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Conserved domains on  [gi|24664709|ref|NP_730060|]
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Rho GTPase activating protein at 71E, isoform C [Drosophila melanogaster]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10069020)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 55-228 4.84e-29

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


:

Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 113.94  E-value: 4.84e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  55 PGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGR-LVNVDNYSVFTIASVLKKFLRKIPNGIFGRSGEMELF 133
Cdd:cd00159   1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEdIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 134 AINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNaaHASTGMTSEALGVSVAPSFFQSCVSDgktarMEDV 213
Cdd:cd00159  81 ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQN--SEVNKMTASNLAIVFAPTLLRPPDSD-----DELL 153

                       170
                ....*....|....*
gi 24664709 214 LKFKVSTKIMQNIID 228
Cdd:cd00159 154 EDIKKLNEIVEFLIE 168
 
Name Accession Description Interval E-value
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 55-228 4.84e-29

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 113.94  E-value: 4.84e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  55 PGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGR-LVNVDNYSVFTIASVLKKFLRKIPNGIFGRSGEMELF 133
Cdd:cd00159   1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEdIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 134 AINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNaaHASTGMTSEALGVSVAPSFFQSCVSDgktarMEDV 213
Cdd:cd00159  81 ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQN--SEVNKMTASNLAIVFAPTLLRPPDSD-----DELL 153

                       170
                ....*....|....*
gi 24664709 214 LKFKVSTKIMQNIID 228
Cdd:cd00159 154 EDIKKLNEIVEFLIE 168
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 55-200 8.95e-29

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 112.25  E-value: 8.95e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709    55 PGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGRLVNVD--NYSVFTIASVLKKFLRKIPNGIFGRSGEMEL 132
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDleEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24664709   133 FAINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNAahASTGMTSEALGVSVAPSFFQS 200
Cdd:pfam00620  81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNS--DVNKMNAHNLAIVFGPTLLRP 146
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 53-229 2.28e-14

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 71.91  E-value: 2.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709     53 NIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAG--RLVNVDNYSVFTIASVLKKFLRKIPNGIFGRSGEM 130
Cdd:smart00324   2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGpdPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709    131 ELFAINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNaaHASTGMTSEALGVSVAPSFFQScvSDGKTARM 210
Cdd:smart00324  82 EFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEH--SEENKMTARNLAIVFGPTLLRP--PDGEVASL 157

                          170
                   ....*....|....*....
gi 24664709    211 EDVlkfKVSTKIMQNIIDK 229
Cdd:smart00324 158 KDI---RHQNTVIEFLIEN 173
 
Name Accession Description Interval E-value
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 55-228 4.84e-29

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 113.94  E-value: 4.84e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  55 PGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGR-LVNVDNYSVFTIASVLKKFLRKIPNGIFGRSGEMELF 133
Cdd:cd00159   1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEdIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 134 AINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNaaHASTGMTSEALGVSVAPSFFQSCVSDgktarMEDV 213
Cdd:cd00159  81 ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQN--SEVNKMTASNLAIVFAPTLLRPPDSD-----DELL 153

                       170
                ....*....|....*
gi 24664709 214 LKFKVSTKIMQNIID 228
Cdd:cd00159 154 EDIKKLNEIVEFLIE 168
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 55-200 8.95e-29

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 112.25  E-value: 8.95e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709    55 PGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGRLVNVD--NYSVFTIASVLKKFLRKIPNGIFGRSGEMEL 132
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDleEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24664709   133 FAINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNAahASTGMTSEALGVSVAPSFFQS 200
Cdd:pfam00620  81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNS--DVNKMNAHNLAIVFGPTLLRP 146
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 40-239 2.22e-24

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 101.22  E-value: 2.22e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLEEVCKhNNNIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGRLVNVDNYSVFTIASVLKKFLRKI 119
Cdd:cd04402   2 FGQPLSNICE-DDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 120 PNGIFgRSGEMELF-AINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNAahASTGMTSEALGVSVAPSFF 198
Cdd:cd04402  81 PGSLL-SSDLYEEWmSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNS--ETNKMDAFNLAVCIAPSLL 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 24664709 199 QScvSDGKTARMEDVLKFkvsTKIMQNIIDKFAthDIFGRD 239
Cdd:cd04402 158 WP--PASSELQNEDLKKV---TSLVQFLIENCQ--EIFGED 191
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 53-229 2.28e-14

