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Conserved domains on  [gi|24642416|ref|NP_727940|]
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katanin 80, isoform A [Drosophila melanogaster]

Protein Classification

WD repeat KATNB1 family protein( domain architecture ID 10078096)

WD repeat KATNB1 family protein similar to Mus musculus katanin p80 WD40 repeat-containing subunit B1 (KATNB1) that participates in a complex which severs microtubules in an ATP-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-263 2.83e-52

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.81  E-value: 2.83e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  11 IYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLN 90
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  91 SQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNeNNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSIL 170
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 171 IWDIRKSKQIMEFiaDPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVsQTTHFYGQAIRCITFSDNGECLFVG 250
Cdd:COG2319 314 LWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL-RTLTGHTGAVTSVAFSPDGRTLASG 390

                       250
                ....*....|...
gi 24642416 251 SSSGiSVIGWEPD 263
Cdd:COG2319 391 SADG-TVRLWDLA 402
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 663-817 1.15e-40

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


:

Pssm-ID: 464044  Cd Length: 160  Bit Score: 146.60  E-value: 1.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   663 RSHEAVLQELSNRQSSLDLLRHATRSHDVLGALRQARSCG-KSIFIDLLGAILEKPSSWNLDFCMFVLPEIYELLQSQHK 741
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQdPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   742 FHFTRACDTLRIILSNFLPTIQENLdSWAANGLGVDVTREDRQRKCAECQRWLLQIKNLPE-----STHFGSTLSQLQNI 816
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSAL-SAPPSSVGVDLSREERLEKCNECFKELQKIRQILKklarrSGKLGELARELNLL 159


                  .
gi 24642416   817 I 817
Cdd:pfam13925 160 L 160
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-263 2.83e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.81  E-value: 2.83e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  11 IYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLN 90
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  91 SQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNeNNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSIL 170
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 171 IWDIRKSKQIMEFiaDPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVsQTTHFYGQAIRCITFSDNGECLFVG 250
Cdd:COG2319 314 LWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL-RTLTGHTGAVTSVAFSPDGRTLASG 390

                       250
                ....*....|...
gi 24642416 251 SSSGiSVIGWEPD 263
Cdd:COG2319 391 SADG-TVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-260 2.46e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 178.68  E-value: 2.46e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  14 IKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQK 93
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  94 IYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNeNNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWD 173
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 174 IRKSKQIMEFIAdpPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVsQTTHFYGQAIRCITFSDNGEcLFVGSSS 253
Cdd:cd00200 164 LRTGKCVATLTG--HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL-GTLRGHENGVNSVAFSPDGY-LLASGSE 239


                ....*..
gi 24642416 254 GISVIGW 260
Cdd:cd00200 240 DGTIRVW 246
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 663-817 1.15e-40

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 146.60  E-value: 1.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   663 RSHEAVLQELSNRQSSLDLLRHATRSHDVLGALRQARSCG-KSIFIDLLGAILEKPSSWNLDFCMFVLPEIYELLQSQHK 741
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQdPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   742 FHFTRACDTLRIILSNFLPTIQENLdSWAANGLGVDVTREDRQRKCAECQRWLLQIKNLPE-----STHFGSTLSQLQNI 816
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSAL-SAPPSSVGVDLSREERLEKCNECFKELQKIRQILKklarrSGKLGELARELNLL 159


                  .
gi 24642416   817 I 817
Cdd:pfam13925 160 L 160
PTZ00420 PTZ00420
coronin; Provisional
 81-283 1.40e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.50  E-value: 1.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   81 IGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPS-GEYVVSGSNDTTVRLWDVQNENNCIK-------VCRGHMSHVNSVK 152
Cdd:PTZ00420  53 IGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDESVKeikdpqcILKGHKKKISIID 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  153 FSPDGLWI-ASAGLEGSILIWDIRKSKQIMEFIADPPVTAItcvQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQ-TTHF 230
Cdd:PTZ00420 133 WNPMNYYImCSSGFDSFVNIWDIENEKRAFQINMPKKLSSL---KWNIKGNLLSGTCVGKHMHIIDPRKQEIASSfHIHD 209

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24642416  231 YGQAIRCITFSDNGeclfvGSSSGISVIGWEPD--RELD--HIKSTWSSLADMKVVN 283
Cdd:PTZ00420 210 GGKNTKNIWIDGLG-----GDDNYILSTGFSKNnmREMKlwDLKNTTSALVTMSIDN 261
WD40 pfam00400
WD domain, G-beta repeat;
93-130 1.74e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 1.74e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24642416    93 KIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWD 130
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-130 3.34e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.34e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24642416     91 SQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWD 130
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-263 2.83e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.81  E-value: 2.83e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  11 IYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLN 90
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  91 SQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNeNNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSIL 170
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 171 IWDIRKSKQIMEFiaDPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVsQTTHFYGQAIRCITFSDNGECLFVG 250
Cdd:COG2319 314 LWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL-RTLTGHTGAVTSVAFSPDGRTLASG 390

