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Conserved domains on  [gi|24662420|ref|NP_729651|]
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uncharacterized protein Dmel_CG7888, isoform A [Drosophila melanogaster]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
48-450 2.21e-59

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 200.22  E-value: 2.21e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420    48 HPTTNSETLFHLLKGSLGTGILAMPNAFRNSGYITGSIGTIVIGFICTFCIHQLVKAQYELCRRKKmpsmnypmvaeTAM 127
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVTGK-----------RNK 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   128 GEGPKCFRVFAPYIGTVVNTFLLIYQLGTCCVYVVFVASNIKAIVDAVADT-SIDVRLCMIIILLPLILINWVRNLKYLA 206
Cdd:pfam01490  70 SYGDLGYRLLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFDTcPISLVYFIIIFGLIFIPLSFIPNLSALS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   207 PFSTLAN-----AITMVSFGIICYYIFR-EPVTTEGKDAFGKPSNFPLFFGTVLFALEAIGVILPLENEMKTPQKFGGSC 280
Cdd:pfam01490 150 ILSLLAAvsslyYIVILVLSVAEGIVLTaQGVGHLGSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFKAMT 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   281 GVLNVSMVLIVFLYVGMGLFGYLNYGSAVLGSITLNMPEHEVLSMCVKGMLAFAIYITHGLACYVAIDITWNDYVAKRLG 360
Cdd:pfam01490 230 KILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRKEAP 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   361 AQRNALF------WEYAVRTGLVLITFLLAVAIPNLELFISLFGALCLSALGLAFPALIQICTHWYNTKGFAKVWL-VLS 433
Cdd:pfam01490 310 FGASGKNnpksklLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLKKTKKKSQEKLWKpDIL 389
                         410
                  ....*....|....*..
gi 24662420   434 NFVLIIVGILGLVIGTY 450
Cdd:pfam01490 390 DVICIVIGLLLMAYGVA 406
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
48-450 2.21e-59

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 200.22  E-value: 2.21e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420    48 HPTTNSETLFHLLKGSLGTGILAMPNAFRNSGYITGSIGTIVIGFICTFCIHQLVKAQYELCRRKKmpsmnypmvaeTAM 127
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVTGK-----------RNK 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   128 GEGPKCFRVFAPYIGTVVNTFLLIYQLGTCCVYVVFVASNIKAIVDAVADT-SIDVRLCMIIILLPLILINWVRNLKYLA 206
Cdd:pfam01490  70 SYGDLGYRLLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFDTcPISLVYFIIIFGLIFIPLSFIPNLSALS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   207 PFSTLAN-----AITMVSFGIICYYIFR-EPVTTEGKDAFGKPSNFPLFFGTVLFALEAIGVILPLENEMKTPQKFGGSC 280
Cdd:pfam01490 150 ILSLLAAvsslyYIVILVLSVAEGIVLTaQGVGHLGSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFKAMT 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   281 GVLNVSMVLIVFLYVGMGLFGYLNYGSAVLGSITLNMPEHEVLSMCVKGMLAFAIYITHGLACYVAIDITWNDYVAKRLG 360
Cdd:pfam01490 230 KILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRKEAP 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   361 AQRNALF------WEYAVRTGLVLITFLLAVAIPNLELFISLFGALCLSALGLAFPALIQICTHWYNTKGFAKVWL-VLS 433
Cdd:pfam01490 310 FGASGKNnpksklLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLKKTKKKSQEKLWKpDIL 389
                         410
                  ....*....|....*..
gi 24662420   434 NFVLIIVGILGLVIGTY 450
Cdd:pfam01490 390 DVICIVIGLLLMAYGVA 406
PTZ00206 PTZ00206
amino acid transporter; Provisional
57-449 5.04e-07

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 51.79  E-value: 5.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   57 FHLLKGSLGTGILAMPNAFRNSGYITGSIGTIVIGFICTFCIHQLVKAQyelcrrKKMPSMNYPMVAETAMGEGpkcfrv 136
Cdd:PTZ00206  67 FNIASSTVGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAA------DKTNIRTYEGVARVLLGPW------ 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420  137 fAPYIGTVVNTFlliYQLGTCCVYVVFVASNIKAIV------DAVADTSIDVRLCMIIILLPLILINWVRNLKYLAPFST 210
Cdd:PTZ00206 135 -GSYYVAATRAF---HGFSACVAYVISVGDILSATLkgtnapDFLKQKSGNRLLTSLMWLCFMLPLVIPRHIDSLRYVST 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420  211 LANAITMVSFGIICYYIFREPVTTEGKD-AFGKPSNFPL-FFGTVLFALEAIGV--------ILPLENEMK-TPQKFGGS 279
Cdd:PTZ00206 211 IAVSFMVYLVIVIVVHSCMNGLPENIKNvSVGKDDNAEIiLFNSGNRAIEGLGVfifayvfqITAYEVYMDmTNRSVGKF 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420  280 CGVLNVSMVLIVFLYVGMGLFGYLNYGSAVLGSITL-----NMPEHEVLSMCVKGMLaFAIYITHGLACYVAI-DITWND 353
Cdd:PTZ00206 291 VLASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLLmydpvNEPAIMVGFVGVLVKL-FVSYALLGMACRNALyDVIGWD 369
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420  354 YvakrlgaqRNALFWEYAVR-TGLVLITFLLAVAIPNLELFISLFGALCLSALGLAFPALIQICTHWYNTKGFAKVWLvL 432
Cdd:PTZ00206 370 A--------RKVAFWKHCIAvVTLSVVMLLCGLFIPKINTVLGFAGSISGGLLGFILPALLFMYSGGFTWQKVGPFYY-I 440
                        410
                 ....*....|....*..
gi 24662420  433 SNFVLIIVGILGLVIGT 449
Cdd:PTZ00206 441 STYVVLITGVIAIVFGT 457
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
48-450 2.21e-59

