|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
91-551 |
1.49e-86 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 272.80 E-value: 1.49e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 91 LGSLIVATAVERWELHKRIALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMvatnvavdasq 170
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 171 rtmelldknkaselpgsqvvfedpsvqkqEDEETKNMYKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMQELFPDSkdv 250
Cdd:COG0471 70 -----------------------------GSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIP--- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 251 MNFASWFAFALPNMLLMLVMAWlWLLCFYMRPNLKKTciccgrkkkdteKIASKVLYEEYRKLGPLSYAECNVLFCFGLL 330
Cdd:COG0471 118 ISFFEWMLVGLPVALVGLLLLW-LVLYRLLPPEIKEV------------PGSKEVIREELAELGPLSRREKIALAIFALT 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 331 IILWFSRDPGFMPgwlsiawiegntkhvtDATVAIFVAILLFIvpsqkpkfnfsrqteeerktpfypPPLLNWKVTQEKV 410
Cdd:COG0471 185 VLLWITGSLHGIP----------------IAVVALLGAVLLLL------------------------TGVLTWKDAYKSI 224
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 411 PWGIVLLLGGGFAMAKGCETSGLSEWMARQMEP-LSSVRPAIITLILSCIVAMTTECTSNVATTTLFLPIFASMARSIGI 489
Cdd:COG0471 225 PWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGV 304
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24638444 490 HPLYVMIPCTLSASLAFMLPVATPPNAIVFAYGHLKVIDMVKTGLVMNILGIASVFLSVNTW 551
Cdd:COG0471 305 NPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
34-558 |
1.28e-71 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 237.27 E-value: 1.28e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 34 KFARCAYVIILMAIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQ----VCVQYMTDTNMLFLGSLIVATAVERWELHKRI 109
Cdd:pfam00939 29 KAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSGFSSTTTWLVFGAFFISAAFEKTGLGRRI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 110 ALRMLLFVGTKPsrLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMVATNvavdasqrtmelldknkaselpGSQV 189
Cdd:pfam00939 109 ALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPAF----------------------GSDP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 190 vfedpsvqkqEDEETKNMYKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMQELfpdSKDVMNFASWFAFALPNMLLMLV 269
Cdd:pfam00939 165 ----------EKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI---LGVTITWASWFLAAIPPGVILLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 270 MAWLWLLCFYMrPNLKktciccgrKKKDTEKIASKvlyeEYRKLGPLSYAECNVLFCFGLLIILWFSrdpgfmpgwlsia 349
Cdd:pfam00939 232 LAPLLLYVLYP-PEIK--------SVPDAKAIAKT----ELKELGPMTFREKALLGLFVLLLLLWIF------------- 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 350 wieGNTKHVTDATVAIFVAILLFIvpsqkpkfnfsrqteeerktpfypPPLLNWK-VTQEKVPWGIVLLLGGGFAMAKGC 428
Cdd:pfam00939 286 ---GGSLNIDATTVAIIGLALMLL------------------------LRILDWKdIVKNKGAWNTLIWLGGLIMLANGL 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 429 ETSGLSEWMARQMEPLSSVRPAIITL--ILSCIVAMTTECTSNVATTTLFLPIFASMARSI-GIHPLYVMIPCTLSASLA 505
Cdd:pfam00939 339 ERSGFIEWLGNTLSTSLSGFSPAMAFiiILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIpGAPPLLAALLLGFAISLG 418
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 24638444 506 -FMLPVATPPNAIVFAYGHLKVIDMVKTGLVMNILGIASVFLSVNTWGRAVFNL 558
Cdd:pfam00939 419 gFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLGSL 472
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
39-552 |
1.46e-66 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 221.30 E-value: 1.46e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 39 AYVIILMAIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQVCVQYMTDTNMLFLGSLIVATAVERWELHKRIALRMLLFVG 118
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 119 TKPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMvatnvavDASQrtmelldknkaselpgsqvvfedpsvqk 198
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKL-------DISP---------------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 199 qedeetknmyKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMQELFPDSkdvMNFASWFAFALPNMLLMLVMAWLWLLcf 278
