|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
90-543 |
3.72e-90 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 285.89 E-value: 3.72e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 90 TFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTndgsvGPSAVII 169
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPR-----APQALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 170 APTKELITQIYKLFVKLSQALPfLQAINLC---DINEEENSvwLEDRSHVVVTTPGKLL-----RMCSLRpeyctLVSYL 241
Cdd:COG0513 78 APTRELALQVAEELRKLAKYLG-LRVATVYggvSIGRQIRA--LKRGVDIVVATPGRLLdlierGALDLS-----GVETL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 242 VMDEADLLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPViTIKLTEGDLPNsDQLTQYQLTCgSDE 321
Cdd:COG0513 150 VLDEADRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPV-RIEVAPENATA-ETIEQRYYLV-DKR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 322 ERFAILVAMFKlKLIVGRSILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIASDVsdadg 401
Cdd:COG0513 227 DKLELLRRLLR-DEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDV----- 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 402 sklkeeiagksdekpekdekkgkkaskldkesgVSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARGFNKGTALSFCIP 481
Cdd:COG0513 301 ---------------------------------AARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTP 347
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25148203 482 SERAHLEQIQEEINQQMGRKVLQPYEF-RIKELDTFLLRTREALSKCTKGVIKKARLKEIRQE 543
Cdd:COG0513 348 DERRLLRAIEKLIGQKIEEEELPGFEPvEEKRLERLKPKIKEKLKGKKAGRGGRPGPKGERKA 410
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
96-299 |
8.81e-65 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 211.67 E-value: 8.81e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 96 LDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSVGPSAVIIAPTKEL 175
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESGEEQGTRALILVPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 176 ITQIYKLFVKLSQAL-PFLQAINLCD-INEEENSVWLEDRSHVVVTTPGKLLRMC-SLRPEYCTLVSYLVMDEADLLLSF 252
Cdd:cd17961 81 AQQVSKVLEQLTAYCrKDVRVVNLSAsSSDSVQRALLAEKPDIVVSTPARLLSHLeSGSLLLLSTLKYLVIDEADLVLSY 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 25148203 253 GYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPVItIKL 299
Cdd:cd17961 161 GYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAI-LKL 206
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
89-538 |
6.00e-53 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 187.84 E-value: 6.00e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 89 KTFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSvgPSAVI 168
Cdd:PRK11192 1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRRKSGP--PRILI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 169 IAPTKELITQIYKlfvklsQALPFLQAINLcDI----------NEEENsvwLEDRSHVVVTTPGKLLrmcslrpEY---- 234
Cdd:PRK11192 79 LTPTRELAMQVAD------QARELAKHTHL-DIatitggvaymNHAEV---FSENQDIVVATPGRLL-------QYikee 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 235 ---CTLVSYLVMDEADLLLSFGYEEEMIKIRSKLPPTYQCLMTSATLK-DDMTTLKKLFMTGPVItiklTEGDLPNSDQ- 309
Cdd:PRK11192 142 nfdCRAVETLILDEADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPVE----VEAEPSRRERk 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 310 -LTQYQLTCGSDEERFAILVAMFKlKLIVGRSILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSY 388
Cdd:PRK11192 218 kIHQWYYRADDLEHKTALLCHLLK-QPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRV 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 389 QIVIASDVSdadgsklkeeiagksdekpekdekkgkkaskldkesgvSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTAR 468
Cdd:PRK11192 297 NVLVATDVA--------------------------------------ARGIDIDDVSHVINFDMPRSADTYLHRIGRTGR 338
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25148203 469 GFNKGTALSFCipseRAH----LEQIQEEINQQMGRKVlqpyefrIKELDTfllRTREALSKCTKGVIKKARLK 538
Cdd:PRK11192 339 AGRKGTAISLV----EAHdhllLGKIERYIEEPLKARV-------IDELRP---KTKAPSEKKTGKPSKKVLAK 398
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
100-295 |
5.04e-51 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 174.94 E-value: 5.04e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGsvGPSAVIIAPTKELITQI 179
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGR--GPQALVLAPTRELAMQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 180 YKLFVKLSQALPfLQAINLC---DINEEENSvwLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLLSFGYEE 256
Cdd:cd00268 79 AEVARKLGKGTG-LKVAAIYggaPIKKQIEA--LKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEE 155
|
170 180 190
....*....|....*....|....*....|....*....
gi 25148203 257 EMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPVI 295
Cdd:cd00268 156 DVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVR 194
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
2-502 |
5.97e-47 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 172.40 E-value: 5.97e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 2 APDEVTKKKRKSVKFAEEEPPKVKEAPKKQKAGKKievsvelrdknEEKMGRKRKHRMKKSQAEkrQKLMESLVGPQvde 81
Cdd:PRK01297 20 APPSPAAAPAPPPPAKTAAPATKAAAPAAAAPRAE-----------KPKKDKPRRERKPKPASL--WKLEDFVVEPQ--- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 82 mdfepEHKT-FADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDG 160
Cdd:PRK01297 84 -----EGKTrFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKER 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 161 SVG-PSAVIIAPTKELITQIYKLFVKLSQ--ALPFLQAINLCDINEEENSvwLEDR-SHVVVTTPGKLLRMCSLRPEYCT 236
Cdd:PRK01297 159 YMGePRALIIAPTRELVVQIAKDAAALTKytGLNVMTFVGGMDFDKQLKQ--LEARfCDILVATPGRLLDFNQRGEVHLD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 237 LVSYLVMDEADLLLSFGYEEEMIKIRSKLPPT--YQCLMTSATLKDDMTTLKKLFMTGPVITikltegdlpnsdQLTQYQ 314
Cdd:PRK01297 237 MVEVMVLDEADRMLDMGFIPQVRQIIRQTPRKeeRQTLLFSATFTDDVMNLAKQWTTDPAIV------------EIEPEN 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 315 LTCGSDEERFAILVAMFKLKLI--------VGRSILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEG 386
Cdd:PRK01297 305 VASDTVEQHVYAVAGSDKYKLLynlvtqnpWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREG 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 387 SYQIVIASDVsdadgsklkeeiAGksdekpekdekkgkkaskldkesgvsRGIDFHHVSNVVNFDFPETTDAYIHRVGRT 466
Cdd:PRK01297 385 KIRVLVATDV------------AG--------------------------RGIHIDGISHVINFTLPEDPDDYVHRIGRT 426
|
490 500 510
....*....|....*....|....*....|....*.
