|
Name |
Accession |
Description |
Interval |
E-value |
| MCM8 |
cd17759 |
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ... |
433-791 |
8.97e-140 |
|
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350665 [Multi-domain] Cd Length: 289 Bit Score: 416.93 E-value: 8.97e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 433 LLVQSIAPEVYGHELPKAACLLSLLGGKGA---------ETEAINVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQ 503
Cdd:cd17759 1 LIVNSLCPAIYGHELVKAGLLLSLFGGKQKyaddknripIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 504 SAQQLGVTFAGRNKRVLQAGSLMMASGGGHCTLDDVDKLASKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQR 583
Cdd:cd17759 81 SGLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGSQHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 584 GQYDEGRYLLQNINISPSLLREFHLVYILLDKPS-ERDMSLTAHvralhagarkrariaaryalkpkmsdsmcevslnvp 662
Cdd:cd17759 161 GHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSeEHDHLLSEH------------------------------------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 663 aagkdddtikteddndsimqqdydldkrlevlpeegdldllpPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSC 742
Cdd:cd17759 205 ------------------------------------------HQLLRKYISYARQYVNPVLSKDASEALQEFYLELRKQN 242
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 24647251 743 NLdeDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTES 791
Cdd:cd17759 243 QL--ADSSPITTRQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
|
|
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
177-799 |
1.55e-72 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 252.03 E-value: 1.55e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 177 PSLSEDIREHPLRTLGTLSLAmhtvVVNHQLDCNDSttamvstpeqyvlptpRVRKIYARPDDFVPVESIEGISHSRVDT 256
Cdd:COG1241 47 PDLADDLLENPDEVLEAAEEA----LREIDLEPYDV----------------SLGDAHVRITNLPETVPIRDIRSDHIGK 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 257 LFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMRQRGTFQPRPYQCKRSECVARDEFVPLRSSpYTRLsirQIIRVEES 336
Cdd:COG1241 107 LISVEGIVRKATEVKPKITEAAFECPRCGTETYVPQTGEKLQEPHECPGCGRQGPFKLLPEKSE-FIDA---QKIRIQEP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 337 SLNLVhdfETSMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQElgdDTTTGDTSNQMQPYLKAVSIrdassikrEFSER 416
Cdd:COG1241 183 PEDLP---GGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRIEQ---RTSGRGKSTIFDLYLEANSI--------EVEEK 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 417 DLE----------AIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAETE-------AINVLLVGDPGIGK 479
Cdd:COG1241 249 EFEeieiteedeeKIKELSKDPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGVPKVLPdgsrirgDIHILLVGDPGTAK 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 480 TKILQSCAQIAERGAHVSGKrGAQSAqqlGVTFAG-RNKR-----VLQAGSLMMASGGGHCtLDDVDKLASK-QAVLLQC 552
Cdd:COG1241 329 SQLLRYAARLAPRGVYTSGK-GSTAA---GLTAAAvRDDFgtgrwTLEAGALVLADGGLAC-IDELDKMREEdRSALHEA 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 553 LQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPS-ERDMSLTAHVralh 631
Cdd:COG1241 404 MEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDeERDRELARHI---- 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 632 agarkrariaaryalkpkmsdsmcevsLNVPAAGKDDDTIKTEDDNdsimqqdydldkrlEVLPEegdldlLPPILIKKF 711
Cdd:COG1241 480 ---------------------------LKVHRAGELLEQEIEEETE--------------EVKPE------IDPDLLRKY 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 712 LSYARQELNPVLNEDASNAVLRYFLELKGScNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIallteS 791
Cdd:COG1241 513 IAYARRNVFPVLTEEAKDLIEDFYVDMRKK-GEDEDSPVPITARQLEALIRLAEASARMRLSDTVTEEDAERAI-----R 586
|
....*...
