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Conserved domains on  [gi|264681541|ref|NP_766160|]
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inactive rhomboid protein 2 isoform 1 [Mus musculus]

Protein Classification

inactive rhomboid protein 2( domain architecture ID 13782860)

inactive rhomboid protein 2 (iRhom2) regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 98-281 3.16e-101

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


:

Pssm-ID: 463639  Cd Length: 193  Bit Score: 311.42  E-value: 3.16e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541   98 VSGDWEGKrQNWHRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPK-------IVDPLARGRAFRHPD 170
Cdd:pfam12595   1 VSKDSDST-QRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKshhgmqrIVDPLARGRAFRMVE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541  171 EVDRPHAAHPPLTPGVLSLTSFTSVRSGYSHLP-RRKRISVAHMSFQAAAALLKGRSVLDATGQRCRhvKRSFAYPSFLE 249
Cdd:pfam12595  80 EVDGYSVPQTPITPGVASLCSFTSSRSGLNRLPrRRKRESVAKMSFRAAAALMKGRSLRESTLRRRR--RRSFTPPSFLE 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 264681541  250 EDAVDGADTFDSSFFSK----EEMSSMPDDVFESPP 281
Cdd:pfam12595 158 EDTVDFADELDTSFFSKddlhEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 619-762 4.21e-32

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


:

Pssm-ID: 426384  Cd Length: 147  Bit Score: 121.95  E-value: 4.21e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541  619 PEVPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPY-RAEVGPAGSQFG 697
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 264681541  698 LLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGMLLAFAFLPYI 762
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 720-810 2.39e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd06173:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 383  Bit Score: 44.14  E-value: 2.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 720 FFNLSAIVLFLFICGLLpwidnIAHIFG--FLSGMLLAFAFLPYITFGT-----SDKYRKRALILVSLLVFAGLFASLVL 792
Cdd:cd06173    9 LLSALGDWIFTVALPWL-----VLQLTGsaLLVGLVLAAFFLPFLLFSPfagvlADRFDRRRLLILADLLRALLAAVLAL 83

                         90
                 ....*....|....*...
gi 264681541 793 WLYIYPINWPWIeYLTCF 810
Cdd:cd06173   84 LALLGSLSLWLL-LVLAF 100
 
Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 98-281 3.16e-101

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


Pssm-ID: 463639  Cd Length: 193  Bit Score: 311.42  E-value: 3.16e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541   98 VSGDWEGKrQNWHRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPK-------IVDPLARGRAFRHPD 170
Cdd:pfam12595   1 VSKDSDST-QRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKshhgmqrIVDPLARGRAFRMVE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541  171 EVDRPHAAHPPLTPGVLSLTSFTSVRSGYSHLP-RRKRISVAHMSFQAAAALLKGRSVLDATGQRCRhvKRSFAYPSFLE 249
Cdd:pfam12595  80 EVDGYSVPQTPITPGVASLCSFTSSRSGLNRLPrRRKRESVAKMSFRAAAALMKGRSLRESTLRRRR--RRSFTPPSFLE 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 264681541  250 EDAVDGADTFDSSFFSK----EEMSSMPDDVFESPP 281
Cdd:pfam12595 158 EDTVDFADELDTSFFSKddlhEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 619-762 4.21e-32

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 121.95  E-value: 4.21e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541  619 PEVPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPY-RAEVGPAGSQFG 697
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 264681541  698 LLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGMLLAFAFLPYI 762
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 624-760 1.07e-19

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 87.61  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 624 QFYRIWLSLFLHAGIVHclvsVVFQMTIL----RDLEKLAGWHRISIIFILSGITGNLASAIFLPYRAE--VGPAGSQFG 697
Cdd:COG0705   42 ELWRLLTSMFLHGGFLH----LLFNMLALwvfgPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPGSGYplVGASGAIFG 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681541 698 LLACLFV-ELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGMLLAFAFLP 760
Cdd:COG0705  118 LLGALLVlGPRRRVLLLFIPIPALLFLLVWLLLGLLFGLLGGggIAWEAHLGGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
 624-758 1.95e-12

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 68.34  E-value: 1.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 624 QFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNL--ASAIFLPYRaeVGPAGSQFGLLAC 701
Cdd:PTZ00101 101 EIHRLILPIFLHANIFHTFFNVFFQLRMGFTLEKNYGIVKIIILYFLTGIYGNIlsSSVTYCPIK--VGASTSGMGLLGI 178