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 71.91  E-value: 2.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709     53 NIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAG--RLVNVDNYSVFTIASVLKKFLRKIPNGIFGRSGEM 130
Cdd:smart00324   2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGpdPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709    131 ELFAINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNaaHASTGMTSEALGVSVAPSFFQScvSDGKTARM 210
Cdd:smart00324  82 EFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEH--SEENKMTARNLAIVFGPTLLRP--PDGEVASL 157

                          170
                   ....*....|....*....
gi 24664709    211 EDVlkfKVSTKIMQNIIDK 229
Cdd:smart00324 158 KDI---RHQNTVIEFLIEN 173
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 40-228 8.61e-11

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 62.09  E-value: 8.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLEEVCKH---NNNIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGRLVNVDNYS-VFTIASVLKKF 115
Cdd:cd04393   3 FGVPLQELQQAgqpENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEAdVCSAASLLRLF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 116 LRKIPNGIFGRSGE---MELFAinDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNaaHASTGMTSEALGVS 192
Cdd:cd04393  83 LQELPEGLIPASLQirlMQLYQ--DYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQ--HHENRMTAENLAAV 158

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 24664709 193 VAPSFFQscVSDGktarMEDVLKFKVSTKIMQNIID 228
Cdd:cd04393 159 FGPDVFH--VYTD----VEDMKEQEICSRIMAKLLE 188
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 40-215 1.78e-09

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 58.08  E-value: 1.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLEEVCKHNNNIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAG-RLVNVDNYSVFTIASVLKKFLRK 118
Cdd:cd04407   1 FGVRVGSLTSNKTSVPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADpENVKLENYPIHAITGLLKQWLRE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 119 IPNGI--FGRSGEMeLFAInDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFgtFRVIASNAAHASTGMTSEALGVSVAPS 196
Cdd:cd04407  81 LPEPLmtFAQYNDF-LRAV-ELPEKQEQLQAIYRVLEQLPTANHNTLERLI--FHLVKVALEEDVNRMSPNALAIVFAPC 156

                       170
                ....*....|....*....
gi 24664709 197 FFQSCVSDGKTARMEDVLK 215
Cdd:cd04407 157 LLRCPDSSDPLTSMKDVAK 175
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 75-199 1.03e-08

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 55.78  E-value: 1.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  75 VFRAPGHQGAMKKLI-HFLQAGRLVNVD--NYSVFTIASVLKKFLRKIPNGIFGRSGEMELFAINDLQNEAEQTERLHRL 151
Cdd:cd04385  36 IYRKNGKNSSVKKLLeAFRKDARSVQLRegEYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAELENKDERIARYKEL 115

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 24664709 152 FGSLPKYTQHLLVLLFGTFRVIASnaaHASTG-MTSEALGVSVAPSFFQ 199
Cdd:cd04385 116 IRRLPPINRATLKVLIGHLYRVQK---HSDENqMSVHNLALVFGPTLFQ 161
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 40-227 1.18e-07

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 52.83  E-value: 1.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLEEVCKHNNNIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAG-RLVNVDNYSVFTIASVLKKFLRK 118
Cdd:cd04377   1 FGVSLSSLTSEDRSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDpDSVNLEDYPIHVITSVLKQWLRE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 119 IPNGIFGRSGEMELFAINDLQNEAEQTERLHRLFGSLPKYTQHLL-VLLFGTFRViasnAAHASTG-MTSEALGVSVAPS 196
Cdd:cd04377  81 LPEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLeRLIFHLVRV----ALQEEVNrMSANALAIVFAPC 156

                       170       180       190
                ....*....|....*....|....*....|.
gi 24664709 197 FFQSCVSDGKTARMEDVLKfkvSTKIMQNII 227
Cdd:cd04377 157 ILRCPDTADPLQSLQDVSK---TTTCVETLI 184
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 36-195 1.95e-07