gi 24647251 792 ITQTSLKE 799
Cdd:COG1241 587 LVDSCLKD 594
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
243-792 |
1.32e-65 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 228.69 E-value: 1.32e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 243 VESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIA-MRQRGTFQPrPYQCKRSECVARDEFVPLRSSp 321
Cdd:smart00350 2 PSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGpEIQSGRETE-PTVCPPRECQSPTPFSLNHER- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 322 yTRLSIRQIIRVEESSlNLVHDfeTSMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPYLKAV 401
Cdd:smart00350 80 -STFIDFQKIKLQESP-EEVPV--GQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPYGFKLNTVKGLPVFATYIEAN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 402 SIR---------DASSIKREFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGG------KGAETEA 466
Cdd:smart00350 156 HVRkldykrsfeDSSFSVQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEDIKKAILLLLFGGvhknlpDGMKIRG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 467 -INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKrgAQSAqqLGVTFAGR-----NKRVLQAGSLMMASGGgHCTLDDVD 540
Cdd:smart00350 236 dINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGK--GSSA--VGLTAAVTrdpetREFTLEAGALVLADNG-VCCIDEFD 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 541 KLA-SKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE- 618
Cdd:smart00350 311 KMDdSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEe 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 619 RDMSLTAHVRALHAgarkrariaaryalkpkmsdsmcevslnvpaagkdddtikteddndsimqqdydldkRLEVLPEEG 698
Cdd:smart00350 391 RDRELAKHVVDLHR---------------------------------------------------------YSHPEEDEA 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 699 DLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLEL-KGSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVS 777
Cdd:smart00350 414 FEPPLSQEKLRKYIAYAREKIKPKLSEEAADKLVKAYVDLrKEDSQTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVE 493
|
570
....*....|....*
gi 24647251 778 PQHVRDVIALLTESI 792
Cdd:smart00350 494 EADVEEAIRLLRESI 508
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
417-631 |
7.55e-48 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 169.63 E-value: 7.55e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 417 DLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAETEA-------INVLLVGDPGIGKTKILQSCAQI 489
Cdd:pfam00493 1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDgtrlrgdINVLLVGDPGTAKSQLLKYVEKI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 490 AERGAHVSGKrGAQSAqqlGVTFAGR-----NKRVLQAGSLMMASGGgHCTLDDVDKLA-SKQAVLLQCLQSEEVNLPLA 563
Cdd:pfam00493 81 APRAVYTSGK-GSSAA---GLTAAVVrdpvtGEFVLEAGALVLADGG-VCCIDEFDKMNdEDRVALHEAMEQQTISIAKA 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24647251 564 GAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE-RDMSLTAHVRALH 631
Cdd:pfam00493 156 GIVATLNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEeKDERLAKHIVDLH 224
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
252-795 |
1.81e-38 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 154.77 E-value: 1.81e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 252 SRVDTLFSIRGFVSNVGEPSYSLTWQAFRCsRCQMEIamrqrGTFQPRPYQCKRSECVARDEF-VPLR----SSPYTR-- 324
Cdd:PTZ00111 224 SMADSLVQFSGTVVRQTWIVPEITMACFRC-RGQKKI-----GLNDYQPCTCEHYEYVIQGEVnEPLLcnecNSKYTFel 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 325 ------LSIRQIIRVEESS---------------LNLVHDFETSMPAE--MDVELRHDLVDAVRVGQEVVVTGILKLQEL 381
Cdd:PTZ00111 298 nhnmcvYSTKKIVKLLQSNsslnnpdkdgldnsvDNSGLNGEIYMKDNevINLNLYDDLIDSVKTGDRVTVVGILKVTPI 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 382 GDDTTTGDTSNQMQPYLKAVSIR-----DASSIKR---------EFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHEL 447
Cdd:PTZ00111 378 RTSTTRRTLKSLYTYFVNVIHVKvinstNANQPEKglkylgnenDFSDLQVYKILELSRNPMIYRILLDSFAPSIKARNN 457
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 448 PKAACLLSLLGGKGAETE----------------AINVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVT 511
Cdd:PTZ00111 458 VKIGLLCQLFSGNKNSSDfnkspdacykvdnfrgIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIK 537
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 512 FA-GRNKR-VLQAGSLMMASGGgHCTLDDVDKL-ASKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDE 588
Cdd:PTZ00111 538 FNeSDNGRaMIQPGAVVLANGG-VCCIDELDKChNESRLSLYEVMEQQTVTIAKAGIVATLKAETAILASCNPINSRYNK 616
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 589 GRYLLQNINISPSLLREFHLVYILLDKPSERDMSLTAHVRAlhagarkrariaaRYALKPKMSDSmcevslnvpaaGKDD 668
Cdd:PTZ00111 617 NKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIA-------------KDFLLPHMTGS-----------GNDE 672
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 669 DTikteddndsimqqdYDLDKRLEVLPE----EGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELK----G 740
Cdd:PTZ00111 673 DT--------------YDRSNTMHVEDEslrsEKDYNKNDLDMLRMYIKFSKLHCFPKLSDEAKKVITREYVKMRqgnfQ 738
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24647251 741 SCNLDEDVSSQ------------------IGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQT 795
Cdd:PTZ00111 739 TSNLDELEHAQedddddlyyqssgtrmiyVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSSTFQS 811
|
|
| MCM8_WHD |
cd22247 |
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; ... |
819-883 |
5.10e-16 |
|
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; MCM8 is a DNA helicase that is a component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is also required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting its nuclease activity. This model corresponds to the C-terminal winged-helix domain (WHD) of MCM8, which mediates protein-nucleic acid interaction, as well as protein-protein interaction.
