486714 129 YTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18268   83 YTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCL 127
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
72-173 5.95e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 73.94  E-value: 5.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  72 LCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND---PSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAV 148
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDvreATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80
                         90       100
                 ....*....|....*....|....*
gi 124486714 149 YLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18234   81 LLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-163 6.95e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 74.00  E-value: 6.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  60 LEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPS---TKRVDLNDIAPLGLATVIAYAYTGKLTLS 136
Cdd:cd18235    9 FDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSesrANRVTLQDVDGKALLLLIDYVYTAEIQVT 88
                         90       100
                 ....*....|....*....|....*..
gi 124486714 137 LYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18235   89 EENVQVLLPAANLLQLTDVRDACCDFL 115
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
57-173 7.15e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 74.24  E-value: 7.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  57 PNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR------VDLNDIAPLGLATVIAYAYT 130
Cdd:cd18258    2 KEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGggekleLTMSNINADVLELLLEFVYT 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 124486714 131 GKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18258   82 GSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-179 7.41e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 74.54  E-value: 7.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYF---YNILKNDPSTKRVDLNDIAPLGLATVIAYAYTGKLT 134
Cdd:cd18266   11 LVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFnsmFTIGMREAHQKEVELVGASYIGLKAVIDFLYSSELP 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYVVNIA 179
Cdd:cd18266   91 LDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-163 8.33e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 73.53  E-value: 8.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYF-----YNILKNDPSTKRVDLNDIAPLGLATVIAYAYTGKL 133
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFraklnYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80
                         90       100       110
                 ....*....|....*....|....*....|
gi 124486714 134 TLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18245   81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-162 8.88e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 73.43  E-value: 8.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLNDIAplGLATVIAYAYTGKLTLSLY 138
Cdd:cd18206    9 VLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKDVVHLDISNAA--GLGQVLEFMYTAKLSLSPE 86
                         90       100
                 ....*....|....*....|....
gi 124486714 139 TIGSIISAAVYLQIHTLVKMCSDF 162
Cdd:cd18206   87 NVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-163 1.22e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 73.36  E-value: 1.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNI-----LKNDPSTKRVDLndIAPLGLATVIAYAYTGKL 133
Cdd:cd18198   12 ILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLftsgaVVDQQNVYEIDF--VSPEALTALLEFAYTATL 89
                         90       100       110
                 ....*....|....*....|....*....|
gi 124486714 134 TLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18198   90 TVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
49-172 1.29e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 74.09  E-value: 1.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  49 ELTDTSYGPNLLEGLSKMRQESFLCDLVI--------GTKTKSFDVHKSVMASCSEYFYNILK---NDPSTKRVDLNDIA 117
Cdd:cd18273    3 ELEDAAHARALLAQLKSFYDARLLTDVTIevngpgsgPGSGRLFPCNRNVLAAASPYFKSMFTgglYESKQETVTIHDVD 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 124486714 118 PLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENC 172
Cdd:cd18273   83 SESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNC 137
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
52-171 1.38e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 73.54  E-value: 1.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  52 DTSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILkndpSTKRVDLNDIAPLGLATVIAYAYTG 131
Cdd:cd18243   12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF----SINNLVLQGCSSIGLRLVLEYLYTA 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 124486714 132 KLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVEN 171
Cdd:cd18243   88 NVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
52-172 1.45e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 73.26  E-value: 1.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  52 DTSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKN---DPSTKRVDLNDIAPLGLATVIAYA 128
Cdd:cd18250    1 DPAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGelrESRADRVVLHGVSAEILGLLLDFS 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 124486714 129 YTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENC 172
Cdd:cd18250   81 YTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-172 1.62e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 73.24  E-value: 1.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTK---RVDLNDIAPLGLATVIAYAYT 130
Cdd:cd18242    3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKgksEVELQGLTASTMEILLDFVYT 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 124486714 131 GKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENC 172
Cdd:cd18242   83 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-163 2.10e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 72.99  E-value: 2.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNI-----LKNDPSTKRVDLndIAPLGLATVIAYAYTGKL 133
Cdd:cd18328   12 VLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLftagtLADQPYVYEIDF--VTPEALSAILEFAYTSTL 89
                         90       100       110
                 ....*....|....*....|....*....|
gi 124486714 134 TLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18328   90 TITTSNVKHILNAAQMLEIQCIINVCLEIM 119
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-163 4.70e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 71.89  E-value: 4.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLNDI---APLGLATVIAYAYTGKLT 134
Cdd:cd18326   11 DILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIdfvSAEALTALLDFAYTATLT 90
                         90       100
                 ....*....|....*....|....*....
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18326   91 VSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-159 5.00e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 71.99  E-value: 5.00e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYnILKNDPSTKR--VDLN-DI--APlGLATVIAYAYTGKL 133
Cdd:cd18325   10 LLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFH-LFYRDQLDKRdiVHLNsDIvtAP-AFSLLLEFMYEGKL 87
                         90       100
                 ....*....|....*....|....*.
gi 124486714 134 TLSLYTIGSIISAAVYLQIHTLVKMC 159
Cdd:cd18325   88 EFSSLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-159 5.67e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 71.32  E-value: 5.67e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKN-DPSTKRVDLNDIAPLGLATVIAYAYTGKLTLSL 137
Cdd:cd18217    5 LLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDtEDNIVFLDQSQVSADGFQKLLEFIYTGNLNLDS 84
                         90       100
                 ....*....|....*....|..
gi 124486714 138 YTIGSIISAAVYLQIHTLVKMC 159
Cdd:cd18217   85 WNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
52-167 5.68e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 71.64  E-value: 5.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  52 DTSYGPNLLEGLSKMRQESFLCDLVI----GTKTKSFDVHKSVMASCSEYFYNILKN---DPSTKRVDLNDIAPLGLATV 124
Cdd:cd18248    1 LEDHTKEAFQIMNELRLSQQLCDVTLkvkyQDPKEEFMAHKVVLASSSPYFKAMFTSglrECGMEVVPIEGVHPCVMSRL 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 124486714 125 IAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREI 167
Cdd:cd18248   81 IEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
53-163 6.04e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 71.52  E-value: 6.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  53 TSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDL--NDIAPLGLATVIAYAYT 130
Cdd:cd18278   12 TVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSlpEEVTARGFGPLLQFAYT 91
                         90       100       110
                 ....*....|....*....|....*....|...
gi 124486714 131 GKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18278   92 AKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
171-260 8.21e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 70.41  E-value: 8.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18448    6 NCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDpQHRKR 85
                         90
                 ....*....|.
gi 124486714 250 HAADLLSNIRF 260
Cdd:cd18448   86 HLDDLLSQVRL 96
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
47-176 8.47e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 71.53  E-value: 8.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  47 SSELTDTSYGpnllEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTK---RVDLNDIAPLGLAT 123
Cdd:cd18244    9 NSSIHDTSVS----AGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERdqdKIHLKGLTATGFSH 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 124486714 124 VIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYVV 176
Cdd:cd18244   85 VLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEIM 137
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
171-274 8.82e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 70.72  E-value: 8.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK-RVK 249
Cdd:cd18445    5 NCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPEnRKE 84
                         90       100
                 ....*....|....*....|....*
gi 124486714 250 HAADLLSNIRFGTISAQDLVNYVQT 274
Cdd:cd18445   85 HLAELLEHVRLPLLSPEYLVQRVEE 109
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-173 9.87e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 70.90  E-value: 9.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILK---NDPSTKRVDLNDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18256    7 ILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAggmSESSKDVVQIHGVEPDIFHILLDFIYTGVVEV 86
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18256   87 TVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
171-295 1.02e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 71.25  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK-RVK 249
Cdd:cd18513    5 NCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEaRLE 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 124486714 250 HAADLLSNIRFGTISAQDLVNYVQTVPRMMQDADCHKLLVDAMNYH 295
Cdd:cd18513   85 HMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-170 1.05e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 71.61  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKnDPSTKR--VDLN-DI--APlGLATVIAYAYTGK 132
Cdd:cd18324    9 HLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYK-DQLDKRdiVHLNsDIvtAP-AFALLLEFMYEGK 86
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 124486714 133 LTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVE 170
Cdd:cd18324   87 LQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTE 124
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
167-259 1.43e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 69.83  E-value: 1.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-Q 245
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADpK 80
                         90
                 ....*....|....
gi 124486714 246 KRVKHAADLLSNIR 259
Cdd:cd18460   81 HRQHFWPELLQHVR 94
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
68-173 1.54e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 70.46  E-value: 1.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  68 QESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND---PSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSII 144
Cdd:cd18336   15 QHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDvreAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLL 94
                         90       100
                 ....*....|....*....|....*....
gi 124486714 145 SAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18336   95 AAACLLQLSQVIDVCCNFLMKQLHPSNCL 123
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
63-173 2.75e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 69.63  E-value: 2.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  63 LSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND--PST-KRVDLNDIAPLGLATVIAYAYTGKLTLSLYT 139
Cdd:cd18238    6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEmaESKqDSITIKDIDEEAVELLVDFAYTGKLTLTVDN 85
                         90       100       110
                 ....*....|....*....|....*....|....
gi 124486714 140 IGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18238   86 VQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCL 119
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
50-173 3.67e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 69.48  E-value: 3.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  50 LTDTSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTK---RVDLNDIAPLGLATVIA 126
Cdd:cd18271    2 LVAECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERddgSVTISNLSPKAVKAFLD 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 124486714 127 YAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18271   82 YAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-175 3.90e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 69.48  E-value: 3.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND--PSTKR-VDLNDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18340   14 LQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDleESKKReIVLEDVDPDVMGKILHYIYTSEIEI 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYV 175
Cdd:cd18340   94 TEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
168-260 4.10e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 68.50  E-value: 4.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 168 SVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QK 246
Cdd:cd18455    1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDpEE 80
                         90
                 ....*....|....
gi 124486714 247 RVKHAADLLSNIRF 260
Cdd:cd18455   81 RKVHLKDLMSSCWR 94
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-172 7.83e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 68.32  E-value: 7.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR---VDLNDIAPLGLATVIAYAYTGKLT 134
Cdd:cd18253    4 SILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESRemlVEINGILAEAMDCFLQYVYTGKVK 83
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENC 172
Cdd:cd18253   84 ITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
171-266 1.15e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 67.36  E-value: 1.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18444    6 NCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDlPERKK 85
                         90
                 ....*....|....*..
gi 124486714 250 HAADLLSNIRFGTISAQ 266
Cdd:cd18444   86 HLAKLLALIRLPLLTPQ 102
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
171-295 1.28e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 68.13  E-value: 1.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK-RVK 249
Cdd:cd18512    5 NCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEvRQE 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 124486714 250 HAADLLSNIRFGTISAQDLVNYVQTVPRMMQDADCHKLLVDAMNYH 295
Cdd:cd18512   85 HMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
56-163 1.58e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 67.17  E-value: 1.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  56 GPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYN--ILKNdpsTKRVDL-NDIAPLGLATVIAYAYTGK 132
Cdd:cd18210    5 TSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDqvLLKN---MSSISLpGVMDPGAFESVLASAYTGK 81
                         90       100       110
                 ....*....|....*....|....*....|.
gi 124486714 133 LTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18210   82 LTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-159 1.74e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 67.54  E-value: 1.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR-VDLND--IAPLGLATVIAYAYTG 131
Cdd:cd18194    6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDlVRLNSdiVTAPAFGLLLDFMYEG 85
                         90       100
                 ....*....|....*....|....*...
gi 124486714 132 KLTLSLYTIGSIISAAVYLQIHTLVKMC 159
Cdd:cd18194   86 RLALRDLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
53-163 2.49e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 67.01  E-value: 2.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  53 TSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNIL----KNDPSTKRVDLNDIAPLGLATVIAYA 128
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYcqvqKTSDQATVTHLDIVTAQGFKAIIDFM 81
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 124486714 129 YTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18230   82 YSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFI 116
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
167-275 2.81e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 66.19  E-value: 2.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIrdnfiefaeSEQFMKLTFEQINELLvdDDLQLP--SELVAFQIAMKWLEFD 244
Cdd:cd18453    1 ISVQNYKQVCKIAALHGLEETKKLANKYL---------VEDVLLLNFEEMRAML--DSLPPPveSELALFQMSVLWLEHD 69
                         90       100       110
                 ....*....|....*....|....*....|..
gi 124486714 245 QK-RVKHAADLLSNIRFGTISAQDLVNYVQTV 275
Cdd:cd18453   70 REtRMQYAPDLMKRLRFALIPAPELVERVQSV 101
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-165 2.90e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 66.85  E-value: 2.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDpSTKRVDLNDIAPLGLATVIAYAYTGKL 133
Cdd:cd18333    3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHD-NLINLDHEMVSPGIFRLILDYIYTGRL 81
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 124486714 134 T----LSLYTIGSIISAAVYLQIHTLVKMCSDFLIR 165
Cdd:cd18333   82 SegdpGSEQNLGAVLAAASYLQIPDLVALCKKKLKR 117
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
167-260 3.62e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 65.70  E-value: 3.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK 246
Cdd:cd18465    1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80
                         90
                 ....*....|....
gi 124486714 247 RVKHAADLLSNIRF 260
Cdd:cd18465   81 RRASASHVLCHIRF 94
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-163 4.06e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 66.50  E-value: 4.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYN--ILKNdpsTKRVDLNDIA-PLGLATVIAYAYTGKLTL 135
Cdd:cd18227   12 ILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDqvLLKN---SRRIVLPDVMnPRVFENILLSCYTGRLVL 88
                         90       100
                 ....*....|....*....|....*...
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18227   89 PAPEIVSYLTAASFLQMWHVVDKCTELL 116
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-175 6.11e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 66.27  E-value: 6.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND--PSTKR-VDLNDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18269   14 LQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDleESKKKeVVLEDVDPDVMGMILKYLYTSEIDL 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYV 175
Cdd:cd18269   94 NDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
74-159 1.02e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 64.29  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  74 DLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPST---KRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYL 150
Cdd:cd18314    8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIEsnlKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKY 87

