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Concise Results
Standard Results
Full Results
Insulin-degrading enzyme [Caenorhabditis elegans]
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
75-994
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 764.40
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 75 I V K GAQ D A R E YR GLE L T NG IR VLLVSDP TT DKSAAAL D V K VG HLM DP WELP GLAHF C EHMLFLGT A KYP SEN EY SK F LAA 154
Cdd:COG1025 35 I I K SPN D P R Q YR AIT L D NG LK VLLVSDP QA DKSAAAL A V P VG SFD DP DDQQ GLAHF L EHMLFLGT K KYP EPG EY QE F ISK 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 155 H A GS S NA Y T SSDH TNY H F D V KP D Q L PG ALDRF VQ FF LS P Q F TESATE RE VC AV DS E HSNNLNN D LW R FL QV DRSRSK P G H 234
Cdd:COG1025 115 H G GS H NA S T ATER TNY Y F E V EN D A L EE ALDRF AD FF AA P L F DPEYVD RE RN AV NA E YTLKRSD D GR R IY QV HKETLN P A H 194
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 235 DYGK F GT GN KQ TL led AR K K G IEP RD A LL Q F HKKW YS SDI M TCCIVGKEP L NV LE S y L GTLE F D AI E N KKVERKVWEEFP 314
Cdd:COG1025 195 PFSR F SV GN LE TL --- SD K P G SKL RD E LL A F YQRY YS ANL M KLVLYSNQS L DE LE K - L ARQT F G AI P N RNLSVPPITVPL 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 315 Y G P D QL AKR I DV VP I K DT R LVSIS FP F P DLNGEFL S Q P GH YIS H L I G H EG P GSLL SE LK RL G WVS SL QSDSHTQAAG FG V 394
Cdd:COG1025 271 Y T P E QL GII I HI VP L K PR R QLRLE FP I P NNQAYYR S K P LT YIS Y L L G N EG E GSLL DW LK KQ G LAE SL SAGGGISGRN FG D 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 395 YNVTMD L STE GL E H V DEII QLM F N YI GMLQSA G PKQ W VH DE L A E L SAVK FRF KD K EQ PM TMAINVAASLQYI P F E HI L SS 474
Cdd:COG1025 351 FSISVS L TDK GL A H R DEII AAV F A YI ELIRQQ G IQE W YF DE Q A Q L LELA FRF QE K TR PM DYVSWLSDNMLRY P V E DV L DA 430
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 475 R YL LTKYE P ER I KEL L SM L S P A N MQVRVV S Q kfk GQEGNTNEPV Y G T EMK V TD I SP E TMK K YEN A LKTS hh AL H LPE K N E 554
Cdd:COG1025 431 D YL MDGFD P AA I RAR L AQ L T P E N ARIWLI S P --- DVPTDKTAYW Y D T PYS V DP I TQ E QLA K WQQ A SQNP -- AL S LPE L N P 505
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 555 YI ATN F DQKPRES v KNEH P R L IS D DGWS R V W FKQ D DEYNM PK QETK L A L TT P MVAQNP R MSL L SS L WLWC L S D T L A E ET Y 634
Cdd:COG1025 506 YI PDD F SLIKLDK - ESAK P E L LV D EPGL R L W YMP D QYFAE PK ADIY L S L RN P QAVDSA R NQV L TR L LDYL L N D A L N E LS Y 584
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 635 N A DL AGL KCQ L ESSPF G VQMRVY G YDE KQ ALFAKH L ANRMTN F KIDKT RF DVLFES L K R A L T N HAFSQ PY - L L TQHYNQ L 713
Cdd:COG1025 585 Q A SV AGL SYS L YAHQG G LTLSAS G FTQ KQ PKLLEA L LDQLAS F EPTEE RF AQAKSQ L L R Q L D N AEKAK PY s Q L FSPLSR L 664
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 714 L IVDK v WSK E Q LLA VCD S V TL E D VQG F AKEM LQ AF H M E LF V H GN ST E KE A I QL SKE L MDV L KSAAPNSR P lyrnehn P R R 793
Cdd:COG1025 665 L QPPY - FER E E LLA ALE S I TL Q D LRA F REQL LQ QL H L E ML V V GN LS E EQ A K QL ADS L KKQ L APNGTGEE P ------- R R Q 736
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 794 ELQ L NNGDEYVYRHLQKTH D VGCVEV t YQ I G VQNTYDN A VVG L ID Q L I REPA FN T LRT N E A LGY I V WT G S r LNC G TVA - L 872
Cdd:COG1025 737 VVD L DKSGSLNLEKACDHT D SALLIY - YQ S G YDSLASM A LSS L LG Q I I SPWF FN Q LRT E E Q LGY V V GA G Y - MPL G RQP g L 814
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 873 NVI VQ G P - K S VDHV LERI EV FL ESVRKEIAEMPQ EEF DNQVS G M I AR L E E KPKT LS SRFR R F W NE I ECRQYN F AR RE EEV 951
Cdd:COG1025 815 GFY VQ S P v A S PAYL LERI DD FL KQFEERLLALSE EEF AQYKQ G L I NQ L L E PDQN LS EEAQ R L W VD I GNGDFE F DT RE KLI 894
890 900 910 920
....*....|....*....|....*....|....*....|...
