NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24646804|ref|NP_731899|]
View 

uncharacterized protein Dmel_CG31321 [Drosophila melanogaster]

Protein Classification

solute carrier 46 family transporter( domain architecture ID 13024389)

solute carrier 46 (SLC46) family transporter

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 36-561 5.24e-105

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 321.15  E-value: 5.24e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804  36 YLVIEPFFFFYFMASVFNAVAMQNFpldkacrvnlgynkivcdtmldkselgiecddfdfenttqgatpdladlvigatg 115
Cdd:cd17386   1 MLNVEPIVFLYMFASVLSGPVTQNF------------------------------------------------------- 25

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 116 fnytvckaeleaqILAADVSGKRAPMAAIFPLIVLLFAGGWADRYNkRKPCMIMPIIGEALSFTCQIISSIFFeSLPMEF 195
Cdd:cd17386  26 -------------VYAANFYLYMNLMGSIPPLFSSLFLGSWSDRYG-RKPPLLMSLVGLLLSSLILVLIVYFT-TVPSVW 90

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 196 GAYCEAIVPALFGGLTFCLMAIYSYITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVFQLIa 275
Cdd:cd17386  91 WFYLSAIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLI- 169

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 276 ifyiiffikevkttpttsttaneppplptslppkqqgadnmayettnldelqgnknvnfqltpqmepkvevvppkrSLLK 355
Cdd:cd17386 170 ----------------------------------------------------------------------------ALLY 173

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 356 ELFdptlvldCIrfplvkrpnngrMLLILLLCAYFLTVGPTSGENDYWYRFTLKKLAWNGNDFSIYLTLSSGAALVGTFI 435
Cdd:cd17386 174 ILF-------FL------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGMLG 234

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 436 GTAILSKLLKVSDSMIGMLSALSIVCSRVLFAFSSSTASFYVAGVVDMFVSLRVIAIKTIGSSIVAGDELSKMYSIFGIS 515
Cdd:cd17386 235 GVLLLRCLLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVL 314

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*.
gi 24646804 516 EPIAQFIFPPIFSEIYKSTVDSFPGAIWLFGEIFYIPNVLVFVVCY 561
Cdd:cd17386 315 ESLSPLVASPIYNNIYKATLTTFPGFFFLLSAGLLLIPVILIGVVY 360
 
Name Accession Description Interval E-value
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 36-561 5.24e-105

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 321.15  E-value: 5.24e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804  36 YLVIEPFFFFYFMASVFNAVAMQNFpldkacrvnlgynkivcdtmldkselgiecddfdfenttqgatpdladlvigatg 115
Cdd:cd17386   1 MLNVEPIVFLYMFASVLSGPVTQNF------------------------------------------------------- 25

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 116 fnytvckaeleaqILAADVSGKRAPMAAIFPLIVLLFAGGWADRYNkRKPCMIMPIIGEALSFTCQIISSIFFeSLPMEF 195
Cdd:cd17386  26 -------------VYAANFYLYMNLMGSIPPLFSSLFLGSWSDRYG-RKPPLLMSLVGLLLSSLILVLIVYFT-TVPSVW 90

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 196 GAYCEAIVPALFGGLTFCLMAIYSYITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVFQLIa 275
Cdd:cd17386  91 WFYLSAIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLI- 169

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 276 ifyiiffikevkttpttsttaneppplptslppkqqgadnmayettnldelqgnknvnfqltpqmepkvevvppkrSLLK 355
Cdd:cd17386 170 ----------------------------------------------------------------------------ALLY 173

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 356 ELFdptlvldCIrfplvkrpnngrMLLILLLCAYFLTVGPTSGENDYWYRFTLKKLAWNGNDFSIYLTLSSGAALVGTFI 435
Cdd:cd17386 174 ILF-------FL------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGMLG 234

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 436 GTAILSKLLKVSDSMIGMLSALSIVCSRVLFAFSSSTASFYVAGVVDMFVSLRVIAIKTIGSSIVAGDELSKMYSIFGIS 515
Cdd:cd17386 235 GVLLLRCLLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVL 314