Pssm-ID: 439328 [Multi-domain] Cd Length: 66 Bit Score: 72.90 E-value: 5.10e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24647251 819 SAQLRNFLELTKRRSAALGRRIFEFDELKEIGTRAGILTG-FSQLVEMANLGGYLLMKGANMYEVV 883
Cdd:cd22247 1 RKQAKRFVSALQREAERKGNNLFTVDELKQIAKELGLQVDdFDDFIESLNNQGYLLKKGPNLYQLQ 66
|
|
| MCM_OB |
pfam17207 |
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ... |
245-377 |
4.01e-14 |
|
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.
Pssm-ID: 465381 [Multi-domain] Cd Length: 126 Bit Score: 69.82 E-value: 4.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 245 SIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMRqrgTFQPRpyQCKRSECVARDEFVPLrsspyTR 324
Cdd:pfam17207 1 SIRDLRSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGVK---ITEPT--KCPNPECGNKDPFKLV-----HE 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 325 LSI---RQIIRVEESSlnlvhdfET----SMPAEMDVELRHDLVDAVRVGQEVVVTGILK 377
Cdd:pfam17207 71 KSKfvdFQKIKIQESP-------EEvpagELPRSLDVILDDDLVDRVKPGDRVTVTGIYR 123
|
|
| Sms |
COG1066 |
DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and ... |
469-507 |
2.26e-03 |
|
DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and repair];
Pssm-ID: 440685 [Multi-domain] Cd Length: 453 Bit Score: 41.57 E-value: 2.26e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 24647251 469 VLLVGDPGIGK-TKILQSCAQIAERGA---HVSGKrgaQSAQQ 507
Cdd:COG1066 92 VLIGGEPGIGKsTLLLQVAARLAKKGGkvlYVSGE---ESASQ 131
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MCM8 |
cd17759 |
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ... |
433-791 |
8.97e-140 |
|
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350665 [Multi-domain] Cd Length: 289 Bit Score: 416.93 E-value: 8.97e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 433 LLVQSIAPEVYGHELPKAACLLSLLGGKGA---------ETEAINVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQ 503
Cdd:cd17759 1 LIVNSLCPAIYGHELVKAGLLLSLFGGKQKyaddknripIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 504 SAQQLGVTFAGRNKRVLQAGSLMMASGGGHCTLDDVDKLASKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQR 583
Cdd:cd17759 81 SGLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGSQHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 584 GQYDEGRYLLQNINISPSLLREFHLVYILLDKPS-ERDMSLTAHvralhagarkrariaaryalkpkmsdsmcevslnvp 662
Cdd:cd17759 161 GHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSeEHDHLLSEH------------------------------------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 663 aagkdddtikteddndsimqqdydldkrlevlpeegdldllpPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSC 742
Cdd:cd17759 205 ------------------------------------------HQLLRKYISYARQYVNPVLSKDASEALQEFYLELRKQN 242
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 24647251 743 NLdeDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTES 791
Cdd:cd17759 243 QL--ADSSPITTRQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
|
|
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
177-799 |
1.55e-72 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 252.03 E-value: 1.55e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 177 PSLSEDIREHPLRTLGTLSLAmhtvVVNHQLDCNDSttamvstpeqyvlptpRVRKIYARPDDFVPVESIEGISHSRVDT 256
Cdd:COG1241 47 PDLADDLLENPDEVLEAAEEA----LREIDLEPYDV----------------SLGDAHVRITNLPETVPIRDIRSDHIGK 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 257 LFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMRQRGTFQPRPYQCKRSECVARDEFVPLRSSpYTRLsirQIIRVEES 336
Cdd:COG1241 107 LISVEGIVRKATEVKPKITEAAFECPRCGTETYVPQTGEKLQEPHECPGCGRQGPFKLLPEKSE-FIDA---QKIRIQEP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 337 SLNLVhdfETSMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQElgdDTTTGDTSNQMQPYLKAVSIrdassikrEFSER 416
Cdd:COG1241 183 PEDLP---GGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRIEQ---RTSGRGKSTIFDLYLEANSI--------EVEEK 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 417 DLE----------AIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAETE-------AINVLLVGDPGIGK 479
Cdd:COG1241 249 EFEeieiteedeeKIKELSKDPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGVPKVLPdgsrirgDIHILLVGDPGTAK 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 480 TKILQSCAQIAERGAHVSGKrGAQSAqqlGVTFAG-RNKR-----VLQAGSLMMASGGGHCtLDDVDKLASK-QAVLLQC 552
Cdd:COG1241 329 SQLLRYAARLAPRGVYTSGK-GSTAA---GLTAAAvRDDFgtgrwTLEAGALVLADGGLAC-IDELDKMREEdRSALHEA 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 553 LQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPS-ERDMSLTAHVralh 631
Cdd:COG1241 404 MEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDeERDRELARHI---- 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 632 agarkrariaaryalkpkmsdsmcevsLNVPAAGKDDDTIKTEDDNdsimqqdydldkrlEVLPEegdldlLPPILIKKF 711
Cdd:COG1241 480 ---------------------------LKVHRAGELLEQEIEEETE--------------EVKPE------IDPDLLRKY 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 712 LSYARQELNPVLNEDASNAVLRYFLELKGScNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIallteS 791
Cdd:COG1241 513 IAYARRNVFPVLTEEAKDLIEDFYVDMRKK-GEDEDSPVPITARQLEALIRLAEASARMRLSDTVTEEDAERAI-----R 586
|
....*...