                 ....*....
gi 124486714 151 QIHTLVKMC 159
Cdd:cd18314   88 QVPDLEKLC 96
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
170-243 1.14e-12

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 63.52  E-value: 1.14e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124486714 170 ENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEF 243
Cdd:cd18503    4 DNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-163 1.34e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 64.87  E-value: 1.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRV----------DLNDIAPLGLATVIAYA 128
Cdd:cd18327   12 LLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDlgagggqdvcELDFVGPEALGALLEFA 91
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 124486714 129 YTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18327   92 YTATLTISSSNMREVLRAARLLEIPCVADACADIL 126
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
168-244 1.87e-12

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 62.81  E-value: 1.87e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124486714 168 SVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD 244
Cdd:cd18508    1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-165 2.04e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 64.22  E-value: 2.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDpSTKRVDLNDIAPLGLATVIAYAYTGKL 133
Cdd:cd18334    3 NHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHD-NLINLDTDMVNPTVFRQILDFIYTGKL 81
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 124486714 134 TLS----LYTIGSIISAAVYLQIHTLVKMCSDFLIR 165
Cdd:cd18334   82 LTSdqpgEQNFNALLTAASYLQLHDLAALCRKKLKR 117
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
63-165 2.64e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 63.84  E-value: 2.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  63 LSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND---PSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLYT 139
Cdd:cd18247   10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDmveSKQDEITMQGIEPSALEALINFAYSGRIAIDTSN 89
                         90       100
                 ....*....|....*....|....*.
gi 124486714 140 IGSIISAAVYLQIHTLVKMCSDFLIR 165
Cdd:cd18247   90 VQSLLVGASFLQLQSVKDACCEFLKE 115
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-163 2.97e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 63.93  E-value: 2.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYN-ILKNDPSTKRVDL-NDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18277   13 NVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSrIVGQADAELNITLpEEVTVKGFEPLIQFAYTAKLIL 92
                         90       100
                 ....*....|....*....|....*...
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18277   93 SKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-163 3.25e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 64.06  E-value: 3.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR--VDLN-DI--APlGLATVIAYAY 129
Cdd:cd18956    6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRdtVRLNgDIvtAP-AFGRLLDFMY 84
                         90       100       110
                 ....*....|....*....|....*....|....
gi 124486714 130 TGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18956   85 EGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRL 118
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-162 3.35e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 63.35  E-value: 3.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDP--STKRVDLN-DIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18215    6 VLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLknNVSVINLDpEIEPEGFRILLDFMYTSRLNL 85
                         90       100
                 ....*....|....*....|....*..
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDF 162
Cdd:cd18215   86 REGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
63-163 3.53e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 63.59  E-value: 3.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  63 LSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPS---TKRVDLNDIAPLGLATVIAYAYTGKLTLSLYT 139
Cdd:cd18339   12 MNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSeskAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEEN 91
                         90       100
                 ....*....|....*....|....
gi 124486714 140 IGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18339   92 VQVLLPAASLLQLMDVRQNCCDFL 115
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
168-220 3.61e-12