                       250
                ....*....|...
gi 24642416 251 SSSGiSVIGWEPD 263
Cdd:COG2319 391 SADG-TVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
14-254 4.73e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.04  E-value: 4.73e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  14 IKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQK 93
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  94 IYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNeNNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWD 173
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 174 IRKSKQImeFIADPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVsQTTHFYGQAIRCITFSDNGECLFVGSSS 253
Cdd:COG2319 275 LATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTGHTGAVRSVAFSPDGKTLASGSDD 351


                .
gi 24642416 254 G 254
Cdd:COG2319 352 G 352
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-260 2.46e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 178.68  E-value: 2.46e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  14 IKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQK 93
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  94 IYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNeNNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWD 173
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 174 IRKSKQIMEFIAdpPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVsQTTHFYGQAIRCITFSDNGEcLFVGSSS 253
Cdd:cd00200 164 LRTGKCVATLTG--HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL-GTLRGHENGVNSVAFSPDGY-LLASGSE 239


                ....*..
gi 24642416 254 GISVIGW 260
Cdd:cd00200 240 DGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
17-277 7.36e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.88  E-value: 7.36e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  17 HDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYS 96
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  97 TLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNeNNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRK 176
Cdd:COG2319 157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 177 SKQIMEFIADPPvtAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGqAIRCITFSDNGECLFVGSSSGiS 256
Cdd:COG2319 236 GKLLRTLTGHSG--SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDG-T 311

                       250       260
                ....*....|....*....|....*.
gi 24642416 257 VIGWEPD-----RELDHIKSTWSSLA 277
Cdd:COG2319 312 VRLWDLAtgkllRTLTGHTGAVRSVA 337
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-217 8.65e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.67  E-value: 8.65e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  10 KIYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDL 89
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  90 NSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNEnNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSI 169
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 24642416 170 LIWDIRKSKQIMEFIAdpPVTAITCVQFHPFEFLLAAGRVDGTVSIYD 217
Cdd:cd00200 244 RVWDLRTGECVQTLSG--HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
16-277 1.67e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.25  E-value: 1.67e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  16 AHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIY 95
Cdd:COG2319  34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  96 STLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNeNNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIR 175
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 176 KSKQIMEFIADPpvTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVsQTTHFYGQAIRCITFSDNGECLFVGSSSGi 255
Cdd:COG2319 193 TGKLLRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADG- 268

                       250       260
                ....*....|....*....|....*..
gi 24642416 256 SVIGWEPD-----RELDHIKSTWSSLA 277
Cdd:COG2319 269 TVRLWDLAtgellRTLTGHSGGVNSVA 295
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 663-817 1.15e-40

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 146.60  E-value: 1.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   663 RSHEAVLQELSNRQSSLDLLRHATRSHDVLGALRQARSCG-KSIFIDLLGAILEKPSSWNLDFCMFVLPEIYELLQSQHK 741
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQdPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   742 FHFTRACDTLRIILSNFLPTIQENLdSWAANGLGVDVTREDRQRKCAECQRWLLQIKNLPE-----STHFGSTLSQLQNI 816
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSAL-SAPPSSVGVDLSREERLEKCNECFKELQKIRQILKklarrSGKLGELARELNLL 159


                  .
gi 24642416   817 I 817
Cdd:pfam13925 160 L 160
WD40 COG2319
WD40 repeat [General function prediction only];
25-277 6.67e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 6.67e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  25 DLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKS 104
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 105 VRTLDFNPSGEYVVSGSNDTTVRLWDVQNeNNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFI 184
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 185 ADPPvtAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVsQTTHFYGQAIRCITFSDNGECLFVGSSSGiSVIGWEPD- 263
Cdd:COG2319 160 GHSG--AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTGHTGAVRSVAFSPDGKLLASGSADG-TVRLWDLAt 235

                       250
                ....*....|....*...
gi 24642416 264 ----RELDHIKSTWSSLA 277
Cdd:COG2319 236 gkllRTLTGHSGSVRSVA 253
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-263 2.14e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 2.14e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  97 TLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQN------------------------------ENNCIKV------ 140
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrtlkghtgpvrdvaasadgtylasgsSDKTIRLwdletg 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 141 -C----RGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEF--IADPpvtaITCVQFHPFEFLLAAGRVDGTV 213
Cdd:cd00200  84 eCvrtlTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrgHTDW----VNSVAFSPDGTFVASSSQDGTI 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 24642416 214 SIYDLEHQQLVSQTTHFYGQaIRCITFSDNGECLFVGSSSGiSVIGWEPD 263
Cdd:cd00200 160 KLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDG-TIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
14-133 3.63e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 3.63e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  14 IKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQK 93
Cdd:COG2319 284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 24642416  94 IYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQN 133
Cdd:COG2319 364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-261 2.02e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 2.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416 137 CIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFI--ADPpvtaITCVQFHPFEFLLAAGRVDGTVS 214
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghTGP----VRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 24642416 215 IYDLEHQQLVSQ-TTHFygQAIRCITFSDNGECLFVGSSSGiSVIGWE 261
Cdd:cd00200  77 LWDLETGECVRTlTGHT--SYVSSVAFSPDGRILSSSSRDK-TIKVWD 121
PTZ00420 PTZ00420
coronin; Provisional
 81-283 1.40e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.50  E-value: 1.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   81 IGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPS-GEYVVSGSNDTTVRLWDVQNENNCIK-------VCRGHMSHVNSVK 152
Cdd:PTZ00420  53 IGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDESVKeikdpqcILKGHKKKISIID 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  153 FSPDGLWI-ASAGLEGSILIWDIRKSKQIMEFIADPPVTAItcvQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQ-TTHF 230
Cdd:PTZ00420 133 WNPMNYYImCSSGFDSFVNIWDIENEKRAFQINMPKKLSSL---KWNIKGNLLSGTCVGKHMHIIDPRKQEIASSfHIHD 209