gi 24647251 792 ITQTSLKE 799
Cdd:COG1241 587 LVDSCLKD 594
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
243-792 |
1.32e-65 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 228.69 E-value: 1.32e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 243 VESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIA-MRQRGTFQPrPYQCKRSECVARDEFVPLRSSp 321
Cdd:smart00350 2 PSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGpEIQSGRETE-PTVCPPRECQSPTPFSLNHER- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 322 yTRLSIRQIIRVEESSlNLVHDfeTSMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPYLKAV 401
Cdd:smart00350 80 -STFIDFQKIKLQESP-EEVPV--GQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPYGFKLNTVKGLPVFATYIEAN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 402 SIR---------DASSIKREFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGG------KGAETEA 466
Cdd:smart00350 156 HVRkldykrsfeDSSFSVQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEDIKKAILLLLFGGvhknlpDGMKIRG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 467 -INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKrgAQSAqqLGVTFAGR-----NKRVLQAGSLMMASGGgHCTLDDVD 540
Cdd:smart00350 236 dINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGK--GSSA--VGLTAAVTrdpetREFTLEAGALVLADNG-VCCIDEFD 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 541 KLA-SKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE- 618
Cdd:smart00350 311 KMDdSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEe 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 619 RDMSLTAHVRALHAgarkrariaaryalkpkmsdsmcevslnvpaagkdddtikteddndsimqqdydldkRLEVLPEEG 698
Cdd:smart00350 391 RDRELAKHVVDLHR---------------------------------------------------------YSHPEEDEA 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 699 DLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLEL-KGSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVS 777
Cdd:smart00350 414 FEPPLSQEKLRKYIAYAREKIKPKLSEEAADKLVKAYVDLrKEDSQTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVE 493
|
570
....*....|....*
gi 24647251 778 PQHVRDVIALLTESI 792
Cdd:smart00350 494 EADVEEAIRLLRESI 508
|
|
| MCM |
cd17706 |
MCM helicase family; MCM helicases are a family of helicases that play an important role in ... |
433-791 |
4.13e-54 |
|
MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350658 [Multi-domain] Cd Length: 311 Bit Score: 190.25 E-value: 4.13e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 433 LLVQSIAPEVYGHELPKAACLLSLLGG--KGAET-----EAINVLLVGDPGIGKTKILQSCAQIAERGAHVSGKrGAQSA 505
Cdd:cd17706 1 ILADSIAPSIYGHEDVKKAVLLQLFGGvqKILEDgtrirGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGK-GSSGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 506 qqlGVTFA-----GRNKRVLQAGSLMMASGGgHCTLDDVDKLA-SKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACA 579
Cdd:cd17706 80 ---GLTAAvvrdsETGEWYLEAGALVLADGG-VCCIDEFDKMKeLDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 580 NPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE-RDMSLTAHVRALHAGarkrariaaryalkpkmsdsmcevs 658
Cdd:cd17706 156 NPKGGRYNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEeRDEELAEHIIDLHRG------------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 659 lNVPAAGKDDdtikteddndsimqqdydldkrlevlpeEGDLDLLPPILIKKFLSYARQElNPVLNEDASNAVLRYFLEL 738
Cdd:cd17706 211 -SDPEEQVKP----------------------------EEDGIPIDIELLRKYILYARQI-HPKISEEAREKLVRWYVEL 260
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 24647251 739 KGscNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTES 791
Cdd:cd17706 261 RK--ESERRSTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEEAIRLVRHS 311
|
|
| MCM4 |
cd17755 |
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ... |
433-791 |
1.96e-48 |
|
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350661 [Multi-domain] Cd Length: 309 Bit Score: 174.16 E-value: 1.96e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 433 LLVQSIAPEVYGHELPKAACLLSLLGGKGAETEA--------INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQS 504
Cdd:cd17755 1 RLARSIAPSIYELEDVKKGILLQLFGGTRKDFTKtggkyrgdINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 505 AQQLGVTFAGRNKR-VLQAGSLMMaSGGGHCTLDDVDKLA-SKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQ 582
Cdd:cd17755 81 GLTAYVTRDPDTKQlVLESGALVL-SDGGICCIDEFDKMSdSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 583 RGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSER-DMSLTAHVRALHagarkrariaaryalkpkmsdsmcevslnv 661