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 61.52  E-value: 3.61e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 124486714 168 SVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELL 220
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELL 53
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
167-259 3.82e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 62.77  E-value: 3.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-Q 245
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNtE 80
                         90
                 ....*....|....
gi 124486714 246 KRVKHAADLLSNIR 259
Cdd:cd18479   81 SRSQYLSSVLSQIR 94
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
171-264 4.21e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 62.66  E-value: 4.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18467    5 NCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDvQERQK 84
                         90
                 ....*....|....*
gi 124486714 250 HAADLLSNIRFGTIS 264
Cdd:cd18467   85 YLAQLLHCVRLPLLS 99
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
63-167 4.57e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 63.17  E-value: 4.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  63 LSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPS---TKRVDLNDIAPLGLATVIAYAYTGKLTLSLYT 139
Cdd:cd18338   12 MNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSesrAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEEN 91
                         90       100
                 ....*....|....*....|....*...
gi 124486714 140 IGSIISAAVYLQIHTLVKMCSDFLIREI 167
Cdd:cd18338   92 VQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
72-163 4.57e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 62.49  E-value: 4.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  72 LCDLVIGTKTKSFDVHKSVMASCSEYFYN-ILKNDPSTKRVDLND-IAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVY 149
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSrVVGQTDGDLVITLPEeVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80
                         90
                 ....*....|....
gi 124486714 150 LQIHTLVKMCSDFL 163
Cdd:cd18955   81 LGVHNIEKACFDFL 94
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
53-163 5.01e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 62.95  E-value: 5.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  53 TSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNI----LKNDPSTKRVDlNDIAPLGLATVIAYA 128
Cdd:cd18331    5 TRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIftdqLKCNLSVINLD-PEINPEGFNILLDFM 83
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 124486714 129 YTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18331   84 YTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
52-175 6.13e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 63.08  E-value: 6.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  52 DTSYGPNLLEGLSKMRQESFLCDLVIGTKT-KSFDVHKSVMASCSEYFYNILKN---DPSTKRVDLNDIAPLGLATVIAY 127
Cdd:cd18274    2 DPLHACSILQQLKAMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSgltESTQKEVRIVGVEAESMHLVLDY 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 124486714 128 AYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYV 175
Cdd:cd18274   82 AYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
53-173 6.32e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 63.85  E-value: 6.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  53 TSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILK---NDPSTKRVDLND-IAPLGLATVIAYA 128
Cdd:cd18267   21 SSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSgglKESQDSEVNFHDsIHPEVLELLLDYA 100
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 124486714 129 YTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18267  101 YSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCL 145
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-163 6.49e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 62.60  E-value: 6.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR----VDLNDIAplGLATVIAYAYTGKLT 134
Cdd:cd18233    5 LLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNdvfhLDIKNVG--GIGQILDFMYTSHLD 82
                         90       100
                 ....*....|....*....|....*....
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18233   83 LNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
53-173 8.78e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 62.51  E-value: 8.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  53 TSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILK---NDPSTKRVDLNDIAPLGLATVIAYAY 129
Cdd:cd18276    2 QKHSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTcglMECSQREVVLHDITAESVSIILNYMY 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 124486714 130 TGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18276   82 SSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCL 125
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-159 8.94e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 62.54  E-value: 8.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLND---IAPLGLATVIAYAYTG 131
Cdd:cd18323    6 HSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINneiVTAPAFSLLLEFMYEG 85
                         90       100
                 ....*....|....*....|....*...
gi 124486714 132 KLTLSLYTIGSIISAAVYLQIHTLVKMC 159
Cdd:cd18323   86 RLSFNDTPVEDVLAAASYLHMNDIVKVC 113
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-163 1.00e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 62.37  E-value: 1.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILK-NDPSTkrVDLNDIA-PLGLATVIAYAYTGK 132
Cdd:cd18222    8 FSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSlNEMST--VSISVIKnPTVFEQLLSFCYTGR 85
                         90       100       110
                 ....*....|....*....|....*....|.
gi 124486714 133 LTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18222   86 ICLQLADIISYLTAASFLQMQHIIDKCTQIL 116
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-165 1.10e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 62.17  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDpSTKRVDLNDIAPLGLATVIAYAYTGKL 133
Cdd:cd18216    2 SHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHD-NLIHLDQDMVSPTVFQQILDFIYTGKL 80
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 124486714 134 TLSLY---TIGSIISAAVYLQIHTLVKMCSDFLIR 165
Cdd:cd18216   81 LDSLFeepNLSEVLAAANYLQLPDLAALCRSKLKR 115
Kelch smart00612
Kelch domain;
420-466 1.40e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.49  E-value: 1.40e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 124486714   420 LLYAVGGRNSEGSLASLECYVPSTNQWQPKAPLEVARCCHASAVADG 466
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
60-173 1.58e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 61.75  E-value: 1.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  60 LEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR---VDLNDIAPLGLATVIAYAYTGKLTLS 136
Cdd:cd18263    1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTqsvVQLPTIPAKDLRLLISFAYSGILHLS 80
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 124486714 137 LYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18263   81 WENLFEATCTALQLQISGALALCLDFLQREISPARCL 117
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
166-260 2.02e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 60.83  E-value: 2.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 166 EISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQ 245
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80
                         90
                 ....*....|....*.
gi 124486714 246 -KRVKHAADLLSNIRF 260
Cdd:cd18447   81 pNRQPYMVDILAKVRF 96
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
72-173 2.29e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 61.62  E-value: 2.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  72 LCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR---VDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAV 148
Cdd:cd18337   23 LCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKqeeIKMEGVEPNALWALVQYAYTGRLELKEDNIECLLSTAC 102
                         90       100
                 ....*....|....*....|....*
gi 124486714 149 YLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18337  103 LLQLSQVVEACCKFLMKQLHPSNCL 127
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
171-260 2.45e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 60.50  E-value: 2.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK-RVK 249
Cdd:cd18468    4 NCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKnRKQ 83
                         90
                 ....*....|.
gi 124486714 250 HAADLLSNIRF 260
Cdd:cd18468   84 HIAELLAVVRL 94
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-165 2.58e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 61.21  E-value: 2.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLNDIAPLGLATVIAYAYTGKL 133
Cdd:cd18290    9 NFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILSFCYTGRL 88
                         90       100       110
                 ....*....|....*....|....*....|..
gi 124486714 134 TLSLYTIGSIISAAVYLQIHTLVKMCSDFLIR 165
Cdd:cd18290   89 SMNVGDQFLLMYTAGFLQIQEIMEKGTEFFLK 120
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-175 4.21e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 61.02  E-value: 4.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPST---KRVDLNDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18341   14 LQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEekkKEVVLDNVDPNIMDMILKYLYSAEIDL 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYV 175
Cdd:cd18341   94 NDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-163 4.41e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 60.25  E-value: 4.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYN-ILKNDpsTKRVDL-NDIAPLGLATVIAYAYTGK 132
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDkLLLND--TNCLVLpSVIEAAAFENLLQLIYSGR 78
                         90       100       110
                 ....*....|....*....|....*....|.
gi 124486714 133 LTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18200   79 LTLCMDALPSHLLVASGLQMWQVVDRCSELL 109
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
52-163 5.35e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 60.35  E-value: 5.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  52 DTSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNI--LKNDPSTKRVD---LNDIAPLGLATVIA 126
Cdd:cd18201    1 ENSYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLycFTNKESCDQTTvthLDVVAVQGFSVILD 80
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 124486714 127 YAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18201   81 FMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFI 117
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-173 5.96e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 60.16  E-value: 5.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR---VDLNDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18249   10 TLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRqteVTIRDIDERAMELLIDFAYTSQITV 89
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18249   90 EEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
52-172 6.20e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 60.25  E-value: 6.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  52 DTSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTK---RVDLNDIAPLGLATVIAYA 128
Cdd:cd18236    4 DTGLSLVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKyeeKIIIKGVDAETMQILLDYT 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 124486714 129 YTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENC 172
Cdd:cd18236   84 YTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENC 127
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
171-268 7.30e-11