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 200.22  E-value: 2.21e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420    48 HPTTNSETLFHLLKGSLGTGILAMPNAFRNSGYITGSIGTIVIGFICTFCIHQLVKAQYELCRRKKmpsmnypmvaeTAM 127
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVTGK-----------RNK 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   128 GEGPKCFRVFAPYIGTVVNTFLLIYQLGTCCVYVVFVASNIKAIVDAVADT-SIDVRLCMIIILLPLILINWVRNLKYLA 206
Cdd:pfam01490  70 SYGDLGYRLLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFDTcPISLVYFIIIFGLIFIPLSFIPNLSALS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   207 PFSTLAN-----AITMVSFGIICYYIFR-EPVTTEGKDAFGKPSNFPLFFGTVLFALEAIGVILPLENEMKTPQKFGGSC 280
Cdd:pfam01490 150 ILSLLAAvsslyYIVILVLSVAEGIVLTaQGVGHLGSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFKAMT 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   281 GVLNVSMVLIVFLYVGMGLFGYLNYGSAVLGSITLNMPEHEVLSMCVKGMLAFAIYITHGLACYVAIDITWNDYVAKRLG 360
Cdd:pfam01490 230 KILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRKEAP 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   361 AQRNALF------WEYAVRTGLVLITFLLAVAIPNLELFISLFGALCLSALGLAFPALIQICTHWYNTKGFAKVWL-VLS 433
Cdd:pfam01490 310 FGASGKNnpksklLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLKKTKKKSQEKLWKpDIL 389
                         410
                  ....*....|....*..
gi 24662420   434 NFVLIIVGILGLVIGTY 450
Cdd:pfam01490 390 DVICIVIGLLLMAYGVA 406
PTZ00206 PTZ00206
amino acid transporter; Provisional
57-449 5.04e-07

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 51.79  E-value: 5.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420   57 FHLLKGSLGTGILAMPNAFRNSGYITGSIGTIVIGFICTFCIHQLVKAQyelcrrKKMPSMNYPMVAETAMGEGpkcfrv 136
Cdd:PTZ00206  67 FNIASSTVGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAA------DKTNIRTYEGVARVLLGPW------ 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420  137 fAPYIGTVVNTFlliYQLGTCCVYVVFVASNIKAIV------DAVADTSIDVRLCMIIILLPLILINWVRNLKYLAPFST 210
Cdd:PTZ00206 135 -GSYYVAATRAF---HGFSACVAYVISVGDILSATLkgtnapDFLKQKSGNRLLTSLMWLCFMLPLVIPRHIDSLRYVST 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420  211 LANAITMVSFGIICYYIFREPVTTEGKD-AFGKPSNFPL-FFGTVLFALEAIGV--------ILPLENEMK-TPQKFGGS 279
Cdd:PTZ00206 211 IAVSFMVYLVIVIVVHSCMNGLPENIKNvSVGKDDNAEIiLFNSGNRAIEGLGVfifayvfqITAYEVYMDmTNRSVGKF 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420  280 CGVLNVSMVLIVFLYVGMGLFGYLNYGSAVLGSITL-----NMPEHEVLSMCVKGMLaFAIYITHGLACYVAI-DITWND 353
Cdd:PTZ00206 291 VLASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLLmydpvNEPAIMVGFVGVLVKL-FVSYALLGMACRNALyDVIGWD 369
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662420  354 YvakrlgaqRNALFWEYAVR-TGLVLITFLLAVAIPNLELFISLFGALCLSALGLAFPALIQICTHWYNTKGFAKVWLvL 432
Cdd:PTZ00206 370 A--------RKVAFWKHCIAvVTLSVVMLLCGLFIPKINTVLGFAGSISGGLLGFILPALLFMYSGGFTWQKVGPFYY-I 440
                        410
                 ....*....|....*..
gi 24662420  433 SNFVLIIVGILGLVIGT 449
Cdd:PTZ00206 441 STYVVLITGVIAIVFGT 457
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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