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Conserved domains on  [gi|45551880|ref|NP_731649|]
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cadherin 87A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 778-873 2.31e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 2.31e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  778 SYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDD-FGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTP 856
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*..
gi 45551880  857 SLTGTATLTINVQNSND 873
Cdd:cd11304   81 PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1108-1207 1.06e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 1.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1108 YYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGEN-NKYFSIDAYTGNVMVANSsiLDREQIKELTLSVVAQDKAP 1186
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP--LDREEQSSYTLTVTATDGGG 79

                         90       100
                 ....*....|....*....|.
gi 45551880 1187 aaVQKSATATIHINILDVNDN 1207
Cdd:cd11304   80 --PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-353 1.27e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 1.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  248 SLSTVIDEDSPINTLVLTVHARDGDTGEPRKIVYDL-RTNPNDYFLLDAQTGELRTAKPLDREaledSTGIISLVIRARE 326
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*..
gi 45551880  327 lvngvpSDDPLTSATAKATVTIRDVND 353
Cdd:cd11304   77 ------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1015-1099 1.58e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 1.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1015 EEQPVGTVLTTLQANDEDSSIG---EFNISDND---YFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATAD 1088
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENgevTYSIVSGNedgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTAT 87

                         90
                 ....*....|.
gi 45551880 1089 VVVDIINLNDN 1099
Cdd:cd11304   88 VTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1215-1314 6.81e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 6.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1215 VYNSTVAENAAyqPPAALLQVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLSG-KHGAYELTISARDtQ 1293
Cdd:cd11304    1 SYEVSVPENAP--PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDReEQSSYTLTVTATD-G 77

                         90       100
                 ....*....|....*....|.
gi 45551880 1294 GSGTMESTTKAIITVLRVNRH 1314
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1437-1549 1.05e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1437 PYKVSINENSGRDVKIGHIQAASR-SKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILASIKADL 1515
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 45551880 1516 HISeeerasfsiktlnrdnTVAKVAITVLDVNDN 1549
Cdd:cd11304   81 PLS----------------STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1327-1427 1.32e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1327 TIEIPGDiVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQqtgeFKIDEVTGELRAKTQLNRKNRANYDIILVARDA 1406
Cdd:cd11304    3 EVSVPEN-APPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 45551880 1407 GNPPFESLRLLSVSIVDANEN 1427
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-468 4.97e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 4.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  362 EYSVSLLENTLPGTPLALdMSVSDADVGINSKFALRL--DDVSGVFDVEPKlvTGysqvNIRVaNGTLDYENpnQRKFIV 439
Cdd:cd11304    1 SYEVSVPENAPPGTVVLT-VSATDPDSGENGEVTYSIvsGNEDGLFSIDPS--TG----EITT-AKPLDREE--QSSYTL 70

                         90       100
                 ....*....|....*....|....*....
gi 45551880  440 LVVAEETDTnPRLSSTATITVSVLDANDN 468
Cdd:cd11304   71 TVTATDGGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-128 9.08e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 9.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   33 NIILYENVTVGTVVFRLEAYDP---EGSPVTY---GAIGADHFSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEG 106
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPdsgENGEVTYsivSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90       100
                 ....*....|....*....|..
gi 45551880  107 ESerdnvvEVPITFIILDLNDN 128
Cdd:cd11304   83 SS------TATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 476-533 2.82e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 2.82e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 45551880  476 SYSASVSEAALPGQYIATITARDVDSGSYGDsgIRYSL-SGTGAELFHVNEQTGVISLA 533
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGE--VTYSIvSGNEDGLFSIDPSTGEITTA 57
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 882-994 9.21e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 9.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  882 TQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAgtddITAIDKEGkelphydqfkeYFKI-SRNGKVSVNKQLDRNLF 960
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS----IVSGNEDG-----------LFSIdPSTGEITTAKPLDREEQ 65

                         90       100       110
                 ....*....|....*....|....*....|....
gi 45551880  961 AVMRINVLVTDSTAPnVQQGRGLLIIQIIDVNKN 994
Cdd:cd11304   66 SSYTLTVTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1557-1662 1.06e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1557 IYYAGVNANAKMGAAITLVNATDADQGKNAKIEFMIVASNlykfgatkstgsiVPSPFAISQD-GRISANTIMAEYNQDR 1635
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN-------------EDGLFSIDPStGEITTAKPLDREEQSS 67

