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Conserved domains on  [gi|665394488|ref|NP_732443|]
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uncharacterized protein Dmel_CG6184, isoform F [Drosophila melanogaster]

Protein Classification

FG-GAP repeat domain-containing protein( domain architecture ID 10608042)

FG-GAP (VCBS) repeat domain-containing protein characterized by a repeat region that is found in up to seven copies in alpha integrins and related proteins. It forms a 7-fold repeat that adopts a beta-propeller structure

PubMed:  33416871

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 460-518 5.81e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 39.13  E-value: 5.81e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665394488   460 DLNGDGISDVVVAAFNRSVLAF---DGaNYTMMWNYTFPASECVSAIVPGLFNHDRVTDFMV 518
Cdd:pfam13517    1 DLDGDGKLDLVVANDGGLRLYLnngDG-TFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
PQQ super family cl34291
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 263-328 9.74e-04

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG1520:

Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 42.49  E-value: 9.74e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665394488  263 GGVVALNGLDGSILWQSwSVAN------VFSLhcsADVDG----DGGTDCVAA--GRLGmiyAINGRTGSVIWSfREL 328
Cdd:COG1520   192 GKLVALDLANGQPLWEQ-RVAQprgrteLERL---VDVDGtpvvDGGVVYAVAyqGRLA---ALDLRSGRVLWS-RDL 261
 
Name Accession Description Interval E-value
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 460-518 5.81e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 39.13  E-value: 5.81e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665394488   460 DLNGDGISDVVVAAFNRSVLAF---DGaNYTMMWNYTFPASECVSAIVPGLFNHDRVTDFMV 518
Cdd:pfam13517    1 DLDGDGKLDLVVANDGGLRLYLnngDG-TFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 263-328 9.74e-04

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 42.49  E-value: 9.74e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665394488  263 GGVVALNGLDGSILWQSwSVAN------VFSLhcsADVDG----DGGTDCVAA--GRLGmiyAINGRTGSVIWSfREL 328
Cdd:COG1520   192 GKLVALDLANGQPLWEQ-RVAQprgrteLERL---VDVDGtpvvDGGVVYAVAyqGRLA---ALDLRSGRVLWS-RDL 261
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 262-326 7.14e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 39.31  E-value: 7.14e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665394488   262 EGGVVALNGLDGSILWQSWSVANVfslhcSADVDGDGGTDCVAAGRlGMIYAINGRTGSVIWSFR 326
Cdd:pfam13360    2 DGVVTALDAATGAELWRVDLETGL-----GGGVAVDGGRLFVATGG-GQLVALDAATGKLLWRQT 60
 
Name Accession Description Interval E-value
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 460-518 5.81e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 39.13  E-value: 5.81e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665394488   460 DLNGDGISDVVVAAFNRSVLAF---DGaNYTMMWNYTFPASECVSAIVPGLFNHDRVTDFMV 518
Cdd:pfam13517    1 DLDGDGKLDLVVANDGGLRLYLnngDG-TFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 263-328 9.74e-04

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 42.49  E-value: 9.74e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665394488  263 GGVVALNGLDGSILWQSwSVAN------VFSLhcsADVDG----DGGTDCVAA--GRLGmiyAINGRTGSVIWSfREL 328
Cdd:COG1520   192 GKLVALDLANGQPLWEQ-RVAQprgrteLERL---VDVDGtpvvDGGVVYAVAyqGRLA---ALDLRSGRVLWS-RDL 261
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 262-326 7.14e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 39.31  E-value: 7.14e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665394488   262 EGGVVALNGLDGSILWQSWSVANVfslhcSADVDGDGGTDCVAAGRlGMIYAINGRTGSVIWSFR 326
Cdd:pfam13360    2 DGVVTALDAATGAELWRVDLETGL-----GGGVAVDGGRLFVATGG-GQLVALDAATGKLLWRQT 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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