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Conserved domains on  [gi|24651303|ref|NP_733347|]
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uncharacterized protein Dmel_CG31029 [Drosophila melanogaster]

Protein Classification

DUF4776 domain-containing protein( domain architecture ID 11068275)

DUF4776 domain-containing protein with a DUF4788 domain; similar to Drosophila melanogaster protein phosphatase 1c interacting protein 1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4776 pfam16003
Domain of unknown function (DUF4776); This presumed domain is functionally uncharacterized. ...
335-841 0e+00

Domain of unknown function (DUF4776); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 444 and 485 amino acids in length. There is a conserved TLR sequence motif.


:

Pssm-ID: 406413  Cd Length: 502  Bit Score: 696.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   335 YKPPNLCQLCRSDISWLPKISACPYCGYKTFEDIQpsEQPYDLTATAQQLLRDCLRKETCELDPSKGDDEAMGDKNKDDP 414
Cdd:pfam16003   2 IKPPRFCPVCLTNMSWLPKFAACPKCGYKPMPVFE--ERPYDETATADQILNDHLGKPPSTSDDYCEDPCAKASKEKKDE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   415 NVPQQCGCLGGKPCTRCRIRKLCDNFFKENECKIEPLPQAYPQAPSKSQPESKKVNQAN-SDESLRRTQLISIFTEMRNM 493
Cdd:pfam16003  80 KSPCRCTCKGGKVCTHCRIRKLCADIFKDYEPLKPSCPKVEPQSEAQSAKKSEDFCVRNkSTASQCRPHLARVFSELRDL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   494 FGKKKGANEadvVAEELRKECDAACRNTKSAKARRKARKALQKTLDE--IDKAYPKPAKMRIKK--ERTHHKKSRCYTFL 569
Cdd:pfam16003 160 YDIKDTKKK---LAAKLQEICDEACRLAKKSKKRRKATKSLKKKLKEtaIKDATTTPKKKKKRKrlKKKPRVPSKRYSFL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   570 KLKTVSKDSRIGHLDCISGSKhtgysRIPCHMGWMWTKSEMARHKSWRPGAISRPIRQLMSYFLKDFPADNICLSRYHYR 649
Cdd:pfam16003 237 VPKRKPHHPRIGHKTCVRQSG-----KVPRHMGWAWTKSPLARKPGWRPGAIRKPIRQLMKYFLKDYPVDNIPVSRYHYR 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   650 HKKCRRVEEL--EEPLVQHPTLHISRKGDEYIITLRPLKDPKALASSANPYADMKPVVFRITKDPMAAGLRQMRVNLQDK 727
Cdd:pfam16003 312 FKKCQPVDEAekEEDLVQHPTLHIEKKNGEYIITLRPLKDPKSLAVAANPYANMKPVVFRIVKSPLAVALREIKRKLKDK 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   728 GFAPCTCRRPVASCFCRSHIEKKRIQYEVENECRQRGWPNNSDTFVYSpnsDDDDSDREYEFGVTPPAGVIKPERVRQPD 807
Cdd:pfam16003 392 GFPKCTCHKPVMMCFCRSHVDKKRLVYALQKECERRGMESCEDHLVLS---DTSDSEMEFEFGVTPPAGLVKPERLPKPD 468
                         490       500       510
                  ....*....|....*....|....*....|....
gi 24651303   808 RAHVETQYVDHDWAAPTMYPHPANMLVQYGGCVM 841
Cdd:pfam16003 469 VVNAETQYNENDWAMPPMYPHPPNPYVQYGDCVV 502
DUF4788 super family cl24561
Domain of unknown function (DUF4788); This presumed domain is functionally uncharacterized. ...
33-228 1.04e-45

Domain of unknown function (DUF4788); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 230 amino acids in length. There is a single completely conserved residue D that may be functionally important.


The actual alignment was detected with superfamily member pfam16032:

Pssm-ID: 406440  Cd Length: 229  Bit Score: 164.04  E-value: 1.04e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303    33 YSVRLFEDFEELSMERIFVDQFPTEALGGFTSSPCELIGALTSKGVGVTLKENDELIGSGNATLESSILRQLTDPSFSVT 112
Cdd:pfam16032  20 VNVKFNNTPLKLTSSRINVTDFKAGAGTEFVSSPCELRQSLESCGMPVTVRYNGKVLGTGQISFPQSFIDRIDDGMSDLL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   113 QSVTVQLTKGpkNDRVGEVELLLKISSASPDINHGLIpFGCYDVCKPVDHSINKKDIIFTLGRSGKC--ATNSCIT---- 186
Cdd:pfam16032 100 HADTCDLERG--GEVVGTLEVLCRLIIKCPDLDKEPE-SECSRSCRNLDKSINPQDIMFVLGRSQRCpsACDPCLDalep 176
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 24651303   187 ---DERLMSHAGAPFQCPHAASQNQEDQDNKGgafARCGCFLKGM 228
Cdd:pfam16032 177 eegDERLRLDLQRYRSCNHKRPLETLTNKPSG---KEACCELKKM 218
 
Name Accession Description Interval E-value
DUF4776 pfam16003
Domain of unknown function (DUF4776); This presumed domain is functionally uncharacterized. ...
335-841 0e+00

Domain of unknown function (DUF4776); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 444 and 485 amino acids in length. There is a conserved TLR sequence motif.