gi 25146566 952 A LL K TIKKD D VLEL F DKKIRKDAAE R rk L AVFVH G KNEDQEAV 994
Cdd:COG1025 895 A AV K KLTRA D LIDF F QQAVIAPQGL R -- L LSQSQ G TKHSKADE 935
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
75-994
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 764.40
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 75 I V K GAQ D A R E YR GLE L T NG IR VLLVSDP TT DKSAAAL D V K VG HLM DP WELP GLAHF C EHMLFLGT A KYP SEN EY SK F LAA 154
Cdd:COG1025 35 I I K SPN D P R Q YR AIT L D NG LK VLLVSDP QA DKSAAAL A V P VG SFD DP DDQQ GLAHF L EHMLFLGT K KYP EPG EY QE F ISK 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 155 H A GS S NA Y T SSDH TNY H F D V KP D Q L PG ALDRF VQ FF LS P Q F TESATE RE VC AV DS E HSNNLNN D LW R FL QV DRSRSK P G H 234
Cdd:COG1025 115 H G GS H NA S T ATER TNY Y F E V EN D A L EE ALDRF AD FF AA P L F DPEYVD RE RN AV NA E YTLKRSD D GR R IY QV HKETLN P A H 194
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 235 DYGK F GT GN KQ TL led AR K K G IEP RD A LL Q F HKKW YS SDI M TCCIVGKEP L NV LE S y L GTLE F D AI E N KKVERKVWEEFP 314
Cdd:COG1025 195 PFSR F SV GN LE TL --- SD K P G SKL RD E LL A F YQRY YS ANL M KLVLYSNQS L DE LE K - L ARQT F G AI P N RNLSVPPITVPL 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 315 Y G P D QL AKR I DV VP I K DT R LVSIS FP F P DLNGEFL S Q P GH YIS H L I G H EG P GSLL SE LK RL G WVS SL QSDSHTQAAG FG V 394
Cdd:COG1025 271 Y T P E QL GII I HI VP L K PR R QLRLE FP I P NNQAYYR S K P LT YIS Y L L G N EG E GSLL DW LK KQ G LAE SL SAGGGISGRN FG D 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 395 YNVTMD L STE GL E H V DEII QLM F N YI GMLQSA G PKQ W VH DE L A E L SAVK FRF KD K EQ PM TMAINVAASLQYI P F E HI L SS 474
Cdd:COG1025 351 FSISVS L TDK GL A H R DEII AAV F A YI ELIRQQ G IQE W YF DE Q A Q L LELA FRF QE K TR PM DYVSWLSDNMLRY P V E DV L DA 430
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 475 R YL LTKYE P ER I KEL L SM L S P A N MQVRVV S Q kfk GQEGNTNEPV Y G T EMK V TD I SP E TMK K YEN A LKTS hh AL H LPE K N E 554
Cdd:COG1025 431 D YL MDGFD P AA I RAR L AQ L T P E N ARIWLI S P --- DVPTDKTAYW Y D T PYS V DP I TQ E QLA K WQQ A SQNP -- AL S LPE L N P 505
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 555 YI ATN F DQKPRES v KNEH P R L IS D DGWS R V W FKQ D DEYNM PK QETK L A L TT P MVAQNP R MSL L SS L WLWC L S D T L A E ET Y 634
Cdd:COG1025 506 YI PDD F SLIKLDK - ESAK P E L LV D EPGL R L W YMP D QYFAE PK ADIY L S L RN P QAVDSA R NQV L TR L LDYL L N D A L N E LS Y 584
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 635 N A DL AGL KCQ L ESSPF G VQMRVY G YDE KQ ALFAKH L ANRMTN F KIDKT RF DVLFES L K R A L T N HAFSQ PY - L L TQHYNQ L 713
Cdd:COG1025 585 Q A SV AGL SYS L YAHQG G LTLSAS G FTQ KQ PKLLEA L LDQLAS F EPTEE RF AQAKSQ L L R Q L D N AEKAK PY s Q L FSPLSR L 664
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 714 L IVDK v WSK E Q LLA VCD S V TL E D VQG F AKEM LQ AF H M E LF V H GN ST E KE A I QL SKE L MDV L KSAAPNSR P lyrnehn P R R 793
Cdd:COG1025 665 L QPPY - FER E E LLA ALE S I TL Q D LRA F REQL LQ QL H L E ML V V GN LS E EQ A K QL ADS L KKQ L APNGTGEE P ------- R R Q 736
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 794 ELQ L NNGDEYVYRHLQKTH D VGCVEV t YQ I G VQNTYDN A VVG L ID Q L I REPA FN T LRT N E A LGY I V WT G S r LNC G TVA - L 872
Cdd:COG1025 737 VVD L DKSGSLNLEKACDHT D SALLIY - YQ S G YDSLASM A LSS L LG Q I I SPWF FN Q LRT E E Q LGY V V GA G Y - MPL G RQP g L 814
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 873 NVI VQ G P - K S VDHV LERI EV FL ESVRKEIAEMPQ EEF DNQVS G M I AR L E E KPKT LS SRFR R F W NE I ECRQYN F AR RE EEV 951
Cdd:COG1025 815 GFY VQ S P v A S PAYL LERI DD FL KQFEERLLALSE EEF AQYKQ G L I NQ L L E PDQN LS EEAQ R L W VD I GNGDFE F DT RE KLI 894
890 900 910 920
....*....|....*....|....*....|....*....|...