                         90       100
                 ....*....|....*....|....*..
gi 45551880 1636 FELEIVARELEQPQSSASTKVNIWVFD 1662
Cdd:cd11304   68 YTLTVTATDGGGPPLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 136-240 7.44e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 7.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  136 PYEADVNEDAAVGTTIFdKITVKDRDIvGESLDLKC-LpqqQSPEACRKFRLHIIkrdatilEAAVVLNDTLNYNQRMVY 214
Cdd:cd11304    1 SYEVSVPENAPPGTVVL-TVSATDPDS-GENGEVTYsI---VSGNEDGLFSIDPS-------TGEITTAKPLDREEQSSY 68

                         90       100
                 ....*....|....*....|....*....
gi 45551880  215 HFQIEATDG---PHKTQTTFEARVKDVQD 240
Cdd:cd11304   69 TLTVTATDGggpPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 692-772 1.35e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.03  E-value: 1.35e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     692 KARDADT--MSRISYRIRGSEqVESIFDIDRETGQIIIrpNATLDVTNLnsDQLIFAVEANDG---LFTAHCGVNITVRD 766
Cdd:smart00112    1 SATDADSgeNGKVTYSILSGN-DDGLFSIDPETGEITT--TKPLDREEQ--PEYTLTVEATDGggpPLSSTATVTITVLD 75


                    ....*.
gi 45551880     767 VNNHVP 772
Cdd:smart00112   76 VNDNAP 81
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 627-667 7.26e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member smart00112:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 81  Bit Score: 43.11  E-value: 7.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 45551880     627 LDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPP 667
Cdd:smart00112   41 LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 778-873 2.31e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 2.31e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  778 SYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDD-FGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTP 856
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*..
gi 45551880  857 SLTGTATLTINVQNSND 873
Cdd:cd11304   81 PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1108-1207 1.06e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 1.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1108 YYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGEN-NKYFSIDAYTGNVMVANSsiLDREQIKELTLSVVAQDKAP 1186
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP--LDREEQSSYTLTVTATDGGG 79

                         90       100
                 ....*....|....*....|.
gi 45551880 1187 aaVQKSATATIHINILDVNDN 1207
Cdd:cd11304   80 --PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
779-869 8.25e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 8.25e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    779 YSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDD-FGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPS 857
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 45551880    858 LTGTATLTINVQ 869
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-353 1.27e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 1.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  248 SLSTVIDEDSPINTLVLTVHARDGDTGEPRKIVYDL-RTNPNDYFLLDAQTGELRTAKPLDREaledSTGIISLVIRARE 326
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*..
gi 45551880  327 lvngvpSDDPLTSATAKATVTIRDVND 353
Cdd:cd11304   77 ------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1015-1099 1.58e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 1.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1015 EEQPVGTVLTTLQANDEDSSIG---EFNISDND---YFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATAD 1088
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENgevTYSIVSGNedgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTAT 87

                         90
                 ....*....|.
gi 45551880 1089 VVVDIINLNDN 1099
Cdd:cd11304   88 VTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 797-876 2.31e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 2.31e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     797 HATDLDTGKNAELRYRIQQGSFDD-FGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKD 875
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 45551880     876 P 876
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1215-1314 6.81e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 6.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1215 VYNSTVAENAAyqPPAALLQVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLSG-KHGAYELTISARDtQ 1293
Cdd:cd11304    1 SYEVSVPENAP--PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDReEQSSYTLTVTATD-G 77

                         90       100
                 ....*....|....*....|.
gi 45551880 1294 GSGTMESTTKAIITVLRVNRH 1314
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1437-1549 1.05e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1437 PYKVSINENSGRDVKIGHIQAASR-SKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILASIKADL 1515
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 45551880 1516 HISeeerasfsiktlnrdnTVAKVAITVLDVNDN 1549
Cdd:cd11304   81 PLS----------------STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1327-1427 1.32e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1327 TIEIPGDiVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQqtgeFKIDEVTGELRAKTQLNRKNRANYDIILVARDA 1406
Cdd:cd11304    3 EVSVPEN-APPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 45551880 1407 GNPPFESLRLLSVSIVDANEN 1427
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1127-1209 2.89e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 2.89e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1127 AHDGDVGVFGEITYTLIGENNK-YFSIDAYTGNVMVANSsiLDREQIKELTLSVVAQDKAPaaVQKSATATIHINILDVN 1205
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDgLFSIDPETGEITTTKP--LDREEQPEYTLTVEATDGGG--PPLSSTATVTITVLDVN 77