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681541 702 LFVELFQSWQLLERPWKAFFNlsaIVLFLFICGLLPW------IDNIAHIFGFLSGMLLAFAF 758
Cdd:PTZ00101 179 VTSELILLWHVIRHRERVVFN---IIFFSLISFFYYFtfngsnIDHVGHLGGLLSGISMGILY 238
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 720-810 2.39e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.14  E-value: 2.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 720 FFNLSAIVLFLFICGLLpwidnIAHIFG--FLSGMLLAFAFLPYITFGT-----SDKYRKRALILVSLLVFAGLFASLVL 792
Cdd:cd06173    9 LLSALGDWIFTVALPWL-----VLQLTGsaLLVGLVLAAFFLPFLLFSPfagvlADRFDRRRLLILADLLRALLAAVLAL 83

                         90
                 ....*....|....*...
gi 264681541 793 WLYIYPINWPWIeYLTCF 810
Cdd:cd06173   84 LALLGSLSLWLL-LVLAF 100
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 658-792 1.90e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.41  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 658 LAGWHRISIIFILSGITGNLASAI---FLPYRAEVGPAGSQfgllacLFVELFQSWQLLERPWKAFFNLSAIVLFLFICG 734
Cdd:cd17325  143 LADALGYRAPFLVCAALALLALVLallLLPEPRPPPNKRAV------SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFG 216

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 264681541 735 ----LLP--WIDNI----AHIFGFLSGMLLAFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVL 792
Cdd:cd17325  217 alepFLPlyAAELGglspAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 745-804 6.55e-03

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 36.32  E-value: 6.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 264681541 745 IFGFLSGMLLAFAFLP-----YITFGTSDkyrkralilVSLLVFAGLFASLVLWLyIYPI---NWPWI 804
Cdd:COG4095    5 IIGLLAGILTTISFLPqviktWKTKSTKD---------ISLGMYLIFTTGVALWL-IYGIligDLPII 62
 
Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 98-281 3.16e-101

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


Pssm-ID: 463639  Cd Length: 193  Bit Score: 311.42  E-value: 3.16e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541   98 VSGDWEGKrQNWHRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPK-------IVDPLARGRAFRHPD 170
Cdd:pfam12595   1 VSKDSDST-QRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKshhgmqrIVDPLARGRAFRMVE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541  171 EVDRPHAAHPPLTPGVLSLTSFTSVRSGYSHLP-RRKRISVAHMSFQAAAALLKGRSVLDATGQRCRhvKRSFAYPSFLE 249
Cdd:pfam12595  80 EVDGYSVPQTPITPGVASLCSFTSSRSGLNRLPrRRKRESVAKMSFRAAAALMKGRSLRESTLRRRR--RRSFTPPSFLE 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 264681541  250 EDAVDGADTFDSSFFSK----EEMSSMPDDVFESPP 281
Cdd:pfam12595 158 EDTVDFADELDTSFFSKddlhEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 619-762 4.21e-32

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 121.95  E-value: 4.21e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541  619 PEVPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPY-RAEVGPAGSQFG 697
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 264681541  698 LLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGMLLAFAFLPYI 762
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 624-760 1.07e-19

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 87.61  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 624 QFYRIWLSLFLHAGIVHclvsVVFQMTIL----RDLEKLAGWHRISIIFILSGITGNLASAIFLPYRAE--VGPAGSQFG 697
Cdd:COG0705   42 ELWRLLTSMFLHGGFLH----LLFNMLALwvfgPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPGSGYplVGASGAIFG 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681541 698 LLACLFV-ELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGMLLAFAFLP 760
Cdd:COG0705  118 LLGALLVlGPRRRVLLLFIPIPALLFLLVWLLLGLLFGLLGGggIAWEAHLGGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
 624-758 1.95e-12

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 68.34  E-value: 1.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 624 QFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNL--ASAIFLPYRaeVGPAGSQFGLLAC 701
Cdd:PTZ00101 101 EIHRLILPIFLHANIFHTFFNVFFQLRMGFTLEKNYGIVKIIILYFLTGIYGNIlsSSVTYCPIK--VGASTSGMGLLGI 178

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681541 702 LFVELFQSWQLLERPWKAFFNlsaIVLFLFICGLLPW------IDNIAHIFGFLSGMLLAFAF 758
Cdd:PTZ00101 179 VTSELILLWHVIRHRERVVFN---IIFFSLISFFYYFtfngsnIDHVGHLGGLLSGISMGILY 238
MFS_1 pfam07690
Major Facilitator Superfamily;
658-809 2.09e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.33  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541  658 LAGWHRISIIFILSGITGNLASAIFL-----PYRAEVGPAGSQFGLLACLFVELFQSWQLLerPWKAFFNLSAIVLFLFI 732
Cdd:pfam07690 144 LASLFGWRAAFLILAILSLLAAVLLLlprppPESKRPKPAEEARLSLIVAWKALLRDPVLW--LLLALLLFGFAFFGLLT 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541  733 cgLLPWIDNIAHIFGFLSGMLLAFAFLPYITFG-----TSDKYRKRALILVSLLVFAGLFASLVLWLYIYPINWPWIEYL 807
Cdd:pfam07690 222 --YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRlllgrLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299