gi 25146566 952 A LL K TIKKD D VLEL F DKKIRKDAAE R rk L AVFVH G KNEDQEAV 994
Cdd:COG1025 895 A AV K KLTRA D LIDF F QQAVIAPQGL R -- L LSQSQ G TKHSKADE 935
PRK15101
PRK15101 protease3; Provisional
75-972
7.33e-106
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 353.51
E-value: 7.33e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 75 I V K GAQ D A R E Y RGLE L T NG IR VLLVSDP TTD KS A AAL DVK VG H L M DP WELP GLAH FC EHM LFL G TA KYP SENEYSK FL AA 154
Cdd:PRK15101 34 I R K SEK D P R Q Y QAIR L D NG MT VLLVSDP QAV KS L AAL ALP VG S L E DP DAQQ GLAH YL EHM VLM G SK KYP QPDSLAE FL KK 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 155 H A GS S NA Y T S S DH T NYHFD V KP D Q LP G A L DR FVQFFLS P QFTESATE RE VC AV DS E HSNNLNN D LW R FL QV DRSRSK P G H 234
Cdd:PRK15101 114 H G GS H NA S T A S YR T AFYLE V EN D A LP P A V DR LADAIAE P LLDPKNAD RE RN AV NA E LTMARSR D GM R MA QV SAETIN P A H 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 235 DYGK F GT GN KQ TL LE dar K K G IEPR DAL LQ F HKKW YS SDI M TCC I VGKE PL NV L ES y L GTLE F DAIE NK KVERKVWEEFP 314
Cdd:PRK15101 194 PGSR F SG GN LE TL SD --- K P G SKLQ DAL VD F YQRY YS ANL M KAV I YSNQ PL PE L AK - L AADT F GRVP NK NASVPEITVPV 269
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 315 YGPD Q LAKR I DV VP IKDTRLVSIS F PFPDLNGE F L S QPGH YIS H LIG HEG PG S L LSE L KRL G WVSSLQSDSHTQAAG - F G 393
Cdd:PRK15101 270 VTDA Q KGII I HY VP AQPRKVLRVE F RIDNNSAK F R S KTDE YIS Y LIG NRS PG T L SDW L QKQ G LAEGISAGADPMVDR n S G 349
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 394 V YNVTMD L STE GL EHV D EIIQLM F N Y IGM L QSA G PKQWVH DELA ELSAVK FR FKDKEQP M TMAINV A ASLQYI P F EH I L S 473
Cdd:PRK15101 350 V FAISVS L TDK GL AQR D QVVAAI F S Y LNL L REK G IDKSYF DELA HVLDLD FR YPSITRD M DYIEWL A DTMLRV P V EH T L D 429
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 474 SR Y LLTK Y E P ER IK EL L SMLS P A N MQVRVV S QKFK gqegn T N EPV Y GTEM -- K V TD IS PE T MKKY ena LKTSHH - AL H LP 550
Cdd:PRK15101 430 AP Y IADR Y D P KA IK AR L AEMT P Q N ARIWYI S PQEP ----- H N KTA Y FVDA py Q V DK IS EQ T FADW --- QQKAQN i AL S LP 501
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 551 E K N E YI ATN F DQ - K PRESV K ne HP R LI S D DGWS RV WFKQDDEY - NM PK QETK L A L TT P MVAQNP R MSL L SS L WLWCLSDT 628
Cdd:PRK15101 502 E L N P YI PDD F SL i K ADKAY K -- HP E LI V D EPGL RV VYMPSQYF a DE PK ADIS L V L RN P KAMDSA R NQV L FA L NDYLAGLA 579
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 629 L AEETYN A DLA G LKCQL e SSPF G VQMRVY GY DEKQALFAKH L ANRMTN F KID ------- K TRF dvl F E S L KR A LTNH A FS 701
Cdd:PRK15101 580 L DQLSNQ A SVG G ISFST - NANN G LMVNAN GY TQRLPQLLQA L LEGYFS F TPT eeqlaqa K SWY --- R E Q L DS A EKGK A YE 655
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 702 Q PYLLT Q HYN Q L livd KVWSKEQLLAVCD S V TL E DV QGFAKEM L QAFHM E LF V H GN S TE KEAIQ L SKELMDV L KS aap NS 781
Cdd:PRK15101 656 Q AIMPA Q MLS Q V ---- PYFERDERRKLLP S I TL K DV LAYRDAL L SGATP E FL V V GN L TE EQVTT L ARDVQKQ L GA --- DG 728
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 782 RPLY R NEHNPRREL Q LN N gdeyvyrh LQ K T -- HDVGCVEVT Y qig V QNT YD N ---- A VVG L ID Q L I REPAF N T LRT N E A L 855
Cdd:PRK15101 729 TEWW R GKDVVVDKK Q SV N -------- FE K A gs STDSALAAV Y --- V PTG YD E yqss A YSS L LG Q I I QPWFY N Q LRT E E Q L 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 856 GY I V WT g SRLNC G - TVALNVIV Q GP - K SVDHVLE R IEV F LESVRKEIAE M PQ EEF DNQVSGM I AR L EEK P K TL SSRFR R F 933
Cdd:PRK15101 798 GY A V FA - FPMSV G r QWGMGFLL Q SN d K QPAYLWQ R YQA F FPQAEAKLRA M KP EEF AQYQQAL I NQ L LQA P Q TL GEEAS R L 876
890 900 910
....*....|....*....|....*....|....*....