Cdd:cd01115 126 ----------SRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG---FSFFEFTPIGLPLLIIGLLYLWFIFR-- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 279 ymrpnlkktciccgrkkkdtekiaskvlyeeyrklgplsyaecNVLFCFGLLIILWFSRDPGFMPgwlsiawiegntkhV 358
Cdd:cd01115 191 -------------------------------------------LAVLIITIVLLAALAAITGLLP--------------V 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 359 TDATVAIFVAILLFIVpsqkpkfnfsrqteeerktpfyppplLNWKVTQEKVPWGIVLLLGGGFAMAKGCETSGLSEWMA 438
Cdd:cd01115 214 SVAIAIGAIVLVFGGV--------------------------LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIA 267
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 439 RQMEPLSSVRPAIITLILSCIVAMT-TECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTLSASLAFMLPVATPPNAI 517
Cdd:cd01115 268 EALISLLGGLPPFAILLLLCLLTLVlTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAI 347
|
490 500 510
....*....|....*....|....*....|....*
gi 24638444 518 VFAYGHLKVIDMVKTGLVMNILGIASVFLSVNTWG 552
Cdd:cd01115 348 VLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
41-551 |
6.41e-48 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 172.91 E-value: 6.41e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 41 VIILMAIYWCTDVIPVAITSLLPVLLFP----LLKVLDSKQVCVQYMTDTNMLFLGSLIVATAVERWELHKRIALRMLLF 116
Cdd:TIGR00785 16 IFVAAIVGWILEPLPLPVTALLAIPIIAvllgVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 117 VGTKPSRL-MLGFMFVTAFLSMWISNTA-TTAMMIPIVEAMLEQMvatnvavdasqrtmelldknkaselpgsqvvfedp 194
Cdd:TIGR00785 96 MGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL----------------------------------- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 195 svQKQEDEETKNMYKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMqelFPDSKDVMNFASWFAFALPNMLLMLVMAWlW 274
Cdd:TIGR00785 141 --GSKPEKSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGIL---SKILGIQISWGDWFLAGLPLGIILLLLVP-L 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 275 LLCFYMRPNLKKtciccgrkKKDTEKIASkvlyEEYRKLGPLSYAECNVLFCFGLLIILWFSrdpgfmpgwlsiawieGN 354
Cdd:TIGR00785 215 LLYVLFPPELKL--------KDEVDLWAK----EELEEMGPMSFREKALLGIFLLALLLWIF----------------GG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 355 TKHVTDATVAIFVAILLFIVPsqkpkfnfsrqteeerktpfypppLLNWK-VTQEKVPWGIVLLLGGGFAMAKGCETSGL 433
Cdd:TIGR00785 267 SLGINASVVALLAVVLMLFLG------------------------IVTWKdIQKNKVAWNTLILFGGLIGLAGGLKKSGF 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 434 SEWMARQMEP-LSSVRPAIITLILSCIVAMT-TECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTLSASLA-FMLPV 510
Cdd:TIGR00785 323 IKWFSEKLVGiLDGLSPTIAVLVLVVLFYIIlYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPY 402
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 24638444 511 ATPPNAIVFAYGHLKVIDMVKTGLVMNILGIAsVFLSVNTW 551
Cdd:TIGR00785 403 ATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLI-VLLLVGTL 442
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
11-168 |
1.98e-05 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 46.92 E-value: 1.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 11 FKSFVILFFAPILLLPLIILVPDKFARCAYVIILMAIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQVCVQYMTDTNMLF 90
Cdd:pfam03600 181 FRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFF 260
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24638444 91 LGSLIVATAVERWELHKRIALRMLLFVGtkPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMVATNVAVDA 168
Cdd:pfam03600 261 AGLFILVGALEKTGLADALADALGGLSG--LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
91-551 |
1.49e-86 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 272.80 E-value: 1.49e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 91 LGSLIVATAVERWELHKRIALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMvatnvavdasq 170
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 171 rtmelldknkaselpgsqvvfedpsvqkqEDEETKNMYKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMQELFPDSkdv 250
