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Conserved domains on  [gi|24641752|ref|NP_727694|]
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uncharacterized protein Dmel_CG15747, isoform A [Drosophila melanogaster]

Protein Classification

nuclear speckle splicing regulatory protein 1 family protein( domain architecture ID 10560920)

nuclear speckle splicing regulatory protein 1 (NSRP1) family protein is a DUF2040 domain-containing protein similar to Schizosaccharomyces pombe NSRP1 homolog, also called coiled-coil domain-containing protein 55 homolog

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NSRP1_N pfam09745
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
 63-181 8.00e-38

Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


:

Pssm-ID: 462876 [Multi-domain]  Cd Length: 121  Bit Score: 132.26  E-value: 8.00e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641752    63 ARRQQEKALAEDPTIFQYDELYDDMDSKREEAKQTKSQE--PRKPKYIGRLMEHAERRKLEKELRIERQVQKDREAEGEM 140
Cdd:pfam09745   1 AKKEAEKALEEDPSVFDYDEVYDSMKAAKEEKKAAKKAErkERKPKYIENLLKAAERRKRERERAEERKLQKEREAEGDE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 24641752   141 YKDKDTYVTAAYRKKLESIRQMQEQEQRDEYLEAIGDVTKQ 181
Cdd:pfam09745  81 FADKEKFVTSAYKKKLEELRKLEEEEKRREELEEKKDVTKG 121
 
Name Accession Description Interval E-value
NSRP1_N pfam09745
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
 63-181 8.00e-38

Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


Pssm-ID: 462876 [Multi-domain]  Cd Length: 121  Bit Score: 132.26  E-value: 8.00e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641752    63 ARRQQEKALAEDPTIFQYDELYDDMDSKREEAKQTKSQE--PRKPKYIGRLMEHAERRKLEKELRIERQVQKDREAEGEM 140
Cdd:pfam09745   1 AKKEAEKALEEDPSVFDYDEVYDSMKAAKEEKKAAKKAErkERKPKYIENLLKAAERRKRERERAEERKLQKEREAEGDE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 24641752   141 YKDKDTYVTAAYRKKLESIRQMQEQEQRDEYLEAIGDVTKQ 181
Cdd:pfam09745  81 FADKEKFVTSAYKKKLEELRKLEEEEKRREELEEKKDVTKG 121
 
Name Accession Description Interval E-value
NSRP1_N pfam09745
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
 63-181 8.00e-38

Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


Pssm-ID: 462876 [Multi-domain]  Cd Length: 121  Bit Score: 132.26  E-value: 8.00e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641752    63 ARRQQEKALAEDPTIFQYDELYDDMDSKREEAKQTKSQE--PRKPKYIGRLMEHAERRKLEKELRIERQVQKDREAEGEM 140
Cdd:pfam09745   1 AKKEAEKALEEDPSVFDYDEVYDSMKAAKEEKKAAKKAErkERKPKYIENLLKAAERRKRERERAEERKLQKEREAEGDE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 24641752   141 YKDKDTYVTAAYRKKLESIRQMQEQEQRDEYLEAIGDVTKQ 181
Cdd:pfam09745  81 FADKEKFVTSAYKKKLEELRKLEEEEKRREELEEKKDVTKG 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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