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 59.41  E-value: 7.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18466    5 NCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDvGKRKK 84
                         90
                 ....*....|....*....
gi 124486714 250 HAADLLSNIRFGTISAQDL 268
Cdd:cd18466   85 HVVEVLEPVRFPLLPPQRL 103
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
53-170 9.15e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 59.98  E-value: 9.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  53 TSYGPNLLEGLSKMRQES-FLCDLVIGTKTKSFDVHKSVMASCSEYFYNIL----KNDPSTKRVDLNDIAPLGLATVIAY 127
Cdd:cd18207    7 SQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFsaqeGDGGTPRELEMHTISSKVFGDILDF 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 124486714 128 AYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDfLIREISVE 170
Cdd:cd18207   87 AYTSRIVVRLESFPELMTAAKFLLMRSVIDICQE-VIKQSNVQ 128
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
171-270 1.02e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 58.88  E-value: 1.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18509    6 NCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDmQRRCS 85
                         90       100
                 ....*....|....*....|.
gi 124486714 250 HAADLLSNIRFGTISAQDLVN 270
Cdd:cd18509   86 DLSMLLAYIRLPLLPPQLLAD 106
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
166-242 1.97e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 57.40  E-value: 1.97e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124486714 166 EISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLE 242
Cdd:cd18463    1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVY 77
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-172 2.38e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 58.89  E-value: 2.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLNDIAPLGLATVIAYAYTGKL 133
Cdd:cd18289   11 NFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQILSFCYTGKL 90
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 124486714 134 TLSLYTIGSIISAAVYLQIHTLVKMCSDFLIReISVENC 172
Cdd:cd18289   91 TMAASEQLVVMYTAGFLQIQHIVERGTDLMFK-VSSPHC 128
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
52-173 2.72e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 58.30  E-value: 2.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  52 DTSYGPNLLEGLSKMRQESFLCDLVIGTKT-KSFDVHKSVMASCSEYFYNILKND---PSTKRVDLNDIAPLGLATVIAY 127
Cdd:cd18252    1 DSSHPADFLDAFRTFYLDGLFTDITLQCASgQIFHCHKAALAACSSYFKVMFTADmkeKSNNVIKLSGIDHDILEALVNY 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 124486714 128 AYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18252   81 VYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
72-163 2.97e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 58.01  E-value: 2.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  72 LCD--LVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLN--DIAPLGLATVIAYAYTGKLTLSLYTIGSIISAA 147
Cdd:cd18231   14 LCDvdIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSleALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAA 93
                         90
                 ....*....|....*.
gi 124486714 148 VYLQIHTLVKMCSDFL 163
Cdd:cd18231   94 AVLQMNDIAASCQELI 109
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
64-173 3.33e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 58.13  E-value: 3.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  64 SKMRQESfLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND---PSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTI 140
Cdd:cd18335   12 SYLKQQQ-LCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDvceAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTI 90
                         90       100       110
                 ....*....|....*....|....*....|...
gi 124486714 141 GSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18335   91 ENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCL 123
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-163 5.23e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 57.17  E-value: 5.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDpSTKRVDL----NDIAPLGLATVIAYAYTGKL 133
Cdd:cd18332    5 DVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGR-VGEGVSVltlpSGLEARGFQLLLDFMYTSRL 83
                         90       100       110
                 ....*....|....*....|....*....|
gi 124486714 134 TLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18332   84 PLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
171-259 6.01e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 56.67  E-value: 6.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18459    6 NCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNiQERRP 85
                         90
                 ....*....|
gi 124486714 250 HAADLLSNIR 259
Cdd:cd18459   86 HLPQVLQHVR 95
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
49-159 6.06e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 57.15  E-value: 6.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  49 ELTDTSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND----PSTKRVDLndIAPLGLATV 124
Cdd:cd18224    3 KLHSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTeldvARTYVVDF--ITPANFEKV 80
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 124486714 125 IAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMC 159
Cdd:cd18224   81 LSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
170-260 6.07e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 56.71  E-value: 6.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 170 ENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEF-DQKRV 248
Cdd:cd18446    4 ENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYkESERL 83
                         90
                 ....*....|..
gi 124486714 249 KHAADLLSNIRF 260
Cdd:cd18446   84 PLLPRVLENVRL 95
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
167-264 7.94e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 56.39  E-value: 7.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMK-LTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQ 245
Cdd:cd18475    1 VSEENYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDFLQnVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSP 80
                         90
                 ....*....|....*....
gi 124486714 246 KRVKHAADLLSNIRFGTIS 264
Cdd:cd18475   81 ERENEAYQVLSNIHFPLIP 99
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
73-162 8.74e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 55.97  E-value: 8.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  73 CDLVIGTKTKSFDVHKSVMASCSEYFYNILKN------DPSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISA 146
Cdd:cd18307    2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSndmkatDELSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKG 81
                         90
                 ....*....|....*.
gi 124486714 147 AVYLQIHTLVKMCSDF 162
Cdd:cd18307   82 AKYFNIPRLKDHCVDF 97
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-163 1.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 56.47  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNIL------KNDPSTKRVDLndIAPLGLATVIAYA 128
Cdd:cd18330    1 YYTKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLihyiqdSGRHSTASLDI--VTSEAFSIILDFL 78
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 124486714 129 YTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18330   79 YSGKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
167-244 1.13e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 55.02  E-value: 1.13e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD 244
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHD 78
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
167-244 1.20e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 54.92  E-value: 1.20e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAE-SEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD 244
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-158 1.23e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 55.96  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLS--KMRQESFlCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLNDIAPLGLATVIAYAYTGK 132
Cdd:cd18226    4 YNKNLLKYLNddRQKQSSF-CDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTDAVTLDHVSYSVFQHLLEFLYTSE 82
                         90       100
                 ....*....|....*....|....*.
gi 124486714 133 LTLSLYTIGSIISAAVYLQIHTLVKM 158
Cdd:cd18226   83 FFVYENEIPLVLEAAKFLDIIDAVKL 108
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
171-270 1.28e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 55.69  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18510    6 NCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDlQNRQK 85
                         90       100
                 ....*....|....*....|.
gi 124486714 250 HAADLLSNIRFGTISAQDLVN 270
Cdd:cd18510   86 DLGMLLSYIRLPLLPPQLLAD 106
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
167-244 1.39e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 54.82  E-value: 1.39e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD 244
Cdd:cd18474    1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
167-260 1.46e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 55.55  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK 246
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80
                         90
                 ....*....|....*
gi 124486714 247 -RVKHAADLLSNIRF 260
Cdd:cd18517   81 nRVKSLGEIFDCIRF 95
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-171 1.58e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 55.98  E-value: 1.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILK---NDPSTKRVDLNDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18251   10 LLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAgglREMQQTEVLIHGVSYNAMCKILDFIYTSELEL 89
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVEN 171
Cdd:cd18251   90 SLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
171-264 1.75e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 55.39  E-value: 1.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18456    5 NCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDvDGRRQ 84
                         90
                 ....*....|....*
gi 124486714 250 HAADLLSNIRFGTIS 264
Cdd:cd18456   85 HVPRLMKCVRLPLLS 99
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-173 1.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 56.17  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKN---DPSTKRVDLND-IAPLGLATVIAYAY 129
Cdd:cd18254    4 SHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNglrESLDSTVNFHDsLHPEVLELLLDFAY 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 124486714 130 TGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18254   84 SSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
409-452 2.32e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 53.00  E-value: 2.32e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 124486714  409 RTHFSLSVFNGLLYAVGGRNSEGSLASLECYVPSTNQWQPKAPL 452
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
53-163 2.84e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 55.22  E-value: 2.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  53 TSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKN------DPSTKRVDLndIAPLGLATVIA 126
Cdd:cd18329    2 SSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQnaketgQPTVATFDV--FSPDTFTIILD 79
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 124486714 127 YAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18329   80 FVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
72-153 3.16e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 54.09  E-value: 3.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  72 LCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTK--RVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVY 149
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEhpVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....
gi 124486714 150 LQIH 153
Cdd:cd18315   81 LQIK 84
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-163 5.11e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 54.65  E-value: 5.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFynilkNDPSTkrvdLNDIAPLGLATV---------I 125
Cdd:cd18220    8 YSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYF-----RDHSA----LSTMSGLSISVIknpnvfeqlL 78
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 124486714 126 AYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18220   79 SFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
167-250 7.70e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 53.04  E-value: 7.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-Q 245
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNaE 80