Cdd:COG0471 70 -----------------------------GSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIP--- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 251 MNFASWFAFALPNMLLMLVMAWlWLLCFYMRPNLKKTciccgrkkkdteKIASKVLYEEYRKLGPLSYAECNVLFCFGLL 330
Cdd:COG0471 118 ISFFEWMLVGLPVALVGLLLLW-LVLYRLLPPEIKEV------------PGSKEVIREELAELGPLSRREKIALAIFALT 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 331 IILWFSRDPGFMPgwlsiawiegntkhvtDATVAIFVAILLFIvpsqkpkfnfsrqteeerktpfypPPLLNWKVTQEKV 410
Cdd:COG0471 185 VLLWITGSLHGIP----------------IAVVALLGAVLLLL------------------------TGVLTWKDAYKSI 224
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 411 PWGIVLLLGGGFAMAKGCETSGLSEWMARQMEP-LSSVRPAIITLILSCIVAMTTECTSNVATTTLFLPIFASMARSIGI 489
Cdd:COG0471 225 PWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGV 304
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24638444 490 HPLYVMIPCTLSASLAFMLPVATPPNAIVFAYGHLKVIDMVKTGLVMNILGIASVFLSVNTW 551
Cdd:COG0471 305 NPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
34-558 |
1.28e-71 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 237.27 E-value: 1.28e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 34 KFARCAYVIILMAIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQ----VCVQYMTDTNMLFLGSLIVATAVERWELHKRI 109
Cdd:pfam00939 29 KAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSGFSSTTTWLVFGAFFISAAFEKTGLGRRI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 110 ALRMLLFVGTKPsrLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMVATNvavdasqrtmelldknkaselpGSQV 189
Cdd:pfam00939 109 ALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPAF----------------------GSDP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 190 vfedpsvqkqEDEETKNMYKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMQELfpdSKDVMNFASWFAFALPNMLLMLV 269
Cdd:pfam00939 165 ----------EKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI---LGVTITWASWFLAAIPPGVILLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 270 MAWLWLLCFYMrPNLKktciccgrKKKDTEKIASKvlyeEYRKLGPLSYAECNVLFCFGLLIILWFSrdpgfmpgwlsia 349
Cdd:pfam00939 232 LAPLLLYVLYP-PEIK--------SVPDAKAIAKT----ELKELGPMTFREKALLGLFVLLLLLWIF------------- 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 350 wieGNTKHVTDATVAIFVAILLFIvpsqkpkfnfsrqteeerktpfypPPLLNWK-VTQEKVPWGIVLLLGGGFAMAKGC 428
Cdd:pfam00939 286 ---GGSLNIDATTVAIIGLALMLL------------------------LRILDWKdIVKNKGAWNTLIWLGGLIMLANGL 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 429 ETSGLSEWMARQMEPLSSVRPAIITL--ILSCIVAMTTECTSNVATTTLFLPIFASMARSI-GIHPLYVMIPCTLSASLA 505
Cdd:pfam00939 339 ERSGFIEWLGNTLSTSLSGFSPAMAFiiILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIpGAPPLLAALLLGFAISLG 418
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 24638444 506 -FMLPVATPPNAIVFAYGHLKVIDMVKTGLVMNILGIASVFLSVNTWGRAVFNL 558
Cdd:pfam00939 419 gFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLGSL 472
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
39-552 |
1.46e-66 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 221.30 E-value: 1.46e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 39 AYVIILMAIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQVCVQYMTDTNMLFLGSLIVATAVERWELHKRIALRMLLFVG 118
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 119 TKPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMvatnvavDASQrtmelldknkaselpgsqvvfedpsvqk 198
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKL-------DISP---------------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 199 qedeetknmyKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMQELFPDSkdvMNFASWFAFALPNMLLMLVMAWLWLLcf 278
Cdd:cd01115 126 ----------SRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG---FSFFEFTPIGLPLLIIGLLYLWFIFR-- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 279 ymrpnlkktciccgrkkkdtekiaskvlyeeyrklgplsyaecNVLFCFGLLIILWFSRDPGFMPgwlsiawiegntkhV 358
Cdd:cd01115 191 -------------------------------------------LAVLIITIVLLAALAAITGLLP--------------V 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 359 TDATVAIFVAILLFIVpsqkpkfnfsrqteeerktpfyppplLNWKVTQEKVPWGIVLLLGGGFAMAKGCETSGLSEWMA 438