gi 25148203 467 ARGFNKGTALSFCIPSERAHLEQIQEEInqqmGRKV 502
Cdd:PRK01297 427 GRAGASGVSISFAGEDDAFQLPEIEELL----GRKI 458
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
81-498 |
7.91e-43 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 158.84 E-value: 7.91e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 81 EMDFEPEHKTFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLiaesktNDG 160
Cdd:PTZ00424 20 ESNYDEIVDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLI------DYD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 161 SVGPSAVIIAPTKELITQIYKLFVKLSQALPFlqAINLC--------DINEEENSVwledrsHVVVTTPGKLLRMCSLRP 232
Cdd:PTZ00424 94 LNACQALILAPTRELAQQIQKVVLALGDYLKV--RCHACvggtvvrdDINKLKAGV------HMVVGTPGRVYDMIDKRH 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 233 EYCTLVSYLVMDEADLLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV-ITIKLTEGDLpnsDQLT 311
Cdd:PTZ00424 166 LRVDDLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKrILVKKDELTL---EGIR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 312 QYQLTCGSDEERFAILVAMFKlKLIVGRSILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIV 391
Cdd:PTZ00424 243 QFYVAVEKEEWKFDTLCDLYE-TLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 392 IASDVsdadgsklkeeiagksdekpekdekkgkkaskldkesgVSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARGFN 471
Cdd:PTZ00424 322 ITTDL--------------------------------------LARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGR 363
|
410 420
....*....|....*....|....*..
gi 25148203 472 KGTALSFCIPSERAHLEQIQEEINQQM 498
Cdd:PTZ00424 364 KGVAINFVTPDDIEQLKEIERHYNTQI 390
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
91-502 |
1.54e-40 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 153.80 E-value: 1.54e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 91 FADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLiaesktNDGSVGPSAVIIA 170
Cdd:PRK11776 6 FSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKL------DVKRFRVQALVLC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 171 PTKELITQIYKLFVKLSQALPFLQAINLCD---INEEENSvwLEDRSHVVVTTPGKLLRmcSLRPEYCTL--VSYLVMDE 245
Cdd:PRK11776 80 PTRELADQVAKEIRRLARFIPNIKVLTLCGgvpMGPQIDS--LEHGAHIIVGTPGRILD--HLRKGTLDLdaLNTLVLDE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 246 ADLLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPViTIKL-TEGDLPNSDQLTqYQLtcgSDEERF 324
Cdd:PRK11776 156 ADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPV-EVKVeSTHDLPAIEQRF-YEV---SPDERL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 325 AIlvamfkLKLIVGR-----SILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIASDVSda 399
Cdd:PRK11776 231 PA------LQRLLLHhqpesCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVA-- 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 400 dgsklkeeiagksdekpekdekkgkkaskldkesgvSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARGFNKGTALSFC 479
Cdd:PRK11776 303 ------------------------------------ARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLV 346
|
410 420
....*....|....*....|...
gi 25148203 480 IPSERAHLEQIQEeinqQMGRKV 502
Cdd:PRK11776 347 APEEMQRANAIED----YLGRKL 365
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
87-481 |
4.09e-40 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 154.55 E-value: 4.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 87 EHKTFADFglderILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSvGPSA 166
Cdd:PTZ00110 133 EYTSFPDY-----ILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLLRYGD-GPIV 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 167 VIIAPTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEA 246
Cdd:PTZ00110 207 LVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEA 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 247 DLLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPVITIKLTEGDLPNSDQLTQYQLTCGSDEERFAI 326
Cdd:PTZ00110 287 DRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEEPVHVNVGSLDLTACHNIKQEVFVVEEHEKRGKL 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 327 LVAMFKLKLIVGRSILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIASDVSdadgsklke 406
Cdd:PTZ00110 367 KMLLQRIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVA--------- 437
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25148203 407 eiagksdekpekdekkgkkaskldkesgvSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARGFNKGTALSFCIP 481
Cdd:PTZ00110 438 -----------------------------SRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTP 483
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
113-281 |
8.24e-40 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 143.15 E-value: 8.24e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 113 NQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLiaesktNDGSVGPSAVIIAPTKELITQIYKLFVKLSQALpf 192
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEAL------DKLDNGPQALVLAPTRELAEQIYEELKKLGKGL-- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 193 lqAINLCDI--NEEENSVWLE-DRSHVVVTTPGKLLRMCSLRpEYCTLVSYLVMDEADLLLSFGYEEEMIKIRSKLPPTY 269
Cdd:pfam00270 73 --GLKVASLlgGDSRKEQLEKlKGPDILVGTPGRLLDLLQER-KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKR 149
|
170
....*....|..
gi 25148203 270 QCLMTSATLKDD 281
Cdd:pfam00270 150 QILLLSATLPRN 161
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
90-294 |
2.75e-38 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 140.53 E-value: 2.75e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 90 TFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIaesktnDGSVGPSAVII 169
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALL------ENPQRFFALVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 170 APTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRSHVVVTTPGKLL------RMCSLRPeyctlVSYLVM 243
Cdd:cd17954 75 APTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVdhlentKGFSLKS-----LKFLVM 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 25148203 244 DEADLLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17954 150 DEADRLLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPV 200
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
310-479 |
2.68e-37 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 134.94 E-value: 2.68e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 310 LTQYQLTCgSDEERFAILVAMFKLKLIVGRSILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQ 389
Cdd:cd18787 1 IKQLYVVV-EEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 390 IVIASDVsdadgsklkeeiagksdekpekdekkgkkaskldkesgVSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARG 469
Cdd:cd18787 80 VLVATDV--------------------------------------AARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRA 121
|
170
....*....|
gi 25148203 470 FNKGTALSFC 479
Cdd:cd18787 122 GRKGTAITFV 131
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
91-294 |
4.13e-37 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 137.36 E-value: 4.13e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 91 FADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLiAEsktnDGSvGPSAVIIA 170
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL-SE----DPY-GIFALVLT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 171 PTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRSHVVVTTPGKL---LRMCSLRPEYCTLVSYLVMDEAD 247
Cdd:cd17955 75 PTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLadhLRSSDDTTKVLSRVKFLVLDEAD 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 25148203 248 LLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17955 155 RLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
90-491 |
1.08e-36 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 145.38 E-value: 1.08e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 90 TFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKtndgsvGPSAVII 169
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELK------APQILVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 170 APTKELITQIYKLFVKLSQALPFLQAINL-----CDINEEEnsvwLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMD 244
Cdd:PRK11634 81 APTRELAVQVAEAMTDFSKHMRGVNVVALyggqrYDVQLRA----LRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 245 EADLLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV-ITIKLTEGDLPNSDQltQYQLTCGsdeer 323
Cdd:PRK11634 157 EADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQeVRIQSSVTTRPDISQ--SYWTVWG----- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 324 failvaMFKLKLIV--------GRSILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIASD 395
Cdd:PRK11634 230 ------MRKNEALVrfleaedfDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATD 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 396 VSdadgsklkeeiagksdekpekdekkgkkaskldkesgvSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARGFNKGTA 475
Cdd:PRK11634 304 VA--------------------------------------ARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRA 345
|
410
....*....|....*.