Cdd:cd17755 160 GSRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKyDRRLAKHLVSLY------------------------------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 662 paagkdddtikteddndsimqqdydldkrLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKgs 741
Cdd:cd17755 210 -----------------------------LEDTPEHIQDEVLDVEVLTDYISYAREHIHPKLSEEAAQELVQAYVDMR-- 258
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 24647251 742 cNLDEDVSSQIGAG--QLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTES 791
Cdd:cd17755 259 -KMGSDARKRITATprQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLIREA 309
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
417-631 |
7.55e-48 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 169.63 E-value: 7.55e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 417 DLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAETEA-------INVLLVGDPGIGKTKILQSCAQI 489
Cdd:pfam00493 1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDgtrlrgdINVLLVGDPGTAKSQLLKYVEKI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 490 AERGAHVSGKrGAQSAqqlGVTFAGR-----NKRVLQAGSLMMASGGgHCTLDDVDKLA-SKQAVLLQCLQSEEVNLPLA 563
Cdd:pfam00493 81 APRAVYTSGK-GSSAA---GLTAAVVrdpvtGEFVLEAGALVLADGG-VCCIDEFDKMNdEDRVALHEAMEQQTISIAKA 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24647251 564 GAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE-RDMSLTAHVRALH 631
Cdd:pfam00493 156 GIVATLNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEeKDERLAKHIVDLH 224
|
|
| MCM_arch |
cd17761 |
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ... |
433-789 |
1.33e-46 |
|
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork
Pssm-ID: 350667 [Multi-domain] Cd Length: 308 Bit Score: 169.17 E-value: 1.33e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 433 LLVQSIAPEVYGHELPKAACLLSLLGG------KGAETEA-INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKrGAQSA 505
Cdd:cd17761 2 KIISSIAPSIYGHEDVKEAIALQLFGGvpkvlpDGTRIRGdIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGK-GSTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 506 qqlGVTFAG-RNKR----VLQAGSLMMASGGGHCtLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACA 579
Cdd:cd17761 81 ---GLTAAVvRDEGtgewYLEAGALVLADKGIAV-VDEIDKMRKEDRSALhEAMEQQTISIAKAGIVATLNARAAVLAAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 580 NPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKP-SERDMSLTAHVRALHAgarkrariaaryalkpkmsdsmcevs 658
Cdd:cd17761 157 NPKFGRFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPnEEKDRRLANHILDTHS-------------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 659 lnvpaagkdddtikteddndsimqqdydLDKRLEVLPEegdldlLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLEL 738
Cdd:cd17761 211 ----------------------------GGEMREIKPE------IDPDLLRKYIAYARKNVRPVLTEEAKQLIKDFYVEM 256
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 24647251 739 KGScNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLT 789
Cdd:cd17761 257 RKS-GQETPSPVPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRIML 306
|
|
| MCM7 |
cd17758 |
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ... |
434-791 |
2.44e-44 |
|
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350664 [Multi-domain] Cd Length: 306 Bit Score: 162.58 E-value: 2.44e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 434 LVQSIAPEVYGHELPKAACLLSLLGGKGAETEA------INVLLVGDPGIGKTKILQSCAQIAERGAHVSGkRGAQSAqq 507
Cdd:cd17758 2 LAASIAPEIYGHEDVKKALLLLLVGGVDKRGDGmkirgdINICLMGDPGVAKSQLLKYICRIAPRSVYTTG-RGSSGV-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 508 lGVTFA-----GRNKRVLQAGSLMMASGGgHCTLDDVDKLA-SKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANP 581
Cdd:cd17758 79 -GLTAAvmkdpVTGEMTLEGGALVLADQG-ICCIDEFDKMDeSDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 582 QRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPS-ERDMSLTAHVRALHagarkrariaaryalkpkmsdsmcevsln 660
Cdd:cd17758 157 AYGRYNPRRSPEQNINLPAALLSRFDLLFLILDKPDrDNDLRLAEHVTYVH----------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 661 vpaagkdddtiKTEDDNDSimqqdydldkrlevlpeegDLDLLPPILIKKFLSYARQeLNPVLNEDASNAVLRYFLELKG 740
Cdd:cd17758 208 -----------QHNKQPDS-------------------DFEPLDPKLLRAYIALAKR-KRPTVPPALADYIVQAYVEMRQ 256
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 24647251 741 SCNLDEDvSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTES 791
Cdd:cd17758 257 EAKRSKD-FTFTTPRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
|
|
| MCM6 |
cd17757 |
