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Conserved domains on  [gi|1677703379|ref|NP_757349|]
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macrophage colony-stimulating factor 1 isoform b precursor [Homo sapiens]

Protein Classification

CSF-1 and PRK14959 domain-containing protein( domain architecture ID 10526391)

protein containing domains CSF-1, PRK14959, and PHA03247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CSF-1 pfam05337
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 41-180 5.49e-104

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


:

Pssm-ID: 398810  Cd Length: 140  Bit Score: 304.67  E-value: 5.49e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379  41 HMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLK 120
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379 121 SCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSS 180
Cdd:pfam05337  81 SCFTKDYEEQDKACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNNSFAKCSS 140
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 202-351 9.14e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 9.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379  202 PASVSPHQPLAPSMAPVAGLTwedsegteGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGGSPQPR 281
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRLA--------RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379  282 PsvgafnpgmedilDSAMGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLP 351
Cdd:PHA03247  2939 P-------------QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
 
Name Accession Description Interval E-value
CSF-1 pfam05337
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 41-180 5.49e-104

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


Pssm-ID: 398810  Cd Length: 140  Bit Score: 304.67  E-value: 5.49e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379  41 HMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLK 120
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379 121 SCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSS 180
Cdd:pfam05337  81 SCFTKDYEEQDKACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNNSFAKCSS 140
PHA03247 PHA03247
large tegument protein UL36; Provisional
 202-351 9.14e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 9.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379  202 PASVSPHQPLAPSMAPVAGLTwedsegteGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGGSPQPR 281
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRLA--------RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379  282 PsvgafnpgmedilDSAMGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLP 351
Cdd:PHA03247  2939 P-------------QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
 
Name Accession Description Interval E-value
CSF-1 pfam05337
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 41-180 5.49e-104

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


Pssm-ID: 398810  Cd Length: 140  Bit Score: 304.67  E-value: 5.49e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379  41 HMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLK 120
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379 121 SCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSS 180
Cdd:pfam05337  81 SCFTKDYEEQDKACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNNSFAKCSS 140
PHA03247 PHA03247
large tegument protein UL36; Provisional
 202-351 9.14e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 9.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379  202 PASVSPHQPLAPSMAPVAGLTwedsegteGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGGSPQPR 281
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRLA--------RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677703379  282 PsvgafnpgmedilDSAMGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLP 351
Cdd:PHA03247  2939 P-------------QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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