gi 25148203 476 LSFCIPSERAHLEQIQ 491
Cdd:PRK11634 346 LLFVENRERRLLRNIE 361
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
90-520 |
2.51e-36 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 143.94 E-value: 2.51e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 90 TFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKL-----IAESKTNDgsvgP 164
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLlsrpaLADRKPED----P 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 165 SAVIIAPTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRSHVVVTTPGKLL------RMCSLRP-EYCtl 237
Cdd:PRK04537 86 RALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIdyvkqhKVVSLHAcEIC-- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 238 vsylVMDEADLLLSFGYEEEMIKIRSKLPP--TYQCLMTSATLKDDMTTLKKLFMTGPVitiKL-TEGDLPNSDQLTQyQ 314
Cdd:PRK04537 164 ----VLDEADRMFDLGFIKDIRFLLRRMPErgTRQTLLFSATLSHRVLELAYEHMNEPE---KLvVETETITAARVRQ-R 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 315 LTCGSDEERFAILVAMFKlKLIVGRSILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIAS 394
Cdd:PRK04537 236 IYFPADEEKQTLLLGLLS-RSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVAT 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 395 DVSdadgsklkeeiagksdekpekdekkgkkaskldkesgvSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARGFNKGT 474
Cdd:PRK04537 315 DVA--------------------------------------ARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGD 356
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 25148203 475 ALSFCIPSERAHLEQIQEEINQQMgrkvlqPYEFRIKELDTFLLRT 520
Cdd:PRK04537 357 AISFACERYAMSLPDIEAYIEQKI------PVEPVTAELLTPLPRP 396
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
91-294 |
3.07e-36 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 134.73 E-value: 3.07e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 91 FADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKtndgsvGPSAVIIA 170
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKD------VIQALILV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 171 PTKELITQIYKLFVKLSQalpFLQAINLC---------DINEEENSVwledrsHVVVTTPGKLLRMcsLRPEYCTL--VS 239
Cdd:cd17940 75 PTRELALQTSQVCKELGK---HMGVKVMVttggtslrdDIMRLYQTV------HVLVGTPGRILDL--AKKGVADLshCK 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 25148203 240 YLVMDEADLLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17940 144 TLVLDEADKLLSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPY 198
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
96-290 |
5.58e-36 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 134.25 E-value: 5.58e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 96 LDERILKSIGELGWEKANQVQESVISLALEN-KNIMGRARTGSGKTGAFLIPLVQKLIaESKTNDGSVGPSAVIIAPTKE 174
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILSTgDDVLARAKTGTGKTLAFLLPAIQSLL-NTKPAGRRSGVSALIISPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 175 LITQIYKLFVKLSQalpFLQAINLC------DINEEENSvWLEDRSHVVVTTPGKL---LRMCSLRpEYCTLVSYLVMDE 245
Cdd:cd17964 80 LALQIAAEAKKLLQ---GLRKLRVQsavggtSRRAELNR-LRRGRPDILVATPGRLidhLENPGVA-KAFTDLDYLVLDE 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 25148203 246 ADLLLSFGYEEEMIKIRSKLPPTY----QCLMTSATLKDDMTTLKKLFM 290
Cdd:cd17964 155 ADRLLDMGFRPDLEQILRHLPEKNadprQTLLFSATVPDEVQQIARLTL 203
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
90-295 |
6.27e-36 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 133.97 E-value: 6.27e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 90 TFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTndgsVGPSAVII 169
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPT----VGARALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 170 APTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLL 249
Cdd:cd17959 78 SPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 25148203 250 LSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPVI 295
Cdd:cd17959 158 FEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVL 203
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
100-294 |
2.83e-35 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 131.99 E-value: 2.83e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSvgpSAVIIAPTKELITQI 179
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKAAT---RVLVLVPTRELAMQC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 180 YKLFVKLSQ--ALPFLQAINLCDINEEENSvwLEDRSHVVVTTPGKLLRMCSLRPEY-CTLVSYLVMDEADLLLSFGYEE 256
Cdd:cd17947 78 FSVLQQLAQftDITFALAVGGLSLKAQEAA--LRARPDIVIATPGRLIDHLRNSPSFdLDSIEILVLDEADRMLEEGFAD 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 25148203 257 EMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17947 156 ELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPV 193
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
90-507 |
1.66e-34 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 136.48 E-value: 1.66e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 90 TFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSVGPSAVII 169
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVRALIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 170 APTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLL 249
Cdd:PRK10590 82 TPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 250 LSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPViTIKLTEGDLPnSDQLTQYQLTCgsDEERFAILva 329
Cdd:PRK10590 162 LDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPL-EIEVARRNTA-SEQVTQHVHFV--DKKRKREL-- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 330 mfkLKLIVGRS-----ILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIASDVSdadgskl 404
Cdd:PRK10590 236 ---LSQMIGKGnwqqvLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIA------- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 405 keeiagksdekpekdekkgkkaskldkesgvSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARGFNKGTALSFCIPSER 484
Cdd:PRK10590 306 -------------------------------ARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEH 354
|
410 420
....*....|....*....|...
gi 25148203 485 AHLEQIQEEINQQMGRKVLQPYE 507
Cdd:PRK10590 355 KLLRDIEKLLKKEIPRIAIPGYE 377
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
100-294 |
5.54e-34 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 128.18 E-value: 5.54e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSVGpsAVIIAPTKELITQI 179
Cdd:cd17941 1 TLKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEDGLG--ALIISPTRELAMQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 180 YKLFVK------LSQALpflqAINLCDINEEENSVwleDRSHVVVTTPGKLLRMCSLRPEY-CTLVSYLVMDEADLLLSF 252
Cdd:cd17941 79 FEVLRKvgkyhsFSAGL----IIGGKDVKEEKERI---NRMNILVCTPGRLLQHMDETPGFdTSNLQMLVLDEADRILDM 151
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 25148203 253 GYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17941 152 GFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPE 193
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
100-295 |
7.15e-34 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 128.59 E-value: 7.15e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKL-----IAESKTNDgsvGPSAVIIAPTKE 174
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYIsrlppLDEETKDD---GPYALILAPTRE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 175 LITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRSHVVVTTPGKLL-----RMCSLRPeyctlVSYLVMDEADLL 249
Cdd:cd17945 78 LAQQIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLdclerRLLVLNQ-----CTYVVLDEADRM 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25148203 250 LSFGYEEEMIKIRSKLPPTY--------------------QCLMTSATLKDDMTTLKKLFMTGPVI 295
Cdd:cd17945 153 IDMGFEPQVTKILDAMPVSNkkpdteeaeklaasgkhryrQTMMFTATMPPAVEKIAKGYLRRPVV 218
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
100-294 |
1.27e-33 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 127.31 E-value: 1.27e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLiAESKTNDGSVGPSAVIIAPTKELITQI 179
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEIL-LKRKANLKKGQVGALIISPTRELATQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 180 YKLFVKLSQALPFLQAINLC---DINEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTL--VSYLVMDEADLLLSFGY 254
Cdd:cd17960 80 YEVLQSFLEHHLPKLKCQLLiggTNVEEDVKKFKRNGPNILVGTPGRLEELLSRKADKVKVksLEVLVLDEADRLLDLGF 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 25148203 255 EEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17960 160 EADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPV 199
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
104-297 |
2.62e-33 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 126.45 E-value: 2.62e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 104 IGELGWEKANQVQESVISLALEN-KNIMGRARTGSGKTGAFLIPLVQKLIAESktndgsvGPSAVIIAPTKELITQIYKL 182
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGK-------GGRVLVLVPTRELAEQWAEE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 183 FVKLSQALPFLQAINLCDINEEEN-SVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLLSFGYEEEMIKI 261
Cdd:smart00487 74 LKKLGPSLGLKVVGLYGGDSKREQlRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKL 153
|
170 180 190
....*....|....*....|....*....|....*.