gi 25146566 934 WNEIECRQYN F AR R EEEV A LL K TIKKDDVLEL F DKKIRK 972
Cdd:PRK15101 877 SKDFDRGNMR F DS R DKII A QI K LLTPQKLADF F HQAVIE 915
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
444-728
5.68e-88
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 284.08
E-value: 5.68e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 444 FRF KD K EQ P MTMAINV A ASL Q YI P F E H ILS SR YLL TK Y E PE R I K ELL SM L S P A N MQVRV VS QK F K G q E GNTN EP V YGTE M 523
Cdd:pfam16187 1 FRF QE K SP P SDYVSSL A SNM Q PY P P E D ILS GD YLL RE Y D PE L I Q ELL DY L T P E N ARITL VS KE F E G - E TDQK EP W YGTE Y 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 524 K V TD I SP E TM KK YE NA LKT s HHA LHLPE K N EY I A T N FD Q K PR E SVK - NEH P R LI S D DGW SR V W F K Q DD EYNM PK QETK L A 602
Cdd:pfam16187 80 S V EP I PE E LL KK WK NA PEP - NPE LHLPE P N PF I P T D FD L K KK E VKE p AKY P V LI R D TPL SR L W Y K K DD TFWV PK ANIY L S 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 603 L TT P MVAQN PR MSL L SS L WLWC L S D T L A E ET Y N A D LAGL KCQ L ESSPF G VQMR V Y GY DE K QALFAKHLANRMTN F K ID KT 682
Cdd:pfam16187 159 L RS P LAYSS PR NAV L TR L YVEL L K D S L N E YA Y D A E LAGL SYS L SATER G LTLS V S GY ND K LPVLLEKILEKLRD F E ID PD 238
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 25146566 683 RF DVLF E S L K R ALT N H A FS QPY LLTQH Y NQL L IVDKV W SK E QL L AV 728
Cdd:pfam16187 239 RF EIIK E Q L L R SYK N F A LE QPY QQAFD Y LLY L LEERS W TP E EK L EA 284
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
86-472
1.51e-30
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 129.22
E-value: 1.51e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 86 R GLE L T NG I RV L L VSD P TTDKS AA A L D V KV G HLMD P WEL PGLAHF C EH M LFLG TAKYPSENEYSKFLAAHA G SS NA Y T SS 165
Cdd:TIGR02110 1 R RIT L P NG L RV H L YHQ P DAKRA AA L L R V AA G SHDE P SAW PGLAHF L EH L LFLG GERFQGDDRLMPWVQRQG G QV NA T T LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 166 DH T NYH F DVKPDQ L PGA L D R FVQFFLS P QF T ESATE RE VCAVDS E HS nnlnnd L W R fl QVDRSRSK -------- P GH DYG 237
Cdd:TIGR02110 81 RT T AFF F ELPAAA L AAG L A R LCDMLAR P LL T AEDQQ RE REVLEA E YI ------ A W Q -- NDADTLRE aalldalq A GH PLR 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 238 K F GT G NKQT L LEDAR kkgi EPRD AL LQ FH KKW Y SSDI M TCCIV G KEP L NV LE SYLGTLEFDAIENKKVERKVWEEF - PYG 316
Cdd:TIGR02110 153 R F HA G SRDS L ALPNT ---- AFQQ AL RD FH RRH Y QAGN M QLWLQ G PQS L DE LE QLAARFGASLAAGGECAQAPPAPL l RFD 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 317 PDQ LA KRI dvvpik DT RL V s IS F PFPD L NGE f LSQPGHYISHLIGH E G PG S LL SE L KRL G WVS S LQSDSHT Q A AG FGVYN 396
Cdd:TIGR02110 229 RLT LA GGS ------ EP RL W - LL F ALAG L PAT - ARDNVTLLCEFLQD E A PG G LL AQ L RER G LAE S VAATWLY Q D AG QALLA 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 397 VTMDLSTEGLEHVDE I I QL MFNYI G M L QS - AGPK Q WV H -------------- DE LA E L SAVKFR F KDKEQPMTMAINVA A 461
Cdd:TIGR02110 301 LEFSARCISAAAAQQ I E QL LTQWL G A L AE q TWAE Q LE H yaqlaqrrfqtlal SP LA Q L RGRALG F ALGCALPDALTDFL A 380
410
....*....|.