                 ....*
gi 124486714 246 KRVKH 250
Cdd:cd18451   81 ERERY 85
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-173 8.72e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 54.01  E-value: 8.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR---VDLNDIAPLGLATVIAYAYTGKLT 134
Cdd:cd18265    9 RILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRqavVEIQKVSAAAMEVLLDYMYGGGLR 88
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18265   89 IQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCL 127
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-163 9.31e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 53.58  E-value: 9.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKN------DPSTKRVDLndIAPLGLATVIAYAYTGK 132
Cdd:cd18199    5 LLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHyiqdtgRPSTASFDV--FSSDAFSIILDFVYSGK 82
                         90       100       110
                 ....*....|....*....|....*....|.
gi 124486714 133 LTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18199   83 LSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
171-247 1.01e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 52.68  E-value: 1.01e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQKR 247
Cdd:cd18458    6 NCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEEN 82
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-162 1.31e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 52.84  E-value: 1.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTkrvdlNDIAPLGLATVIA----YAYTGKLT 134
Cdd:cd18232    5 VLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSG-----SVVLPESFAEVFGllldFFYTGELA 79
                         90       100
                 ....*....|....*....|....*...
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDF 162
Cdd:cd18232   80 LTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-159 1.63e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 53.02  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLY 138
Cdd:cd18218    5 LLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQWCLGEGISPSTFKQLLDFVYGESVEVQPG 84
                         90       100
                 ....*....|....*....|.
gi 124486714 139 TIGSIISAAVYLQIHTLVKMC 159
Cdd:cd18218   85 ELRPLLEAARALEVESLEEAC 105
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-161 1.64e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 53.32  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTK----TKSFDVHKSVMASCSEYFYNILKNDPS--TKR--VDLNDIAPLGLATVIAYAY 129
Cdd:cd18211   11 NLLNEMHKLRLLGHLCDVTVQVEhqgsKEEFSAHKAVLAASSKYFKEVFLNEKIsdGKNtnVMLNEIYTADFASFLEFVY 90
                         90       100       110
                 ....*....|....*....|....*....|..
gi 124486714 130 TGKLTLSLYTIGSIISAAVYLQIHTLVKMCSD 161
Cdd:cd18211   91 TAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQ 122
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
167-260 1.70e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 52.59  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYS--LKNAKATAQKFIRDNFIEFAESEQFMK-LTFEQINELLVDDDLQLPSELVAFQIAMKWLEF 243
Cdd:cd18454    1 ICLDNCAEIMRLLDDFSvnIEGVREKLDSFLLENFVPLMSRPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRH 80
                         90
                 ....*....|....*..
gi 124486714 244 DQKRVKHAADLLSNIRF 260
Cdd:cd18454   81 DRRRWRHTDTIIQNIRF 97
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
170-260 1.85e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 52.17  E-value: 1.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 170 ENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQ-KRV 248
Cdd:cd18483    4 QNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQsKRE 83
                         90
                 ....*....|...
gi 124486714 249 KHAADLLSN-IRF 260
Cdd:cd18483   84 MHLPEIFAKcIRM 96
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
165-266 2.10e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 52.45  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 165 REISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD 244
Cdd:cd18469    1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80
                         90       100
                 ....*....|....*....|...
gi 124486714 245 -QKRVKHAADLLSNIRFGTISAQ 266
Cdd:cd18469   81 pQARAAHLPELLSLVHLSLLTDQ 103
Kelch smart00612
Kelch domain;
467-513 2.34e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 50.25  E-value: 2.34e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 124486714   467 RVIVTGGYIGSAYSRSVCAYDPALDAWQELPQLSTPRGWHCAVALGD 513
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
53-161 3.07e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 52.13  E-value: 3.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  53 TSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDP-STKRVDLND--IAPLGLATVIAYAY 129
Cdd:cd18192    2 PSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQhTTAQLNLSNmkISAECFDLILQFMY 81
                         90       100       110
                 ....*....|....*....|....*....|..
gi 124486714 130 TGKLTLSLYTIGSIISAAVYLQIHTLVKMCSD 161
Cdd:cd18192   82 LGKIMTAPSDFEQLKVAMNYLQLYYIPECLED 113
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-163 4.30e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 51.75  E-value: 4.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDpSTKRVDLNDIAPLGLATVIAYAYTGKL 133
Cdd:cd18225    5 NYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDST-DTISIDASVVSPEEFALLLEMVYTGKL 83
                         90       100       110
                 ....*....|....*....|....*....|
gi 124486714 134 TLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18225   84 PPGKHNFTKIISVADSLQMFDVAVSCKNLL 113
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
53-163 4.46e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 51.79  E-value: 4.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  53 TSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYN-ILKNDPSTKRVDLNDIAPLGLATVIAyAYTG 131
Cdd:cd18197    6 EQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDqFLLNQSKQVRITILQSAEVGRKLLLS-CYTG 84
                         90       100       110
                 ....*....|....*....|....*....|..
gi 124486714 132 KLTLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18197   85 ALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-161 6.46e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 51.33  E-value: 6.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTK----RVDLNDIAPLGLATVIAYAYTGKLT 134
Cdd:cd18293    2 AFLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAgqkvVLELQGLKAHTLLKLVDFLYTSELE 81
                         90       100
                 ....*....|....*....|....*..
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSD 161
Cdd:cd18293   82 VSSEEAQDVLAAARRLQISELESLCLE 108
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
167-241 1.07e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 49.31  E-value: 1.07e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWL 241
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-159 1.26e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 50.62  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  55 YGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR----VDLNDIAPLGLATVIAYAYT 130
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSheavVDLSGFCKSSFLPLLEFAYT 81
                         90       100
                 ....*....|....*....|....*....
gi 124486714 131 GKLTLSLYTIGSIISAAVYLQIHTLVKMC 159
Cdd:cd18202   82 SELTFDFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-167 1.28e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 50.65  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  60 LEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYN-ILKNDPSTKRVDLNDIAPLgLATVIAYAYTGKLTLSLY 138
Cdd:cd18203   13 LRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDqFLLNPSSELQVSLMHSSRV-VADLLLSCYTGALEFSVR 91
                         90       100
                 ....*....|....*....|....*....
gi 124486714 139 TIGSIISAAVYLQIHTLVKMCSDFLIREI 167
Cdd:cd18203   92 DIVNYLTAASYLQMEHVVEKCRGALSQFI 120
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-157 1.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 50.38  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLNDIAPLGLATVIAYAYTGKLTL-SL 137
Cdd:cd18221    5 MLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVqGE 84
                         90       100
                 ....*....|....*....|
gi 124486714 138 YTIGSIISAAVYLQIHTLVK 157
Cdd:cd18221   85 EEANDVWKAAEYLQMQEAIK 104
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-163 1.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 50.82  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYF---YNILKNDPSTKRVDLND--IAPLGLATVIAYAYTGKL 133
Cdd:cd18196    8 IFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFralFTVAEGDQTMNMIQLDSevVTAEAFAALIDMMYTSTL 87
                         90       100       110
                 ....*....|....*....|....*....|
gi 124486714 134 TLSLYTIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18196   88 MLGESNVMDVLLAASHLHLNSVVKACKHYL 117
PRK14131 PRK14131
N-acetylneuraminate epimerase;
340-504 1.84e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 53.48  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 340 DPENGWSKLTEMPAKSFNQCVAV-MDGFLYVAGG--EDQNDARNQakhAVSNFCRYDPRFNTWIHLGSmnqkRT------ 410
Cdd:PRK14131  59 APSKGWTKIAAFPGGPREQAVAAfIDGKLYVFGGigKTNSEGSPQ---VFDDVYKYDPKTNSWQKLDT----RSpvglag 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 411 HFSLSVFNGLLYAVGGRNSE---GSLASLE-------------------------------CYVPSTNQWQ-----PKAP 451
Cdd:PRK14131 132 HVAVSLHNGKAYITGGVNKNifdGYFEDLAaagkdktpkdkindayfdkkpedyffnkevlSYDPSTNQWKnagesPFLG 211
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124486714 452 levaRCCHASAVADGRVIVTGGYIGSAYsRSVCAYDPALDA----WQELPQLSTPRG 504
Cdd:PRK14131 212 ----TAGSAVVIKGNKLWLINGEIKPGL-RTDAVKQGKFTGnnlkWQKLPDLPPAPG 263
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
46-176 1.84e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 50.66  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  46 VSSELTDTSYGPNLLEGLSKM-RQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR---VDLNDIAPLGL 121
Cdd:cd18272    5 VSYTFTDRSHSSRVAQSIMDLcLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARnrvIELKDVSESVF 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 124486714 122 ATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYVV 176
Cdd:cd18272   85 QLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQVM 139
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
47-162 3.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 49.41  E-value: 3.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  47 SSELTDTsygpnLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNIL--KNDPSTKRVDLNDIAPLGLATV 124
Cdd:cd18212    3 SKTHKDT-----VLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFadEGEVGQSIYMLEGMVAETFGAL 77
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 124486714 125 IAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDF 162
Cdd:cd18212   78 LEFIYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
67-172 3.25e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 49.86  E-value: 3.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  67 RQESFLCDLVI---GTKTKSFDVHKSVMASCSEYFYNILK---NDPSTKRVDLNDIA------PLGLATVIAYAYTGKLT 134
Cdd:cd18241   18 RKQGLFCDITLafgGAGGREFRAHRSVLAAATEYFTPLLSgqfSESRSGRVEMRKWSsepgpdPDTVEAVIQYMYTGRIR 97
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 124486714 135 LSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENC 172
Cdd:cd18241   98 VSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
76-150 3.27e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 48.05  E-value: 3.27e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124486714  76 VIGTKTKSFDVHKSVMASCSEYFYNILK---NDPSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYL 150
Cdd:cd01165    2 VLVVEGEKFHVNKELLAQSSEYFRALFRggfRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-160 3.30e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 49.26  E-value: 3.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDP--STKRVDLNDIAPLGLATVIAYAYTGKLTLS 136
Cdd:cd18204    5 FLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEvdSSSVIEIDFLRSDIFEEVLNYMYTAKISVK 84
                         90       100
                 ....*....|....*....|....
gi 124486714 137 LYTIGSIISAAVYLQIHTLVKMCS 160
Cdd:cd18204   85 KEDVNLMMSSGQILGIRFLDKLCS 108
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
171-270 3.36e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 48.91  E-value: 3.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18511    6 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDvEQRRK 85
                         90       100
                 ....*....|....*....|.
gi 124486714 250 HAADLLSNIRFGTISAQDLVN 270
Cdd:cd18511   86 DLSKLLAYIRLPLLAPQFLAD 106
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
455-500 3.39e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.22  E-value: 3.39e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 124486714  455 ARCCHASAVADGRVIVTGGYIGSAYSRSVCAYDPALDAWQELPQLS 500
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-172 4.77e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 48.86  E-value: 4.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNilKNDPSTKRVDLNDIAPLGLATVIAYAYTGKLTLSL 137
Cdd:cd18303    4 RLLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSEKWSN--ENLASTNELDLSDISYEVVLALLRWLYTDELDLTL 81
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 124486714 138 yTIG---SIISAAVYLQIHTLVKMCSDFLIREISVENC 172
Cdd:cd18303   82 -DDEfllELMKAAKRFQLTDLVERCERALMSSVNVDNC 118
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
167-260 1.34e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 47.14  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK 246
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80
                         90
                 ....*....|....*
gi 124486714 247 -RVKHAADLLSNIRF 260
Cdd:cd18477   81 nRQKALPTVFESIRF 95
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
74-176 1.34e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 47.10  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  74 DLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPstkrVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIH 153
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDI----LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMP 81
                         90       100
                 ....*....|....*....|...
gi 124486714 154 TLVKMCSDFLIREISVENCMYVV 176
Cdd:cd18275   82 CAAQCAVDAVRAQLCLGNCYEVL 104
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
52-133 1.45e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 47.13  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  52 DTSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKndPSTKRVDLNDIAPLGLATVIAYAYTG 131
Cdd:cd18219    1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFS--VAGQVVELNFIRADIFAEILNYIYSS 78