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24642416  231 YGQAIRCITFSDNGeclfvGSSSGISVIGWEPD--RELD--HIKSTWSSLADMKVVN 283
Cdd:PTZ00420 210 GGKNTKNIWIDGLG-----GDDNYILSTGFSKNnmREMKlwDLKNTTSALVTMSIDN 261
WD40 pfam00400
WD domain, G-beta repeat;
93-130 1.74e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 1.74e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24642416    93 KIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWD 130
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-130 3.34e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.34e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24642416     91 SQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWD 130
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 136-173 3.50e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.50e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24642416    136 NCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWD 173
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
135-173 9.47e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 9.47e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24642416   135 NNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWD 173
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 11-153 3.65e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 3.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   11 IYDIKAHDSRVTSLDLGETG-RVLVTGGEDRNVNLWAIGQ-----------NEC---FMSLTGhnRSIdcvRFAYKDNFV 75
Cdd:PLN00181 568 VTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQgvsigtiktkaNICcvqFPSESG--RSL---AFGSADHKV 642

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   76 YSaddigiirrWDLNSQKI-YSTLNGHMKSVRTLDFNPSGEyVVSGSNDTTVRLWDVQNENNCIKVCRGH--MSHVNSVK 152
Cdd:PLN00181 643 YY---------YDLRNPKLpLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHsfMGHTNVKN 712


                 .
gi 24642416  153 F 153
Cdd:PLN00181 713 F 713
PTZ00420 PTZ00420
coronin; Provisional
 54-140 2.28e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 2.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   54 MSLTGHNRSIDCVRF--AYKDNFVYSADDIGI----IRRWDLNSQKIYS---TLNGHMKSVRTLDFNPSGEYVVSGSN-D 123
Cdd:PTZ00420  68 IKLKGHTSSILDLQFnpCFSEILASGSEDLTIrvweIPHNDESVKEIKDpqcILKGHKKKISIIDWNPMNYYIMCSSGfD 147

                         90
                 ....*....|....*..
gi 24642416  124 TTVRLWDVQNENNCIKV 140
Cdd:PTZ00420 148 SFVNIWDIENEKRAFQI 164
WD40 pfam00400
WD domain, G-beta repeat;
9-45 2.38e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.38e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 24642416     9 SKIYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLW 45
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 9-45 2.86e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.86e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24642416      9 SKIYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLW 45
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 33-224 2.49e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.42  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416   33 LVTGGEDRNVNLWAI-----GQN--ECFMSLTGHNRSIDCVRF-AYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKS 104
Cdd:PTZ00421  91 LFTASEDGTIMGWGIpeeglTQNisDPIVHLQGHTKKVGIVSFhPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQ 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  105 VRTLDFNPSGEYVVSGSNDTTVRLWDVQnenNCIKVCRGHmSHvNSVKfSPDGLW------IASAGLEGS----ILIWDI 174
Cdd:PTZ00421 171 ITSLEWNLDGSLLCTTSKDKKLNIIDPR---DGTIVSSVE-AH-ASAK-SQRCLWakrkdlIITLGCSKSqqrqIMLWDT 244

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 24642416  175 RKskqiMEFIADPPVTAITCVQFHPF-----EFLLAAGRVDGTVSIYDLEHQQLV 224
Cdd:PTZ00421 245 RK----MASPYSTVDLDQSSALFIPFfdedtNLLYIGSKGEGNIRCFELMNERLT 295
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
16-151 6.68e-03

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 40.01  E-value: 6.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  16 AHDSRVTSLDLGETGRVLVTGgEDRNVNLWAIGQ-NECF--MSLTGHNRS-----IDCVRFAYKDN--FVYSADDiGIIR 85
Cdd:COG5170 170 AHPYHINSISFNSDKETLLSA-DDLRINLWNLEIiDGSFniVDIKPHNMEeltevITSAEFHPEMCnvFMYSSSK-GEIK 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642416  86 RWDL-------NSQKIY---------STLNGHMKSVRTLDFNPSGEYVVSGSNDTtVRLWDVQNENNCIKVCRGH---MS 146
Cdd:COG5170 248 LNDLrqsalcdNSKKLFeltidgvdvDFFEEIVSSISDFKFSDNGRYILSRDYLT-VKIWDVNMAKNPIKTIPMHcdlMD 326


                ....*
gi 24642416 147 HVNSV 151
Cdd:COG5170 327 ELNDV 331
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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