gi 25148203 262 RSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPVITI 297
Cdd:smart00487 154 LKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFID 189
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
100-294 |
7.31e-31 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 119.62 E-value: 7.31e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNdgsvGPSAVIIAPTKELITQI 179
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRKKK----GLRALILAPTRELASQI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 180 YKLFVKLSQALPFlQAINLCDINEEENSVWLEDRSH--VVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLLSFGYEEE 257
Cdd:cd17957 77 YRELLKLSKGTGL-RIVLLSKSLEAKAKDGPKSITKydILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQ 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 25148203 258 MIKIRSKLP-PTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17957 156 TDEILAACTnPNLQRSLFSATIPSEVEELARSVMKDPI 193
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
89-294 |
1.70e-30 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 119.40 E-value: 1.70e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 89 KTFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSvGPSAVI 168
Cdd:cd17953 12 QKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPVKPGE-GPIGLI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 169 IAPTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRSHVVVTTPGKLL--------RMCSLRPeyctlVSY 240
Cdd:cd17953 91 MAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIdiltanngRVTNLRR-----VTY 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 25148203 241 LVMDEADLLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17953 166 VVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
90-290 |
3.41e-30 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 118.36 E-value: 3.41e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 90 TFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSVG----PS 165
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRGRrkayPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 166 AVIIAPTKELITQIYKLFVKLSQ------------ALPFLQAINL---CDIneeensvwledrshvVVTTPGKLLRMC-- 228
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYrsgvrsvvvyggADVVHQQLQLlrgCDI---------------LVATPGRLVDFIer 145
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25148203 229 ---SLrpeycTLVSYLVMDEADLLLSFGYEEEMIKI--RSKLPPT--YQCLMTSATLKDDMTTLKKLFM 290
Cdd:cd17967 146 griSL-----SSIKFLVLDEADRMLDMGFEPQIRKIveHPDMPPKgeRQTLMFSATFPREIQRLAADFL 209
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
86-290 |
5.33e-30 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 118.92 E-value: 5.33e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 86 PEH-KTFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSVG- 163
Cdd:cd18052 39 PPAiLTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASSFSEv 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 164 --PSAVIIAPTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYL 241
Cdd:cd18052 119 qePQALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSKLKYL 198
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 25148203 242 VMDEADLLLSFGYEEEMIKIRSKL--PPT--YQCLMTSATLKDDMTTLKKLFM 290
Cdd:cd18052 199 ILDEADRMLDMGFGPEIRKLVSEPgmPSKedRQTLMFSATFPEEIQRLAAEFL 251
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
100-294 |
9.70e-30 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 116.36 E-value: 9.70e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSvGPSAVIIAPTKELITQI 179
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRELEKGE-GPIAVIVAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 180 YklfvklSQALPFLQAINLCDI------NEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLLSFG 253
Cdd:cd17952 80 Y------LEAKKFGKAYNLRVVavygggSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMG 153
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 25148203 254 YEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17952 154 FEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPI 194
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
93-297 |
2.29e-29 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 115.11 E-value: 2.29e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 93 DFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTndgsvgPSAVIIAPT 172
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRE------TQALVLAPT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 173 KELITQIYKLFVKLSQalpFLQAINLCDI---NEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLL 249
Cdd:cd17939 75 RELAQQIQKVVKALGD---YMGVKVHACIggtSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEM 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 25148203 250 LSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPVITI 297
Cdd:cd17939 152 LSRGFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRIL 199
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
91-294 |
3.46e-28 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 112.15 E-value: 3.46e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 91 FADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTndgsvgPSAVIIA 170
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKA------TQALVLA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 171 PTKELITQIYKLFVKLSQALPF--LQAINLCDINEEENSvwLEDRSHVVVTTPGKLLRMCS---LRPEYctlVSYLVMDE 245
Cdd:cd18046 75 PTRELAQQIQKVVMALGDYMGIkcHACIGGTSVRDDAQK--LQAGPHIVVGTPGRVFDMINrryLRTDY---IKMFVLDE 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 25148203 246 ADLLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd18046 150 ADEMLSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPI 198
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
100-294 |
1.23e-27 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 110.14 E-value: 1.23e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQkLIAESKTNDGSvGPSAVIIAPTKELITQI 179
Cdd:cd17942 1 TLKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIE-LLYKLKFKPRN-GTGVIIISPTRELALQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 180 YKLFVKL----SQALpflqAINLCDINEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTL-VSYLVMDEADLLLSFGY 254
Cdd:cd17942 79 YGVAKELlkyhSQTF----GIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKnLQCLIIDEADRILEIGF 154
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 25148203 255 EEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKL-FMTGPV 294
Cdd:cd17942 155 EEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARIsLKKKPL 195
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
89-478 |
2.35e-27 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 115.07 E-value: 2.35e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 89 KTFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSV-GPSAV 167
Cdd:PRK04837 8 QKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDRKVnQPRAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 168 IIAPTKELITQIYKlfvklsQALPFLQAINL-------CDINEEENSVwLEDRSHVVVTTPGKLLRMcsLRPEYCTL--V 238
Cdd:PRK04837 88 IMAPTRELAVQIHA------DAEPLAQATGLklglaygGDGYDKQLKV-LESGVDILIGTTGRLIDY--AKQNHINLgaI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 239 SYLVMDEADLLLSFGYeeemIK-IR---SKLPPTYQCL--MTSATLK--------DDMTTLKK-----LFMTGPVItikl 299
Cdd:PRK04837 159 QVVVLDEADRMFDLGF----IKdIRwlfRRMPPANQRLnmLFSATLSyrvrelafEHMNNPEYvevepEQKTGHRI---- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 300 tegdlpnsdqltQYQLTCGSDEERFAILvamfkLKLI----VGRSILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANS 375
Cdd:PRK04837 231 ------------KEELFYPSNEEKMRLL-----QTLIeeewPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKK 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 376 RCHVINQFNEGSYQIVIASDVSdadgsklkeeiagksdekpekdekkgkkaskldkesgvSRGIDFHHVSNVVNFDFPET 455
Cdd:PRK04837 294 RLRILEEFTRGDLDILVATDVA--------------------------------------ARGLHIPAVTHVFNYDLPDD 335
|
410 420
....*....|....*....|...