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 52.46  E-value: 1.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  36 EKVKFGVPLEEVCKHNN-NIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAG--RLVNVDNYS-VFTIASV 111
Cdd:cd04386   1 EKPVFGTPLEEHLKRTGrEIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtfSLPLDEFYSdPHAVASA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 112 LKKFLRKIPNGIFGRSGEMELFAINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNaaHASTGMTSEALGV 191
Cdd:cd04386  81 LKSYLRELPDPLLTYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQK--SDENKMSPSNIAI 158


                ....
gi 24664709 192 SVAP 195
Cdd:cd04386 159 VLAP 162
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 40-177 5.88e-06

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 47.78  E-value: 5.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLEEVCKHNNNIPGPLLVLILKLNKESPNRRDV--FRAPGHQGAMKKLIHFLQAG-----------RLVNVdnysvf 106
Cdd:cd04395   2 FGVPLDDCPPSSENPYVPLIVEVCCNIVEARGLETVgiYRVPGNNAAISALQEELNRGgfdidlqdprwRDVNV------ 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24664709 107 tIASVLKKFLRKIPNGIFGRSGEMELFAINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNA 177
Cdd:cd04395  76 -VSSLLKSFFRKLPEPLFTNELYPDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNS 145
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 40-199 9.45e-06

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 47.30  E-value: 9.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLEEVCKHNNNIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQA-GRLVNVDNYSVFTIASVLKKFLRK 118
Cdd:cd04406   1 FGVELSRLTSEDRSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTdANSVNLDDYNIHVIASVFKQWLRD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 119 IPNGIFGRSGEMELFAINDLQNEAEQTERLHRLFGSLPKytQHLLVLLFGTFRVIASNAAHASTGMTSEALGVSVAPSFF 198
Cdd:cd04406  81 LPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSR--THLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCIL 158


                .
gi 24664709 199 Q 199
Cdd:cd04406 159 R 159
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 40-175 3.75e-05

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 45.82  E-value: 3.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLEEVCKHNNNI------PGPLLVLILKLNKESPNRR------DVFRAPGHQGAMKKLIHFLQAGRLVNVD--NYSV 105
Cdd:cd04397   1 FGVPLEILVEKFGADstlgvgPGKLRIPALIDDIISAMRQmdmsveGVFRKNGNIRRLKELTEEIDKNPTEVPDlsKENP 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24664709 106 FTIASVLKKFLRKIPNGIFGRSgEMELFAI-NDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIAS 175
Cdd:cd04397  81 VQLAALLKKFLRELPDPLLTFK-LYRLWISsQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSS 150
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 40-208 5.66e-05

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 45.49  E-value: 5.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLE-EVCKHNNNIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQA-GRLVNVDNYSVFTIASVLKKFLR 117
Cdd:cd04375   5 FGVPLLvNLQRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESsTDNVNYDGQQAYDVADMLKQYFR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 118 KIPNGIFgrSGEM-ELF-AI-----NDLQNEAEQTERLhrlfgSLPKYTQHLLVLLFGTFRVIASNAAHAStgMTSEALG 190
Cdd:cd04375  85 DLPEPLL--TNKLsETFiAIfqyvpKEQRLEAVQCAIL-----LLPDENREVLQTLLYFLSDVAANSQENQ--MTATNLA 155

                       170
                ....*....|....*...
gi 24664709 191 VSVAPSFFQSCVSDGKTA 208
Cdd:cd04375 156 VCLAPSLFHLNTSRRENS 173
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 40-209 6.99e-05

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 44.76  E-value: 6.99e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLEEVCkhnNNIPGPLLV-LILKLNKESPNRRDV-----FRAPGhQGAMKKLIH--FLQAGRLV--NVDNY-SVFTI 108
Cdd:cd04379   1 FGVPLSRLV---EREGESRDVpIVLQKCVQEIERRGLdviglYRLCG-SAAKKKELRdaFERNSAAVelSEELYpDINVI 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 109 ASVLKKFLRKIPNGIFGRS-GEMELFAIN-DLQNEAEQTERLHRLFGS-LPKYTQHLLVLLFGTFRVIASNaaHASTGMT 185
Cdd:cd04379  77 TGVLKDYLRELPEPLITPQlYEMVLEALAvALPNDVQTNTHLTLSIIDcLPLSAKATLLLLLDHLSLVLSN--SERNKMT 154