gi 25146566 462 S LQ YI P FEHI L 472
Cdd:TIGR02110 381 A LQ DC P RTRL L 391
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
75-994
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 764.40
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 75 I V K GAQ D A R E YR GLE L T NG IR VLLVSDP TT DKSAAAL D V K VG HLM DP WELP GLAHF C EHMLFLGT A KYP SEN EY SK F LAA 154
Cdd:COG1025 35 I I K SPN D P R Q YR AIT L D NG LK VLLVSDP QA DKSAAAL A V P VG SFD DP DDQQ GLAHF L EHMLFLGT K KYP EPG EY QE F ISK 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 155 H A GS S NA Y T SSDH TNY H F D V KP D Q L PG ALDRF VQ FF LS P Q F TESATE RE VC AV DS E HSNNLNN D LW R FL QV DRSRSK P G H 234
Cdd:COG1025 115 H G GS H NA S T ATER TNY Y F E V EN D A L EE ALDRF AD FF AA P L F DPEYVD RE RN AV NA E YTLKRSD D GR R IY QV HKETLN P A H 194
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 235 DYGK F GT GN KQ TL led AR K K G IEP RD A LL Q F HKKW YS SDI M TCCIVGKEP L NV LE S y L GTLE F D AI E N KKVERKVWEEFP 314
Cdd:COG1025 195 PFSR F SV GN LE TL --- SD K P G SKL RD E LL A F YQRY YS ANL M KLVLYSNQS L DE LE K - L ARQT F G AI P N RNLSVPPITVPL 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 315 Y G P D QL AKR I DV VP I K DT R LVSIS FP F P DLNGEFL S Q P GH YIS H L I G H EG P GSLL SE LK RL G WVS SL QSDSHTQAAG FG V 394
Cdd:COG1025 271 Y T P E QL GII I HI VP L K PR R QLRLE FP I P NNQAYYR S K P LT YIS Y L L G N EG E GSLL DW LK KQ G LAE SL SAGGGISGRN FG D 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 395 YNVTMD L STE GL E H V DEII QLM F N YI GMLQSA G PKQ W VH DE L A E L SAVK FRF KD K EQ PM TMAINVAASLQYI P F E HI L SS 474
Cdd:COG1025 351 FSISVS L TDK GL A H R DEII AAV F A YI ELIRQQ G IQE W YF DE Q A Q L LELA FRF QE K TR PM DYVSWLSDNMLRY P V E DV L DA 430
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 475 R YL LTKYE P ER I KEL L SM L S P A N MQVRVV S Q kfk GQEGNTNEPV Y G T EMK V TD I SP E TMK K YEN A LKTS hh AL H LPE K N E 554
Cdd:COG1025 431 D YL MDGFD P AA I RAR L AQ L T P E N ARIWLI S P --- DVPTDKTAYW Y D T PYS V DP I TQ E QLA K WQQ A SQNP -- AL S LPE L N P 505
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 555 YI ATN F DQKPRES v KNEH P R L IS D DGWS R V W FKQ D DEYNM PK QETK L A L TT P MVAQNP R MSL L SS L WLWC L S D T L A E ET Y 634
Cdd:COG1025 506 YI PDD F SLIKLDK - ESAK P E L LV D EPGL R L W YMP D QYFAE PK ADIY L S L RN P QAVDSA R NQV L TR L LDYL L N D A L N E LS Y 584
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 635 N A DL AGL KCQ L ESSPF G VQMRVY G YDE KQ ALFAKH L ANRMTN F KIDKT RF DVLFES L K R A L T N HAFSQ PY - L L TQHYNQ L 713
Cdd:COG1025 585 Q A SV AGL SYS L YAHQG G LTLSAS G FTQ KQ PKLLEA L LDQLAS F EPTEE RF AQAKSQ L L R Q L D N AEKAK PY s Q L FSPLSR L 664
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 714 L IVDK v WSK E Q LLA VCD S V TL E D VQG F AKEM LQ AF H M E LF V H GN ST E KE A I QL SKE L MDV L KSAAPNSR P lyrnehn P R R 793
Cdd:COG1025 665 L QPPY - FER E E LLA ALE S I TL Q D LRA F REQL LQ QL H L E ML V V GN LS E EQ A K QL ADS L KKQ L APNGTGEE P ------- R R Q 736
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 794 ELQ L NNGDEYVYRHLQKTH D VGCVEV t YQ I G VQNTYDN A VVG L ID Q L I REPA FN T LRT N E A LGY I V WT G S r LNC G TVA - L 872
Cdd:COG1025 737 VVD L DKSGSLNLEKACDHT D SALLIY - YQ S G YDSLASM A LSS L LG Q I I SPWF FN Q LRT E E Q LGY V V GA G Y - MPL G RQP g L 814
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 873 NVI VQ G P - K S VDHV LERI EV FL ESVRKEIAEMPQ EEF DNQVS G M I AR L E E KPKT LS SRFR R F W NE I ECRQYN F AR RE EEV 951
Cdd:COG1025 815 GFY VQ S P v A S PAYL LERI DD FL KQFEERLLALSE EEF AQYKQ G L I NQ L L E PDQN LS EEAQ R L W VD I GNGDFE F DT RE KLI 894
890 900 910 920
....*....|....*....|....*....|....*....|...