                 ..
gi 124486714 132 KL 133
Cdd:cd18219   79 KI 80
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
59-158 1.56e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 47.19  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKT-KSFDVHKSVMASCSEYFYNILKNDPSTKRVDL--NDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18311    1 FLQRLQNLFNKTEYCDLTLQFRDnEQLKVHRLVLSACTDYFNVLEQTCEIVDDTLImpNELQADAVVPVINFMYTGQLEF 80
                         90       100
                 ....*....|....*....|...
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKM 158
Cdd:cd18311   81 EEKSYGKLLRTAKELNMTVLLKL 103
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
63-147 1.82e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 46.82  E-value: 1.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  63 LSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNIL--KNDPstkRVDLN-DIAPLGLATVIAYAYTGKLTLSLYT 139
Cdd:cd18262    9 AQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLlgSNGP---LPPLSlEVTPVGWEAVLTFAYTGVLGRNPAT 85

                 ....*...
gi 124486714 140 IGSIISAA 147
Cdd:cd18262   86 VGDILVAA 93
Kelch_6 pfam13964
Kelch motif;
455-503 2.88e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 44.63  E-value: 2.88e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 124486714  455 ARCCHASAVADGRVIVTGGY-IGSAYSRSVCAYDPALDAWQELPQLSTPR 503
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-160 3.40e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 46.52  E-value: 3.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNI-LKNDPSTKRVDLNDIAPLGLATVIAYAYTGK 132
Cdd:cd18193    3 NHGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLfVHQTSECVRLKPTDIQPDIFSYLLHLMYTGK 82
                         90       100
                 ....*....|....*....|....*...
gi 124486714 133 LTLSLYTIGSIISAAVYLQIHTLVKMCS 160
Cdd:cd18193   83 MAPQLIDPVRLEQGIKFLHAYPLIQEAS 110
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
73-171 3.43e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 46.54  E-value: 3.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  73 CDLVIGTKtkSFDVHKSVMASCSEYFYNILKN---DPSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVY 149
Cdd:cd18343   24 CSLFVGGQ--EFKAHKSILAARSPVFNAMFEHemeESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADK 101
                         90       100
                 ....*....|....*....|..
gi 124486714 150 LQIHTLVKMCSDFLIREISVEN 171
Cdd:cd18343  102 YALERLKVMCEEALCNNLSVEN 123
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-163 3.55e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 46.18  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDpsTKRVDLNDIAPLGLATVIAYAYTGKLTLSLY 138
Cdd:cd18205    5 LLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRN--SQHYTLDFLSPKTFQQILEYAYTATLQAKVE 82
                         90       100
                 ....*....|....*....|....*
gi 124486714 139 TIGSIISAAVYLQIHTLVKMCSDFL 163
Cdd:cd18205   83 DLDDLLYAAEILEIEYLEEQCLKIL 107
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
73-163 3.65e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 46.08  E-value: 3.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  73 CDL--VIGTKTKSFDVHKSVMASCSEYFYNILKNDPS----TKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISA 146
Cdd:cd18294   15 SDVkfLVGPERQEIFAHKCILAARCEVFRAMFLTGPQkestQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAA 94
                         90
                 ....*....|....*..
gi 124486714 147 AVYLQIHTLVKMCSDFL 163
Cdd:cd18294   95 AVEYGLDELRKLCERFI 111
PLN02193 PLN02193
nitrile-specifier protein
367-546 4.82e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 49.57  E-value: 4.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 367 LYVAGGEDqndarnqAKHAVSNFCRYDPRFNTWIHLGSMNQ---KRTHFSLSVFNGLLYAVGGRNSEGSLASLECYVPST 443
Cdd:PLN02193 231 LYVFGGRD-------ASRQYNGFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVD 303
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 444 NQW-QPKAPLE--VARCCHASAVADGRVIVTGGYIGSAYSrSVCAYDPALDAWQELPQLS---TPRGWHCAVALGDRLYV 517
Cdd:PLN02193 304 KKWfHCSTPGDsfSIRGGAGLEVVQGKVWVVYGFNGCEVD-DVHYYDPVQDKWTQVETFGvrpSERSVFASAAVGKHIVI 382
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 124486714 518 MGG-------SQLGP---------------RGERVDVLTVESFSPAARQWS 546
Cdd:PLN02193 383 FGGeiamdplAHVGPgqltdgtfaldtetlQWERLDKFGEEEETPSSRGWT 433
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
169-259 4.83e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 45.49  E-value: 4.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 169 VENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKR 247
Cdd:cd18462    3 IDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDvEKR 82
                         90
                 ....*....|..
gi 124486714 248 VKHAADLLSNIR 259
Cdd:cd18462   83 IECAYDLLSSIK 94
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
171-260 4.99e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 45.57  E-value: 4.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIE-FAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK-RV 248
Cdd:cd18482    5 NCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKeRA 84
                         90
                 ....*....|..
gi 124486714 249 KHAADLLSNIRF 260
Cdd:cd18482   85 ASAAEVLKCVRW 96
PRK14131 PRK14131
N-acetylneuraminate epimerase;
493-575 5.09e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 49.24  E-value: 5.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 493 WQELPQL-STPRGWHCAVALGDRLYVMGGSQLGPRGERVDVL-TVESFSPAARQWSFVAPL-PVG-VSTAGVSALHGRAY 568
Cdd:PRK14131  64 WTKIAAFpGGPREQAVAAFIDGKLYVFGGIGKTNSEGSPQVFdDVYKYDPKTNSWQKLDTRsPVGlAGHVAVSLHNGKAY 143