                    ....
gi 45551880    1206 DNAP 1209
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-468 4.97e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 4.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  362 EYSVSLLENTLPGTPLALdMSVSDADVGINSKFALRL--DDVSGVFDVEPKlvTGysqvNIRVaNGTLDYENpnQRKFIV 439
Cdd:cd11304    1 SYEVSVPENAPPGTVVLT-VSATDPDSGENGEVTYSIvsGNEDGLFSIDPS--TG----EITT-AKPLDREE--QSSYTL 70

                         90       100
                 ....*....|....*....|....*....
gi 45551880  440 LVVAEETDTnPRLSSTATITVSVLDANDN 468
Cdd:cd11304   71 TVTATDGGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-128 9.08e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 9.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   33 NIILYENVTVGTVVFRLEAYDP---EGSPVTY---GAIGADHFSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEG 106
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPdsgENGEVTYsivSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90       100
                 ....*....|....*....|..
gi 45551880  107 ESerdnvvEVPITFIILDLNDN 128
Cdd:cd11304   83 SS------TATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1345-1429 1.92e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 1.92e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1345 RAMDNDTEENGKVSYHLQVNNRNeqqtGEFKIDEVTGELRAKTQLNRKNRANYDIILVARDAGNPPFESLRLLSVSIVDA 1424
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 45551880    1425 NENRP 1429
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
250-348 1.29e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 1.29e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    250 STVIDEDSPINTLVLTVHARDGDTGEPRKIVYD-LRTNPNDYFLLDAQTGELRTAKPLDREaledSTGIISLVIRARElv 328
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRE----SIGEYELTVEATD-- 75

                           90       100
                   ....*....|....*....|
gi 45551880    329 ngvpSDDPLTSATAKATVTI 348
Cdd:pfam00028   76 ----SGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1461-1551 1.79e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 1.79e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1461 SKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILASikaDLHIseeerasfsiktlNRDNTVAKVA 1540
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT---DGGG-------------PPLSSTATVT 70

                            90
                    ....*....|.
gi 45551880    1541 ITVLDVNDNPP 1551
Cdd:smart00112   71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1108-1202 1.81e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 1.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   1108 YYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGEN-NKYFSIDAYTGNVMVANSsiLDREQIKELTLSVVAQDKAP 1186
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpGGNFRIDPDTGDISTTKP--LDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....*.
gi 45551880   1187 AAvqKSATATIHINIL 1202
Cdd:pfam00028   79 PP--LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1027-1101 5.99e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 5.99e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1027 QANDEDSSIG---EFNISDND---YFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATADVVVDIINLNDND 1100
Cdd:smart00112    1 SATDADSGENgkvTYSILSGNddgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 45551880    1101 P 1101
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1438-1510 1.50e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 1.50e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45551880   1438 YKVSINENSGRDVKIGHIQAASRSKH-NRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILAS 1510
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 267-356 1.63e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 1.63e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     267 HARDGDTGEPRKIVYDL-RTNPNDYFLLDAQTGELRTAKPLDREaledSTGIISLVIRARElvngvpSDDPLTSATAKAT 345
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATD------GGGPPLSSTATVT 70

                            90
                    ....*....|.
gi 45551880     346 VTIRDVNDSPP 356
Cdd:smart00112   71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1216-1309 4.17e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 4.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   1216 YNSTVAENAAYQPPaaLLQVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLSGKHGA-YELTISARDtQG 1294
Cdd:pfam00028    1 YSASVPENAPVGTE--VLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGeYELTVEATD-SG 77