gi 25148203 456 TDAYIHRVGRTARGFNKGTALSF 478
Cdd:PRK04837 336 CEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
107-294 |
7.25e-27 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 108.44 E-value: 7.25e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 107 LGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSVGPSAVIIAPTKELITQIYKLFVKL 186
Cdd:cd17949 9 MGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDGTLALVLVPTRELALQIYEVLEKL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 187 SQALPFLQAINLCDineeensvwLEDRSH----------VVVTTPGKLL---------RMCSLRpeyctlvsYLVMDEAD 247
Cdd:cd17949 89 LKPFHWIVPGYLIG---------GEKRKSekarlrkgvnILIATPGRLLdhlkntqsfDVSNLR--------WLVLDEAD 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 248 LLLSFGYEEEMIKIRSKL-------------PPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17949 152 RLLDMGFEKDITKILELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPV 211
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
17-478 |
8.42e-27 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 114.50 E-value: 8.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 17 AEEEPPKVKEAPKKQKAGKKievSVELRDKNEekmgrkrKHRMKKSQAEK-RQKLMESLVGPQVdemdfEPEHKTFADFG 95
Cdd:PLN00206 63 AKSRVAVGAPKPKRLPATDE---CFYVRDPGS-------TSGLSSSQAELlRRKLEIHVKGEAV-----PPPILSFSSCG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 96 LDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIA-ESKTNDGSVGPSAVIIAPTKE 174
Cdd:PLN00206 128 LPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTiRSGHPSEQRNPLAMVLTPTRE 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 175 LITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLLSFGY 254
Cdd:PLN00206 208 LCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLERGF 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 255 EEEMIKIRSKLpPTYQCLMTSATLKDDMTTLKKlFMTGPVITIKLTEGDLPNS--DQLTQYQLTCGSDEERFAILVAMFK 332
Cdd:PLN00206 288 RDQVMQIFQAL-SQPQVLLFSATVSPEVEKFAS-SLAKDIILISIGNPNRPNKavKQLAIWVETKQKKQKLFDILKSKQH 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 333 LKlivGRSILFVNTidRCYKLML---ILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIASDVsdadgsklkeeia 409
Cdd:PLN00206 366 FK---PPAVVFVSS--RLGADLLanaITVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGV------------- 427
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25148203 410 gksdekpekdekkgkkaskldkesgVSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARGFNKGTALSF 478
Cdd:PLN00206 428 -------------------------LGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVF 471
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
100-294 |
3.93e-26 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 105.91 E-value: 3.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSvGPSAVIIAPTKELITQI 179
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLERGD-GPIVLVLAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 180 YKLFVKLSQAlpfLQAINLC---------DINEeensvwLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLL 250
Cdd:cd17966 80 QQEANKFGGS---SRLRNTCvyggapkgpQIRD------LRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRML 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 25148203 251 SFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17966 151 DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYI 194
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
86-290 |
1.72e-25 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 105.89 E-value: 1.72e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 86 PEH-KTFADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLI----AESKTNDG 160
Cdd:cd18051 17 PPHiETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYeqgpGESLPSES 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 161 SVG------PSAVIIAPTKELITQIY---KLFVKLSQALPflqainlC------DINEEENSvwLEDRSHVVVTTPGKLL 225
Cdd:cd18051 97 GYYgrrkqyPLALVLAPTRELASQIYdeaRKFAYRSRVRP-------CvvyggaDIGQQMRD--LERGCHLLVATPGRLV 167
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25148203 226 RMCS---LRPEYCtlvSYLVMDEADLLLSFGYEEEMIKIRSK--LPPT--YQCLMTSATLKDDMTTLKKLFM 290
Cdd:cd18051 168 DMLErgkIGLDYC---KYLVLDEADRMLDMGFEPQIRRIVEQdtMPPTgeRQTLMFSATFPKEIQMLARDFL 236
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
91-288 |
2.51e-25 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 103.94 E-value: 2.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 91 FADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLiaesktndgsvgpSAVIIA 170
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIV-------------VALILE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 171 PTKELITQIYKLFVKLSQAL--PFLQ-AINLCDINEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEAD 247
Cdd:cd17938 68 PSRELAEQTYNCIENFKKYLdnPKLRvALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEAD 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 25148203 248 LLLSFGYEEEMIKIRSKLPP------TYQCLMTSATLKDDmtTLKKL 288
Cdd:cd17938 148 RLLSQGNLETINRIYNRIPKitsdgkRLQVIVCSATLHSF--EVKKL 192
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
91-294 |
1.04e-23 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 99.34 E-value: 1.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 91 FADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLiaesKTNDGSVgpSAVIIA 170
Cdd:cd17950 4 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQL----EPVDGQV--SVLVIC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 171 PTKELITQIYKLFVKLSQALPFLQ-AINLCDINEEENSVWLEDRS-HVVVTTPGkllRMCSL-RPEYCTL--VSYLVMDE 245
Cdd:cd17950 78 HTRELAFQISNEYERFSKYMPNVKtAVFFGGVPIKKDIEVLKNKCpHIVVGTPG---RILALvREKKLKLshVKHFVLDE 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 25148203 246 ADLLL-SFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17950 155 CDKMLeQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPL 204
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
100-278 |
7.38e-23 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 97.69 E-value: 7.38e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLAL-ENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSV---GPSAVIIAPTKEL 175
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIrDGKDVIGAAETGSGKTLAFGIPILERLLSQKSSNGVGGkqkPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 176 ITQIYKlfvKLSQALPFLQaINLCDI-----NEEENSVwLEDRSHVVVTTPGKLLRMCSLRPEYCTL---VSYLVMDEAD 247
Cdd:cd17946 81 AVQVKD---HLKAIAKYTN-IKIASIvgglaVQKQERL-LKKRPEIVVATPGRLWELIQEGNEHLANlksLRFLVLDEAD 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 25148203 248 LLLSFGYEEEMIKIRSKL---PPTY----QCLMTSATL 278
Cdd:cd17946 156 RMLEKGHFAELEKILELLnkdRAGKkrkrQTFVFSATL 193
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
96-295 |
2.16e-22 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 95.33 E-value: 2.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 96 LDERILKSIGELGWEKANQVQESVISLALEN--KNIMGRARTGSGKTGAFLIPLVQKLIAESKTndgsvgPSAVIIAPTK 173
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKS------PQALCLAPTR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 174 ELITQIYKLFVKLSQAL---PFLqAINLCDINEEENSvwledRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLL 250
Cdd:cd17963 75 ELARQIGEVVEKMGKFTgvkVAL-AVPGNDVPRGKKI-----TAQIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVML 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 25148203 251 -SFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPVI 295
Cdd:cd17963 149 dTQGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANT 194
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
91-294 |
7.38e-22 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 93.69 E-value: 7.38e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 91 FADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLiaesktnDGSV-GPSAVII 169
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCL-------DIQVrETQALIL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 170 APTKELITQIYKLFVKLSQALPFlqAINLC--DINEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEAD 247
Cdd:cd18045 74 SPTRELAVQIQKVLLALGDYMNV--QCHACigGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEAD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 25148203 248 LLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd18045 152 EMLNKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPI 198
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
100-294 |
8.95e-22 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 93.48 E-value: 8.95e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESktndgsVGPSAVIIAPTKELITQI 179
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLER------RHPQVLILAPTREIAVQI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 180 YKLFVKLSQALPFLQA---INLCDINEEENSVwleDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLLSFGYEE 256
Cdd:cd17943 75 HDVFKKIGKKLEGLKCevfIGGTPVKEDKKKL---KGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQK 151
|
170 180 190
....*....|....*....|....*....|....*....