Pssm-ID: 406413  Cd Length: 502  Bit Score: 696.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   335 YKPPNLCQLCRSDISWLPKISACPYCGYKTFEDIQpsEQPYDLTATAQQLLRDCLRKETCELDPSKGDDEAMGDKNKDDP 414
Cdd:pfam16003   2 IKPPRFCPVCLTNMSWLPKFAACPKCGYKPMPVFE--ERPYDETATADQILNDHLGKPPSTSDDYCEDPCAKASKEKKDE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   415 NVPQQCGCLGGKPCTRCRIRKLCDNFFKENECKIEPLPQAYPQAPSKSQPESKKVNQAN-SDESLRRTQLISIFTEMRNM 493
Cdd:pfam16003  80 KSPCRCTCKGGKVCTHCRIRKLCADIFKDYEPLKPSCPKVEPQSEAQSAKKSEDFCVRNkSTASQCRPHLARVFSELRDL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   494 FGKKKGANEadvVAEELRKECDAACRNTKSAKARRKARKALQKTLDE--IDKAYPKPAKMRIKK--ERTHHKKSRCYTFL 569
Cdd:pfam16003 160 YDIKDTKKK---LAAKLQEICDEACRLAKKSKKRRKATKSLKKKLKEtaIKDATTTPKKKKKRKrlKKKPRVPSKRYSFL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   570 KLKTVSKDSRIGHLDCISGSKhtgysRIPCHMGWMWTKSEMARHKSWRPGAISRPIRQLMSYFLKDFPADNICLSRYHYR 649
Cdd:pfam16003 237 VPKRKPHHPRIGHKTCVRQSG-----KVPRHMGWAWTKSPLARKPGWRPGAIRKPIRQLMKYFLKDYPVDNIPVSRYHYR 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   650 HKKCRRVEEL--EEPLVQHPTLHISRKGDEYIITLRPLKDPKALASSANPYADMKPVVFRITKDPMAAGLRQMRVNLQDK 727
Cdd:pfam16003 312 FKKCQPVDEAekEEDLVQHPTLHIEKKNGEYIITLRPLKDPKSLAVAANPYANMKPVVFRIVKSPLAVALREIKRKLKDK 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   728 GFAPCTCRRPVASCFCRSHIEKKRIQYEVENECRQRGWPNNSDTFVYSpnsDDDDSDREYEFGVTPPAGVIKPERVRQPD 807
Cdd:pfam16003 392 GFPKCTCHKPVMMCFCRSHVDKKRLVYALQKECERRGMESCEDHLVLS---DTSDSEMEFEFGVTPPAGLVKPERLPKPD 468
                         490       500       510
                  ....*....|....*....|....*....|....
gi 24651303   808 RAHVETQYVDHDWAAPTMYPHPANMLVQYGGCVM 841
Cdd:pfam16003 469 VVNAETQYNENDWAMPPMYPHPPNPYVQYGDCVV 502
DUF4788 pfam16032
Domain of unknown function (DUF4788); This presumed domain is functionally uncharacterized. ...
33-228 1.04e-45

Domain of unknown function (DUF4788); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 230 amino acids in length. There is a single completely conserved residue D that may be functionally important.


Pssm-ID: 406440  Cd Length: 229  Bit Score: 164.04  E-value: 1.04e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303    33 YSVRLFEDFEELSMERIFVDQFPTEALGGFTSSPCELIGALTSKGVGVTLKENDELIGSGNATLESSILRQLTDPSFSVT 112
Cdd:pfam16032  20 VNVKFNNTPLKLTSSRINVTDFKAGAGTEFVSSPCELRQSLESCGMPVTVRYNGKVLGTGQISFPQSFIDRIDDGMSDLL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   113 QSVTVQLTKGpkNDRVGEVELLLKISSASPDINHGLIpFGCYDVCKPVDHSINKKDIIFTLGRSGKC--ATNSCIT---- 186
Cdd:pfam16032 100 HADTCDLERG--GEVVGTLEVLCRLIIKCPDLDKEPE-SECSRSCRNLDKSINPQDIMFVLGRSQRCpsACDPCLDalep 176
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 24651303   187 ---DERLMSHAGAPFQCPHAASQNQEDQDNKGgafARCGCFLKGM 228
Cdd:pfam16032 177 eegDERLRLDLQRYRSCNHKRPLETLTNKPSG---KEACCELKKM 218
 
Name Accession Description Interval E-value
DUF4776 pfam16003
Domain of unknown function (DUF4776); This presumed domain is functionally uncharacterized. ...
335-841 0e+00

Domain of unknown function (DUF4776); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 444 and 485 amino acids in length. There is a conserved TLR sequence motif.