gi 25146566 952 A LL K TIKKD D VLEL F DKKIRKDAAE R rk L AVFVH G KNEDQEAV 994
Cdd:COG1025 895 A AV K KLTRA D LIDF F QQAVIAPQGL R -- L LSQSQ G TKHSKADE 935
PRK15101
PRK15101 protease3; Provisional
75-972
7.33e-106
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 353.51
E-value: 7.33e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 75 I V K GAQ D A R E Y RGLE L T NG IR VLLVSDP TTD KS A AAL DVK VG H L M DP WELP GLAH FC EHM LFL G TA KYP SENEYSK FL AA 154
Cdd:PRK15101 34 I R K SEK D P R Q Y QAIR L D NG MT VLLVSDP QAV KS L AAL ALP VG S L E DP DAQQ GLAH YL EHM VLM G SK KYP QPDSLAE FL KK 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 155 H A GS S NA Y T S S DH T NYHFD V KP D Q LP G A L DR FVQFFLS P QFTESATE RE VC AV DS E HSNNLNN D LW R FL QV DRSRSK P G H 234
Cdd:PRK15101 114 H G GS H NA S T A S YR T AFYLE V EN D A LP P A V DR LADAIAE P LLDPKNAD RE RN AV NA E LTMARSR D GM R MA QV SAETIN P A H 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 235 DYGK F GT GN KQ TL LE dar K K G IEPR DAL LQ F HKKW YS SDI M TCC I VGKE PL NV L ES y L GTLE F DAIE NK KVERKVWEEFP 314
Cdd:PRK15101 194 PGSR F SG GN LE TL SD --- K P G SKLQ DAL VD F YQRY YS ANL M KAV I YSNQ PL PE L AK - L AADT F GRVP NK NASVPEITVPV 269
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 315 YGPD Q LAKR I DV VP IKDTRLVSIS F PFPDLNGE F L S QPGH YIS H LIG HEG PG S L LSE L KRL G WVSSLQSDSHTQAAG - F G 393
Cdd:PRK15101 270 VTDA Q KGII I HY VP AQPRKVLRVE F RIDNNSAK F R S KTDE YIS Y LIG NRS PG T L SDW L QKQ G LAEGISAGADPMVDR n S G 349
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 394 V YNVTMD L STE GL EHV D EIIQLM F N Y IGM L QSA G PKQWVH DELA ELSAVK FR FKDKEQP M TMAINV A ASLQYI P F EH I L S 473
Cdd:PRK15101 350 V FAISVS L TDK GL AQR D QVVAAI F S Y LNL L REK G IDKSYF DELA HVLDLD FR YPSITRD M DYIEWL A DTMLRV P V EH T L D 429
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 474 SR Y LLTK Y E P ER IK EL L SMLS P A N MQVRVV S QKFK gqegn T N EPV Y GTEM -- K V TD IS PE T MKKY ena LKTSHH - AL H LP 550
Cdd:PRK15101 430 AP Y IADR Y D P KA IK AR L AEMT P Q N ARIWYI S PQEP ----- H N KTA Y FVDA py Q V DK IS EQ T FADW --- QQKAQN i AL S LP 501
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 551 E K N E YI ATN F DQ - K PRESV K ne HP R LI S D DGWS RV WFKQDDEY - NM PK QETK L A L TT P MVAQNP R MSL L SS L WLWCLSDT 628
Cdd:PRK15101 502 E L N P YI PDD F SL i K ADKAY K -- HP E LI V D EPGL RV VYMPSQYF a DE PK ADIS L V L RN P KAMDSA R NQV L FA L NDYLAGLA 579
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 629 L AEETYN A DLA G LKCQL e SSPF G VQMRVY GY DEKQALFAKH L ANRMTN F KID ------- K TRF dvl F E S L KR A LTNH A FS 701
Cdd:PRK15101 580 L DQLSNQ A SVG G ISFST - NANN G LMVNAN GY TQRLPQLLQA L LEGYFS F TPT eeqlaqa K SWY --- R E Q L DS A EKGK A YE 655
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 702 Q PYLLT Q HYN Q L livd KVWSKEQLLAVCD S V TL E DV QGFAKEM L QAFHM E LF V H GN S TE KEAIQ L SKELMDV L KS aap NS 781
Cdd:PRK15101 656 Q AIMPA Q MLS Q V ---- PYFERDERRKLLP S I TL K DV LAYRDAL L SGATP E FL V V GN L TE EQVTT L ARDVQKQ L GA --- DG 728
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 782 RPLY R NEHNPRREL Q LN N gdeyvyrh LQ K T -- HDVGCVEVT Y qig V QNT YD N ---- A VVG L ID Q L I REPAF N T LRT N E A L 855
Cdd:PRK15101 729 TEWW R GKDVVVDKK Q SV N -------- FE K A gs STDSALAAV Y --- V PTG YD E yqss A YSS L LG Q I I QPWFY N Q LRT E E Q L 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 856 GY I V WT g SRLNC G - TVALNVIV Q GP - K SVDHVLE R IEV F LESVRKEIAE M PQ EEF DNQVSGM I AR L EEK P K TL SSRFR R F 933
Cdd:PRK15101 798 GY A V FA - FPMSV G r QWGMGFLL Q SN d K QPAYLWQ R YQA F FPQAEAKLRA M KP EEF AQYQQAL I NQ L LQA P Q TL GEEAS R L 876
890 900 910
....*....|....*....|....*....|....*....