                 ....*..
gi 124486714 569 LLGGWNE 575
Cdd:PRK14131 144 ITGGVNK 150
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
340-618 5.40e-06

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 48.86  E-value: 5.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  340 DPENGWSKLTEMPAKSFNQCVA-VMDGFLYVAGGEDQNDARNQAKhAVSNFCRYDPRFNTWIHLgsmnQKRT------HF 412
Cdd:TIGR03547  38 KPSKGWQKIADFPGGPRNQAVAaAIDGKLYVFGGIGKANSEGSPQ-VFDDVYRYDPKKNSWQKL----DTRSpvgllgAS 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  413 SLSVFNGLLYAVGGRNSE---GSLASLECYVPSTNQWQpkaplEVARCCHASAVADGRvivtggyigsaYSRSVCAYDPA 489
Cdd:TIGR03547 113 GFSLHNGQAYFTGGVNKNifdGYFADLSAADKDSEPKD-----KLIAAYFSQPPEDYF-----------WNKNVLSYDPS 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  490 LDAWQ---ELPQLSTprgwhCAVAL---GDRLYVMGGsQLGPrGERVDVLTVESFSPAARQWSFVAPLPV-------GVS 556
Cdd:TIGR03547 177 TNQWRnlgENPFLGT-----AGSAIvhkGNKLLLING-EIKP-GLRTAEVKQYLFTGGKLEWNKLPPLPPpksssqeGLA 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  557 TA------GVSALHGRAYLLGGW---NEGE--------KKYKKCIQCFNPelNEWTEDDELPEA-TVGVScctLAMPNSV 618
Cdd:TIGR03547 250 GAfagisnGVLLVAGGANFPGAQenyKNGKlyahegliKAWSSEVYALDN--GKWSKVGKLPQGlAYGVS---VSWNNGV 324
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
191-259 1.29e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 44.33  E-value: 1.29e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 191 AQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK-RVKHAADLLSNIR 259
Cdd:cd18485   25 ARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKsRVQHLVELLKQVR 94
Kelch smart00612
Kelch domain;
367-419 1.63e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.16  E-value: 1.63e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 124486714   367 LYVAGGEDqndaRNQAKHAVSnfcRYDPRFNTWIHLGSMNQKRTHFSLSVFNG 419
Cdd:smart00612   2 IYVVGGFD----GGQRLKSVE---VYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
167-260 1.95e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 43.59  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQ- 245
Cdd:cd18516    1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQe 80
                         90
                 ....*....|....*
gi 124486714 246 KRVKHAADLLSNIRF 260
Cdd:cd18516   81 ERTKALPVLLESIRF 95
Kelch_6 pfam13964
Kelch motif;
356-409 3.17e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.55  E-value: 3.17e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 124486714  356 FNQCVAVmDGFLYVAGGedqndaRNQAKHAVSNFCRYDPRFNTWIHLGSMNQKR 409
Cdd:pfam13964   4 FHSVVSV-GGYIYVFGG------YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
171-260 7.49e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 41.88  E-value: 7.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18515    4 NCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDlKKRHC 83
                         90
                 ....*....|.
gi 124486714 250 HAADLLSNIRF 260
Cdd:cd18515   84 YLSELLQTVRL 94
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
171-260 8.46e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 41.75  E-value: 8.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVK 249
Cdd:cd18514    5 NCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDlEKRKD 84
                         90
                 ....*....|.
gi 124486714 250 HAADLLSNIRF 260
Cdd:cd18514   85 YLPELLRNVRL 95
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-135 9.30e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 42.08  E-value: 9.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDP---STKRVDLNDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18223    5 VLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEiwiSSHVLELPDLKAEVFAEILNFIYSSKVVV 84
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
82-144 1.15e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 41.84  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124486714  82 KSFDVHKSVMASCSEYF----YNILKnDPSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSII 144
Cdd:cd18287   32 KRFPAHRVILAARSEYFrallYGGMR-ESQQSEIELKDTNAEAFKALLKYIYTGRLTLTDLKEDVLL 97
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-171 1.54e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 41.75  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND--PSTK-RVDLNDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18279    5 LAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEmeESKKnRVEINDVDPEVFKEMMRFIYTGKAPN 84
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVEN 171
Cdd:cd18279   85 LDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-133 1.84e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 41.40  E-value: 1.84e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNIL--KNDPSTKRVDLNDIAPLGLATVIAYAYTGKL 133
Cdd:cd18209    4 SLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFteKENESQSVFQLDFCEPDAFENVLNYIYSSSL 81
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-171 1.96e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 41.63  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND---PSTKRVDLNDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18342    9 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEmeeSKKNRVEINDVEPEVFKEMMCFIYTGKAPN 88
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVEN 171
Cdd:cd18342   89 LDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 124
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
502-552 2.26e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 2.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 124486714  502 PRGWHCAVALGDRLYVMGGSQlgpRGERVDvlTVESFSPAARQWSFVAPLP 552
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFD---GNQSLN--SVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
53-132 2.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 41.42  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  53 TSYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPS-TKRVDLNDIAPLGLATVIAYAYTG 131
Cdd:cd18213    2 SSHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSeCIKIQPTDIQPDIFSYLLHIMYTG 81

                 .
gi 124486714 132 K 132
Cdd:cd18213   82 K 82
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
57-162 2.73e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 40.73  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  57 PNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKN----DPSTKRVDLNDiaPLGLATV----IAYA 128
Cdd:cd18292    2 REFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNdwwsESKQSEIELVE--DPECAAVfekfLRYL 79
                         90       100       110
                 ....*....|....*....|....*....|....
gi 124486714 129 YTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDF 162
Cdd:cd18292   80 YTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
168-268 2.82e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 40.29  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 168 SVEN-CMyVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPsELVAFQIAMKWLEFDQK 246
Cdd:cd14822    2 NIRNvCL-IYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAP-EVDIFNAVRRWCEHNPD 79
                         90       100
                 ....*....|....*....|..
gi 124486714 247 RVKHAADLLSNIRFGTISAQDL 268
Cdd:cd14822   80 SKEDAKEILEAVRLPLMSLTEL 101
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
170-260 3.19e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 40.51  E-value: 3.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 170 ENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKW------LEF 243
Cdd:cd18461    4 ENILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLYhytpeqVEK 83
                         90
                 ....*....|....*..
gi 124486714 244 DQKRVKHAADLLSNIRF 260
Cdd:cd18461   84 DQVSLQEPPKLLEAVRF 100
Kelch smart00612
Kelch domain;
514-565 3.53e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.69  E-value: 3.53e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 124486714   514 RLYVMGGSqlgPRGERVDvlTVESFSPAARQWSFVAPLPVGVSTAGVSALHG 565
Cdd:smart00612   1 KIYVVGGF---DGGQRLK--SVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
171-241 4.45e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 39.10  E-value: 4.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124486714 171 NCMYVVN---IAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWL 241
Cdd:cd18493    1 SVNHAVSwlqYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-160 4.91e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 40.23  E-value: 4.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDlNDIAPLGLATVIAYAYTGKLTLSL 137
Cdd:cd18229    4 SLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVP-PVVPAQTVRQLVEFMYSGSLVVAQ 82
                         90       100
                 ....*....|....*....|...
gi 124486714 138 YTIGSIISAAVYLQIHTLVKMCS 160
Cdd:cd18229   83 SEALQILTAASILQIKTVIDECT 105
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
67-164 6.30e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 39.97  E-value: 6.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  67 RQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNIL--------KNDPSTKRVDLNDIAPLGLATVIAYAYTGKLTLSLY 138
Cdd:cd18296   12 EQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLrdhfaeseENNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPE 91
                         90       100
                 ....*....|....*....|....*.
gi 124486714 139 TIGSIISAAVYLQIHTLVKMCSDFLI 164
Cdd:cd18296   92 NAYDVLYVADMYLLPGLKRLCGTVLA 117
Kelch_3 pfam13415
Galactose oxidase, central domain;
418-464 6.54e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.04  E-value: 6.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 124486714  418 NGLLYAVGGRNSEGSLASLECYV--PSTNQWQPKAPLEVARCCHASAVA 464
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVydLDTNTWTQIGDLPPPRSGHSATYI 49
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-160 6.73e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 39.66  E-value: 6.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKRVDlNDIAPLGLATVIAYAYTGKL 133
Cdd:cd18208    7 NFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIP-SVVSVQSVQKLIDFMYSGVL 85
                         90       100
                 ....*....|....*....|....*..
gi 124486714 134 TLSLYTIGSIISAAVYLQIHTLVKMCS 160
Cdd:cd18208   86 RVSQSEALQILTAASILQIKTVIDECT 112
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
57-135 6.81e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 39.88  E-value: 6.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  57 PNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND---------------PSTKRV-DLNDIAPLG 120
Cdd:cd18195    3 GALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPlplgaaavaaapgatQSPERVlELPGVKAGV 82
                         90
                 ....*....|....*
gi 124486714 121 LATVIAYAYTGKLTL 135
Cdd:cd18195   83 FSDVLNFIYSSRVAL 97
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-171 8.95e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 39.45  E-value: 8.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTK---RVDLNDIAPLGLATVIAYAYTGKLTL 135
Cdd:cd18345    5 LSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERkqnRVEITDVDHEVMREMLRFIYTGKAPN 84
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 124486714 136 SLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVEN 171
Cdd:cd18345   85 LDKMADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-171 9.09e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 39.55  E-value: 9.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPS---TKRVDLNDIAPLGLATVIAYAYTGKL-T 134
Cdd:cd18344   10 LTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEerlKNPIEIHDLDPQVFKEMMGFIYTGKApH 89
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 124486714 135 LSLYTIG-SIISAAVYLQIHTLVKMCSDFLIREISVEN 171
Cdd:cd18344   90 LHSHSMAcDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
198-259 9.44e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 39.02  E-value: 9.44e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124486714 198 NFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFD-QKRVKHAADLLSNIR 259
Cdd:cd18464   31 NFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDlPRRHEVLPELLRSVR 93
DUF1668 pfam07893
Protein of unknown function (DUF1668); The hypothetical proteins found in this family are ...
450-538 1.03e-03