Cdd:cd01115 214 SVAIAIGAIVLVFGGV--------------------------LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIA 267
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 439 RQMEPLSSVRPAIITLILSCIVAMT-TECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTLSASLAFMLPVATPPNAI 517
Cdd:cd01115 268 EALISLLGGLPPFAILLLLCLLTLVlTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAI 347
|
490 500 510
....*....|....*....|....*....|....*
gi 24638444 518 VFAYGHLKVIDMVKTGLVMNILGIASVFLSVNTWG 552
Cdd:cd01115 348 VLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
41-551 |
6.41e-48 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 172.91 E-value: 6.41e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 41 VIILMAIYWCTDVIPVAITSLLPVLLFP----LLKVLDSKQVCVQYMTDTNMLFLGSLIVATAVERWELHKRIALRMLLF 116
Cdd:TIGR00785 16 IFVAAIVGWILEPLPLPVTALLAIPIIAvllgVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 117 VGTKPSRL-MLGFMFVTAFLSMWISNTA-TTAMMIPIVEAMLEQMvatnvavdasqrtmelldknkaselpgsqvvfedp 194
Cdd:TIGR00785 96 MGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL----------------------------------- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 195 svQKQEDEETKNMYKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMqelFPDSKDVMNFASWFAFALPNMLLMLVMAWlW 274
Cdd:TIGR00785 141 --GSKPEKSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGIL---SKILGIQISWGDWFLAGLPLGIILLLLVP-L 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 275 LLCFYMRPNLKKtciccgrkKKDTEKIASkvlyEEYRKLGPLSYAECNVLFCFGLLIILWFSrdpgfmpgwlsiawieGN 354
Cdd:TIGR00785 215 LLYVLFPPELKL--------KDEVDLWAK----EELEEMGPMSFREKALLGIFLLALLLWIF----------------GG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 355 TKHVTDATVAIFVAILLFIVPsqkpkfnfsrqteeerktpfypppLLNWK-VTQEKVPWGIVLLLGGGFAMAKGCETSGL 433
Cdd:TIGR00785 267 SLGINASVVALLAVVLMLFLG------------------------IVTWKdIQKNKVAWNTLILFGGLIGLAGGLKKSGF 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 434 SEWMARQMEP-LSSVRPAIITLILSCIVAMT-TECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTLSASLA-FMLPV 510
Cdd:TIGR00785 323 IKWFSEKLVGiLDGLSPTIAVLVLVVLFYIIlYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPY 402
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 24638444 511 ATPPNAIVFAYGHLKVIDMVKTGLVMNILGIAsVFLSVNTW 551
Cdd:TIGR00785 403 ATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLI-VLLLVGTL 442
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
46-542 |
3.34e-36 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 139.31 E-value: 3.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 46 AIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQVCVQYMTDTNMLFLGSLIVATAVERWELHKRIALRMLLFvGTKPSRLM 125
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 126 LGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMvatnvavdasqrtmelldknkaselpgsqvvfedpsvqkqedeeTK 205
Cdd:cd00625 80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKL--------------------------------------------GL 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 206 NMYKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMQelfpdskdvMNFASWFAFALPNMLLMLVMAWLWLLCFYmrpnlk 285
Cdd:cd00625 116 SPPVPLLLALAFAANIGGAATPIGNPPNLIIASLSG---------LGFLDFLAFMAPPALGLLLLLLGLLYLLF------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 286 ktciccGRKKKDTEKIASKVLYEEYRKLGPLSYAECNVLFCFGLLIILWFSRDPGFMPgwlsiawiegntkhvtdATVAI 365
Cdd:cd00625 181 ------RKKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLI-----------------ALLGA 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 366 FVAILLFIVpsqkpkfnfsrqteeerktpfypppLLNWKVTQEKVPWGIVLLLGGGFAMAKGCETSGLSEWMARQMEPLS 445
Cdd:cd00625 238 LLLLLLLVR-------------------------GLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALV 292
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 446 SVRPAIITLILSCIVAMTTECTSNVATTTLFLPIFASMAR-----SIGIHPLYVMIPCTLSASLAFMLPVATPPNAIVfa 520
Cdd:cd00625 293 GLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPpepawLALALGSTLGGNLTLIGSLANLIPLGAAENAGV-- 370
|
490 500
....*....|....*....|..