gi 25146566 934 WNEIECRQYN F AR R EEEV A LL K TIKKDDVLEL F DKKIRK 972
Cdd:PRK15101 877 SKDFDRGNMR F DS R DKII A QI K LLTPQKLADF F HQAVIE 915
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
444-728
5.68e-88
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 284.08
E-value: 5.68e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 444 FRF KD K EQ P MTMAINV A ASL Q YI P F E H ILS SR YLL TK Y E PE R I K ELL SM L S P A N MQVRV VS QK F K G q E GNTN EP V YGTE M 523
Cdd:pfam16187 1 FRF QE K SP P SDYVSSL A SNM Q PY P P E D ILS GD YLL RE Y D PE L I Q ELL DY L T P E N ARITL VS KE F E G - E TDQK EP W YGTE Y 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 524 K V TD I SP E TM KK YE NA LKT s HHA LHLPE K N EY I A T N FD Q K PR E SVK - NEH P R LI S D DGW SR V W F K Q DD EYNM PK QETK L A 602
Cdd:pfam16187 80 S V EP I PE E LL KK WK NA PEP - NPE LHLPE P N PF I P T D FD L K KK E VKE p AKY P V LI R D TPL SR L W Y K K DD TFWV PK ANIY L S 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 603 L TT P MVAQN PR MSL L SS L WLWC L S D T L A E ET Y N A D LAGL KCQ L ESSPF G VQMR V Y GY DE K QALFAKHLANRMTN F K ID KT 682
Cdd:pfam16187 159 L RS P LAYSS PR NAV L TR L YVEL L K D S L N E YA Y D A E LAGL SYS L SATER G LTLS V S GY ND K LPVLLEKILEKLRD F E ID PD 238
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 25146566 683 RF DVLF E S L K R ALT N H A FS QPY LLTQH Y NQL L IVDKV W SK E QL L AV 728
Cdd:pfam16187 239 RF EIIK E Q L L R SYK N F A LE QPY QQAFD Y LLY L LEERS W TP E EK L EA 284
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
95-233
1.55e-47
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 166.33
E-value: 1.55e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 95 RV LLV SDP TT D K S AAA L DVKV G HLMD P WELP GLAHF C EHM L F L GT A KYPS e NE YSKF L AAHA GS S NA Y TS SDH T N Y HFD V 174
Cdd:pfam00675 1 RV ASE SDP PA D T S TVG L WIDA G SRYE P DNNN GLAHF L EHM A F K GT K KYPS - NE LEEE L EKLG GS L NA F TS REN T V Y YAE V 79
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 175 KP D Q LP G A L DR FVQ FF LS P Q FTES AT ER ------- EV C AVDSE HSN ---- NL NNDLW R FLQVD RS RSK PG 233
Cdd:pfam00675 80 LN D D LP K A V DR LAD FF RN P L FTES EI ER erlvvly EV E AVDSE PQL vvle NL HAAAY R NTPLG RS LLG PG 149
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
75-503
6.41e-43
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 162.40
E-value: 6.41e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 75 IVKG A Q D AR E YR gle L T NG I RV L LV S DP TTDKSAAA L D V K VG HLMD P WELP GLAHF C EHMLF L GT A K YPS e N E YSKF L A A 154
Cdd:COG0612 8 APAA A P D VE E FT --- L P NG L RV I LV P DP EAPVVSVR L W V R VG SRDE P PGKT GLAHF L EHMLF K GT K K RSA - G E IAEE L E A 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 155 HA GS S NA Y TS S D H T N Y HFD V KPDQ L PG AL DRFVQFF L S P Q F T E SAT ERE VCA V DS E HSNNLNNDLWRFLQVDRSRSKPG H 234
Cdd:COG0612 84 LG GS L NA F TS F D Y T V Y YLS V LSED L EL AL ELLADRL L N P T F D E EEL ERE RGV V LE E IRRYEDDPDGLAFEALLAALYGD H 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 235 D YG KFGT G NKQTL ledark KG I e P R DA L LQ F H K KW Y SSDIMTCCI VG ---- K E P L NVL E S Y L G T L E fdai ENKKVE R KV w 310
Cdd:COG0612 164 P YG RPII G TEESI ------ EA I - T R ED L RA F Y K RY Y RPNNAVLVV VG dvdp E E V L ALV E K Y F G D L P ---- AGPAPP R PD - 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 311 eef P YG P D Q LAK R ID VV PIK D TRL -- VSISF P F P DLNG eflsq P GH Y ISHLIGH --- E G PG S L L SELK R -- L G WVS S LQ S 383
Cdd:COG0612 232 --- P AE P P Q TGP R RV VV DDP D AEQ ah ILLGY P G P ARDD ----- P DY Y ALDVLNE ilg G G FS S R L FQEL R ek K G LAY S VG S 303
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 384 d S HTQAAGF G VYNVTMDLST egl EHVD E IIQLMFNYIGM L QSA G PKQ wvhdel A EL SAV K FRFK ----- DK E QPMTM A IN 458
Cdd:COG0612 304 - S FSPYRDA G LFTIYAGTAP --- DKLE E ALAAILEELER L AKE G VTE ------ E EL ERA K NQLL gslal SL E SNSGL A SQ 373