Protein of unknown function (DUF1668); The hypothetical proteins found in this family are expressed by Oryza sativa and are of unknown function.


Pssm-ID: 369579 [Multi-domain]  Cd Length: 330  Bit Score: 41.59  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  450 APLEVARCCHASAVADGRVIVTGGyigsaySRSVCAYDPALDAWQELPQLSTPRGWHCAVALGDRLYVMGGSqlgPRGER 529
Cdd:pfam07893  52 SPASSGGGMSFAALVGDKIVGVDG------SGRTLLYDTDTRAVRTGPNLLSPKLRPVSVPVGDGLYALDRS---PSPEK 122

                  ....*....
gi 124486714  530 VDVLTVESF 538
Cdd:pfam07893 123 VGGLDFECF 131
Kelch_6 pfam13964
Kelch motif;
506-554 1.10e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.31  E-value: 1.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 124486714  506 HCAVALGDRLYVMGGSQLGPRgervDVLTVESFSPAARQWSFVAPLPVG 554
Cdd:pfam13964   5 HSVVSVGGYIYVFGGYTNASP----ALNKLEVYNPLTKSWEELPPLPTP 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
359-406 1.75e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 1.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 124486714  359 CVAVMDGFLYVAGGEDQNDArnqakhaVSNFCRYDPRFNTWIHLGSMN 406
Cdd:pfam01344   6 GVVVVGGKIYVIGGFDGNQS-------LNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
54-167 1.93e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 38.65  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  54 SYGPNLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYN-ILKNDPSTKRVDLNDIAPLGLATVIAyAYTGK 132
Cdd:cd18214    7 NYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDqFLLNDSREVQISILQNSEVGRQLLLS-CYTGV 85
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 124486714 133 LTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREI 167
Cdd:cd18214   86 LEFPEMELVNYLTAASFLQMSHIVERCTQALWKFI 120
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
82-163 2.21e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 37.96  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  82 KSFDVHKSVMASCSEYFYNILkndpSTKRVDL--NDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMC 159
Cdd:cd18299   23 VRIFAHRIVLAAASSVFADLF----LMMTVVTldSDITPEAFRRVLEFLYTGVLDENEDDLKELKDAAELLELFDLVMMC 98

                 ....
gi 124486714 160 SDFL 163
Cdd:cd18299   99 TNVL 102
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
171-261 2.41e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 37.58  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714 171 NCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAES--EQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQkRV 248
Cdd:cd18471    5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHNC-RY 83
                         90
                 ....*....|...
gi 124486714 249 KHAADLLSNIRFG 261
Cdd:cd18471   84 QYMDELLQYVRFG 96
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
58-147 2.52e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 38.39  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  58 NLLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND---PSTKRVDLNDIAPLGLATVIAYAYTGKLT 134
Cdd:cd18286    3 RLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSwaeSNSSEITLTGVSHAAVSFVLLFIYGGVLD 82
                         90
                 ....*....|....
gi 124486714 135 LSLY-TIGSIISAA 147
Cdd:cd18286   83 LPDDvNLGELLSLA 96
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
82-171 2.62e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 38.02  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  82 KSFDVHKSVMASCSEYFYNILKN---DPSTKRVDLNDIAPLGLATVIAYAYTGK---LTLSLYTIGSIISAAVYLQIHTL 155
Cdd:cd18297   22 RPFYAHKIVLVTASDRFKSMLSSgstEAQTPVIEIPDIRYDIFQLMMQYLYTGGvesLDVAQDDALELLRAASFFQLDGL 101
                         90
                 ....*....|....*.
gi 124486714 156 VKMCSDFLIREISVEN 171
Cdd:cd18297  102 KRHCEILLSQQIDLDN 117
Kelch_6 pfam13964
Kelch motif;
409-456 2.87e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.16  E-value: 2.87e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 124486714  409 RTHFSLSVFNGLLYAVGGR-NSEGSLASLECYVPSTNQWQPKAPLEVAR 456
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_LGALS3BP cd18496
BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding ...
198-241 2.98e-03

BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding protein (LGALS3BP); LGALS3BP, also called galectin-3-binding protein, or basement membrane autoantigen p105, or Mac-2-binding protein (MAC2BP/M2BP), or tumor-associated antigen 90K, promotes integrin-mediated cell adhesion. It may stimulate host defense against viruses and tumor cells.


Pssm-ID: 350571  Cd Length: 74  Bit Score: 36.61  E-value: 2.98e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 124486714 198 NFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWL 241
Cdd:cd18496   31 NCEALISSEAWLDLPWDQLKALLTRSDLVVPDELVLLKALEAWA 74
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
72-173 4.17e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 38.04  E-value: 4.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  72 LCDLVIGTKTKSFDVHKSVMASCSEYFYNILKNDPSTKR--VDLNDIAPLGLATVIAYAYTG---KLTLSLYTIGSIISA 146
Cdd:cd18351   24 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENtcIEISYVKYHIFQLVMQYLYCGgteSLLIKNNEIMELLSA 103
                         90       100
                 ....*....|....*....|....*..
gi 124486714 147 AVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18351  104 AKFFQLEALQRHCEIICAKSINTENCV 130
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
64-151 4.53e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 37.31  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  64 SKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNI--LKNDPSTKRVDLNDIaPLGLAT--VIA-YAYTGKLTLSLY 138
Cdd:cd18312    1 SWFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLasSSSESDPSEIELNDF-PGGAEAfeLVAkFCYGMPINLTAT 79
                         90
                 ....*....|...
gi 124486714 139 TIGSIISAAVYLQ 151
Cdd:cd18312   80 NVVGLRCAAEYLE 92
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
81-163 5.37e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 36.88  E-value: 5.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  81 TKSFDVHKSVMASCSEYFYNILKNDPSTKRVDLN--DIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKM 158
Cdd:cd18349   21 SQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHipDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKA 100

                 ....*
gi 124486714 159 CSDFL 163
Cdd:cd18349  101 CVNFL 105
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
72-173 6.84e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 37.13  E-value: 6.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486714  72 LCDLVIGTKTKSFDVHKSVMASCSEYFYNILKN-----DPSTKRVDLNDIAPLGLATVIAYAYTG---KLTLSLYTIGSI 143
Cdd:cd18350   24 MSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNkseqeSQGSKTIEISDIKYHIFQMLMQYLYYGgteSMEIPIADVLEL 103
                         90       100       110
                 ....*....|....*....|....*....|
gi 124486714 144 ISAAVYLQIHTLVKMCSDFLIREISVENCM 173
Cdd:cd18350  104 LSAASLFQLDALQRHCEILCSQTINLENAV 133
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
167-241 9.13e-03

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 36.06  E-value: 9.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124486714 167 ISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDD-LQLPSELVAFQIAMKWL 241
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNQeLESINERKLCQLVLEWV 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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