                           90
                   ....*....|....*
gi 45551880   1295 SGTMESTTKAIITVL 1309
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 476-533 2.82e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 2.82e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 45551880  476 SYSASVSEAALPGQYIATITARDVDSGSYGDsgIRYSL-SGTGAELFHVNEQTGVISLA 533
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGE--VTYSIvSGNEDGLFSIDPSTGEITTA 57
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1236-1316 6.86e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.06  E-value: 6.86e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1236 QAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLS-GKHGAYELTISARDtQGSGTMESTTKAIITVLRVNRH 1314
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDrEEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 45551880    1315 KP 1316
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
1015-1094 1.06e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   1015 EEQPVGTVLTTLQANDEDS--------SIGEFNISDNdyFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTAT 1086
Cdd:pfam00028    7 ENAPVGTEVLTVTATDPDLgpngrifySILGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 45551880   1087 ADVVVDII 1094
Cdd:pfam00028   85 ATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 53-130 1.07e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 1.07e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880      53 DPEGSPVTY---GAIGADHFSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEgeserdNVVEVPITFIILDLNDNP 129
Cdd:smart00112    7 SGENGKVTYsilSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP------LSSTATVTITVLDVNDNA 80


                    .
gi 45551880     130 P 130
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 382-470 6.74e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 6.74e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     382 SVSDADVGINSKFALRL--DDVSGVFDVEPKlvTGysqvnIRVANGTLDYENpnQRKFIVLVVAEETDTnPRLSSTATIT 459
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPE--TG-----EITTTKPLDREE--QPEYTLTVEATDGGG-PPLSSTATVT 70

                            90
                    ....*....|.
gi 45551880     460 VSVLDANDNKP 470
Cdd:smart00112   71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1327-1421 7.17e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 7.17e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   1327 TIEIPGDiVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQqtgeFKIDEVTGELRAKTQLNRKNRANYDIILVARDA 1406
Cdd:pfam00028    2 SASVPEN-APVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN----FRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 45551880   1407 GNPPFESLRLLSVSI 1421
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 882-994 9.21e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 9.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  882 TQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAgtddITAIDKEGkelphydqfkeYFKI-SRNGKVSVNKQLDRNLF 960
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS----IVSGNEDG-----------LFSIdPSTGEITTAKPLDREEQ 65

                         90       100       110
                 ....*....|....*....|....*....|....
gi 45551880  961 AVMRINVLVTDSTAPnVQQGRGLLIIQIIDVNKN 994
Cdd:cd11304   66 SSYTLTVTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1557-1662 1.06e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1557 IYYAGVNANAKMGAAITLVNATDADQGKNAKIEFMIVASNlykfgatkstgsiVPSPFAISQD-GRISANTIMAEYNQDR 1635
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN-------------EDGLFSIDPStGEITTAKPLDREEQSS 67

                         90       100
                 ....*....|....*....|....*..
gi 45551880 1636 FELEIVARELEQPQSSASTKVNIWVFD 1662
Cdd:cd11304   68 YTLTVTATDGGGPPLSSTATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
33-119 9.88e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.23  E-value: 9.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     33 NIILYENVTVGTVVFRLEAYDPEGSP---VTYGAIG---ADHFSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRvdpeG 106
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGggpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS----G 77

                           90
                   ....*....|...
gi 45551880    107 ESERDNVVEVPIT 119
Cdd:pfam00028   78 GPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
477-533 7.59e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 7.59e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 45551880    477 YSASVSEAALPGQYIATITARDVDSGSygDSGIRYSLSGTGAE-LFHVNEQTGVISLA 533
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGGGPGgNFRIDPDTGDISTT 56
Cadherin pfam00028
Cadherin domain;
363-463 1.10e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.15  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    363 YSVSLLENTLPGTPLALdMSVSDADVGINSK--FALRLDDVSGVFDVEPKlvTGYsqvnIRVAnGTLDYENPNQrkFIVL 440
Cdd:pfam00028    1 YSASVPENAPVGTEVLT-VTATDPDLGPNGRifYSILGGGPGGNFRIDPD--TGD----ISTT-KPLDRESIGE--YELT 70

                           90       100
                   ....*....|....*....|...
gi 45551880    441 VVAEETDTNPRlSSTATITVSVL 463
Cdd:pfam00028   71 VEATDSGGPPL-SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 136-240 7.44e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 7.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  136 PYEADVNEDAAVGTTIFdKITVKDRDIvGESLDLKC-LpqqQSPEACRKFRLHIIkrdatilEAAVVLNDTLNYNQRMVY 214
Cdd:cd11304    1 SYEVSVPENAPPGTVVL-TVSATDPDS-GENGEVTYsI---VSGNEDGLFSIDPS-------TGEITTAKPLDREEQSSY 68

