CYFIP-related Rac1 interactor (CYRI) family protein is a DUF1394 domain-containing protein; similar to Homo sapiens proteins, CYRIA and CYRIB, which may negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling
CYRIA/CYRIB Rac1 binding domain; This domain has been annotated as Rac1-binding domain. It can ...
22-319
0e+00
CYRIA/CYRIB Rac1 binding domain; This domain has been annotated as Rac1-binding domain. It can be found in human CYRIA/CYRIB and at the N terminus of CYFIP1/2. CYFIP proteins are known RAC1 effectors that stimulate actin polymerization. In mice, CYRIB (also known as CYRI or FAM49B) negatively regulates RAC1-driven cytoskeletal remodelling and plays a role in restricting infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes.
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Pssm-ID: 462106 Cd Length: 301 Bit Score: 502.16 E-value: 0e+00
CYRIA/CYRIB Rac1 binding domain; This domain has been annotated as Rac1-binding domain. It can ...
22-319
0e+00
CYRIA/CYRIB Rac1 binding domain; This domain has been annotated as Rac1-binding domain. It can be found in human CYRIA/CYRIB and at the N terminus of CYFIP1/2. CYFIP proteins are known RAC1 effectors that stimulate actin polymerization. In mice, CYRIB (also known as CYRI or FAM49B) negatively regulates RAC1-driven cytoskeletal remodelling and plays a role in restricting infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes.
Pssm-ID: 462106 Cd Length: 301 Bit Score: 502.16 E-value: 0e+00
CYRIA/CYRIB Rac1 binding domain; This domain has been annotated as Rac1-binding domain. It can ...
22-319
0e+00
CYRIA/CYRIB Rac1 binding domain; This domain has been annotated as Rac1-binding domain. It can be found in human CYRIA/CYRIB and at the N terminus of CYFIP1/2. CYFIP proteins are known RAC1 effectors that stimulate actin polymerization. In mice, CYRIB (also known as CYRI or FAM49B) negatively regulates RAC1-driven cytoskeletal remodelling and plays a role in restricting infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes.
Pssm-ID: 462106 Cd Length: 301 Bit Score: 502.16 E-value: 0e+00
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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