gi 24638444 521 ygHLKVIDMVKTGLVMNILGIA 542
Cdd:cd00625 371 --GISFGEFLKVGLPLTLLSLV 390
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
46-496 |
1.21e-23 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 102.39 E-value: 1.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 46 AIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQVCVQYMTDTNMLFLGSLIVATAVERWELHKRIALRMLLFVGTKPSRLM 125
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 126 LGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMvatnvavdasqrtmelldknkaselpgsqvvfedpsvqkqedeetK 205
Cdd:pfam03600 81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRL---------------------------------------------G 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 206 NMYKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMQELFPDskdvmnfasWFAFALPNMLLMLVMAWLWLLCFYMRPNLk 285
Cdd:pfam03600 116 LPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFGD---------FGFFMFPPVGVALLLVGLLPLLLIFRKLL- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 286 ktciccgrKKKDTEKIASKVLYEEYRKLGPLSYAECNVLFCFGLLIILwfsrdpgfmpgwlsiawiegntkHVTDATVAI 365
Cdd:pfam03600 186 --------PVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLL-----------------------LSVLALAGA 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 366 FVAILLfivpsqkpkfnfsrqteeerktpfyppPLLNWKVTQEKVPWGIVLLLGGGFAMAKGCETSGLSEWMARQMEPLS 445
Cdd:pfam03600 235 LLLLLT---------------------------GVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS 287
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 24638444 446 svRPAIITLILSCIVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMI 496
Cdd:pfam03600 288 --GLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
412-546 |
4.68e-10 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 61.50 E-value: 4.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 412 WGIVLLLGGGFAMAKGCETSGLSEWMARQMEPLS--SVRPAIITLILSCIVAMTtecTSNVATTTLFLPIFASMARSIGI 489
Cdd:cd00625 39 WETILLLFGMMILSAALEETGLFDRLAAKLARASkgSRRLLLLLMLLTAALSAF---FSNDATAVLLTPIVLALLRKLGL 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 24638444 490 -HPLYVMIPCTLSASLA-FMLPVATPPNAIVFAYGHLKVIDMVKTGLVMNILGIASVFL 546
Cdd:cd00625 116 sPPVPLLLALAFAANIGgAATPIGNPPNLIIASLSGLGFLDFLAFMAPPALGLLLLLLG 174
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
397-546 |
9.45e-10 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 60.40 E-value: 9.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 397 PPPLLNWKVTQEKVPWGIVLLLGGGFAMAKGCETSGLSEWMARQMEPLSSVRPAIITLILSCIVAMTTECTSNVATTTLF 476
Cdd:pfam03600 24 LLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIM 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24638444 477 LPIFASMARSIGIHPLYVMIPCTLSASLAFML-PVATPPNAIVFAYGHLKVIDMVKTGLVMNILGIASVFL 546
Cdd:pfam03600 104 IPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGL 174
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
85-505 |
2.00e-06 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 50.13 E-value: 2.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 85 DTNMLFLGSLIVATAVERWELHKRIALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVeamleqmvatnv 164
Cdd:COG1055 54 NTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVV------------ 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 165 avdasqrtMELLDKNKASELPgsqvvfedpsvqkqedeetknmykaMNLCVCYAASIGGTATLTGTGPNVVLLGQMQelf 244
Cdd:COG1055 122 --------LAIARRLGLNPVP-------------------------FLIAIVFAANIGGAATPIGNPTNIMIASAGG--- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 245 pdskdvMNFASWFAFALPNMLLMLVMAWLWLLcFYMRPNLKKTciccgRKKKDTEKIASKvlyeeYRKLGPLSyaecnvL 324
Cdd:COG1055 166 ------LSFLDFLANLFPPSLVSLLVTLLVLY-LLFRKELPAA-----PDLEDDPKEAIK-----DRRLLRIS------L 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 325 FCFGLLIILWFSRDPGfmpgwlsiawiegntkHVTDATVAIFVAILLFIVpsqkpkfnfsrqteeerkTPFYPPPLLnwk 404
Cdd:COG1055 223 LVLALLLVGFVLHSFL----------------GLPPALIALLGAAVLLLL------------------ARVDVREVL--- 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 405 vtqEKVPWGIVLLLGGGFAMAKGCETSGLSEWMARQMEPLSSVRPAIITLILSCIVAMTTECTSNVATTTLFLPIFASMA 484
Cdd:COG1055 266 ---KKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLG 342
|
410 420
....*....|....*....|.