                         90       100
                 ....*....|....*....|....*....
gi 45551880  215 HFQIEATDG---PHKTQTTFEARVKDVQD 240
Cdd:cd11304   69 TLTVTATDGggpPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 692-772 1.35e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.03  E-value: 1.35e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     692 KARDADT--MSRISYRIRGSEqVESIFDIDRETGQIIIrpNATLDVTNLnsDQLIFAVEANDG---LFTAHCGVNITVRD 766
Cdd:smart00112    1 SATDADSgeNGKVTYSILSGN-DDGLFSIDPETGEITT--TKPLDREEQ--PEYTLTVEATDGggpPLSSTATVTITVLD 75


                    ....*.
gi 45551880     767 VNNHVP 772
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 938-996 5.85e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.11  E-value: 5.85e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     938 KEYFKI-SRNGKVSVNKQLDRNLFAVMRINVLVTDSTAPNvQQGRGLLIIQIIDVNKNPP 996
Cdd:smart00112   23 DGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 627-667 7.26e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.11  E-value: 7.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 45551880     627 LDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPP 667
Cdd:smart00112   41 LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
883-989 9.82e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 9.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    883 QHAEVRADAPPGQLVYTLIALDPDVANHNALEFA----GTDDITAIDKEgkelphydqfkeyfkisrNGKVSVNKQLDRN 958
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSilggGPGGNFRIDPD------------------TGDISTTKPLDRE 62

                           90       100       110
                   ....*....|....*....|....*....|.
gi 45551880    959 LFAVMRINVLVTDSTAPNvQQGRGLLIIQII 989
Cdd:pfam00028   63 SIGEYELTVEATDSGGPP-LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1558-1660 7.71e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 40.36  E-value: 7.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   1558 YYAGVNANAKMGAAITLVNATDADQGKNAKIEFMIVASNlykfgatkstgsiVPSPFAISQD-GRISANTIMAEYNQDRF 1636
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG-------------PGGNFRIDPDtGDISTTKPLDRESIGEY 67

                           90       100
                   ....*....|....*....|....
gi 45551880   1637 ELEIVARELEQPQSSASTKVNIWV 1660
Cdd:pfam00028   68 ELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1576-1658 3.95e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 3.95e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1576 NATDADQGKNAKIEFMIVASNlykfgatkstgsiVPSPFAI-SQDGRISANTIMAEYNQDRFELEIVARELEQPQSSAST 1654
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN-------------DDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTA 67


                    ....
gi 45551880    1655 KVNI 1658
Cdd:smart00112   68 TVTI 71
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 200-243 7.41e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 37.33  E-value: 7.41e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 45551880     200 VVLNDTLNYNQRMVYHFQIEATDG---PHKTQTTFEARVKDVQDKPP 243
Cdd:smart00112   35 ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 778-873 2.31e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 2.31e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  778 SYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDD-FGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTP 856
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*..
gi 45551880  857 SLTGTATLTINVQNSND 873
Cdd:cd11304   81 PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1108-1207 1.06e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 1.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1108 YYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGEN-NKYFSIDAYTGNVMVANSsiLDREQIKELTLSVVAQDKAP 1186
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP--LDREEQSSYTLTVTATDGGG 79

                         90       100
                 ....*....|....*....|.
gi 45551880 1187 aaVQKSATATIHINILDVNDN 1207
Cdd:cd11304   80 --PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
779-869 8.25e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 8.25e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    779 YSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDD-FGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPS 857
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 45551880    858 LTGTATLTINVQ 869
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-353 1.27e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 1.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  248 SLSTVIDEDSPINTLVLTVHARDGDTGEPRKIVYDL-RTNPNDYFLLDAQTGELRTAKPLDREaledSTGIISLVIRARE 326
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*..
gi 45551880  327 lvngvpSDDPLTSATAKATVTIRDVND 353
Cdd:cd11304   77 ------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1015-1099 1.58e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 1.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1015 EEQPVGTVLTTLQANDEDSSIG---EFNISDND---YFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATAD 1088
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENgevTYSIVSGNedgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTAT 87