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 25146566 459 VAASLQ Y ipfeh ILSSR YL LTKY E ------ P E RIKELL - SM L S P A N MQ V R VV 503
Cdd:COG0612 374 LGRYEL Y ----- GGDLD YL EEYL E rieavt A E DVQAVA r KY L D P D N LV V V VV 420
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
86-472
1.51e-30
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 129.22
E-value: 1.51e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 86 R GLE L T NG I RV L L VSD P TTDKS AA A L D V KV G HLMD P WEL PGLAHF C EH M LFLG TAKYPSENEYSKFLAAHA G SS NA Y T SS 165
Cdd:TIGR02110 1 R RIT L P NG L RV H L YHQ P DAKRA AA L L R V AA G SHDE P SAW PGLAHF L EH L LFLG GERFQGDDRLMPWVQRQG G QV NA T T LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 166 DH T NYH F DVKPDQ L PGA L D R FVQFFLS P QF T ESATE RE VCAVDS E HS nnlnnd L W R fl QVDRSRSK -------- P GH DYG 237
Cdd:TIGR02110 81 RT T AFF F ELPAAA L AAG L A R LCDMLAR P LL T AEDQQ RE REVLEA E YI ------ A W Q -- NDADTLRE aalldalq A GH PLR 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 238 K F GT G NKQT L LEDAR kkgi EPRD AL LQ FH KKW Y SSDI M TCCIV G KEP L NV LE SYLGTLEFDAIENKKVERKVWEEF - PYG 316
Cdd:TIGR02110 153 R F HA G SRDS L ALPNT ---- AFQQ AL RD FH RRH Y QAGN M QLWLQ G PQS L DE LE QLAARFGASLAAGGECAQAPPAPL l RFD 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 317 PDQ LA KRI dvvpik DT RL V s IS F PFPD L NGE f LSQPGHYISHLIGH E G PG S LL SE L KRL G WVS S LQSDSHT Q A AG FGVYN 396
Cdd:TIGR02110 229 RLT LA GGS ------ EP RL W - LL F ALAG L PAT - ARDNVTLLCEFLQD E A PG G LL AQ L RER G LAE S VAATWLY Q D AG QALLA 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 397 VTMDLSTEGLEHVDE I I QL MFNYI G M L QS - AGPK Q WV H -------------- DE LA E L SAVKFR F KDKEQPMTMAINVA A 461
Cdd:TIGR02110 301 LEFSARCISAAAAQQ I E QL LTQWL G A L AE q TWAE Q LE H yaqlaqrrfqtlal SP LA Q L RGRALG F ALGCALPDALTDFL A 380
410
....*....|.
gi 25146566 462 S LQ YI P FEHI L 472
Cdd:TIGR02110 381 A LQ DC P RTRL L 391
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
259-436
9.69e-30
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 116.72
E-value: 9.69e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 259 R DA L LQ F H KK W YS S D I M TCC IVG KEP ---- L NVL E S Y L G T L EF daie NK K VE rkv WEEF P YG P DQ L AK R ID VVP I KD TRL 334
Cdd:pfam05193 4 R ED L RD F Y KK H YS P D N M VLV IVG DVD heel L DLA E K Y F G D L PA ---- SP K GK --- PRPP P LE P AK L KG R EV VVP K KD EPQ 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 335 -- VSIS FP F P D LN GEFL S QPGHYISH L I G HEGPGS L LS EL K - RL G WVS S LQ S d SHTQAAGF G VYNVTMDLST egl E H VDE 411
Cdd:pfam05193 77 ah LALA FP G P P LN NDED S LALDVLNE L L G GGMSSR L FQ EL R e KE G LAY S VS S - FNDSYSDS G LFGIYATVDP --- E N VDE 152
170 180
....*....|....*....|....*
gi 25146566 412 I I Q L MFNYIGM L QSA G PKQWVHDEL 436
Cdd:pfam05193 153 V I E L ILEELEK L AQE G VTEEELERA 177
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
731-915
6.31e-19
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 85.52
E-value: 6.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 731 S V T L ED VQG F A K EMLQAFH M E L FVH G NSTEK E AIQ L SKELMDV L KSAAPNSRP lyrneh N P RR E LQLNN G D E Y V YRHLQK 810
Cdd:pfam05193 1 S L T R ED LRD F Y K KHYSPDN M V L VIV G DVDHE E LLD L AEKYFGD L PASPKGKPR ------ P P PL E PAKLK G R E V V VPKKDE 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25146566 811 th DVGCVEVTYQI - GVQ N TY D NAVVGLIDQ L IREPA ---- F NT LR TN E A L G Y I V WTGSRLNCGTVALNVIVQG pk SVDH V 885
Cdd:pfam05193 75 -- PQAHLALAFPG p PLN N DE D SLALDVLNE L LGGGM ssrl F QE LR EK E G L A Y S V SSFNDSYSDSGLFGIYATV -- DPEN V 150
170 180 190
....*....|....*....|....*....|.
gi 25146566 886 L E R IE VF LE SVR K EIA E - MPQ EE FDNQVSGM 915
Cdd:pfam05193 151 D E V IE LI LE ELE K LAQ E g VTE EE LERAKNQL 181
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