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ... |
434-791 |
8.78e-43 |
|
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350663 [Multi-domain] Cd Length: 307 Bit Score: 158.30 E-value: 8.78e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 434 LVQSIAPEVYGHELPKAACLLSLLGGKGAETEA-------INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKrgAQSAQ 506
Cdd:cd17757 2 LVRSIAPSIYGHEEVKKGILLMLLGGVHKITREgislrgdINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGK--ASSAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 507 qlGVTFA-----GRNKRVLQAGSLMMASGGgHCTLDDVDKLASK-QAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACAN 580
Cdd:cd17757 80 --GLTAAvvrdeETGDFVIEAGALMLADNG-ICCIDEFDKMDIKdQVAIHEAMEQQTISITKAGIQATLNARTSILAAAN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 581 PQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE-RDMSLTAHVRALHAGArkrariaaryalkpkmsdsmcEVSL 659
Cdd:cd17757 157 PVGGRYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEvTDYAIASHIVDLHSKR---------------------EEAI 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 660 NVPaagkdddtikteddndsimqqdYDLDKrlevlpeegdldllppilIKKFLSYARQeLNPVLNEDASNAVLRYFLEL- 738
Cdd:cd17757 216 EPP----------------------FTAEQ------------------LKRYIAYART-FKPKLTKEAKDELVEQYKELr 254
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 24647251 739 KGSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTES 791
Cdd:cd17757 255 QDDASGSTRSSYRITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLLKKS 307
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
252-795 |
1.81e-38 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 154.77 E-value: 1.81e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 252 SRVDTLFSIRGFVSNVGEPSYSLTWQAFRCsRCQMEIamrqrGTFQPRPYQCKRSECVARDEF-VPLR----SSPYTR-- 324
Cdd:PTZ00111 224 SMADSLVQFSGTVVRQTWIVPEITMACFRC-RGQKKI-----GLNDYQPCTCEHYEYVIQGEVnEPLLcnecNSKYTFel 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 325 ------LSIRQIIRVEESS---------------LNLVHDFETSMPAE--MDVELRHDLVDAVRVGQEVVVTGILKLQEL 381
Cdd:PTZ00111 298 nhnmcvYSTKKIVKLLQSNsslnnpdkdgldnsvDNSGLNGEIYMKDNevINLNLYDDLIDSVKTGDRVTVVGILKVTPI 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 382 GDDTTTGDTSNQMQPYLKAVSIR-----DASSIKR---------EFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHEL 447
Cdd:PTZ00111 378 RTSTTRRTLKSLYTYFVNVIHVKvinstNANQPEKglkylgnenDFSDLQVYKILELSRNPMIYRILLDSFAPSIKARNN 457
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 448 PKAACLLSLLGGKGAETE----------------AINVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVT 511
Cdd:PTZ00111 458 VKIGLLCQLFSGNKNSSDfnkspdacykvdnfrgIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIK 537
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 512 FA-GRNKR-VLQAGSLMMASGGgHCTLDDVDKL-ASKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDE 588
Cdd:PTZ00111 538 FNeSDNGRaMIQPGAVVLANGG-VCCIDELDKChNESRLSLYEVMEQQTVTIAKAGIVATLKAETAILASCNPINSRYNK 616
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 589 GRYLLQNINISPSLLREFHLVYILLDKPSERDMSLTAHVRAlhagarkrariaaRYALKPKMSDSmcevslnvpaaGKDD 668
Cdd:PTZ00111 617 NKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIA-------------KDFLLPHMTGS-----------GNDE 672
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 669 DTikteddndsimqqdYDLDKRLEVLPE----EGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELK----G 740
Cdd:PTZ00111 673 DT--------------YDRSNTMHVEDEslrsEKDYNKNDLDMLRMYIKFSKLHCFPKLSDEAKKVITREYVKMRqgnfQ 738
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24647251 741 SCNLDEDVSSQ------------------IGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQT 795
Cdd:PTZ00111 739 TSNLDELEHAQedddddlyyqssgtrmiyVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSSTFQS 811
|
|
| MCM2 |
cd17753 |
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ... |
434-791 |
1.98e-38 |
|
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350659 [Multi-domain] Cd Length: 325 Bit Score: 146.05 E-value: 1.98e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 434 LVQSIAPEVYGHELPKAACLLSLLGGKGAETEA-------INVLLVGDPGIGKTKILQSCAQIAERGAHVSGkrgaQSAQ 506
Cdd:cd17753 2 IINSIAPSIYGHDDIKTAIALALFGGVAKNPGGkhrirgdINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTG----QGAS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 507 QLGVTFAGRNKRV-----LQAGSLMMASGGgHCTLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACAN 580