                         90
                 ....*....|.
gi 45551880 1089 VVVDIINLNDN 1099
Cdd:cd11304   88 VTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 797-876 2.31e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 2.31e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     797 HATDLDTGKNAELRYRIQQGSFDD-FGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKD 875
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 45551880     876 P 876
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1215-1314 6.81e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 6.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1215 VYNSTVAENAAyqPPAALLQVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLSG-KHGAYELTISARDtQ 1293
Cdd:cd11304    1 SYEVSVPENAP--PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDReEQSSYTLTVTATD-G 77

                         90       100
                 ....*....|....*....|.
gi 45551880 1294 GSGTMESTTKAIITVLRVNRH 1314
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1437-1549 1.05e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1437 PYKVSINENSGRDVKIGHIQAASR-SKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILASIKADL 1515
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 45551880 1516 HISeeerasfsiktlnrdnTVAKVAITVLDVNDN 1549
Cdd:cd11304   81 PLS----------------STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1327-1427 1.32e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1327 TIEIPGDiVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQqtgeFKIDEVTGELRAKTQLNRKNRANYDIILVARDA 1406
Cdd:cd11304    3 EVSVPEN-APPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 45551880 1407 GNPPFESLRLLSVSIVDANEN 1427
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1127-1209 2.89e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 2.89e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1127 AHDGDVGVFGEITYTLIGENNK-YFSIDAYTGNVMVANSsiLDREQIKELTLSVVAQDKAPaaVQKSATATIHINILDVN 1205
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDgLFSIDPETGEITTTKP--LDREEQPEYTLTVEATDGGG--PPLSSTATVTITVLDVN 77


                    ....
gi 45551880    1206 DNAP 1209
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-468 4.97e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 4.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  362 EYSVSLLENTLPGTPLALdMSVSDADVGINSKFALRL--DDVSGVFDVEPKlvTGysqvNIRVaNGTLDYENpnQRKFIV 439
Cdd:cd11304    1 SYEVSVPENAPPGTVVLT-VSATDPDSGENGEVTYSIvsGNEDGLFSIDPS--TG----EITT-AKPLDREE--QSSYTL 70

                         90       100
                 ....*....|....*....|....*....
gi 45551880  440 LVVAEETDTnPRLSSTATITVSVLDANDN 468
Cdd:cd11304   71 TVTATDGGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-128 9.08e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 9.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   33 NIILYENVTVGTVVFRLEAYDP---EGSPVTY---GAIGADHFSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEG 106
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPdsgENGEVTYsivSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90       100
                 ....*....|....*....|..
gi 45551880  107 ESerdnvvEVPITFIILDLNDN 128
Cdd:cd11304   83 SS------TATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1345-1429 1.92e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 1.92e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1345 RAMDNDTEENGKVSYHLQVNNRNeqqtGEFKIDEVTGELRAKTQLNRKNRANYDIILVARDAGNPPFESLRLLSVSIVDA 1424
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 45551880    1425 NENRP 1429
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
250-348 1.29e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 1.29e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    250 STVIDEDSPINTLVLTVHARDGDTGEPRKIVYD-LRTNPNDYFLLDAQTGELRTAKPLDREaledSTGIISLVIRARElv 328
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRE----SIGEYELTVEATD-- 75

                           90       100
                   ....*....|....*....|
gi 45551880    329 ngvpSDDPLTSATAKATVTI 348
Cdd:pfam00028   76 ----SGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1461-1551 1.79e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 1.79e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1461 SKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILASikaDLHIseeerasfsiktlNRDNTVAKVA 1540
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT---DGGG-------------PPLSSTATVT 70

                            90
                    ....*....|.
gi 45551880    1541 ITVLDVNDNPP 1551
Cdd:smart00112   71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1108-1202 1.81e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 1.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   1108 YYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGEN-NKYFSIDAYTGNVMVANSsiLDREQIKELTLSVVAQDKAP 1186
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpGGNFRIDPDTGDISTTKP--LDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....*.
gi 45551880   1187 AAvqKSATATIHINIL 1202
Cdd:pfam00028   79 PP--LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1027-1101 5.99e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 5.99e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1027 QANDEDSSIG---EFNISDND---YFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATADVVVDIINLNDND 1100
Cdd:smart00112    1 SATDADSGENgkvTYSILSGNddgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 45551880    1101 P 1101
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1438-1510 1.50e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 1.50e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45551880   1438 YKVSINENSGRDVKIGHIQAASRSKH-NRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILAS 1510
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 267-356 1.63e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 1.63e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     267 HARDGDTGEPRKIVYDL-RTNPNDYFLLDAQTGELRTAKPLDREaledSTGIISLVIRARElvngvpSDDPLTSATAKAT 345
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATD------GGGPPLSSTATVT 70