gi 24638444 485 RSIGIHPLYVMIpcTLSASLA 505
Cdd:COG1055 343 ATGNPEPLWLAL--ALGATLG 361
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
412-524 |
1.41e-05 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 47.43 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 412 WGIVLLLGGGFAMAKGCETSGLSEWMARQMEPLSSVRPAIITLILSCIVAMTTECTSNVATTTLFLPIFASMARSIGIHP 491
Cdd:COG1055 53 WNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNP 132
|
90 100 110
....*....|....*....|....*....|....
gi 24638444 492 LYVMIPCTLSASLA-FMLPVATPPNAIVFAYGHL 524
Cdd:COG1055 133 VPFLIAIVFAANIGgAATPIGNPTNIMIASAGGL 166
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
11-168 |
1.98e-05 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 46.92 E-value: 1.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 11 FKSFVILFFAPILLLPLIILVPDKFARCAYVIILMAIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQVCVQYMTDTNMLF 90
Cdd:pfam03600 181 FRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFF 260
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24638444 91 LGSLIVATAVERWELHKRIALRMLLFVGtkPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMVATNVAVDA 168
Cdd:pfam03600 261 AGLFILVGALEKTGLADALADALGGLSG--LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
41-159 |
1.87e-04 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 43.99 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 41 VIILMAIYWCTD---VIPVAITSLLPVLLFPLLKVLDSKQVcvQYMTDTNMLFL--GSLIVATAVERWELHKRIALRMLL 115
Cdd:COG0471 180 IFALTVLLWITGslhGIPIAVVALLGAVLLLLTGVLTWKDA--YKSIPWGVLLLfgGGLALGAALEKTGLAAWLADALLP 257
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 24638444 116 FVGTKPSRLML-GFMFVTAFLSMWISNTATTAMMIPIVEAMLEQM 159
Cdd:COG0471 258 LLGGLSPLLLLlLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
41-155 |
1.91e-03 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 40.70 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 41 VIILMAIYWCTDVIPVAITSLLPVL-LFPLLKVLDSKQVCVQYMTDTNMLFLGSLIVATAVERWELHKRIALRMLLFVGT 119
Cdd:cd00625 215 LLLLFVLLFFFLIPLGLIALLGALLlLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGL 294
|
90 100 110
....*....|....*....|....*....|....*.
gi 24638444 120 KPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAM 155
Cdd:cd00625 295 PPLAALLLIGLLSALLSNFISNVPTVALLLPIAASL 330
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
408-518 |
2.17e-03 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 40.70 E-value: 2.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638444 408 EKVPWGIVLLLGGGFAMAKGCETSGLSEWMARQMEPLSSVRPAIITLILSCIVAMTTECTSNVATTTLFLPIFASMARSI 487
Cdd:cd01116 266 SRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQL 345
|
90 100 110
....*....|....*....|....*....|..
gi 24638444 488 GIHPLYVMIPCTLSASLA-FMLPVATPPNAIV 518
Cdd:cd01116 346 GIPLLPLWWALALGACLGgNGTLIGASANVVA 377
|
|
| |
