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Conserved domains on  [gi|24646912|ref|NP_731942|]
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senescence marker protein-30, isoform B [Drosophila melanogaster]

Protein Classification

SMP-30/gluconolactonase/LRE family protein( domain architecture ID 12093833)

SMP-30/gluconolactonase/LRE family protein similar to Pseudomonas putida 6-deoxy-6-sulfogluconolactonase, which catalyzes the hydrolysis of 6-deoxy-6-sulfo-D-glucono-1,5-lactone to form 6-deoxy-6-sulfo-D-gluconate

CATH:  2.120.10.30
EC:  3.1.1.-
Gene Ontology:  GO:0046872|GO:0016787|GO:0005509
PubMed:  20329768|17166853|18848569
SCOP:  4003251

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 15-274 1.50e-68

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


:

Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 213.28  E-value: 1.50e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912    15 LGEGPHWDVDRQSLYYVDLESAGINRYDFKQNKVYRAKIEGEIfaSFILPVENKPQEFAVGCGLRtvIVQWDGVSavakv 94
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPV--GAIAPRDDGGLIVALKDGVA--LLDLATGE----- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912    95 TRTLFEVQPDLKE-NRLNDAKTDPNGRFYGGTMADSGDiFTQWKGELYSWQAGGQPNAIRSKVGISNGLAWDVKAKKFYF 173
Cdd:pfam08450  72 LTPLADPEDDDWPlNRFNDGKVDPDGRFWFGTMGDDEA-PGGDPGALYRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYF 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912   174 IDTNNHEVLAYDYNQSTGAVSNPKVIFDLRKirpeGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPStGKILLEIKIPTT 253
Cdd:pfam08450 151 ADSPARKIWAYDYDLDGGLISNRRVFADFKP----GLGRPDGMAVDAEGNVWVARWGGGKVVRFDPD-GKLLREIELPAK 225

                         250       260
                  ....*....|....*....|.
gi 24646912   254 QITSVAFGGPNLDILYVTTAN 274
Cdd:pfam08450 226 RPTSCAFGGPDLRTLYVTSAR 246
 
Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 15-274 1.50e-68

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 213.28  E-value: 1.50e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912    15 LGEGPHWDVDRQSLYYVDLESAGINRYDFKQNKVYRAKIEGEIfaSFILPVENKPQEFAVGCGLRtvIVQWDGVSavakv 94
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPV--GAIAPRDDGGLIVALKDGVA--LLDLATGE----- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912    95 TRTLFEVQPDLKE-NRLNDAKTDPNGRFYGGTMADSGDiFTQWKGELYSWQAGGQPNAIRSKVGISNGLAWDVKAKKFYF 173
Cdd:pfam08450  72 LTPLADPEDDDWPlNRFNDGKVDPDGRFWFGTMGDDEA-PGGDPGALYRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYF 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912   174 IDTNNHEVLAYDYNQSTGAVSNPKVIFDLRKirpeGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPStGKILLEIKIPTT 253
Cdd:pfam08450 151 ADSPARKIWAYDYDLDGGLISNRRVFADFKP----GLGRPDGMAVDAEGNVWVARWGGGKVVRFDPD-GKLLREIELPAK 225

                         250       260
                  ....*....|....*....|.
gi 24646912   254 QITSVAFGGPNLDILYVTTAN 274
Cdd:pfam08450 226 RPTSCAFGGPDLRTLYVTSAR 246
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 7-295 2.78e-56

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 182.78  E-value: 2.78e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912   7 AVPDSYAALGEGPHWDVDrQSLYYVDLESAGINRYDFKQNKVyrakiegEIFASfilpvenkPQEFAVGCGLR---TVIV 83
Cdd:COG3386   1 KLADAGFRLGEGPVWDPD-GRLYWVDIPGGRIHRYDPDGGAV-------EVFAE--------PSGRPNGLAFDpdgRLLV 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912  84 --QWDGVSAVAKVTRTLFEV--QPDLKENRLNDAKTDPNGRFYGGTMADSGDiftqwKGELYSWQAGGQPNAIRSKVGIS 159
Cdd:COG3386  65 adHGRGLVRFDPADGEVTVLadEYGKPLNRPNDGVVDPDGRLYFTDMGEYLP-----TGALYRVDPDGSLRVLADGLTFP 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 160 NGLAWDVKAKKFYFIDTNNHEVLAYDYNQsTGAVSNPKVIFDLrkirPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNP 239
Cdd:COG3386 140 NGIAFSPDGRTLYVADTGAGRIYRFDLDA-DGTLGNRRVFADL----PDGPGGPDGLAVDADGNLWVALWGGGGVVRFDP 214

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24646912 240 sTGKILLEIKIPTTQITSVAFGGPNLDILYVTTANKFDQpkpAGTTFQVTgLNAKG 295
Cdd:COG3386 215 -DGELLGRIELPERRPTNVAFGGPDLRTLYVTTARSLPL---AGALFRVR-VDVPG 265
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 165-245 3.45e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.51  E-value: 3.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 165 DVKAKKFYFIDTNNHEVLAYDYNqstgavSNPKVIFDLRKIRPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPStGKI 244
Cdd:cd14963  16 AVSDGRIYVADTNNHRVQVFDYE------GKFKKSFGGPGTGPGEFKYPYGIAVDSDGNIYVADLYNGRIQVFDPD-GKF 88


                .
gi 24646912 245 L 245
Cdd:cd14963  89 L 89
 
Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 15-274 1.50e-68

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 213.28  E-value: 1.50e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912    15 LGEGPHWDVDRQSLYYVDLESAGINRYDFKQNKVYRAKIEGEIfaSFILPVENKPQEFAVGCGLRtvIVQWDGVSavakv 94
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPV--GAIAPRDDGGLIVALKDGVA--LLDLATGE----- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912    95 TRTLFEVQPDLKE-NRLNDAKTDPNGRFYGGTMADSGDiFTQWKGELYSWQAGGQPNAIRSKVGISNGLAWDVKAKKFYF 173
Cdd:pfam08450  72 LTPLADPEDDDWPlNRFNDGKVDPDGRFWFGTMGDDEA-PGGDPGALYRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYF 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912   174 IDTNNHEVLAYDYNQSTGAVSNPKVIFDLRKirpeGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPStGKILLEIKIPTT 253
Cdd:pfam08450 151 ADSPARKIWAYDYDLDGGLISNRRVFADFKP----GLGRPDGMAVDAEGNVWVARWGGGKVVRFDPD-GKLLREIELPAK 225

                         250       260
                  ....*....|....*....|.
gi 24646912   254 QITSVAFGGPNLDILYVTTAN 274
Cdd:pfam08450 226 RPTSCAFGGPDLRTLYVTSAR 246
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 7-295 2.78e-56

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 182.78  E-value: 2.78e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912   7 AVPDSYAALGEGPHWDVDrQSLYYVDLESAGINRYDFKQNKVyrakiegEIFASfilpvenkPQEFAVGCGLR---TVIV 83
Cdd:COG3386   1 KLADAGFRLGEGPVWDPD-GRLYWVDIPGGRIHRYDPDGGAV-------EVFAE--------PSGRPNGLAFDpdgRLLV 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912  84 --QWDGVSAVAKVTRTLFEV--QPDLKENRLNDAKTDPNGRFYGGTMADSGDiftqwKGELYSWQAGGQPNAIRSKVGIS 159
Cdd:COG3386  65 adHGRGLVRFDPADGEVTVLadEYGKPLNRPNDGVVDPDGRLYFTDMGEYLP-----TGALYRVDPDGSLRVLADGLTFP 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 160 NGLAWDVKAKKFYFIDTNNHEVLAYDYNQsTGAVSNPKVIFDLrkirPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNP 239
Cdd:COG3386 140 NGIAFSPDGRTLYVADTGAGRIYRFDLDA-DGTLGNRRVFADL----PDGPGGPDGLAVDADGNLWVALWGGGGVVRFDP 214

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24646912 240 sTGKILLEIKIPTTQITSVAFGGPNLDILYVTTANKFDQpkpAGTTFQVTgLNAKG 295
Cdd:COG3386 215 -DGELLGRIELPERRPTNVAFGGPDLRTLYVTTARSLPL---AGALFRVR-VDVPG 265
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
172-254 1.92e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.09  E-value: 1.92e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 172 YFIDTNNHEVLAYDYnqSTGAVSnpkvIFDLrkirPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPSTGKIlLEIKIP 251
Cdd:COG4257  73 WFTDNGNNRIGRIDP--KTGEIT----TFAL----PGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGEV-TEFPLP 141


                ...
gi 24646912 252 TTQ 254
Cdd:COG4257 142 TGG 144
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
145-271 2.18e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.07  E-value: 2.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 145 AGGQPNAIRSKVGISNGLAWDVKAKKFYFIDTNNHEVLAYDynQSTGAVsnpkvifdLRKIRPEGplFPDGMTVDTDGN- 223
Cdd:COG3391  56 LLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVID--LATGKV--------VATIPVGG--GPRGLAVDPDGGr 123

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 24646912 224 IYVATFNGGTVFKVNPSTGKILLEIKIPtTQITSVAFgGPNLDILYVT 271
Cdd:COG3391 124 LYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAV-DPDGKRLYVA 169
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
172-274 4.01e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 44.24  E-value: 4.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 172 YFIDTNNHEVLAYDynQSTGAVsnpkvifdlRKIRPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPSTGKIlLEIKIP 251
Cdd:COG4257  31 WFTDQGGGRIGRLD--PATGEF---------TEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDPKTGEI-TTFALP 98

                        90       100
                ....*....|....*....|....*
gi 24646912 252 TT--QITSVAFGGPnlDILYVTTAN 274
Cdd:COG4257  99 GGgsNPHGIAFDPD--GNLWFTDQG 121
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
172-244 8.08e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 43.47  E-value: 8.08e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24646912 172 YFIDTNNHEVLAYDynQSTGAVSnpkvIFDLrkirPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPSTGKI 244
Cdd:COG4257 159 WVTDFGANAIGRID--PDTGTLT----EYAL----PTPGAGPRGLAVDPDGNLWVADTGSGRIGRFDPKTGTV 221
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
160-252 3.18e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.54  E-value: 3.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 160 NGLAWDvKAKKFYFIDTNNHEVLAYDynQSTGAVSNPKVifdlrkirPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNP 239
Cdd:COG4257 191 RGLAVD-PDGNLWVADTGSGRIGRFD--PKTGTVTEYPL--------PGGGARPYGVAVDGDGRVWFAESGANRIVRFDP 259

                        90
                ....*....|...
gi 24646912 240 STGkiLLEIKIPT 252
Cdd:COG4257 260 DTE--LTEYVLPS 270
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 165-245 3.45e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.51  E-value: 3.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 165 DVKAKKFYFIDTNNHEVLAYDYNqstgavSNPKVIFDLRKIRPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPStGKI 244
Cdd:cd14963  16 AVSDGRIYVADTNNHRVQVFDYE------GKFKKSFGGPGTGPGEFKYPYGIAVDSDGNIYVADLYNGRIQVFDPD-GKF 88


                .
gi 24646912 245 L 245
Cdd:cd14963  89 L 89
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
23-244 6.29e-04

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 41.51  E-value: 6.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912  23 VDRQSLYYVDLESAGINRYDFKQNKvyrakiegeiFASFILPVENKPQEFAVGCGLR----TVIVQ-W-----DGVSAVA 92
Cdd:COG3292 228 EDREGNLWVGTYGGGLNYLDPNNSK----------FKSYRHNDPNGLSGNSVRSIAEdsdgNLWIRlWigtygGGLFRLD 297

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912  93 KVTRTLFEVQPD-LKENRLNDAKTDPNGRFYGGTMADSGDIFTQWKGEL--YSWQAGGQPNAIRSKVGISNGLAWDVKAK 169
Cdd:COG3292 298 PKTGKFKRYNPNgLPSNSVYSILEDSDGNLWIGTSGGGLYRYDPKTGKFtkFSEDNGLSNNFIRSILEDSDGNLWVGTNG 377

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24646912 170 KFYFIDTNNHEVLAYDYNQSTGAVSNPKVIfdlrkirpegplfpdGMTVDTDGNIYVATFNGGtVFKVNPSTGKI 244
Cdd:COG3292 378 GLYRLDPKTGKFTNFTHDPDKNGLSSNYIN---------------SIFEDSDGRLWIGTDGGG-LYRYDPKTGKF 436
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 116-227 1.96e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 39.11  E-value: 1.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 116 DPNGRFYggtMADSGdiftqwKGELYSWQAGGQP-NAIRSKVGIS--NGLAWDVKAKKFYFIDTNNHEVLAYDynqstga 192
Cdd:cd14962  65 DANGNLY---VSDAE------LGKVFVFDRDGKFlRAIGAGALFKrpTGIAVDPAGKRLYVVDTLAHKVKVFD------- 128

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 24646912 193 vSNPKVIFDLRKiRPEGP---LFPDGMTVDTDGNIYVA 227
Cdd:cd14962 129 -LDGRLLFDIGK-RGSGPgefNLPTDLAVDRDGNLYVT 164
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 116-246 2.67e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 38.84  E-value: 2.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 116 DPNGRFYggtMADSGD----IFTQWKGELYSWQAGGQPNAIRSKVGisnGLAWDvKAKKFYFIDTNNHEVLAYDynqSTG 191
Cdd:cd05819  63 DSDGNLY---VADTGNhriqKFDPDGNFLASFGGSGDGDGEFNGPR---GIAVD-SSGNIYVADTGNHRIQKFD---PDG 132

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24646912 192 avsnpKVIFDL-RKIRPEGPL-FPDGMTVDTDGNIYVATFNGGTVFKVNPSTGKILL 246
Cdd:cd05819 133 -----EFLTTFgSGGSGPGQFnGPTGVAVDSDGNIYVADTGNHRIQVFDPDGNFLTT 184
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 160-230 3.79e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 38.40  E-value: 3.79e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24646912 160 NGLAWDVkAKKFYFIDTNNHEVLAY----DYNQSTGAVSNPKVIFDlrkirpegplFPDGMTVDTDGNIYVA-TFN 230
Cdd:cd14957  21 RGIAVDS-AGNIYVADTGNNRIQVFtssgVYSYSIGSGGTGSGQFN----------SPYGIAVDSNGNIYVAdTDN 85
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 160-274 6.81e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 37.27  E-value: 6.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 160 NGLAWDvKAKKFYFIDTNNHEVLAYDYNqstgavSNPKVIFDLRKIRPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNP 239
Cdd:cd14963 151 NGIAVD-EDGNIYVADSGNGRIQVFDKN------GKFIKELNGSPDGKSGFVNPRGIAVDPDGNLYVVDNLSHRVYVFDE 223

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 24646912 240 sTGKILLEIKIPTTQITSVAFggPN-LDI-----LYVT-TAN 274
Cdd:cd14963 224 -QGKELFTFGGRGKDDGQFNL--PNgLFIdddgrLYVTdREN 262
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 172-237 7.46e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 37.30  E-value: 7.46e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24646912 172 YFIDTNNHEVLAYDYNQSTGAVSNPKVIFDLRKIRPEGplfpdgMTVDTDGNIYVATFNGGTVFKV 237
Cdd:cd05819 210 YVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRPSG------LAVDSDGNLYVADTGNNRIQVF 269
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 212-279 7.87e-03

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 37.51  E-value: 7.87e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 212 FPDGMTVDTDGNIYVATFNGGTVFKVNPStgkilleikiptTQITSVAFGGPNL--DILYVTTAnKFDQP 279
Cdd:cd14953 243 NPTGVAVDAAGNLYVADSGNHRIRKITPA------------GVVTTVAGGGAGFsgDGGPATSA-QFNNP 299
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 175-263 8.17e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 37.30  E-value: 8.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646912 175 DTNNHEVLAYDynqSTGavsNPKVIFDLRKIRPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPSTGKIlleIKIPTTQ 254
Cdd:cd05819  25 DTGNNRIQVFD---PDG---NFITSFGSFGSGDGQFNEPAGVAVDSDGNLYVADTGNHRIQKFDPDGNFL---ASFGGSG 95


                ....*....
gi 24646912 255 ITSVAFGGP 263
Cdd:cd05819  96 DGDGEFNGP 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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