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*.
gi 24646804 516 EPIAQFIFPPIFSEIYKSTVDSFPGAIWLFGEIFYIPNVLVFVVCY 561
Cdd:cd17386 315 ESLSPLVASPIYNNIYKATLTTFPGFFFLLSAGLLLIPVILIGVVY 360
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
141-271 4.32e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.20  E-value: 4.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 141 MAAIFPLIVLLFAGGWADRYNKRKPCMIMpiigeALSFTCQIISSIFFESLPMEFGAyceAIVPALFGGLTFclMAIYSY 220
Cdd:COG2814  53 AYLLGAALGAPLAGRLADRFGRRRVLLLG-----LLLFALGSLLCALAPSLWLLLAA---RFLQGLGAGALF--PAALAL 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 24646804 221 ITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVF 271
Cdd:COG2814 123 IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
MFS_1 pfam07690
Major Facilitator Superfamily;
141-271 4.39e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 4.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804   141 MAAIFPLIVLLFAGGWADRYNkRKPCMIMPIIGEALSFTCqiisSIFFESLPMEFGAyceAIVPALFGGLTFclMAIYSY 220
Cdd:pfam07690  40 LFSLGYALAQPLAGRLSDRFG-RRRVLLIGLLLFALGLLL----LLFASSLWLLLVL---RVLQGLGAGALF--PAALAL 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 24646804   221 ITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVF 271
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
 
Name Accession Description Interval E-value
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 36-561 5.24e-105

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 321.15  E-value: 5.24e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804  36 YLVIEPFFFFYFMASVFNAVAMQNFpldkacrvnlgynkivcdtmldkselgiecddfdfenttqgatpdladlvigatg 115
Cdd:cd17386   1 MLNVEPIVFLYMFASVLSGPVTQNF------------------------------------------------------- 25

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 116 fnytvckaeleaqILAADVSGKRAPMAAIFPLIVLLFAGGWADRYNkRKPCMIMPIIGEALSFTCQIISSIFFeSLPMEF 195
Cdd:cd17386  26 -------------VYAANFYLYMNLMGSIPPLFSSLFLGSWSDRYG-RKPPLLMSLVGLLLSSLILVLIVYFT-TVPSVW 90

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 196 GAYCEAIVPALFGGLTFCLMAIYSYITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVFQLIa 275
Cdd:cd17386  91 WFYLSAIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLI- 169

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 276 ifyiiffikevkttpttsttaneppplptslppkqqgadnmayettnldelqgnknvnfqltpqmepkvevvppkrSLLK 355
Cdd:cd17386 170 ----------------------------------------------------------------------------ALLY 173

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 356 ELFdptlvldCIrfplvkrpnngrMLLILLLCAYFLTVGPTSGENDYWYRFTLKKLAWNGNDFSIYLTLSSGAALVGTFI 435
Cdd:cd17386 174 ILF-------FL------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGMLG 234

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 436 GTAILSKLLKVSDSMIGMLSALSIVCSRVLFAFSSSTASFYVAGVVDMFVSLRVIAIKTIGSSIVAGDELSKMYSIFGIS 515
Cdd:cd17386 235 GVLLLRCLLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVL 314

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*.
gi 24646804 516 EPIAQFIFPPIFSEIYKSTVDSFPGAIWLFGEIFYIPNVLVFVVCY 561
Cdd:cd17386 315 ESLSPLVASPIYNNIYKATLTTFPGFFFLLSAGLLLIPVILIGVVY 360
MFS_SLC46A2_TSCOT cd17450
Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the ...
 406-549 3.92e-09

Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 2 (SLC46A2) is also called thymic stromal cotransporter protein (TSCOT). It is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. Polymorphisms in TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. TSCOT belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341008  Cd Length: 383  Bit Score: 58.99  E-value: 3.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 406 FTLKK-LAWNGNDFSiYLTLSSGAALVGTFIGTAILSKLLKvSDSMIgMLSALSIVCSRVLFAFSSSTASFYVAGVVDMF 484
Cdd:cd17450 230 FVLKEpLSWGAVEVG-YGNAAGYMIFITSFLGVFVFSRCLR-DTTMI-MIGMVSFSSGILIMAFVKWTFMFYIARAVMLF 306