Pssm-ID: 406413  Cd Length: 502  Bit Score: 696.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   335 YKPPNLCQLCRSDISWLPKISACPYCGYKTFEDIQpsEQPYDLTATAQQLLRDCLRKETCELDPSKGDDEAMGDKNKDDP 414
Cdd:pfam16003   2 IKPPRFCPVCLTNMSWLPKFAACPKCGYKPMPVFE--ERPYDETATADQILNDHLGKPPSTSDDYCEDPCAKASKEKKDE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   415 NVPQQCGCLGGKPCTRCRIRKLCDNFFKENECKIEPLPQAYPQAPSKSQPESKKVNQAN-SDESLRRTQLISIFTEMRNM 493
Cdd:pfam16003  80 KSPCRCTCKGGKVCTHCRIRKLCADIFKDYEPLKPSCPKVEPQSEAQSAKKSEDFCVRNkSTASQCRPHLARVFSELRDL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   494 FGKKKGANEadvVAEELRKECDAACRNTKSAKARRKARKALQKTLDE--IDKAYPKPAKMRIKK--ERTHHKKSRCYTFL 569
Cdd:pfam16003 160 YDIKDTKKK---LAAKLQEICDEACRLAKKSKKRRKATKSLKKKLKEtaIKDATTTPKKKKKRKrlKKKPRVPSKRYSFL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   570 KLKTVSKDSRIGHLDCISGSKhtgysRIPCHMGWMWTKSEMARHKSWRPGAISRPIRQLMSYFLKDFPADNICLSRYHYR 649
Cdd:pfam16003 237 VPKRKPHHPRIGHKTCVRQSG-----KVPRHMGWAWTKSPLARKPGWRPGAIRKPIRQLMKYFLKDYPVDNIPVSRYHYR 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   650 HKKCRRVEEL--EEPLVQHPTLHISRKGDEYIITLRPLKDPKALASSANPYADMKPVVFRITKDPMAAGLRQMRVNLQDK 727
Cdd:pfam16003 312 FKKCQPVDEAekEEDLVQHPTLHIEKKNGEYIITLRPLKDPKSLAVAANPYANMKPVVFRIVKSPLAVALREIKRKLKDK 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   728 GFAPCTCRRPVASCFCRSHIEKKRIQYEVENECRQRGWPNNSDTFVYSpnsDDDDSDREYEFGVTPPAGVIKPERVRQPD 807
Cdd:pfam16003 392 GFPKCTCHKPVMMCFCRSHVDKKRLVYALQKECERRGMESCEDHLVLS---DTSDSEMEFEFGVTPPAGLVKPERLPKPD 468
                         490       500       510
                  ....*....|....*....|....*....|....
gi 24651303   808 RAHVETQYVDHDWAAPTMYPHPANMLVQYGGCVM 841
Cdd:pfam16003 469 VVNAETQYNENDWAMPPMYPHPPNPYVQYGDCVV 502
DUF4788 pfam16032
Domain of unknown function (DUF4788); This presumed domain is functionally uncharacterized. ...
33-228 1.04e-45

Domain of unknown function (DUF4788); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 230 amino acids in length. There is a single completely conserved residue D that may be functionally important.


Pssm-ID: 406440  Cd Length: 229  Bit Score: 164.04  E-value: 1.04e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303    33 YSVRLFEDFEELSMERIFVDQFPTEALGGFTSSPCELIGALTSKGVGVTLKENDELIGSGNATLESSILRQLTDPSFSVT 112
Cdd:pfam16032  20 VNVKFNNTPLKLTSSRINVTDFKAGAGTEFVSSPCELRQSLESCGMPVTVRYNGKVLGTGQISFPQSFIDRIDDGMSDLL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651303   113 QSVTVQLTKGpkNDRVGEVELLLKISSASPDINHGLIpFGCYDVCKPVDHSINKKDIIFTLGRSGKC--ATNSCIT---- 186
Cdd:pfam16032 100 HADTCDLERG--GEVVGTLEVLCRLIIKCPDLDKEPE-SECSRSCRNLDKSINPQDIMFVLGRSQRCpsACDPCLDalep 176
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 24651303   187 ---DERLMSHAGAPFQCPHAASQNQEDQDNKGgafARCGCFLKGM 228
Cdd:pfam16032 177 eegDERLRLDLQRYRSCNHKRPLETLTNKPSG---KEACCELKKM 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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