gi 25148203 257 EMIKIRSKLPPTYQCLMTSATL-KDDMTTLKKlFMTGPV 294
Cdd:cd17943 152 DVNWIFSSLPKNKQVIAFSATYpKNLDNLLAR-YMRKPV 189
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
100-250 |
3.33e-21 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 92.70 E-value: 3.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALE-NKNIMGR--------ARTGSGKTGAFLIPLVQKLiaeSKTndgsVGPS--AVI 168
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPsSKSTPPYrpgdlcvsAPTGSGKTLAYVLPIVQAL---SKR----VVPRlrALI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 169 IAPTKELITQIYKLFVKLSQALPfLQAINLC---DINEEENSVW------LEDRSHVVVTTPGKLLR---------MCSL 230
Cdd:cd17956 74 VVPTKELVQQVYKVFESLCKGTG-LKVVSLSgqkSFKKEQKLLLvdtsgrYLSRVDILVATPGRLVDhlnstpgftLKHL 152
|
170 180
....*....|....*....|
gi 25148203 231 RpeyctlvsYLVMDEADLLL 250
Cdd:cd17956 153 R--------FLVIDEADRLL 164
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
100-278 |
5.26e-21 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 91.63 E-value: 5.26e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTND--GSVGPSAVIIAPTKELIT 177
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPfiKGEGPYGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 178 QIYKLFVKLSQAL-----PFLQ---AINLCDINEEENSVwlEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLL 249
Cdd:cd17951 81 QTHEVIEYYCKALqeggyPQLRcllCIGGMSVKEQLEVI--RKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRM 158
|
170 180
....*....|....*....|....*....
gi 25148203 250 LSFGYEEEMIKIRSKLPPTYQCLMTSATL 278
Cdd:cd17951 159 IDMGFEEDIRTIFSYFKGQRQTLLFSATM 187
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
108-294 |
1.39e-20 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 89.92 E-value: 1.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 108 GWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTndgsvgPSAVIIAPTKELITQIYKLFVKLS 187
Cdd:cd17962 9 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRN------PSALILTPTRELAVQIEDQAKELM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 188 QALPFLQAINLCDINEEENSVW-LEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLLSFGYEEEMIKIRSKLP 266
Cdd:cd17962 83 KGLPPMKTALLVGGLPLPPQLYrLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLDILENIS 162
|
170 180
....*....|....*....|....*...
gi 25148203 267 PTYQCLMTSATLKDDMTTLKKLFMTGPV 294
Cdd:cd17962 163 HDHQTILVSATIPRGIEQLAGQLLQNPV 190
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
100-295 |
1.60e-20 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 89.83 E-value: 1.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSVGPSAVIIAPTKELITQI 179
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQRNGPGVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 180 YKLFVKLSqalpFLQAINLC-----DINEEENSvwLEDRSHVVVTTPGKL--LRM---CSLRPeyctlVSYLVMDEADLL 249
Cdd:cd17958 81 EAECSKYS----YKGLKSVCvygggNRNEQIED--LSKGVDIIIATPGRLndLQMnnvINLKS-----ITYLVLDEADRM 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 25148203 250 LSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPVI 295
Cdd:cd17958 150 LDMGFEPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMI 195
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
89-304 |
5.18e-20 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 89.31 E-value: 5.18e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 89 KTFADFGLDERILKSIGELGWEKANQVQESVISLALEN--KNIMGRARTGSGKTGAFLIPLVQKLIAESKTndgsvgPSA 166
Cdd:cd18048 18 KSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLY------PQC 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 167 VIIAPTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEdrSHVVVTTPGKLLRMC-SLRPEYCTLVSYLVMDE 245
Cdd:cd18048 92 LCLSPTFELALQTGKVVEEMGKFCVGIQVIYAIRGNRPGKGTDIE--AQIVIGTPGTVLDWCfKLRLIDVTNISVFVLDE 169
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 246 ADLLLSF-GYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPVItIKLTEGDL 304
Cdd:cd18048 170 ADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNI-IKLKKEEL 228
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
322-468 |
2.00e-18 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 81.10 E-value: 2.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 322 ERFAILVAMFKLKlIVGRSILFVNTIDRCyKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIASDVsdadg 401
Cdd:pfam00271 1 EKLEALLELLKKE-RGGKVLIFSQTKKTL-EAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDV----- 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25148203 402 sklkeeiagksdekpekdekkgkkaskldkesgVSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTAR 468
Cdd:pfam00271 74 ---------------------------------AERGLDLPDVDLVINYDLPWNPASYIQRIGRAGR 107
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
133-289 |
4.60e-18 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 84.35 E-value: 4.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 133 ARTGSGKTGAFLIPLVQKLI---AESKTNDG--------SVGPSAVIIAPTKELITQIYKLFVKLSQALPFLQAI---NL 198
Cdd:cd17965 68 AETGSGKTLAYLAPLLDYLKrqeQEPFEEAEeeyesakdTGRPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTfssGF 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 199 CDINEEeNSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLLSFGYEEEMIKIRSKLPPTYQCLMTSATL 278
Cdd:cd17965 148 GPSYQR-LQLAFKGRIDILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATI 226
|
170
....*....|..
gi 25148203 279 -KDDMTTLKKLF 289
Cdd:cd17965 227 pKEFDKTLRKLF 238
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
91-290 |
1.18e-17 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 82.75 E-value: 1.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 91 FADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSvGPSAVIIA 170
Cdd:cd18049 26 FYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGD-GPICLVLA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 171 PTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLL 250
Cdd:cd18049 105 PTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRML 184
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 25148203 251 SFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFM 290
Cdd:cd18049 185 DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFL 224
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
89-295 |
4.37e-17 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 80.15 E-value: 4.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 89 KTFADFGLDERILKSIGELGWEKANQVQESVISLALEN--KNIMGRARTGSGKTGAFLIPLVQKLIAESKTNdgsvgpSA 166
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYP------QC 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 167 VIIAPTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSVWLEDRshVVVTTPGKLLRMC-SLRPEYCTLVSYLVMDE 245
Cdd:cd18047 75 LCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQ--IVIGTPGTVLDWCsKLKFIDPKKIKVFVLDE 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 25148203 246 ADLLLSF-GYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLFMTGPVI 295
Cdd:cd18047 153 ADVMIATqGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNV 203
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
57-290 |
6.47e-17 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 81.21 E-value: 6.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 57 HRMKKSQAEK-RQKLMESLVGPQVDEMDFEPEHKTFADFGLDERILKSIGElgwekANQVQESVISLALENKNIMGRART 135
Cdd:cd18050 34 ARMTQYDVEElRRKKEITIRGVGCPKPVFAFHQANFPQYVMDVLLDQNFKE-----PTPIQCQGFPLALSGRDMVGIAQT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 136 GSGKTGAFLIPLVQKLIAESKTNDGSvGPSAVIIAPTKELITQI------YKLFVKLSQALPFLQAINLCDINEEENSVw 209
Cdd:cd18050 109 GSGKTLAYLLPAIVHINHQPYLERGD-GPICLVLAPTRELAQQVqqvaddYGKSSRLKSTCIYGGAPKGPQIRDLERGV- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 210 ledrsHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLLSFGYEEEMIKIRSKLPPTYQCLMTSATLKDDMTTLKKLF 289
Cdd:cd18050 187 -----EICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDF 261
|
.