Cdd:cd17753 78 AVGLTASVRKDPVtkewtLEGGALVLADKG-VCLIDEFDKMNDQDRTSIhEAMEQQSISISKAGIVTSLQARCSVIAAAN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 581 PQRGQYDEGRYLLQNINISPSLLREFHLVYILLDK-PSERDMSLTAHVRALHagarkrariaaryalkpkmsdsmcevSL 659
Cdd:cd17753 157 PIGGRYNPTLTFAQNVNLTEPILSRFDILCVVRDTvDPEEDERLAKFVVGSH--------------------------VR 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 660 NVPAAGKDDDTIKTEDDNDSimqqdydldkrlevlPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELK 739
Cdd:cd17753 211 SHPENDEDREGEEEKNQRQR---------------PKETKVEPIPQELLRKYIHYAREKVRPKLNQMDMDKVSRVYADLR 275
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 24647251 740 GSCnlDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTES 791
Cdd:cd17753 276 KES--MATGSLPITVRHLESIIRISEAHAKMHLREYVSEEDVDMAIRVMLDS 325
|
|
| MCM5 |
cd17756 |
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ... |
433-791 |
4.53e-34 |
|
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350662 [Multi-domain] Cd Length: 317 Bit Score: 133.28 E-value: 4.53e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 433 LLVQSIAPEVYGHELPKAACLLSLLGGKGAETEA-------INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKrGAQSA 505
Cdd:cd17756 1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDgmrlrgdINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGK-GSSAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 506 qqlGVTfAGRNKR------VLQAGSLMMASGGGHCtLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIAC 578
Cdd:cd17756 80 ---GLT-ASVMRDpstrefYLEGGAMVLADGGVVC-IDEFDKMREDDRVAIhEAMEQQTISIAKAGITTTLNSRTSVLAA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 579 ANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE-RDMSLTAHVRALHAGarkrariaaryalkpkmsdsmcev 657
Cdd:cd17756 155 ANPVFGRYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEeRDITIAKHVINIHAS------------------------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 658 slnvpaagkdDDTIKTEDDNDSIMQQDYdldkrlevlpeegdldllppilIKKFLSYARQELNPVLNEDASNAVLRYFLE 737
Cdd:cd17756 211 ----------ARKASQSQENEGEIPISK----------------------LKRYIAYCRAKCAPRLSEEAAEKLSNHYVT 258
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 24647251 738 LKGSCNLDEDVSSQ-----IGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTES 791
Cdd:cd17756 259 IRKDVRQNELESDNrssipITVRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQVS 317
|
|
| MCM3 |
cd17754 |
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ... |
433-788 |
1.38e-30 |
|
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350660 [Multi-domain] Cd Length: 299 Bit Score: 122.58 E-value: 1.38e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 433 LLVQSIAPEVYGHELPKAACLLSLLGGKGAETEA-------INVLLVGDPGIGKTKILQSCAQIAERGAHVSGkRGAQSa 505
Cdd:cd17754 1 LLSKSLAPSIYGHEYIKKAILLMLLGGVEKNLENgshlrgdINILLVGDPSVAKSQLLRYVLNTAPLAIATTG-RGSSG- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 506 qqLGVTFA-----GRNKRVLQAGSLMMASGGGHCtLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACA 579
Cdd:cd17754 79 --VGLTAAvttdqETGERRLEAGAMVLADRGVVC-IDEFDKMSDIDRVAIhEVMEQQTVTIAKAGIHASLNARCSVLAAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 580 NPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDK-PSERDMSLTAHVRALHAGARkrariaaryalkpkmsdsmcevs 658
Cdd:cd17754 156 NPVYGRYDVYKTPMENIGLPDSLLSRFDLLFIVLDDiDEERDRSISEHVLRMHRYIK----------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 659 lnvpaagkdddtikteddndsimqqdydldkrlevlpeegdldllppiLIKKFLSYARQELNPVLNEDASNAVLRYFLEL 738
Cdd:cd17754 213 ------------------------------------------------FLRKYIHYAKERIKPKLTQEAAEYIAEEYADL 244
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 24647251 739 K--GSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALL 788
Cdd:cd17754 245 RndDNTKTDKARTSPITARTLETLIRLATAHAKARLSKTVDKVDAEVALNLL 296
|
|
| MCM9 |
cd17760 |
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ... |
433-619 |
6.50e-22 |
|
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350666 [Multi-domain] Cd Length: 299 Bit Score: 97.23 E-value: 6.50e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 433 LLVQSIAPEVYGHELPKAACLLSLLGG-KGAETEAINV------LLVGDPGIGKTKILQSCAQIAERGAHVSGKrGAQSA 505
Cdd:cd17760 1 EILASLCPQVFGLYNVKLAVAMVLAGGvQRIDASGTRVrgeshlLLVGDPGTGKSQFLKYAAKITPRSVLTAGI-GSTSA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 506 qQLGVTfAGRNKR--VLQAGSLMMASgGGHCTLDDVDKL-ASKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPq 582
Cdd:cd17760 80 -GLTVT-AVKDGGewNLEAGALVLAD-GGLCCIDEFNSLkEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP- 155
|
170 180 190
....*....|....*....|....*....|....*..
