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Conserved domains on  [gi|24647413|ref|NP_732131|]
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uncharacterized protein Dmel_CG14879, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GLECT super family cl00071
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 21-169 4.07e-19

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


The actual alignment was detected with superfamily member pfam00337:

Pssm-ID: 469601  Cd Length: 124  Bit Score: 78.45  E-value: 4.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647413    21 TRLSISGNLLQDPQQFSVNFVNSPDCTDNITYHFKVVIPTQTIIENYKRNGEWSslHQEKylnifdgtgaSDKNPnmtes 100
Cdd:pfam00337   8 SSLTIKGIVLPDAQRFSINLQTGVGPSDDIALHFNPRFDENVIVRNSRQNGQWG--QEER----------EGGFP----- 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24647413   101 FARiiteidealqlsstESSFCLEFAFDyaNSMMRVYQGRDSGHNFITEyetlFSLSDIQAVQVWGDVQ 169
Cdd:pfam00337  71 FQP--------------GQPFELTILVG--DDHFKIYVNGQHFTTFKHR----LPPEDIDALQVRGDVK 119
 
Name Accession Description Interval E-value
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 21-169 4.07e-19

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 78.45  E-value: 4.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647413    21 TRLSISGNLLQDPQQFSVNFVNSPDCTDNITYHFKVVIPTQTIIENYKRNGEWSslHQEKylnifdgtgaSDKNPnmtes 100
Cdd:pfam00337   8 SSLTIKGIVLPDAQRFSINLQTGVGPSDDIALHFNPRFDENVIVRNSRQNGQWG--QEER----------EGGFP----- 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24647413   101 FARiiteidealqlsstESSFCLEFAFDyaNSMMRVYQGRDSGHNFITEyetlFSLSDIQAVQVWGDVQ 169
Cdd:pfam00337  71 FQP--------------GQPFELTILVG--DDHFKIYVNGQHFTTFKHR----LPPEDIDALQVRGDVK 119
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 22-169 1.37e-13

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 63.76  E-value: 1.37e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647413     22 RLSISGNLLQDPQQFSVNFVNSPDctDNITYHFKVVIPTQTIIENYKRNGEWSSLHQEKYLNIFDGtgasdknpnmtesf 101
Cdd:smart00908   9 SITIRGIVLPDAKRFSINLQCGPN--ADIALHFNPRFDEGTIVRNSKQNGKWGKEERSGGFPFQPG-------------- 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24647413    102 ariiteidealqlssteSSFCLEFAFDYANSMMRVyqgrdsGHNFITEYETLFSLSDIQAVQVWGDVQ 169
Cdd:smart00908  73 -----------------QPFELEILVEEDEFKVAV------NGQHFLEFPHRLPLESIDTLEISGDVQ 117
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 22-169 2.49e-06

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 44.55  E-value: 2.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647413  22 RLSISGNLLQDPQQFSVNFVNSPdctDNITYHFKVVIPTQTIIENYKRNGEWSSlhQEKylnifdgtgaSDKNPnmtesF 101
Cdd:cd00070  15 TLTVKGRVLPNAKRFSINLGTGS---SDIALHFNPRFDENVIVRNSFLNGNWGP--EER----------SGGFP-----F 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24647413 102 ARiiteidealqlsstESSFCLEFAFDYANSMMRVyqgrdsGHNFITEYETLFSLSDIQAVQVWGDVQ 169
Cdd:cd00070  75 QP--------------GQPFELTILVEEDKFQIFV------NGQHFFSFPHRLPLESIDYLSINGDVS 122
 
Name Accession Description Interval E-value
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 21-169 4.07e-19

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 78.45  E-value: 4.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647413    21 TRLSISGNLLQDPQQFSVNFVNSPDCTDNITYHFKVVIPTQTIIENYKRNGEWSslHQEKylnifdgtgaSDKNPnmtes 100
Cdd:pfam00337   8 SSLTIKGIVLPDAQRFSINLQTGVGPSDDIALHFNPRFDENVIVRNSRQNGQWG--QEER----------EGGFP----- 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24647413   101 FARiiteidealqlsstESSFCLEFAFDyaNSMMRVYQGRDSGHNFITEyetlFSLSDIQAVQVWGDVQ 169
Cdd:pfam00337  71 FQP--------------GQPFELTILVG--DDHFKIYVNGQHFTTFKHR----LPPEDIDALQVRGDVK 119
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 22-169 1.37e-13

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 63.76  E-value: 1.37e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647413     22 RLSISGNLLQDPQQFSVNFVNSPDctDNITYHFKVVIPTQTIIENYKRNGEWSSLHQEKYLNIFDGtgasdknpnmtesf 101
Cdd:smart00908   9 SITIRGIVLPDAKRFSINLQCGPN--ADIALHFNPRFDEGTIVRNSKQNGKWGKEERSGGFPFQPG-------------- 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24647413    102 ariiteidealqlssteSSFCLEFAFDYANSMMRVyqgrdsGHNFITEYETLFSLSDIQAVQVWGDVQ 169
Cdd:smart00908  73 -----------------QPFELEILVEEDEFKVAV------NGQHFLEFPHRLPLESIDTLEISGDVQ 117
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 22-169 2.49e-06

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 44.55  E-value: 2.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647413  22 RLSISGNLLQDPQQFSVNFVNSPdctDNITYHFKVVIPTQTIIENYKRNGEWSSlhQEKylnifdgtgaSDKNPnmtesF 101
Cdd:cd00070  15 TLTVKGRVLPNAKRFSINLGTGS---SDIALHFNPRFDENVIVRNSFLNGNWGP--EER----------SGGFP-----F 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24647413 102 ARiiteidealqlsstESSFCLEFAFDYANSMMRVyqgrdsGHNFITEYETLFSLSDIQAVQVWGDVQ 169
Cdd:cd00070  75 QP--------------GQPFELTILVEEDKFQIFV------NGQHFFSFPHRLPLESIDYLSINGDVS 122
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 21-75 1.37e-03

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 37.21  E-value: 1.37e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 24647413     21 TRLSISGNLLQDPQQFSVNFVNSPdctDNITYHFKVVIPTQTIIENYKRNGEWSS 75
Cdd:smart00276  13 QTLTVRGIVLPDAKRFSINLLTGG---DDIALHFNPRFNENKIVCNSKLNGSWGS 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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