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Conserved domains on  [gi|221459691|ref|NP_733162|]
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beaten path VII [Drosophila melanogaster]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208967)

immunoglobulin domain-containing protein such as human platelet-derived growth factor receptor-like protein, which has been implicated in colorectal cancer and susceptibility to Behcet disease

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 141-183 1.68e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam08205:

Pssm-ID: 472250  Cd Length: 89  Bit Score: 40.48  E-value: 1.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221459691  141 PTIKFRKRTPFAVGEKLFALCNTTRGRPAPHITWLINGKKVED 183
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLEA 43
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 34-118 6.02e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 6.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221459691    34 YVERGSSATFKCTHNVRPEIlfKVTWLKvdkgkffefiNGRNPPFRNSTIEGAEidwdNSNEQQVTLKDVQFDLSGQFYC 113
Cdd:smart00410   5 TVKEGESVTLSCEASGSPPP--EVTWYK----------QGGKLLAESGRFSVSR----SGSTSTLTISNVTPEDSGTYTC 68


                   ....*
gi 221459691   114 EVSTD 118
Cdd:smart00410  69 AATNS 73
 
Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 141-183 1.68e-04

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 40.48  E-value: 1.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221459691  141 PTIKFRKRTPFAVGEKLFALCNTTRGRPAPHITWLINGKKVED 183
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLEA 43
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 34-118 6.02e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 6.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221459691    34 YVERGSSATFKCTHNVRPEIlfKVTWLKvdkgkffefiNGRNPPFRNSTIEGAEidwdNSNEQQVTLKDVQFDLSGQFYC 113
Cdd:smart00410   5 TVKEGESVTLSCEASGSPPP--EVTWYK----------QGGKLLAESGRFSVSR----SGSTSTLTISNVTPEDSGTYTC 68


                   ....*
gi 221459691   114 EVSTD 118
Cdd:smart00410  69 AATNS 73
 
Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 141-183 1.68e-04

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 40.48  E-value: 1.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221459691  141 PTIKFRKRTPFAVGEKLFALCNTTRGRPAPHITWLINGKKVED 183
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLEA 43
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 34-118 6.02e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 6.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221459691    34 YVERGSSATFKCTHNVRPEIlfKVTWLKvdkgkffefiNGRNPPFRNSTIEGAEidwdNSNEQQVTLKDVQFDLSGQFYC 113
Cdd:smart00410   5 TVKEGESVTLSCEASGSPPP--EVTWYK----------QGGKLLAESGRFSVSR----SGSTSTLTISNVTPEDSGTYTC 68


                   ....*
gi 221459691   114 EVSTD 118
Cdd:smart00410  69 AATNS 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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