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Conserved domains on  [gi|27437049|ref|NP_757373|]
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granulocyte colony-stimulating factor isoform b precursor [Homo sapiens]

Protein Classification

GCSF domain-containing protein( domain architecture ID 11244616)

GCSF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GCSF pfam16647
Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte ...
 51-199 3.56e-95

Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte colony-stimulating factor proteins. Granulocyte colony-stimulating factors are cytokines that are involved in haematopoeisis. They control the production, differentiation and function of white blood cell granulocytes. GCSF binds to the extracellular Ig-like and CRH domain of its receptor GCSFR, thereby triggering the receptor to homodimerize. Homodimerization result in activation of Janus tyrosine kinase-signal transducers and other activators of transcription (JAK-STAT)-type signalling cascades.


:

Pssm-ID: 406939  Cd Length: 149  Bit Score: 273.80  E-value: 3.56e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437049    51 VRKIQGDGAALQEKLCATYKLCHPEELVLLGHSLGIPWAPLSSCPSQALQLAGCLSQLHSGLFLYQGLLQALEGISPELG 130
Cdd:pfam16647   1 VRKIQADGAVLQEQLCATYKLCHPEELVLLGHSLGIPKAPLSSCSSQALQLTGCLSQLHSGLFLYQGLLQALSGISPELA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27437049   131 PTLDTLQLDVADFATTIWQQMEELGMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLR 199
Cdd:pfam16647  81 PTLDTLQLDVADFATTIWQQMENLGVAPAVQPTQGAMPAFTSAFQRRAGGVLVASYLQGFLETAYRALR 149
 
Name Accession Description Interval E-value
GCSF pfam16647
Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte ...
 51-199 3.56e-95

Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte colony-stimulating factor proteins. Granulocyte colony-stimulating factors are cytokines that are involved in haematopoeisis. They control the production, differentiation and function of white blood cell granulocytes. GCSF binds to the extracellular Ig-like and CRH domain of its receptor GCSFR, thereby triggering the receptor to homodimerize. Homodimerization result in activation of Janus tyrosine kinase-signal transducers and other activators of transcription (JAK-STAT)-type signalling cascades.


Pssm-ID: 406939  Cd Length: 149  Bit Score: 273.80  E-value: 3.56e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437049    51 VRKIQGDGAALQEKLCATYKLCHPEELVLLGHSLGIPWAPLSSCPSQALQLAGCLSQLHSGLFLYQGLLQALEGISPELG 130
Cdd:pfam16647   1 VRKIQADGAVLQEQLCATYKLCHPEELVLLGHSLGIPKAPLSSCSSQALQLTGCLSQLHSGLFLYQGLLQALSGISPELA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27437049   131 PTLDTLQLDVADFATTIWQQMEELGMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLR 199
Cdd:pfam16647  81 PTLDTLQLDVADFATTIWQQMENLGVAPAVQPTQGAMPAFTSAFQRRAGGVLVASYLQGFLETAYRALR 149
IL6 smart00126
Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and ...
 51-199 2.38e-50

Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and myelomonocytic growth factor (MGF). IL-6 is also known as B-cell stimulatory factor 2.


Pssm-ID: 128431  Cd Length: 154  Bit Score: 160.25  E-value: 2.38e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437049     51 VRKIQGDGAALQEKLCATYKLCHPEELVLLGHSLGIPWA-PLSSCPSQALQLAGCLSQLHSGLFLYQGLLQALEGISPEL 129
Cdd:smart00126   1 IRKILWDIAELRKELCNRFSLCENSEEALAENNLKLPKMnEKDGCFQSGFNQEICLVKITAGLLEYQVYLEYLQNEFPEN 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27437049    130 GPTLDTLQLDVADFATTIWQQMEELGM--APALQPTQGAMPAFASAFQ--RRAGGVLVASHLQSFLEVSYRVLR 199
Cdd:smart00126  81 KENVDTLQLDTKTLIQIIQQEMKDLGKitYPTPTANRGLLPKLQSQNQwvRNATGFLILSSLERFLQFALRALR 154
 
Name Accession Description Interval E-value
GCSF pfam16647
Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte ...
 51-199 3.56e-95

Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte colony-stimulating factor proteins. Granulocyte colony-stimulating factors are cytokines that are involved in haematopoeisis. They control the production, differentiation and function of white blood cell granulocytes. GCSF binds to the extracellular Ig-like and CRH domain of its receptor GCSFR, thereby triggering the receptor to homodimerize. Homodimerization result in activation of Janus tyrosine kinase-signal transducers and other activators of transcription (JAK-STAT)-type signalling cascades.


Pssm-ID: 406939  Cd Length: 149  Bit Score: 273.80  E-value: 3.56e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437049    51 VRKIQGDGAALQEKLCATYKLCHPEELVLLGHSLGIPWAPLSSCPSQALQLAGCLSQLHSGLFLYQGLLQALEGISPELG 130
Cdd:pfam16647   1 VRKIQADGAVLQEQLCATYKLCHPEELVLLGHSLGIPKAPLSSCSSQALQLTGCLSQLHSGLFLYQGLLQALSGISPELA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27437049   131 PTLDTLQLDVADFATTIWQQMEELGMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLR 199
Cdd:pfam16647  81 PTLDTLQLDVADFATTIWQQMENLGVAPAVQPTQGAMPAFTSAFQRRAGGVLVASYLQGFLETAYRALR 149
IL6 smart00126
Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and ...
 51-199 2.38e-50

Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and myelomonocytic growth factor (MGF). IL-6 is also known as B-cell stimulatory factor 2.


Pssm-ID: 128431  Cd Length: 154  Bit Score: 160.25  E-value: 2.38e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437049     51 VRKIQGDGAALQEKLCATYKLCHPEELVLLGHSLGIPWA-PLSSCPSQALQLAGCLSQLHSGLFLYQGLLQALEGISPEL 129
Cdd:smart00126   1 IRKILWDIAELRKELCNRFSLCENSEEALAENNLKLPKMnEKDGCFQSGFNQEICLVKITAGLLEYQVYLEYLQNEFPEN 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27437049    130 GPTLDTLQLDVADFATTIWQQMEELGM--APALQPTQGAMPAFASAFQ--RRAGGVLVASHLQSFLEVSYRVLR 199
Cdd:smart00126  81 KENVDTLQLDTKTLIQIIQQEMKDLGKitYPTPTANRGLLPKLQSQNQwvRNATGFLILSSLERFLQFALRALR 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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