                  ..
gi 264681541  808 TC 809
Cdd:pfam07690 300 LL 301
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 720-810 2.39e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.14  E-value: 2.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 720 FFNLSAIVLFLFICGLLpwidnIAHIFG--FLSGMLLAFAFLPYITFGT-----SDKYRKRALILVSLLVFAGLFASLVL 792
Cdd:cd06173    9 LLSALGDWIFTVALPWL-----VLQLTGsaLLVGLVLAAFFLPFLLFSPfagvlADRFDRRRLLILADLLRALLAAVLAL 83

                         90
                 ....*....|....*...
gi 264681541 793 WLYIYPINWPWIeYLTCF 810
Cdd:cd06173   84 LALLGSLSLWLL-LVLAF 100
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
665-810 3.04e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.12  E-value: 3.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 665 SIIFILSGITGNLASAIFLPYRAEVGPAGSQ--------FGLLACLFV------------------ELFQSWQLLERPwK 718
Cdd:COG2211  150 SWRFAFAGLGGLLASVLPPPLVAAFGGDAALgyrltaliFAVLGLLAFlltffgtkerpvpeeekvSLKESLKALLKN-R 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 719 AFFNLSAIVLFLFICGLLPW----------IDNIAHIFGFLSGMLLAFAFLPYITFGT-SDKYRKRALILVSLLVFAGLF 787
Cdd:COG2211  229 PFLLLLLAYLLFFLALALVAalllyyfkyvLGLSAALVGLLLALYFLAALLGAPLWPRlAKRFGKKKAFIIGLLLAALGL 308

                        170       180
                 ....*....|....*....|...
gi 264681541 788 aslvLWLYIYPINWPWIEYLTCF 810
Cdd:COG2211  309 ----LLLFFLGPGNLWLLLVLAA 327
GtrA pfam04138
GtrA-like protein; Members of this family are predicted to be integral membrane proteins with ...
 719-804 4.01e-04

GtrA-like protein; Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.


Pssm-ID: 427738  Cd Length: 116  Bit Score: 40.61  E-value: 4.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541  719 AFFNLSAIVLFLFICGLLPWIdniAHIFGFLSGMLLAFAFLPYITFGTSDKYRKRALILVSLLVFAGLFAS-LVLWLYIY 797
Cdd:pfam04138  10 TLVDLAVFLLLLELFGLSYLL---ANAIAFVVAILVNFLLNRRWTFRDRRSGSLRELLRFFLVSLAGLLLNlLLLWLLVD 86


                  ....*..
gi 264681541  798 PINWPWI 804
Cdd:pfam04138  87 GLGLPPL 93
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 658-792 1.90e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.41  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 658 LAGWHRISIIFILSGITGNLASAI---FLPYRAEVGPAGSQfgllacLFVELFQSWQLLERPWKAFFNLSAIVLFLFICG 734
Cdd:cd17325  143 LADALGYRAPFLVCAALALLALVLallLLPEPRPPPNKRAV------SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFG 216

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 264681541 735 ----LLP--WIDNI----AHIFGFLSGMLLAFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVL 792
Cdd:cd17325  217 alepFLPlyAAELGglspAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 745-804 6.55e-03

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 36.32  E-value: 6.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 264681541 745 IFGFLSGMLLAFAFLP-----YITFGTSDkyrkralilVSLLVFAGLFASLVLWLyIYPI---NWPWI 804
Cdd:COG4095    5 IIGLLAGILTTISFLPqviktWKTKSTKD---------ISLGMYLIFTTGVALWL-IYGIligDLPII 62
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
715-794 7.61e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.57  E-value: 7.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681541 715 RPWKAFFNLSAIVLFLFICG--LLPWIDNIAHIFG---FLSGMLLAFAFLPYITFGT-----SDKYRKRALILVSLLVFA 784
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIgiVLPALPLIAADLGaspAQAGLVVTAYLLGAALGAPlagrlADRFGRRRVLLLGLLLFA 86

                         90
                 ....*....|
gi 264681541 785 glFASLVLWL 794
Cdd:COG2814   87 --LGSLLCAL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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