gi 25148203 290 M 290
Cdd:cd18050 262 L 262
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
100-278 |
2.12e-16 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 78.95 E-value: 2.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 100 ILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSV-GPSAVIIAPTKELITQ 178
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPFnAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 179 IYKLFVKLSQALPFL-QAI-------NLCDINEEENSvwledrshVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLL 250
Cdd:cd17948 81 IGSVAQSLTEGLGLKvKVItggrtkrQIRNPHFEEVD--------ILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLL 152
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 25148203 251 SFGYEEEMIKIRSKLP-------------PTYQCLMTSATL 278
Cdd:cd17948 153 DDSFNEKLSHFLRRFPlasrrsentdgldPGTQLVLVSATM 193
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
115-290 |
3.67e-15 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 74.50 E-value: 3.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 115 VQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSVGPSAVIIAPTKELITQIYKLFVKLSQAL---- 190
Cdd:cd17944 16 IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGRAPKVLVLAPTRELANQVTKDFKDITRKLsvac 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 191 -----PFLQAINLcdineeensvwLEDRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLLSFGYE---EEMIKIR 262
Cdd:cd17944 96 fyggtPYQQQIFA-----------IRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAeqvEEILSVS 164
|
170 180 190
....*....|....*....|....*....|
gi 25148203 263 SKLPP--TYQCLMTSATLKDDMTTLKKLFM 290
Cdd:cd17944 165 YKKDSedNPQTLLFSATCPDWVYNVAKKYM 194
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
352-468 |
4.29e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 67.62 E-value: 4.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 352 KLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIASDVsdadgsklkeeiagksdekpekdekkgkkaskldk 431
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDV----------------------------------- 46
|
90 100 110
....*....|....*....|....*....|....*..
gi 25148203 432 esgVSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTAR 468
Cdd:smart00490 47 ---AERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
135-396 |
7.08e-13 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 71.59 E-value: 7.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 135 TGSGKTGAFLiplvqKLIAESKTndgsvGPSAVIIAPTKELITQIYKLFVKLsqalpflqainLCDINEEENSVwlEDRS 214
Cdd:COG1061 109 TGTGKTVLAL-----ALAAELLR-----GKRVLVLVPRRELLEQWAEELRRF-----------LGDPLAGGGKK--DSDA 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 215 HVVVTTPGKLLRMCSLR--PEYCTLVsylVMDEADLLLSFGYEeemiKIRSKLPPTYqCLMTSATL--KDDMTTLKKLFm 290
Cdd:COG1061 166 PITVATYQSLARRAHLDelGDRFGLV---IIDEAHHAGAPSYR----RILEAFPAAY-RLGLTATPfrSDGREILLFLF- 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 291 TGPVITIKLTE----GDL------PNSDQLTQYQLTCGSDEERFAILVAMF---KLKLI---------VGRSILFVNTID 348
Cdd:COG1061 237 DGIVYEYSLKEaiedGYLappeyyGIRVDLTDERAEYDALSERLREALAADaerKDKILrellrehpdDRKTLVFCSSVD 316
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 25148203 349 RCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIASDV 396
Cdd:COG1061 317 HAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDV 364
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
113-249 |
7.80e-11 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 61.51 E-value: 7.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 113 NQVQESVI-SLALENKNIMGRARTGSGKTGAFLIPLVQKLIAEsktndgsvGPSAVIIAPTKELITQIYKLFVKLSQALP 191
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLIAELAILRALATS--------GGKAVYIAPTRALVNQKEADLRERFGPLG 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 25148203 192 FLqaINLCDINEEENSVWLEDrSHVVVTTPGKLLRMCSLRPEYCT-LVSYLVMDEADLL 249
Cdd:cd17921 75 KN--VGLLTGDPSVNKLLLAE-ADILVATPEKLDLLLRNGGERLIqDVRLVVVDEAHLI 130
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
135-277 |
1.32e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 57.03 E-value: 1.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 135 TGSGKTGAFLIPLVQKLIaesktndgSVGPSAVIIAPTKELITQIYKLFVKLSQA-LPFlqAINLCDINEEENSVWLEDR 213
Cdd:cd00046 10 TGSGKTLAALLAALLLLL--------KKGKKVLVLVPTKALALQTAERLRELFGPgIRV--AVLVGGSSAEEREKNKLGD 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25148203 214 SHVVVTTPGKLLRMCSLRPEYCTL-VSYLVMDEADLLL--SFGYEEEMIKIRSKLPPTYQCLMTSAT 277
Cdd:cd00046 80 ADIIIATPDMLLNLLLREDRLFLKdLKLIIVDEAHALLidSRGALILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
116-279 |
1.32e-07 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 51.82 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 116 QESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESktndgsvGPSAVIIAPTKELIT-QIYKLFVKLSQALPFLq 194
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDP-------GSRALYLYPTKALAQdQLRSLRELLEQLGLGI- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 195 AINLC--DINEEENSVWLEDRSHVVVTTPGKL----LRMCSLRPEYCTLVSYLVMDEADLLL-SFGYEEEMIkIR----- 262
Cdd:cd17923 77 RVATYdgDTPREERRAIIRNPPRILLTNPDMLhyalLPHHDRWARFLRNLRYVVLDEAHTYRgVFGSHVALL-LRrlrrl 155
|
170
....*....|....*...
gi 25148203 263 -SKLPPTYQCLMTSATLK 279
Cdd:cd17923 156 cRRYGADPQFILTSATIG 173
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
79-246 |
6.10e-07 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 52.53 E-value: 6.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 79 VDEMDFEPEHKTFADF--GLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESk 156
Cdd:COG1205 22 VHVRTIPAREARYAPWpdWLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDP- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 157 tndgsvGPSAVIIAPTKELIT-QIYKLfVKLSQALPflQAINLC----DINEEENSvWLEDRSHVVVTTP---------- 221
Cdd:COG1205 101 ------GATALYLYPTKALARdQLRRL-RELAEALG--LGVRVAtydgDTPPEERR-WIREHPDIVLTNPdmlhygllph 170
|
170 180
....*....|....*....|....*....