                            90
                    ....*....|.
gi 45551880     346 VTIRDVNDSPP 356
Cdd:smart00112   71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1216-1309 4.17e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 4.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   1216 YNSTVAENAAYQPPaaLLQVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLSGKHGA-YELTISARDtQG 1294
Cdd:pfam00028    1 YSASVPENAPVGTE--VLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGeYELTVEATD-SG 77

                           90
                   ....*....|....*
gi 45551880   1295 SGTMESTTKAIITVL 1309
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 476-533 2.82e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 2.82e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 45551880  476 SYSASVSEAALPGQYIATITARDVDSGSYGDsgIRYSL-SGTGAELFHVNEQTGVISLA 533
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGE--VTYSIvSGNEDGLFSIDPSTGEITTA 57
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1236-1316 6.86e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.06  E-value: 6.86e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1236 QAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLS-GKHGAYELTISARDtQGSGTMESTTKAIITVLRVNRH 1314
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDrEEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 45551880    1315 KP 1316
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
1015-1094 1.06e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   1015 EEQPVGTVLTTLQANDEDS--------SIGEFNISDNdyFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTAT 1086
Cdd:pfam00028    7 ENAPVGTEVLTVTATDPDLgpngrifySILGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 45551880   1087 ADVVVDII 1094
Cdd:pfam00028   85 ATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 53-130 1.07e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 1.07e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880      53 DPEGSPVTY---GAIGADHFSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEgeserdNVVEVPITFIILDLNDNP 129
Cdd:smart00112    7 SGENGKVTYsilSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP------LSSTATVTITVLDVNDNA 80


                    .
gi 45551880     130 P 130
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 382-470 6.74e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 6.74e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     382 SVSDADVGINSKFALRL--DDVSGVFDVEPKlvTGysqvnIRVANGTLDYENpnQRKFIVLVVAEETDTnPRLSSTATIT 459
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPE--TG-----EITTTKPLDREE--QPEYTLTVEATDGGG-PPLSSTATVT 70

                            90
                    ....*....|.
gi 45551880     460 VSVLDANDNKP 470
Cdd:smart00112   71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1327-1421 7.17e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 7.17e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   1327 TIEIPGDiVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQqtgeFKIDEVTGELRAKTQLNRKNRANYDIILVARDA 1406
Cdd:pfam00028    2 SASVPEN-APVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN----FRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 45551880   1407 GNPPFESLRLLSVSI 1421
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 882-994 9.21e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 9.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  882 TQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAgtddITAIDKEGkelphydqfkeYFKI-SRNGKVSVNKQLDRNLF 960
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS----IVSGNEDG-----------LFSIdPSTGEITTAKPLDREEQ 65

                         90       100       110
                 ....*....|....*....|....*....|....
gi 45551880  961 AVMRINVLVTDSTAPnVQQGRGLLIIQIIDVNKN 994
Cdd:cd11304   66 SSYTLTVTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1557-1662 1.06e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880 1557 IYYAGVNANAKMGAAITLVNATDADQGKNAKIEFMIVASNlykfgatkstgsiVPSPFAISQD-GRISANTIMAEYNQDR 1635
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN-------------EDGLFSIDPStGEITTAKPLDREEQSS 67

                         90       100
                 ....*....|....*....|....*..
gi 45551880 1636 FELEIVARELEQPQSSASTKVNIWVFD 1662
Cdd:cd11304   68 YTLTVTATDGGGPPLSSTATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
33-119 9.88e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.23  E-value: 9.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     33 NIILYENVTVGTVVFRLEAYDPEGSP---VTYGAIG---ADHFSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRvdpeG 106
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGggpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS----G 77