gi 24647251 583 RGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSER 619
Cdd:cd17760 156 KGQYDPNESISVNIALASPLLSRFDLVLVLLDTKNED 192
|
|
| MCM_lid |
pfam17855 |
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins. |
707-792 |
2.53e-17 |
|
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
Pssm-ID: 465534 [Multi-domain] Cd Length: 86 Bit Score: 77.58 E-value: 2.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 707 LIKKFLSYARQELNPVLNEDASNAVLRYFLELKgSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIA 786
Cdd:pfam17855 2 LLRKYIAYAREKIKPKLSEEAREKLVDAYVELR-KESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIR 80
|
....*.
gi 24647251 787 LLTESI 792
Cdd:pfam17855 81 LLKESL 86
|
|
| MCM8_WHD |
cd22247 |
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; ... |
819-883 |
5.10e-16 |
|
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; MCM8 is a DNA helicase that is a component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is also required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting its nuclease activity. This model corresponds to the C-terminal winged-helix domain (WHD) of MCM8, which mediates protein-nucleic acid interaction, as well as protein-protein interaction.
Pssm-ID: 439328 [Multi-domain] Cd Length: 66 Bit Score: 72.90 E-value: 5.10e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24647251 819 SAQLRNFLELTKRRSAALGRRIFEFDELKEIGTRAGILTG-FSQLVEMANLGGYLLMKGANMYEVV 883
Cdd:cd22247 1 RKQAKRFVSALQREAERKGNNLFTVDELKQIAKELGLQVDdFDDFIESLNNQGYLLKKGPNLYQLQ 66
|
|
| MCM_OB |
pfam17207 |
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ... |
245-377 |
4.01e-14 |
|
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.
Pssm-ID: 465381 [Multi-domain] Cd Length: 126 Bit Score: 69.82 E-value: 4.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 245 SIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMRqrgTFQPRpyQCKRSECVARDEFVPLrsspyTR 324
Cdd:pfam17207 1 SIRDLRSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGVK---ITEPT--KCPNPECGNKDPFKLV-----HE 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 325 LSI---RQIIRVEESSlnlvhdfET----SMPAEMDVELRHDLVDAVRVGQEVVVTGILK 377
Cdd:pfam17207 71 KSKfvdFQKIKIQESP-------EEvpagELPRSLDVILDDDLVDRVKPGDRVTVTGIYR 123
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
468-606 |
6.45e-05 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 43.44 E-value: 6.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647251 468 NVLLVGDPGIGKTKILQS-CAQIAERGAH-VSGKRGAQSAQQLGVTFAGRNKRVLQAGSLMMASGGGH-CTLDDVDKLAS 544
Cdd:pfam07728 1 GVLLVGPPGTGKTELAERlAAALSNRPVFyVQLTRDTTEEDLFGRRNIDPGGASWVDGPLVRAAREGEiAVLDEINRANP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24647251 545 KQAVLLQCLQSEEVNLPLAGAFASFPAQPS--VIACANPQRGQYDEgryllqninISPSLLREF 606
Cdd:pfam07728 81 DVLNSLLSLLDERRLLLPDGGELVKAAPDGfrLIATMNPLDRGLNE---------LSPALRSRF 135
|
|
| RadA_SMS_N |
cd01121 |
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a ... |
469-509 |
2.13e-03 |
|
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a role in recombination and recombinational repair of DNA damaged by UV radiation, X-rays, and chemical agent and is responsible for the stabilization or processing of branched DNA molecules.
Pssm-ID: 410866 [Multi-domain] Cd Length: 268 Bit Score: 40.98 E-value: 2.13e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 24647251 469 VLLVGDPGIGK-TKILQSCAQIAERGA---HVSGKrgaQSAQQLG 509
Cdd:cd01121 85 VLIGGDPGIGKsTLLLQVAARLAQRGGkvlYVSGE---ESLSQIK 126
|
|
| Sms |
COG1066 |
DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and ... |
469-507 |
2.26e-03 |
|
DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and repair];
Pssm-ID: 440685 [Multi-domain] Cd Length: 453 Bit Score: 41.57 E-value: 2.26e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 24647251 469 VLLVGDPGIGK-TKILQSCAQIAERGA---HVSGKrgaQSAQQ 507
Cdd:COG1066 92 VLIGGEPGIGKsTLLLQVAARLAKKGGkvlYVSGE---ESASQ 131
|
|
| |