gi 25148203 222 ----GKLLRmcSLRpeyctlvsYLVMDEA 246
Cdd:COG1205 171 htrwARFFR--NLR--------YVVIDEA 189
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
98-249 |
6.11e-07 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 52.59 E-value: 6.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 98 ERILKSIGELGWEKANQVQESVISLAL-ENKNIMGRARTGSGKTgaFLIPL-VQKLIAESKTndgsvgpsAVIIAPTKEL 175
Cdd:COG1204 9 EKVIEFLKERGIEELYPPQAEALEAGLlEGKNLVVSAPTASGKT--LIAELaILKALLNGGK--------ALYIVPLRAL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25148203 176 ITQIYKLFVKLSQALPFLQAINLCDIneEENSVWLEdRSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLL 249
Cdd:COG1204 79 ASEKYREFKRDFEELGIKVGVSTGDY--DSDDEWLG-RYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAHLI 149
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
113-393 |
1.44e-06 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 51.24 E-value: 1.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 113 NQVQESVISLALENKNIMG-RARTGSGKTGAFLIpLVQKLIAESKtndgsvGPSAVIIAPTKELITQIYKLFVKL----- 186
Cdd:COG1203 133 NEALELALEAAEEEPGLFIlTAPTGGGKTEAALL-FALRLAAKHG------GRRIIYALPFTSIINQTYDRLRDLfgedv 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 187 ----SQALPFLQAInlcDINEEENSVWLEDRSH-----VVVTTPGKLLRmcSL---RPEYC----TLV-SYLVMDEADLl 249
Cdd:COG1203 206 llhhSLADLDLLEE---EEEYESEARWLKLLKElwdapVVVTTIDQLFE--SLfsnRKGQErrlhNLAnSVIILDEVQA- 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 250 lsfgYEEEMikirskLPPT---------YQC---LMTsATL---------------KDDMTTLKKLFMTGPVITIKLTEG 302
Cdd:COG1203 280 ----YPPYM------LALLlrllewlknLGGsviLMT-ATLppllreelleayeliPDEPEELPEYFRAFVRKRVELKEG 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 303 DLpnsdqltqyqltcgSDEErfaiLVAMFKLKLIVGRSILF-VNTIDRCYKLMLILR--VFGLKSCILNSAMPANSRCHV 379
Cdd:COG1203 349 PL--------------SDEE----LAELILEALHKGKSVLViVNTVKDAQELYEALKekLPDEEVYLLHSRFCPADRSEI 410
|
330
....*....|....*...
gi 25148203 380 INQ----FNEGSYQIVIA 393
Cdd:COG1203 411 EKEikerLERGKPCILVS 428
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
113-249 |
1.96e-06 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 48.89 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 113 NQVQESVISLALE-NKNIMGRARTGSGKTGAF---LIPLVQKLIAESKTNdgsvgPSAVIIAPTKELITQIYK-LFVKLS 187
Cdd:cd18023 3 NRIQSEVFPDLLYsDKNFVVSAPTGSGKTVLFelaILRLLKERNPLPWGN-----RKVVYIAPIKALCSEKYDdWKEKFG 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25148203 188 QalpflqaINLCDINEEENSVWLEDRS----HVVVTTPGKLLRMCSLRPEYCTLVSY--LVM-DEADLL 249
Cdd:cd18023 78 P-------LGLSCAELTGDTEMDDTFEiqdaDIILTTPEKWDSMTRRWRDNGNLVQLvaLVLiDEVHII 139
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
117-279 |
2.91e-06 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 48.10 E-value: 2.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 117 ESVISLALENKNIMGRARTGSGKTgafliplvqkLIAE-SKTNDGSVGPSAVIIAPTKELITQIYKLFVKLSqALPFLQA 195
Cdd:cd18028 8 EAVRAGLLKGENLLISIPTASGKT----------LIAEmAMVNTLLEGGKALYLVPLRALASEKYEEFKKLE-EIGLKVG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 196 INLCDINEEENsvWLEDrSHVVVTTPGKLLRMCSLRPEYCTLVSYLVMDEADLLLSF--GYEEEMIKIRSK-LPPTYQCL 272
Cdd:cd18028 77 ISTGDYDEDDE--WLGD-YDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEerGPTLESIVARLRrLNPNTQII 153
|
....*..
gi 25148203 273 MTSATLK 279
Cdd:cd18028 154 GLSATIG 160
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
436-473 |
2.23e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 39.99 E-value: 2.23e-04
10 20 30
....*....|....*....|....*....|....*...
gi 25148203 436 SRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARGFNKG 473
Cdd:cd18785 33 GEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDE 70
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
133-245 |
2.50e-04 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 42.19 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 133 ARTGSGKTGAFLIPLVQKLIAESKTndgsvgPSAVI-IAPTKELITQIYKLFVKLSQA--LPFLQAINLCDINEEENSVW 209
Cdd:cd17922 8 APTGSGKTEAAFLPALSSLADEPEK------GVQVLyISPLKALINDQERRLEEPLDEidLEIPVAVRHGDTSQSEKAKQ 81
|
90 100 110
....*....|....*....|....*....|....*...
gi 25148203 210 LEDRSHVVVTTPGKLLRMCSLR--PEYCTLVSYLVMDE 245
Cdd:cd17922 82 LKNPPGILITTPESLELLLVNKklRELFAGLRYVVVDE 119
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
96-259 |
2.57e-04 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 44.04 E-value: 2.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 96 LDERILKSIGELGWEKANQVQ-ESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAEsktndgsvGPSAVIIAPTKE 174
Cdd:PRK00254 8 VDERIKRVLKERGIEELYPPQaEALKSGVLEGKNLVLAIPTASGKTLVAEIVMVNKLLRE--------GGKAVYLVPLKA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 175 LITQIYKLFvKLSQALPFLQAINLCDINEEENsvWLeDRSHVVVTTPGK---LLRMCSlrpEYCTLVSYLVMDEADLLLS 251
Cdd:PRK00254 80 LAEEKYREF-KDWEKLGLRVAMTTGDYDSTDE--WL-GKYDIIIATAEKfdsLLRHGS---SWIKDVKLVVADEIHLIGS 152
|
170
....*....|
gi 25148203 252 F--GYEEEMI 259
Cdd:PRK00254 153 YdrGATLEMI 162
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
116-266 |
5.04e-04 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 41.65 E-value: 5.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 116 QESVISLALENKNIMGRARTGSGKTgaflipLVQKLIAESKTNDGSVGPSA--VIIAPTKELITQIYKLFVKLSQaLPFL 193
Cdd:cd17927 7 QLELAQPALKGKNTIICLPTGSGKT------FVAVLICEHHLKKFPAGRKGkvVFLANKVPLVEQQKEVFRKHFE-RPGY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 194 QAINLCDINEEENSVWLE-DRSHVVVTTPGKLL------RMCSLrpeycTLVSYLVMDEADL--------LLSFGYEEEM 258
Cdd:cd17927 80 KVTGLSGDTSENVSVEQIvESSDVIIVTPQILVndlksgTIVSL-----SDFSLLVFDECHNttknhpynEIMFRYLDQK 154
|
....*...
gi 25148203 259 IKIRSKLP 266
Cdd:cd17927 155 LGSSGPLP 162
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
212-297 |
1.62e-03 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 39.37 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148203 212 DRSHVVVTTPGKLLRMCsLRPEYCTLVSYLVMDEA-------DLLLSfgyeeeMIKIRSKLPPTYQCLMTSATLkdDMTT 284
Cdd:cd17917 76 SKTRIKFCTDGILLREL-LSDPLLSGYSHVILDEAhersldtDFLLG------LLKDLLRKRPDLKVILMSATL--DAEK 146
|
90
....*....|...
gi 25148203 285 LKKLFMTGPVITI 297
Cdd:cd17917 147 FSSYFGGAPVIHI 159
|
|
| |