                           90
                   ....*....|...
gi 45551880    107 ESERDNVVEVPIT 119
Cdd:pfam00028   78 GPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
477-533 7.59e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 7.59e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 45551880    477 YSASVSEAALPGQYIATITARDVDSGSygDSGIRYSLSGTGAE-LFHVNEQTGVISLA 533
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGGGPGgNFRIDPDTGDISTT 56
Cadherin pfam00028
Cadherin domain;
363-463 1.10e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.15  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    363 YSVSLLENTLPGTPLALdMSVSDADVGINSK--FALRLDDVSGVFDVEPKlvTGYsqvnIRVAnGTLDYENPNQrkFIVL 440
Cdd:pfam00028    1 YSASVPENAPVGTEVLT-VTATDPDLGPNGRifYSILGGGPGGNFRIDPD--TGD----ISTT-KPLDRESIGE--YELT 70

                           90       100
                   ....*....|....*....|...
gi 45551880    441 VVAEETDTNPRlSSTATITVSVL 463
Cdd:pfam00028   71 VEATDSGGPPL-SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 136-240 7.44e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 7.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880  136 PYEADVNEDAAVGTTIFdKITVKDRDIvGESLDLKC-LpqqQSPEACRKFRLHIIkrdatilEAAVVLNDTLNYNQRMVY 214
Cdd:cd11304    1 SYEVSVPENAPPGTVVL-TVSATDPDS-GENGEVTYsI---VSGNEDGLFSIDPS-------TGEITTAKPLDREEQSSY 68

                         90       100
                 ....*....|....*....|....*....
gi 45551880  215 HFQIEATDG---PHKTQTTFEARVKDVQD 240
Cdd:cd11304   69 TLTVTATDGggpPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 692-772 1.35e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.03  E-value: 1.35e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     692 KARDADT--MSRISYRIRGSEqVESIFDIDRETGQIIIrpNATLDVTNLnsDQLIFAVEANDG---LFTAHCGVNITVRD 766
Cdd:smart00112    1 SATDADSgeNGKVTYSILSGN-DDGLFSIDPETGEITT--TKPLDREEQ--PEYTLTVEATDGggpPLSSTATVTITVLD 75


                    ....*.
gi 45551880     767 VNNHVP 772
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 938-996 5.85e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.11  E-value: 5.85e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880     938 KEYFKI-SRNGKVSVNKQLDRNLFAVMRINVLVTDSTAPNvQQGRGLLIIQIIDVNKNPP 996
Cdd:smart00112   23 DGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 627-667 7.26e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.11  E-value: 7.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 45551880     627 LDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPP 667
Cdd:smart00112   41 LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
883-989 9.82e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 9.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    883 QHAEVRADAPPGQLVYTLIALDPDVANHNALEFA----GTDDITAIDKEgkelphydqfkeyfkisrNGKVSVNKQLDRN 958
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSilggGPGGNFRIDPD------------------TGDISTTKPLDRE 62

                           90       100       110
                   ....*....|....*....|....*....|.
gi 45551880    959 LFAVMRINVLVTDSTAPNvQQGRGLLIIQII 989
Cdd:pfam00028   63 SIGEYELTVEATDSGGPP-LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1558-1660 7.71e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 40.36  E-value: 7.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880   1558 YYAGVNANAKMGAAITLVNATDADQGKNAKIEFMIVASNlykfgatkstgsiVPSPFAISQD-GRISANTIMAEYNQDRF 1636
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG-------------PGGNFRIDPDtGDISTTKPLDRESIGEY 67

                           90       100
                   ....*....|....*....|....
gi 45551880   1637 ELEIVARELEQPQSSASTKVNIWV 1660
Cdd:pfam00028   68 ELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1576-1658 3.95e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 3.95e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551880    1576 NATDADQGKNAKIEFMIVASNlykfgatkstgsiVPSPFAI-SQDGRISANTIMAEYNQDRFELEIVARELEQPQSSAST 1654
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN-------------DDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTA 67


                    ....
gi 45551880    1655 KVNI 1658
Cdd:smart00112   68 TVTI 71
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 200-243 7.41e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 37.33  E-value: 7.41e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 45551880     200 VVLNDTLNYNQRMVYHFQIEATDG---PHKTQTTFEARVKDVQDKPP 243
Cdd:smart00112   35 ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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