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24646804 485 VSLRVIAIKTIGSSIVAGDELSKMYSIFGISEPIAQFIFPPIFSEIYKSTVDSFPGAIWLFGEIF 549
Cdd:cd17450 307 ALIPLPTIRSLISKQVQGSSYGKVFVMLQLSLKLTGVATSTIYNKIYQATLDWFPGFCFILSSIL 371
MFS_SLC46A3 cd17448
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 142-546 1.31e-06

Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341006  Cd Length: 396  Bit Score: 50.88  E-value: 1.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 142 AAIFPLIVLLFAGGWADRYNkRKPCMIMPIIGEALSFTCQIISSIFFESLPMEFGAYceaIVPALFGGLTFCLMAIYSYI 221
Cdd:cd17448  78 GLIPSLIVTLILVSYSDRHG-RKFSIILPSIGALLTSLSYCLVSYFSFPLNLLIASS---FISGLFGGFTTFIGGCFAYV 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 222 T-IATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVFQLIaifyiiffikevkttpttsttanepp 300
Cdd:cd17448 154 AdLCKDHKQKTIRMAVVDMILGVLTGLAGLSSGYFIRALGFNWPFLTIALLHVV-------------------------- 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 301 plptslppkqqgadNMAYettnldelqgnknvnfqltpqmepkvevvppkrsllkelfdptlvldcIRFPLVkrpnngrm 380
Cdd:cd17448 208 --------------NLLY------------------------------------------------ILFFLV-------- 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 381 LLILLLCAYFLTVGPTSGEndyWYRFTLKK----LAWNgndfSIYLTLSSGAAL---VGTFIGTAILSKLLKvsDSMIGM 453
Cdd:cd17448 218 VLCLLLFAFSTYLLANFGG---ASIFILYElnapLCWN----EVLVGYGSAASTaifLTSFVGVALFSRCLP--DIYIVF 288

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 454 LSALSIVCSRVLFAFSSSTASFYVAGVVDMFVSLRVIAIKTIGSSIVAGDELSKMYSIFGISEPIAQFIFPPIFSEIYKS 533
Cdd:cd17448 289 IGIFSVAGGMIMTAFAKTTLLMFLVRLPLLFAIMPFPVLRSMMSKVVLPSEQGALFACVAFLETLSGVLSVTIFNSIYAA 368

                       410
                ....*....|...
gi 24646804 534 TVDSFPGAIWLFG 546
Cdd:cd17448 369 TVAWFPGFSFLLS 381
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
141-271 4.32e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.20  E-value: 4.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 141 MAAIFPLIVLLFAGGWADRYNKRKPCMIMpiigeALSFTCQIISSIFFESLPMEFGAyceAIVPALFGGLTFclMAIYSY 220
Cdd:COG2814  53 AYLLGAALGAPLAGRLADRFGRRRVLLLG-----LLLFALGSLLCALAPSLWLLLAA---RFLQGLGAGALF--PAALAL 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 24646804 221 ITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVF 271
Cdd:COG2814 123 IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
MFS_1 pfam07690
Major Facilitator Superfamily;
141-271 4.39e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 4.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804   141 MAAIFPLIVLLFAGGWADRYNkRKPCMIMPIIGEALSFTCqiisSIFFESLPMEFGAyceAIVPALFGGLTFclMAIYSY 220
Cdd:pfam07690  40 LFSLGYALAQPLAGRLSDRFG-RRRVLLIGLLLFALGLLL----LLFASSLWLLLVL---RVLQGLGAGALF--PAALAL 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 24646804   221 ITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVF 271
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 142-273 8.82e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 48.34  E-value: 8.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 142 AAIFPLIVLLFAGGWADRYNKRKPCMImpiigealsftCQIISSIFFESLPMEFGAYCEAIVPALFG-GLTFCLMAIYSY 220
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGRKPLILI-----------GLLLSAVALLLLPLATSFWLLLLLLALLGlGLGLVFPATLAL 312

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24646804 221 ITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVFQL 273
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLL 365
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 141-278 2.69e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.34  E-value: 2.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 141 MAAIFPLIVLLFA---GGWADRYNkRKPCMIMPIIGEALSFTCQIISSIFFeslpmefGAYCEAIVPALFGGltfCLMAI 217
Cdd:cd17330  39 LQSSYSLGQFLASplwGRLSDRYG-RKPVLLLSLAGSAVSYVLLGLSRNLW-------LLFLARFLDGLTGG---NVSVA 107

