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Conserved domains on  [gi|85816212|ref|NP_729162|]
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odorant receptor 65b [Drosophila melanogaster]

Protein Classification

odorant receptor( domain architecture ID 139944)

odorant receptor (OR) found in insects similar to Drosophila ORs, novel seven-transmembrane domain proteins that can signal independently of heterotrimeric G proteins, and which show no obvious sequence homology with G protein-coupled receptors (GPCRs) and display an inverted topology with an intracellular N-terminus and an extracellular C-terminus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_6 super family cl20237
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 83-395 1.30e-19

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


The actual alignment was detected with superfamily member pfam02949:

Pssm-ID: 251636  Cd Length: 313  Bit Score: 88.50  E-value: 1.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85816212    83 VQMGRDLAFILGAFFIIFKTYYFCWYGDELDQVISDLDALhPWAQKGPNPVEYQTGKRWYFVMAFFLATSWSFFLCILLL 162
Cdd:pfam02949   3 TEALTNLQVLVTSIVCLFKFLLILLKRKEIVELISLLREL-DPRCLEEEEERIFERLVATASRVRFLLFIIYILAYALFC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85816212   163 LLITSPMWV---HQQNLPFHAAFPFQWHeksLHPISHAIIYLFQsYFAVYCLTWL-LCIEGLSICIYAEITFGIEVLCLE 238
Cdd:pfam02949  82 ISALVSMVLsleRGLPLPYYLPFPFDWE---ASRPPYYIAYIYQ-VLGMTVTVLQnIGSDSLFCSFLLFLVLHLRLLQLR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85816212   239 LRQI-HRHNYGLQELRMETNRLVKLHQKIVEILDRTNDVFHGTLIMQMGVNFSLVSLSVLEAVEArKDPKVVAQFAVLML 317
Cdd:pfam02949 158 LERLgLDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNLLFF-SGPLQGIYYVLYLL 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 85816212   318 LALGHLSMWSYCGDQLSQKSLQISEAAYEAyDPTKGSKDVYRDLCVIIRRGQDPLIMRASPFPSFNLINYSAILNQCY 395
Cdd:pfam02949 237 AMLIQLFPYCYYGNELTEASEELANAIYSS-NWYDASRRYRRTLLIFIMRAQRPITIKAGGFFPISLPTFISILKFAY 313
 
Name Accession Description Interval E-value
7tm_6 pfam02949
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 83-395 1.30e-19

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


Pssm-ID: 251636  Cd Length: 313  Bit Score: 88.50  E-value: 1.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85816212    83 VQMGRDLAFILGAFFIIFKTYYFCWYGDELDQVISDLDALhPWAQKGPNPVEYQTGKRWYFVMAFFLATSWSFFLCILLL 162
Cdd:pfam02949   3 TEALTNLQVLVTSIVCLFKFLLILLKRKEIVELISLLREL-DPRCLEEEEERIFERLVATASRVRFLLFIIYILAYALFC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85816212   163 LLITSPMWV---HQQNLPFHAAFPFQWHeksLHPISHAIIYLFQsYFAVYCLTWL-LCIEGLSICIYAEITFGIEVLCLE 238
Cdd:pfam02949  82 ISALVSMVLsleRGLPLPYYLPFPFDWE---ASRPPYYIAYIYQ-VLGMTVTVLQnIGSDSLFCSFLLFLVLHLRLLQLR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85816212   239 LRQI-HRHNYGLQELRMETNRLVKLHQKIVEILDRTNDVFHGTLIMQMGVNFSLVSLSVLEAVEArKDPKVVAQFAVLML 317
Cdd:pfam02949 158 LERLgLDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNLLFF-SGPLQGIYYVLYLL 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 85816212   318 LALGHLSMWSYCGDQLSQKSLQISEAAYEAyDPTKGSKDVYRDLCVIIRRGQDPLIMRASPFPSFNLINYSAILNQCY 395
Cdd:pfam02949 237 AMLIQLFPYCYYGNELTEASEELANAIYSS-NWYDASRRYRRTLLIFIMRAQRPITIKAGGFFPISLPTFISILKFAY 313
 
Name Accession Description Interval E-value
7tm_6 pfam02949
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 83-395 1.30e-19

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


Pssm-ID: 251636  Cd Length: 313  Bit Score: 88.50  E-value: 1.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85816212    83 VQMGRDLAFILGAFFIIFKTYYFCWYGDELDQVISDLDALhPWAQKGPNPVEYQTGKRWYFVMAFFLATSWSFFLCILLL 162
Cdd:pfam02949   3 TEALTNLQVLVTSIVCLFKFLLILLKRKEIVELISLLREL-DPRCLEEEEERIFERLVATASRVRFLLFIIYILAYALFC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85816212   163 LLITSPMWV---HQQNLPFHAAFPFQWHeksLHPISHAIIYLFQsYFAVYCLTWL-LCIEGLSICIYAEITFGIEVLCLE 238
Cdd:pfam02949  82 ISALVSMVLsleRGLPLPYYLPFPFDWE---ASRPPYYIAYIYQ-VLGMTVTVLQnIGSDSLFCSFLLFLVLHLRLLQLR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85816212   239 LRQI-HRHNYGLQELRMETNRLVKLHQKIVEILDRTNDVFHGTLIMQMGVNFSLVSLSVLEAVEArKDPKVVAQFAVLML 317
Cdd:pfam02949 158 LERLgLDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNLLFF-SGPLQGIYYVLYLL 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 85816212   318 LALGHLSMWSYCGDQLSQKSLQISEAAYEAyDPTKGSKDVYRDLCVIIRRGQDPLIMRASPFPSFNLINYSAILNQCY 395
Cdd:pfam02949 237 AMLIQLFPYCYYGNELTEASEELANAIYSS-NWYDASRRYRRTLLIFIMRAQRPITIKAGGFFPISLPTFISILKFAY 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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