                       170       180
                ....*....|....*....|....
gi 24664709 186 SEALGVSVAPSFFQSCVSDGKTAR 209
Cdd:cd04379 155 PQNLAVCFGPVLMFCSQEFSRYGI 178
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 39-197 7.73e-05

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 44.64  E-value: 7.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  39 KFGVPLE---EVCKHNNNIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGRLVNVDNY-SVFTIASVLKK 114
Cdd:cd04404   5 QFGVSLQflkEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYeDVHLPAVILKT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 115 FLRKIPNGIFGRSGEMELFAINDLQNEaEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNAAHasTGMTSEALGVSVA 194
Cdd:cd04404  85 FLRELPEPLLTFDLYDDIVGFLNVDKE-ERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ--NKMTNSNLAVVFG 161


                ...
gi 24664709 195 PSF 197
Cdd:cd04404 162 PNL 164
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 40-228 9.36e-05

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 44.39  E-value: 9.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLE----EVCKHNNNIPgPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGRLVnVDNYSVFTIASVLKKF 115
Cdd:cd04394   2 FGVPLHslphSTVPEYGNVP-KFLVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLEGGEAC-LSSALPCDVAGLLKQF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 116 LRKIPNGIFGRSGEMELFAINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNAAhaSTGMTSEALGVSVAP 195
Cdd:cd04394  80 FRELPEPLLPYDLHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCS--ENKMDSSNLAVIFAP 157

                       170       180       190
                ....*....|....*....|....*....|...
gi 24664709 196 SFFQsCVSDGKTARMEDVLKFKVSTKIMQNIID 228
Cdd:cd04394 158 NLFQ-SEEGGEKMSSSTEKRLRLQAAVVQTLID 189
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 40-198 1.42e-04

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 44.26  E-value: 1.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLEEVCKH------NNNIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQA---GRLVNVDNYSVFTIAS 110
Cdd:cd04391   2 FGVPLSTLLERdqkkvpGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAkfyEGTFLWDQVKQHDAAS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 111 VLKKFLRKIPNGIFgrsgEMELF----AINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNaaHASTGMTS 186
Cdd:cd04391  82 LLKLFIRELPQPLL----TVEYLpafySVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDH--EEKNKMNL 155

                       170
                ....*....|..
gi 24664709 187 EALGVSVAPSFF 198
Cdd:cd04391 156 WNVAMIMAPNLF 167
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 40-177 1.96e-04

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 43.12  E-value: 1.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLEEV----CKHNNNIPGPLLV---LILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGRLVNVDNYS----VFTI 108
Cdd:cd04400   2 FGSPLEEAvelsSHKYNGRDLPSVVyrcIEYLDKNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSlypdVHTV 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 109 ASVLKKFLRKIPNGIFGRSGEMELFAINDLQ-NEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNA 177
Cdd:cd04400  82 AGLLKLYLRELPTLILGGELHNDFKRLVEENhDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHS 151
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 40-198 4.72e-03

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 39.70  E-value: 4.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709  40 FGVPLEEVCKHNN------------NIPGPLLVLILK----LNKESPNRRDVFRAPGHQGAMKKLIHFLQA----GRLVN 99
Cdd:cd04396   2 FGVSLEESLKYASvaisivdedgeqYVYGYIPVVVAKcgvyLKENATEVEGIFRVAGSSKRIRELQLIFSTppdyGKSFD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664709 100 VDNYSVFTIASVLKKFL-------------------RKIPNGIFGRSGEMELFAINDLQNEAEQTERlhRLFGSLPKYTQ 160
Cdd:cd04396  82 WDGYTVHDAASVLRRYLnnlpeplvpldlyeefrnpLRKRPRILQYMKGRINEPLNTDIDQAIKEYR--DLITRLPNLNR 159

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 24664709 161 HLLVLLFGTFRVIASNAahASTGMTSEALGVSVAPSFF 198
Cdd:cd04396 160 QLLLYLLDLLAVFARNS--DKNLMTASNLAAIFQPGIL 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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