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24646804 218 YSYITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVFQLIAIFY 278
Cdd:cd17330 108 QAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVL 168
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 141-270 1.03e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.83  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 141 MAAIFPLIVL-LFAGGWADRYNKRKpcmIMpiigealsFTCQIISSIFFESLPmeFGAYCEAIVPALFGGLTFCLMAI-- 217
Cdd:cd06173  41 AAFFLPFLLFsPFAGVLADRFDRRR---LL--------ILADLLRALLAAVLA--LLALLGSLSLWLLLVLAFLLGIAsa 107

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24646804 218 ------YSYITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIV 270
Cdd:cd06173 108 ffgparQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINAL 166
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
141-271 1.41e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.39  E-value: 1.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 141 MAAIFPLIVLL--FAGGW-ADRYNKRKPCMIMpiigeaLSFTCQIISSIFFESLPMEFGAYCEAIVPALFGGLTFclMAI 217
Cdd:COG2271 221 LLSLPFLAGIVgsLLGGWlSDRLGRRRKLVLA------IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAF--GLL 292

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 24646804 218 YSYITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVF 271
Cdd:COG2271 293 WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 141-271 1.68e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 1.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 141 MAAIFPLIVLLFAGGWADRYNKRKPcMIMPIIGEALSFtcqiISSIFFESLPMEFGAYceaIVPALFGGLTFclMAIYSY 220
Cdd:cd17325  39 AYALAQLLFSPPAGRLSDRFGRKRL-LLLGLLLLAVST----LLFAFATSYWQLLLAR---FLQGLASAAVW--PAAMAL 108

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 24646804 221 ITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVF 271
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 141-270 2.48e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.49  E-value: 2.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 141 MAAIFPLIVLLFAGGWADRYNKRKPCMIMPIIGEALSFTcqiisSIFFESLPMefgayceAIVPALFGGLTFCLM--AIY 218
Cdd:cd06174  39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL-----FAFAPSFWL-------LLLGRFLLGLGSGLIdpAVL 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 24646804 219 SYITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYTWSFASAIV 270
Cdd:cd06174 107 ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 381-568 4.29e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 39.72  E-value: 4.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 381 LLILLLCAYFLTVGPTSGENDYwyrftLKKLAWNGNDFSIYLTLSSGAALVGTFIGTAILSKLLKVSdSMIGMLSALSIV 460
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPAL-----LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRP-VLLLGLLLFALG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804 461 CsrVLFAFSSSTASFYVAGVV-DMFVSLRVIAIKTIGSSIVAGDELSKMYSIFGISEPIAQFIFPPIFSEIYKSTVDSFP 539
Cdd:cd06174  75 A--LLFAFAPSFWLLLLGRFLlGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWR 152

                       170       180
                ....*....|....*....|....*....
gi 24646804 540 GAIWLFGeifyIPNVLVFVVCYFLLRRRK 568
Cdd:cd06174 153 AVFLIAA----ALALLAAILLLLVVPDPP 177
MFS_1 pfam07690
Major Facilitator Superfamily;
411-577 8.03e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 8.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804   411 LAWNGNDFSIYLTLSSGAALVGTFIGtAILSKLLKVSDSMIGMLSALSIVCsrVLFAFSSSTASFYVAGVVD-MFVSLRV 489
Cdd:pfam07690  27 LGISPTEIGLLLTLFSLGYALAQPLA-GRLSDRFGRRRVLLIGLLLFALGL--LLLLFASSLWLLLVLRVLQgLGAGALF 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646804   490 IAIKTIGSSIVAGDELSKMYSIFGISEPIAQFIFPPIFSEIYKSTvdSFPGAIWLFGeifyIPNVLVFVVCYFLLRRRKA 569
Cdd:pfam07690 104 PAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF--GWRAAFLILA----ILSLLAAVLLLLPRPPPES 177


                  ....*...
gi 24646804   570 NEEKSVVE 577
Cdd:pfam07690 178 KRPKPAEE 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH