NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24640875|ref|NP_727362|]
View 

uncharacterized protein Dmel_CG1354, isoform C [Drosophila melanogaster]

Protein Classification

YchF/Obg family ATPase( domain architecture ID 11488321)

YchF/Obg family ATPase with similarity to bacterial ribosome-binding ATPase YchF and eukaryotic Obg-like ATPase 1

EC:  3.6.-.-
Gene Ontology:  GO:0016887|GO:0005524|GO:0005525|GO:0032555
PubMed:  21527254|11916378
SCOP:  4004039

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 1-387 0e+00

GTP-binding protein; Provisional


:

Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 596.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875    1 MPPKKHDEPERKPLIGRIGTNLRIGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESRVPVPDERFDYLVEYHKPA 80
Cdd:PTZ00258   1 MPPKKKMEEEKKVLLGRPGNNLKMGIVGLPNVGKSTTFNALCKQQVPAENFPFCTIDPNTARVNVPDERFDWLCKHFKPK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   81 SVVPAYLNVVDIAGLVKGAAEGQGLGNDFLSHISACDAIFHLCRAFEDPDVTHVEGEVDPVRDLEIISEELRLKDEENLL 160
Cdd:PTZ00258  81 SIVPAQLDITDIAGLVKGASEGEGLGNAFLSHIRAVDGIYHVVRAFEDEDITHVEGEIDPVRDLEIISSELILKDLEFVE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  161 KNLDKLEKVvaRGGDKKLK---PEYDSMLKIKDILIDqKRHLRFEDWNAHDIEALNKYLFLTSKPVIYLVNLSDKDFIRK 237
Cdd:PTZ00258 161 KRLDELTKK--RKKKKKKKeekVELDVLKKVLEWLEE-GKPVRDGDWTDKEIEILNEYQLLTAKPMIYLVNMSEKDFIRQ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  238 KNKWLPKIKEWIDKNDPGaLLIPFSGAFEHQLTE-KDELERKAYETETKCK-SMLEKIVVTGYKGLQLEYFFTAGPDEVK 315
Cdd:PTZ00258 238 KNKWLAKIKEWVGEKGGG-PIIPYSAEFEEELAElGSEEERKEYLEEYGIKqSMLDKIIKTGYKLLNLIHFFTAGPDEVR 316

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24640875  316 AWTIQKGTKAPQAAGRIHTDFEKGFIMAEVMHFEDFKAEGSEANAKAAGKYRQQGRNYTVEDGDIIFFKFNA 387
Cdd:PTZ00258 317 CWTIQKGTKAPQAAGVIHSDFEKGFICAEVMKYEDFLELGSEAAVKAEGKYRQEGKDYVVQDGDIIFFKFNV 388
 
Name Accession Description Interval E-value
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 1-387 0e+00

GTP-binding protein; Provisional


Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 596.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875    1 MPPKKHDEPERKPLIGRIGTNLRIGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESRVPVPDERFDYLVEYHKPA 80
Cdd:PTZ00258   1 MPPKKKMEEEKKVLLGRPGNNLKMGIVGLPNVGKSTTFNALCKQQVPAENFPFCTIDPNTARVNVPDERFDWLCKHFKPK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   81 SVVPAYLNVVDIAGLVKGAAEGQGLGNDFLSHISACDAIFHLCRAFEDPDVTHVEGEVDPVRDLEIISEELRLKDEENLL 160
Cdd:PTZ00258  81 SIVPAQLDITDIAGLVKGASEGEGLGNAFLSHIRAVDGIYHVVRAFEDEDITHVEGEIDPVRDLEIISSELILKDLEFVE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  161 KNLDKLEKVvaRGGDKKLK---PEYDSMLKIKDILIDqKRHLRFEDWNAHDIEALNKYLFLTSKPVIYLVNLSDKDFIRK 237
Cdd:PTZ00258 161 KRLDELTKK--RKKKKKKKeekVELDVLKKVLEWLEE-GKPVRDGDWTDKEIEILNEYQLLTAKPMIYLVNMSEKDFIRQ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  238 KNKWLPKIKEWIDKNDPGaLLIPFSGAFEHQLTE-KDELERKAYETETKCK-SMLEKIVVTGYKGLQLEYFFTAGPDEVK 315
Cdd:PTZ00258 238 KNKWLAKIKEWVGEKGGG-PIIPYSAEFEEELAElGSEEERKEYLEEYGIKqSMLDKIIKTGYKLLNLIHFFTAGPDEVR 316

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24640875  316 AWTIQKGTKAPQAAGRIHTDFEKGFIMAEVMHFEDFKAEGSEANAKAAGKYRQQGRNYTVEDGDIIFFKFNA 387
Cdd:PTZ00258 317 CWTIQKGTKAPQAAGVIHSDFEKGFICAEVMKYEDFLELGSEAAVKAEGKYRQEGKDYVVQDGDIIFFKFNV 388
GTP1 COG0012
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ...
 22-386 1.25e-166

Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439783 [Multi-domain]  Cd Length: 362  Bit Score: 470.66  E-value: 1.25e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  22 LRIGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESRVPVPDERFDYLVEYHKPASVVPAYLNVVDIAGLVKGAAE 101
Cdd:COG0012   1 LKCGIVGLPNVGKSTLFNALTKAGAEAANYPFCTIEPNVGVVPVPDERLDKLAEIVKPKKIVPATIEFVDIAGLVKGASK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 102 GQGLGNDFLSHISACDAIFHLCRAFEDPDVTHVEGEVDPVRDLEIISEELRLKDEENLLKNLDKLEKvVARGGDKKLKPE 181
Cdd:COG0012  81 GEGLGNQFLANIREVDAIVHVVRCFEDDNVTHVEGSVDPLRDIETINTELILADLETVEKRLERLEK-KAKSGDKEAKAE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 182 YDSMLKIKDILiDQKRHLRFEDWNAHDIEALNKYLFLTSKPVIYLVNLSDKDFIrKKNKWLPKIKEWIDKNdpGALLIPF 261
Cdd:COG0012 160 LELLEKLKEHL-EEGKPARSLELSEEEKKLLKELQLLTAKPVLYVANVDEDDLA-EGNPYVEKVREYAAKE--GAEVVVI 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 262 SGAFEHQLTEKDELERKAYETETKCK-SMLEKIVVTGYKGLQLEYFFTAGPDEVKAWTIQKGTKAPQAAGRIHTDFEKGF 340
Cdd:COG0012 236 CAKIEAELAELDEEERAEFLEELGLEeSGLDRLIRAGYDLLGLITFFTAGPKEVRAWTIKKGTTAPQAAGVIHTDFERGF 315

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*.
gi 24640875 341 IMAEVMHFEDFKAEGSEANAKAAGKYRQQGRNYTVEDGDIIFFKFN 386
Cdd:COG0012 316 IRAEVISYDDLIAYGSEAAAKEAGKLRLEGKDYVVQDGDVIHFRFN 361
YchF cd01900
YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of ...
 24-301 6.84e-148

YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated with the ribosome. Several members of the family, including YchF, possess the TGS domain related to the RNA-binding proteins. Experimental data and genomic analysis suggest that YchF may be part of a nucleoprotein complex and may function as a GTP-dependent translational factor.


Pssm-ID: 206687 [Multi-domain]  Cd Length: 274  Bit Score: 419.94  E-value: 6.84e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  24 IGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESRVPVPDERFDYLVEYHKPASVVPAYLNVVDIAGLVKGAAEGQ 103
Cdd:cd01900   1 IGIVGLPNVGKSTLFNALTKSNAEAANYPFCTIEPNVGIVPVPDERLDKLAEIVKPKKIVPATIEFVDIAGLVKGASKGE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 104 GLGNDFLSHISACDAIFHLCRAFEDPDVTHVEGEVDPVRDLEIISEELRLKDEENLLKNLDKLEKvVARGGDKKLKPEYD 183
Cdd:cd01900  81 GLGNKFLSHIREVDAIAHVVRCFEDDDITHVEGSVDPVRDIEIINTELILADLETIEKRLERLEK-KAKSGDKEAKEELE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 184 SMLKIKDILIDQKRhLRFEDWNAHDIEALNKYLFLTSKPVIYLVNLSDKDFIRKKNKWLpkiKEWIDKNDPGALLIPFSG 263
Cdd:cd01900 160 LLEKIKEHLEEGKP-ARTLELTDEEIKILKSLQLLTAKPVIYVANVSEDDLIRGNNKVL---KVREIAAKEGAEVIPISA 235

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 24640875 264 AFEHQLTEKDELERKAYETETKCK-SMLEKIVVTGYKGL 301
Cdd:cd01900 236 KLEAELAELDEEEAAEFLEELGLEeSGLDKLIRAGYELL 274
TIGR00092 TIGR00092
GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in ...
 22-386 7.09e-106

GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in every complete bacterial genome, and is found in Eukaryotes. A more distantly related protein, separated from this model, is found in the archaea. It is known to bind GTP and double-stranded nucleic acid. It is suggested to belong to a nucleoprotein complex and act as a translation factor. [Unknown function, General]


Pssm-ID: 129200 [Multi-domain]  Cd Length: 368  Bit Score: 316.72  E-value: 7.09e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875    22 LRIGIVGVPNVGKSTFFNVLTQSA-APAENFPFCTIKPNESRVPVPDERFDYLVEYHKPASVVPAYLNVVDIAGLVKGAA 100
Cdd:TIGR00092   3 LSGGIVGLPNVGKSTLFAATTNLLgNEAANPPFTTIEPNAGVVNPSDPRLDLLAIYIKPEKVPPTTTEFVDIAGLVGGAS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   101 EGQGLGNDFLSHISACDAIFHLCRAFEDpDVTHVEGEVDPVRDLEIISEELRLKDEENLLKNLDKLEKVVARGGDKKLkp 180
Cdd:TIGR00092  83 KGEGLGNQFLANIREVDIIQHVVRCFED-DIIHHVGNVDDPRDDFEIIDEELLKADEFLVEKRIGRSKKSAEGGKDKK-- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   181 EYDSMLKIKDILIDQKRHLRFEdWNAHDIEALNKYLFLTSKPVIYLVNLSDKDFIRKKNKWLPKIKEWIDKNDPGALLIP 260
Cdd:TIGR00092 160 EELLLLEIILPLLNGGQMARHV-DLSKEELILIKSLNLLTKKPIILIANVSEDYLRNLNNNYLLIVEWIAAYSKGDPKVV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   261 FSGAFEHQ-LTEKDELERKAYETE--TKCKSMLEKIVVTGYKGLQLEYFFTAGPDEVKAWTIQKGTKAPQAAGRIHTDFE 337
Cdd:TIGR00092 239 FVCALEESeLSELDDEERQEFLQKlgLTESAGLNIIIRARYKLLLLSFFFTGGKEEVRAWTRKGGWAAPQAAGIIHTDFE 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 24640875   338 KGFIMAEVMHFEDFKAEGSEANAKAAGKYRQQGRNYTVEDGDIIFFKFN 386
Cdd:TIGR00092 319 TGFIAAEVISWDDFIYKKSSQGAKKGGLMRLEGKYYVVDDGDVLFFAFN 367
YchF-GTPase_C pfam06071
Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF ...
 303-384 6.86e-55

Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF GTP-binding protein and is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies.


Pssm-ID: 461819 [Multi-domain]  Cd Length: 82  Bit Score: 175.62  E-value: 6.86e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   303 LEYFFTAGPDEVKAWTIQKGTKAPQAAGRIHTDFEKGFIMAEVMHFEDFKAEGSEANAKAAGKYRQQGRNYTVEDGDIIF 382
Cdd:pfam06071   1 LITFFTAGPKEVRAWTIRKGTTAPQAAGVIHTDFEKGFIRAEVISYDDLIEYGSEAAAKEAGKLRLEGKDYVVQDGDIIH 80


                  ..
gi 24640875   383 FK 384
Cdd:pfam06071  81 FR 82
 
Name Accession Description Interval E-value
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 1-387 0e+00

GTP-binding protein; Provisional


Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 596.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875    1 MPPKKHDEPERKPLIGRIGTNLRIGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESRVPVPDERFDYLVEYHKPA 80
Cdd:PTZ00258   1 MPPKKKMEEEKKVLLGRPGNNLKMGIVGLPNVGKSTTFNALCKQQVPAENFPFCTIDPNTARVNVPDERFDWLCKHFKPK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   81 SVVPAYLNVVDIAGLVKGAAEGQGLGNDFLSHISACDAIFHLCRAFEDPDVTHVEGEVDPVRDLEIISEELRLKDEENLL 160
Cdd:PTZ00258  81 SIVPAQLDITDIAGLVKGASEGEGLGNAFLSHIRAVDGIYHVVRAFEDEDITHVEGEIDPVRDLEIISSELILKDLEFVE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  161 KNLDKLEKVvaRGGDKKLK---PEYDSMLKIKDILIDqKRHLRFEDWNAHDIEALNKYLFLTSKPVIYLVNLSDKDFIRK 237
Cdd:PTZ00258 161 KRLDELTKK--RKKKKKKKeekVELDVLKKVLEWLEE-GKPVRDGDWTDKEIEILNEYQLLTAKPMIYLVNMSEKDFIRQ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  238 KNKWLPKIKEWIDKNDPGaLLIPFSGAFEHQLTE-KDELERKAYETETKCK-SMLEKIVVTGYKGLQLEYFFTAGPDEVK 315
Cdd:PTZ00258 238 KNKWLAKIKEWVGEKGGG-PIIPYSAEFEEELAElGSEEERKEYLEEYGIKqSMLDKIIKTGYKLLNLIHFFTAGPDEVR 316

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24640875  316 AWTIQKGTKAPQAAGRIHTDFEKGFIMAEVMHFEDFKAEGSEANAKAAGKYRQQGRNYTVEDGDIIFFKFNA 387
Cdd:PTZ00258 317 CWTIQKGTKAPQAAGVIHSDFEKGFICAEVMKYEDFLELGSEAAVKAEGKYRQEGKDYVVQDGDIIFFKFNV 388
GTP1 COG0012
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ...
 22-386 1.25e-166

Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439783 [Multi-domain]  Cd Length: 362  Bit Score: 470.66  E-value: 1.25e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  22 LRIGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESRVPVPDERFDYLVEYHKPASVVPAYLNVVDIAGLVKGAAE 101
Cdd:COG0012   1 LKCGIVGLPNVGKSTLFNALTKAGAEAANYPFCTIEPNVGVVPVPDERLDKLAEIVKPKKIVPATIEFVDIAGLVKGASK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 102 GQGLGNDFLSHISACDAIFHLCRAFEDPDVTHVEGEVDPVRDLEIISEELRLKDEENLLKNLDKLEKvVARGGDKKLKPE 181
Cdd:COG0012  81 GEGLGNQFLANIREVDAIVHVVRCFEDDNVTHVEGSVDPLRDIETINTELILADLETVEKRLERLEK-KAKSGDKEAKAE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 182 YDSMLKIKDILiDQKRHLRFEDWNAHDIEALNKYLFLTSKPVIYLVNLSDKDFIrKKNKWLPKIKEWIDKNdpGALLIPF 261
Cdd:COG0012 160 LELLEKLKEHL-EEGKPARSLELSEEEKKLLKELQLLTAKPVLYVANVDEDDLA-EGNPYVEKVREYAAKE--GAEVVVI 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 262 SGAFEHQLTEKDELERKAYETETKCK-SMLEKIVVTGYKGLQLEYFFTAGPDEVKAWTIQKGTKAPQAAGRIHTDFEKGF 340
Cdd:COG0012 236 CAKIEAELAELDEEERAEFLEELGLEeSGLDRLIRAGYDLLGLITFFTAGPKEVRAWTIKKGTTAPQAAGVIHTDFERGF 315

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*.
gi 24640875 341 IMAEVMHFEDFKAEGSEANAKAAGKYRQQGRNYTVEDGDIIFFKFN 386
Cdd:COG0012 316 IRAEVISYDDLIAYGSEAAAKEAGKLRLEGKDYVVQDGDVIHFRFN 361
YchF cd01900
YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of ...
 24-301 6.84e-148

YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated with the ribosome. Several members of the family, including YchF, possess the TGS domain related to the RNA-binding proteins. Experimental data and genomic analysis suggest that YchF may be part of a nucleoprotein complex and may function as a GTP-dependent translational factor.


Pssm-ID: 206687 [Multi-domain]  Cd Length: 274  Bit Score: 419.94  E-value: 6.84e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  24 IGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESRVPVPDERFDYLVEYHKPASVVPAYLNVVDIAGLVKGAAEGQ 103
Cdd:cd01900   1 IGIVGLPNVGKSTLFNALTKSNAEAANYPFCTIEPNVGIVPVPDERLDKLAEIVKPKKIVPATIEFVDIAGLVKGASKGE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 104 GLGNDFLSHISACDAIFHLCRAFEDPDVTHVEGEVDPVRDLEIISEELRLKDEENLLKNLDKLEKvVARGGDKKLKPEYD 183
Cdd:cd01900  81 GLGNKFLSHIREVDAIAHVVRCFEDDDITHVEGSVDPVRDIEIINTELILADLETIEKRLERLEK-KAKSGDKEAKEELE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 184 SMLKIKDILIDQKRhLRFEDWNAHDIEALNKYLFLTSKPVIYLVNLSDKDFIRKKNKWLpkiKEWIDKNDPGALLIPFSG 263
Cdd:cd01900 160 LLEKIKEHLEEGKP-ARTLELTDEEIKILKSLQLLTAKPVIYVANVSEDDLIRGNNKVL---KVREIAAKEGAEVIPISA 235

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 24640875 264 AFEHQLTEKDELERKAYETETKCK-SMLEKIVVTGYKGL 301
Cdd:cd01900 236 KLEAELAELDEEEAAEFLEELGLEeSGLDKLIRAGYELL 274
TIGR00092 TIGR00092
GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in ...
 22-386 7.09e-106

GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in every complete bacterial genome, and is found in Eukaryotes. A more distantly related protein, separated from this model, is found in the archaea. It is known to bind GTP and double-stranded nucleic acid. It is suggested to belong to a nucleoprotein complex and act as a translation factor. [Unknown function, General]


Pssm-ID: 129200 [Multi-domain]  Cd Length: 368  Bit Score: 316.72  E-value: 7.09e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875    22 LRIGIVGVPNVGKSTFFNVLTQSA-APAENFPFCTIKPNESRVPVPDERFDYLVEYHKPASVVPAYLNVVDIAGLVKGAA 100
Cdd:TIGR00092   3 LSGGIVGLPNVGKSTLFAATTNLLgNEAANPPFTTIEPNAGVVNPSDPRLDLLAIYIKPEKVPPTTTEFVDIAGLVGGAS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   101 EGQGLGNDFLSHISACDAIFHLCRAFEDpDVTHVEGEVDPVRDLEIISEELRLKDEENLLKNLDKLEKVVARGGDKKLkp 180
Cdd:TIGR00092  83 KGEGLGNQFLANIREVDIIQHVVRCFED-DIIHHVGNVDDPRDDFEIIDEELLKADEFLVEKRIGRSKKSAEGGKDKK-- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   181 EYDSMLKIKDILIDQKRHLRFEdWNAHDIEALNKYLFLTSKPVIYLVNLSDKDFIRKKNKWLPKIKEWIDKNDPGALLIP 260
Cdd:TIGR00092 160 EELLLLEIILPLLNGGQMARHV-DLSKEELILIKSLNLLTKKPIILIANVSEDYLRNLNNNYLLIVEWIAAYSKGDPKVV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   261 FSGAFEHQ-LTEKDELERKAYETE--TKCKSMLEKIVVTGYKGLQLEYFFTAGPDEVKAWTIQKGTKAPQAAGRIHTDFE 337
Cdd:TIGR00092 239 FVCALEESeLSELDDEERQEFLQKlgLTESAGLNIIIRARYKLLLLSFFFTGGKEEVRAWTRKGGWAAPQAAGIIHTDFE 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 24640875   338 KGFIMAEVMHFEDFKAEGSEANAKAAGKYRQQGRNYTVEDGDIIFFKFN 386
Cdd:TIGR00092 319 TGFIAAEVISWDDFIYKKSSQGAKKGGLMRLEGKYYVVDDGDVLFFAFN 367
TGS_YchF_OLA1 cd04867
TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 ...
 301-385 4.62e-59

TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 family includes bacterial ribosome-binding ATPase YchF as well as its human homolog Obg-like ATPase 1 (OLA1), both of which belong to the Obg family of GTPases, and are novel ATPases that bind and hydrolyze ATP more efficiently than GTP. They have been associated with various cellular processes and pathologies, including DNA repair, tumorigenesis, and apoptosis, in addition to the regulation of the oxidative stress response. OLA1 is also termed DNA damage-regulated overexpressed in cancer 45 (DOC45), or GTP-binding protein 9 (GTPBP9). It is over-expressed in several human malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus. It is linked to the cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker. Members in this family contain a central Obg-type G (guanine nucleotide-binding) domain, flanked by a coiled-coil domain and this TGS (ThrRS, GTPase, SpoT) domain of unknown function.


Pssm-ID: 340516 [Multi-domain]  Cd Length: 85  Bit Score: 186.58  E-value: 4.62e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 301 LQLEYFFTAGPDEVKAWTIQKGTKAPQAAGRIHTDFEKGFIMAEVMHFEDFKAEGSEANAKAAGKYRQQGRNYTVEDGDI 380
Cdd:cd04867   1 LNLITFFTAGPDEVRAWTIRKGTKAPQAAGVIHTDFEKGFIRAEVIKYDDLKELGSEAAAKEAGKYRQEGKDYVVQDGDI 80


                ....*
gi 24640875 381 IFFKF 385
Cdd:cd04867  81 IHFKF 85
YchF-GTPase_C pfam06071
Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF ...
 303-384 6.86e-55

Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF GTP-binding protein and is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies.


Pssm-ID: 461819 [Multi-domain]  Cd Length: 82  Bit Score: 175.62  E-value: 6.86e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   303 LEYFFTAGPDEVKAWTIQKGTKAPQAAGRIHTDFEKGFIMAEVMHFEDFKAEGSEANAKAAGKYRQQGRNYTVEDGDIIF 382
Cdd:pfam06071   1 LITFFTAGPKEVRAWTIRKGTTAPQAAGVIHTDFEKGFIRAEVISYDDLIEYGSEAAAKEAGKLRLEGKDYVVQDGDIIH 80


                  ..
gi 24640875   383 FK 384
Cdd:pfam06071  81 FR 82
PRK09602 PRK09602
translation-associated GTPase; Reviewed
 22-381 8.80e-32

translation-associated GTPase; Reviewed


Pssm-ID: 236584 [Multi-domain]  Cd Length: 396  Bit Score: 124.15  E-value: 8.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   22 LRIGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNES----RVPVPDERFDylveyHKPASVVPAYLN--------V 89
Cdd:PRK09602   2 ITIGLVGKPNVGKSTFFNAATLADVEIANYPFTTIDPNVGvayvRVECPCKELG-----VKCNPRNGKCIDgtrfipveL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   90 VDIAGLVKGAAEGQGLGNDFLSHISACDAIFHLCrafedpDV---THVEGEV------DPVRDLEIISEELRLKDEENLL 160
Cdd:PRK09602  77 IDVAGLVPGAHEGRGLGNQFLDDLRQADALIHVV------DAsgsTDEEGNPvepgshDPVEDIKFLEEELDMWIYGILE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  161 KNLDKLEKvVARGGDKKLKPEYDSML--------KIKDILIDQKRHLRFEDWNAHDIEALNKYLFLTSKPVIYLVNLSDK 232
Cdd:PRK09602 151 KNWEKFSR-KAQAEKFDIEEALAEQLsglgineeHVKEALRELGLPEDPSKWTDEDLLELARELRKISKPMVIAANKADL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  233 DFIRKKNKWLpkikewidKNDPGALLIPFSGAFEHQL------------------TEKDEL---ERKAYEtetKCKSMLE 291
Cdd:PRK09602 230 PPAEENIERL--------KEEKYYIVVPTSAEAELALrraakaglidyipgdsdfEILGELsekQKKALE---YIREVLK 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  292 KIVVTG---------YKGLQL--------EYFFTAG-----PDevkAWTIQKGTKAPQAAGRIHTDFEKGFIMAevmhfe 349
Cdd:PRK09602 299 KYGGTGvqeaintavFDLLDMivvypvedENKLTDKkgnvlPD---AFLLPKGSTARDLAYKIHTDIGEGFLYA------ 369

                        410       420       430
                 ....*....|....*....|....*....|..
gi 24640875  350 dfkaegseANAKaagKYRQQGRNYTVEDGDII 381
Cdd:PRK09602 370 --------IDAR---TKRRIGEDYELKDGDVI 390
Ygr210 cd01899
Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They ...
 24-266 3.31e-29

Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They are characterized by a distinct glycine-rich motif immediately following the Walker B motif. The Ygr210 and YyaF/YchF subfamilies appear to form one major branch of the Obg-like family. Among eukaryotes, the Ygr210 subfamily is represented only in fungi. These fungal proteins form a tight cluster with their archaeal orthologs, which suggests the possibility of horizontal transfer from archaea to fungi.


Pssm-ID: 206686 [Multi-domain]  Cd Length: 318  Bit Score: 115.40  E-value: 3.31e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  24 IGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNES----RVPVPDERFDylveyhkpASVVPAYLN----------- 88
Cdd:cd01899   1 IGLVGKPNVGKSTFFNAATLADVEIANYPFTTIDPNVGvgyvRVECPCKELG--------VSCNPRYGKcidgkryvpve 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  89 VVDIAGLVKGAAEGQGLGNDFLSHISACDAIFHLCRA--FEDPDVTHVE-GEVDPVRDLEIISEELRLKDEENLLKNLDK 165
Cdd:cd01899  73 LIDVAGLVPGAHEGKGLGNQFLDDLRDADVLIHVVDAsgGTDAEGNGVEtGGYDPLEDIEFLENEIDMWIYGILERNWEK 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 166 LEKVVARGGDKKLK-----------PEYDsmlkIKDILIDQKRHLRFEDWNAHDIEALNKYLFLTSKPVIYLVNLSDkdf 234
Cdd:cd01899 153 IVRKAKAEKTDIVEalseqlsgfgvNEDV----VIEALEELELPADLSKWDDEDLLRLARELRKRRKPMVIAANKAD--- 225

                       250       260       270
                ....*....|....*....|....*....|..
gi 24640875 235 IRKKNkwlpKIKEWIDKNDPGALLIPFSGAFE 266
Cdd:cd01899 226 IPDAE----ENISKLRLKYPDEIVVPTSAEAE 253
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 23-130 7.78e-23

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 92.30  E-value: 7.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875    23 RIGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESRVPVPDERFdylveyhkpasvvpaylNVVDIAGLVKGAAEG 102
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVSDYPGTTRDPNEGRLELKGKQI-----------------ILVDTPGLIEGASEG 63

                          90       100
                  ....*....|....*....|....*...
gi 24640875   103 QGLGNDFLSHISAcDAIFHLCRAFEDPD 130
Cdd:pfam01926  64 EGLGRAFLAIIEA-DLILFVVDSEEGIT 90
Obg_like cd01881
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; ...
 25-156 2.92e-22

Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following the Walker B motif (G3 box). Obg/CgtA is an essential gene that is involved in the initiation of sporulation and DNA replication in the bacteria Caulobacter and Bacillus, but its exact molecular role is unknown. Furthermore, several OBG family members possess a C-terminal RNA-binding domain, the TGS domain, which is also present in threonyl-tRNA synthetase and in bacterial guanosine polyphosphatase SpoT. Nog1 is a nucleolar protein that might function in ribosome assembly. The DRG and Nog1 subfamilies are ubiquitous in archaea and eukaryotes, the Ygr210 subfamily is present in archaea and fungi, and the Obg and YyaF/YchF subfamilies are ubiquitous in bacteria and eukaryotes. The Obg/Nog1 and DRG subfamilies appear to form one major branch of the Obg family and the Ygr210 and YchF subfamilies form another branch. No GEFs, GAPs, or GDIs for Obg have been identified.


Pssm-ID: 206668 [Multi-domain]  Cd Length: 167  Bit Score: 92.46  E-value: 2.92e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  25 GIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESRVPVPDerfdyLVEYHkpasvvpaylnVVDIAGLVKGAAEGQG 104
Cdd:cd01881   1 GLVGLPNVGKSTLLSALTSAKVEIASYPFTTLEPNVGVFEFGD-----GVDIQ-----------IIDLPGLLDGASEGRG 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 24640875 105 LGNDFLSHISACDAIFHLCRAFEDPdvthvegEVDPVRDLEIISEELRLKDE 156
Cdd:cd01881  65 LGEQILAHLYRSDLILHVIDASEDC-------VGDPLEDQKTLNEEVSGSFL 109
obgE PRK12297
GTPase CgtA; Reviewed
 24-161 3.83e-22

GTPase CgtA; Reviewed


Pssm-ID: 237046 [Multi-domain]  Cd Length: 424  Bit Score: 97.48  E-value: 3.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   24 IGIVGVPNVGKSTFFNVLTqSAAPA-ENFPFCTIKPNESRVPVPDERfdylveyhkpaSVVPAylnvvDIAGLVKGAAEG 102
Cdd:PRK12297 161 VGLVGFPNVGKSTLLSVVS-NAKPKiANYHFTTLVPNLGVVETDDGR-----------SFVMA-----DIPGLIEGASEG 223

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 24640875  103 QGLGNDFLSHISACDAIFHLCrafedpDVTHVEGEvDPVRDLEIISEELRLKDEEnLLK 161
Cdd:PRK12297 224 VGLGHQFLRHIERTRVIVHVI------DMSGSEGR-DPIEDYEKINKELKLYNPR-LLE 274
obgE PRK12299
GTPase CgtA; Reviewed
 24-161 9.66e-22

GTPase CgtA; Reviewed


Pssm-ID: 237048 [Multi-domain]  Cd Length: 335  Bit Score: 95.14  E-value: 9.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   24 IGIVGVPNVGKSTFFNVLTqSAAP--AeNFPFCTIKPNESRVPVPDERfdylveyhkpaSVVpaylnVVDIAGLVKGAAE 101
Cdd:PRK12299 161 VGLVGLPNAGKSTLISAVS-AAKPkiA-DYPFTTLHPNLGVVRVDDYK-----------SFV-----IADIPGLIEGASE 222

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  102 GQGLGNDFLSHISACDAIFHLCrafedpDVThvegEVDPVRDLEIISEELRLKDEENLLK 161
Cdd:PRK12299 223 GAGLGHRFLKHIERTRLLLHLV------DIE----AVDPVEDYKTIRNELEKYSPELADK 272
Obg cd01898
Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress ...
 24-161 1.36e-21

Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain.


Pssm-ID: 206685 [Multi-domain]  Cd Length: 170  Bit Score: 90.56  E-value: 1.36e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  24 IGIVGVPNVGKSTFFNVLTqSAAP--AeNFPFCTIKPNESRVPVPDERfdylveyhkpaSVVpaylnVVDIAGLVKGAAE 101
Cdd:cd01898   3 VGLVGLPNAGKSTLLSAIS-NAKPkiA-DYPFTTLVPNLGVVRVDDGR-----------SFV-----IADIPGLIEGASE 64

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 102 GQGLGNDFLSHISACDAIFHLCrafedpDVThveGEVDPVRDLEIISEELRLKDEENLLK 161
Cdd:cd01898  65 GKGLGHRFLRHIERTRVLLHVI------DLS---GEDDPVEDYETIRNELEAYNPGLAEK 115
obgE PRK12296
GTPase CgtA; Reviewed
 24-152 9.60e-17

GTPase CgtA; Reviewed


Pssm-ID: 237045 [Multi-domain]  Cd Length: 500  Bit Score: 81.84  E-value: 9.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   24 IGIVGVPNVGKSTFFNVLtqSAAPAE--NFPFCTIKPNESRVPVPDERFdylveyhkpasvvpaylNVVDIAGLVKGAAE 101
Cdd:PRK12296 162 VGLVGFPSAGKSSLISAL--SAAKPKiaDYPFTTLVPNLGVVQAGDTRF-----------------TVADVPGLIPGASE 222

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 24640875  102 GQGLGNDFLSHISACDAIFHL--CrAFEDPDvthvegeVDPVRDLEIISEELR 152
Cdd:PRK12296 223 GKGLGLDFLRHIERCAVLVHVvdC-ATLEPG-------RDPLSDIDALEAELA 267
obgE PRK12298
GTPase CgtA; Reviewed
 24-157 1.85e-15

GTPase CgtA; Reviewed


Pssm-ID: 237047 [Multi-domain]  Cd Length: 390  Bit Score: 77.22  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875   24 IGIVGVPNVGKSTFFNVLtqSAAPAE--NFPFCTIKPNESRVPVPDERfdylveyhkpaSVVPAylnvvDIAGLVKGAAE 101
Cdd:PRK12298 162 VGLLGLPNAGKSTFIRAV--SAAKPKvaDYPFTTLVPNLGVVRVDDER-----------SFVVA-----DIPGLIEGASE 223

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 24640875  102 GQGLGNDFLSHISACDAIFHLCrafedpDVTHVEGEvDPVRDLEIISEELRLKDEE 157
Cdd:PRK12298 224 GAGLGIRFLKHLERCRVLLHLI------DIAPIDGS-DPVENARIIINELEKYSPK 272
DRG cd01896
Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding ...
 23-152 1.19e-11

Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding protein (DRG) subfamily is an uncharacterized member of the Obg family, an evolutionary branch of GTPase superfamily proteins. GTPases act as molecular switches regulating diverse cellular processes. DRG2 and DRG1 comprise the DRG subfamily in eukaryotes. In view of their widespread expression in various tissues and high conservation among distantly related species in eukaryotes and archaea, DRG proteins may regulate fundamental cellular processes. It is proposed that the DRG subfamily proteins play their physiological roles through RNA binding.


Pssm-ID: 206683 [Multi-domain]  Cd Length: 233  Bit Score: 64.10  E-value: 1.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  23 RIGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKpnesrvPVPDerfdyLVEYHKpasvvpAYLNVVDIAGLVKGAAEG 102
Cdd:cd01896   2 RVALVGFPSVGKSTLLSKLTNTKSEVAAYEFTTLT------CVPG-----VMEYKG------AKIQLLDLPGIIEGASDG 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24640875 103 QGLGNDFLSHISACDAIFHLCRAFEDPDvthvegevdpvrDLEIISEELR 152
Cdd:cd01896  65 KGRGRQVIAVARTADLILIVLDATKPEG------------QREILERELE 102
Rbg1 COG1163
Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];
27-381 3.17e-11

Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440777 [Multi-domain]  Cd Length: 368  Bit Score: 64.05  E-value: 3.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  27 VGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESrvpvpderfdyLVEYHKpasvvpAYLNVVDIAGLVKGAAEGQGLG 106
Cdd:COG1163  69 VGFPSVGKSTLLNKLTNAKSEVGAYEFTTLDVVPG-----------MLEYKG------AKIQILDVPGLIEGAASGKGRG 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 107 NDFLSHISACDAIFHLCRAFEdpdvthvegevdpVRDLEIISEELrlkdEENLLKnLDKLEKVV-----ARGG---DKKL 178
Cdd:COG1163 132 KEVLSVVRNADLILIVLDVFE-------------LEQYDVLKEEL----YDAGIR-LNKPPPDVtiekkGKGGirvNSTG 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 179 KPEYDSMLkIKDILIDQKRHlrfedwNAH-------DIEALNKYLF--LTSKPVIYLVN---LSDKDFIRKKNKWLPKik 246
Cdd:COG1163 194 KLDLDEED-IKKILREYGIV------NADvliredvTLDDLIDALMgnRVYKPAIVVVNkidLADEEYVEELKSKLPD-- 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875 247 ewidkndpGALLIPFSGAFEHQLtekDELERKAYETetkcksmLEKI-VVTGYKGlqleyfftAGPDEVKAWTIQKGTKA 325
Cdd:COG1163 265 --------GVPVIFISAEKGIGL---EELKEEIFEE-------LGLIrVYLKPPG--------GKADMEEPLILRKGSTV 318

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24640875 326 PQAAGRIHTDFEKGFIMAEVMhfedfkaeGSEAnakaagKYRQQ--GRNYTVEDGDII 381
Cdd:COG1163 319 GDVCEKIHRDFVERFRYARVW--------GKSA------KHPGQrvGLDHVLEDGDIV 362
TGS cd01616
TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; ...
 306-383 4.96e-08

TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; This family includes eukaryotic and some bacterial threonyl-tRNA synthetases (ThrRSs), a distinct Obg family GTPases, and guanosine polyphosphate hydrolase (SpoT) and synthetase (RelA), which are involved in stringent response in bacteria, as well as uridine kinase (UDK) from Thermotogales. All family members contain a TGS domain named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs. It is a small domain with a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions. The functions of the TGS domain remains unclear, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, with a regulatory role.


Pssm-ID: 340455 [Multi-domain]  Cd Length: 61  Bit Score: 49.14  E-value: 4.96e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24640875 306 FFTAGPDEVKAWTIQKGTKAPQAAGRIHTDFEKGFIMAEVMHfedfkaegseanakaagkyRQQGRNYTVEDGDIIFF 383
Cdd:cd01616   2 VFTVGKTPGTVFVMNKGATAYSCAMHLHEDYCRKSILALVDG-------------------QLWDMYYPLTKGDEIKF 60
TGS_Obg cd04938
TGS (ThrRS, GTPase and SpoT) domain found in the Obg protein family; The Obg family of GTPases ...
 308-384 2.20e-07

TGS (ThrRS, GTPase and SpoT) domain found in the Obg protein family; The Obg family of GTPases function has been implicated in cellular processes as diverse as sporulation, stress response, control of DNA replication, and ribosome assembly. It consists of several subfamilies such as DRG and YchF with TGS domain. The TGS domain is named after the various RNA-binding multidomain ThrRS, GTPase, and SpoT/RelA proteins in which this domain occurs. The TGS domain of Obg-like GTPases such as those present in DRG (developmentally regulated GTP-binding protein), and GTP-binding proteins Ygr210 and YchF has a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions.


Pssm-ID: 340517 [Multi-domain]  Cd Length: 77  Bit Score: 47.83  E-value: 2.20e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24640875 308 TAGPDEVKAWTIQKGTKAPQAAGRIHTDFEKGFIMAEVmhfedfkaegseanakaAGKYRQQGRNYTVEDGDIIFFK 384
Cdd:cd04938  18 SGNSVFRDCVLVKKGTTVKDFANKIHTDLEKGFINAEG-----------------IGGRRLEGEDYILQDNDVVKFT 77
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 4-46 4.00e-06

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 46.75  E-value: 4.00e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 24640875   4 KKHDEPERKPLIGRIGTNLRIGIVGVPNVGKSTFFNVLTQSAA 46
Cdd:cd01856  98 KLLKENEKLKAKGLLPRPLRAMVVGIPNVGKSTLINRLRGKKV 140
HflX cd01878
HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment ...
 4-69 2.45e-05

HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual biological functions of these GTPases remain unclear. HflX is widespread, but not universally represented in all three superkingdoms.


Pssm-ID: 206666 [Multi-domain]  Cd Length: 204  Bit Score: 44.76  E-value: 2.45e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24640875   4 KKHDEPERKpliGRIGTNL-RIGIVGVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESRVPVPDER 69
Cdd:cd01878  26 KKQRELQRA---RRKRSGVpTVALVGYTNAGKSTLFNALTGADVLAEDQLFATLDPTTRRIKLPGGR 89
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
13-52 4.66e-05

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 44.71  E-value: 4.66e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 24640875  13 PLIGRIGTNLRIGIVGVPNVGKSTFFNVLT-QSAAPAENFP 52
Cdd:COG1161 105 PEKGIKRRPIRVMIVGIPNVGKSTLINRLAgKKVAKTGNKP 145
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
24-44 2.04e-04

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 43.09  E-value: 2.04e-04
                        10        20
                ....*....|....*....|.
gi 24640875  24 IGIVGVPNVGKSTFFNVLTQS 44
Cdd:COG1160   5 VAIVGRPNVGKSTLFNRLTGR 25
FeoB COG0370
Fe2+ transporter FeoB [Inorganic ion transport and metabolism];
21-42 3.53e-04

Fe2+ transporter FeoB [Inorganic ion transport and metabolism];


Pssm-ID: 440139 [Multi-domain]  Cd Length: 662  Bit Score: 42.80  E-value: 3.53e-04
                        10        20
                ....*....|....*....|..
gi 24640875  21 NLRIGIVGVPNVGKSTFFNVLT 42
Cdd:COG0370   3 MITIALVGNPNVGKTTLFNALT 24
FeoB cd01879
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ...
 26-91 5.43e-04

Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 206667 [Multi-domain]  Cd Length: 159  Bit Score: 40.13  E-value: 5.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  26 IVGVPNVGKSTFFNVLTQSAAPAENFPFCT-------IKPNESRVPV-------------PDERF--DYLVEyhKPASVV 83
Cdd:cd01879   2 LVGNPNVGKTTLFNALTGARQKVGNWPGVTvekkegeFKLGGKEIEIvdlpgtysltpysEDEKVarDFLLG--EEPDLI 79


                ....*...
gi 24640875  84 payLNVVD 91
Cdd:cd01879  80 ---VNVVD 84
EngA1 cd01894
EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first ...
 26-52 6.06e-04

EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206681 [Multi-domain]  Cd Length: 157  Bit Score: 40.11  E-value: 6.06e-04
                        10        20
                ....*....|....*....|....*...
gi 24640875  26 IVGVPNVGKSTFFNVLTQS-AAPAENFP 52
Cdd:cd01894   2 IVGRPNVGKSTLFNRLTGRrDAIVSDTP 29
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 23-44 6.48e-04

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 41.57  E-value: 6.48e-04
                         10        20
                 ....*....|....*....|..
gi 24640875   23 RIGIVGVPNVGKSTFFNVLTQS 44
Cdd:PRK00093   3 VVAIVGRPNVGKSTLFNRLTGK 24
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 1-42 6.83e-04

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 41.57  E-value: 6.83e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 24640875    1 MPPKKHDEPERKPLigrigtnlRIGIVGVPNVGKSTFFNVLT 42
Cdd:PRK00093 161 LPEEEEEDEEDEPI--------KIAIIGRPNVGKSSLINALL 194
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
1-41 6.98e-04

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 41.55  E-value: 6.98e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 24640875   1 MPPKKHDEPERKPLigrigtnlRIGIVGVPNVGKSTFFNVL 41
Cdd:COG1160 163 LPEEEEEEEEDDPI--------KIAIVGRPNVGKSSLINAL 195
FeoB_N pfam02421
Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) ...
 22-52 7.72e-04

Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 460552 [Multi-domain]  Cd Length: 156  Bit Score: 39.74  E-value: 7.72e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 24640875    22 LRIGIVGVPNVGKSTFFNVLTQSAAPAENFP 52
Cdd:pfam02421   1 ITIALVGNPNVGKTTLFNALTGANQHVGNWP 31
Nucleostemin_like cd04178
A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein ...
 18-46 1.11e-03

A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein that functions as a regulator of cell growth and proliferation in stem cells and in several types of cancer cells, but is not expressed in the differentiated cells of most mammalian adult tissues. NS shuttles between the nucleolus and nucleoplasm bidirectionally at a rate that is fast and independent of cell type. Lowering GTP levels decreases the nucleolar retention of NS, and expression of NS is abruptly down-regulated during differentiation prior to terminal cell division. Found only in eukaryotes, NS consists of an N-terminal basic domain, a coiled-coil domain, a GTP-binding domain, an intermediate domain, and a C-terminal acidic domain. Experimental evidence indicates that NS uses its GTP-binding property as a molecular switch to control the transition between the nucleolus and nucleoplasm, and this process involves interaction between the basic, GTP-binding, and intermediate domains of the protein.


Pssm-ID: 206753 [Multi-domain]  Cd Length: 171  Bit Score: 39.48  E-value: 1.11e-03
                        10        20
                ....*....|....*....|....*....
gi 24640875  18 IGTNLRIGIVGVPNVGKSTFFNVLTQSAA 46
Cdd:cd04178 113 IKTSITVGVVGYPNVGKSSVINSLKRSRA 141
HflX COG2262
50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]; ...
 23-55 1.16e-03

50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441863 [Multi-domain]  Cd Length: 419  Bit Score: 40.84  E-value: 1.16e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 24640875  23 RIGIVGVPNVGKSTFFNVLTQSAAPAENFPFCT 55
Cdd:COG2262 201 TVALVGYTNAGKSTLFNRLTGADVLAEDKLFAT 233
PRK09435 PRK09435
methylmalonyl Co-A mutase-associated GTPase MeaB;
14-41 1.22e-03

methylmalonyl Co-A mutase-associated GTPase MeaB;


Pssm-ID: 236515  Cd Length: 332  Bit Score: 40.57  E-value: 1.22e-03
                         10        20
                 ....*....|....*....|....*...
gi 24640875   14 LIGRIGTNLRIGIVGVPNVGKSTFFNVL 41
Cdd:PRK09435  49 LLPHTGNALRIGITGVPGVGKSTFIEAL 76
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 25-154 1.31e-03

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 39.15  E-value: 1.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  25 GIVGVPNVGKSTFFNVLT-QSAAPAENFPFCTIKPNESRVPVPDERfdylveyhkpaSVVpaylnVVDIAGLVKGAAEGQ 103
Cdd:cd00880   1 AIFGRPNVGKSSLLNALLgQNVGIVSPIPGTTRDPVRKEWELLPLG-----------PVV-----LIDTPGLDEEGGLGR 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 24640875 104 GLGNDFLSHISACDAIFHLcrafedpdvthVEGEVDPVRDLEIISEELRLK 154
Cdd:cd00880  65 ERVEEARQVADRADLVLLV-----------VDSDLTPVEEEAKLGLLRERG 104
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 25-153 1.62e-03

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 38.98  E-value: 1.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875  25 GIVGVPNVGKSTFFNVLT-QSAAPAENFPFCTIKPNESRVPVPDERFDylveyhkpasvvpayLNVVDIAGLVKGaaEGQ 103
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLgGEVGEVSDVPGTTRDPDVYVKELDKGKVK---------------LVLVDTPGLDEF--GGL 63

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24640875 104 GLGNDFLSHISACDAIFHLCrafeDPDVTHVEGEVDPVRDLEIISEELRL 153
Cdd:cd00882  64 GREELARLLLRGADLILLVV----DSTDRESEEDAKLLILRRLRKEGIPI 109
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 23-102 2.30e-03

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 38.51  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640875    23 RIGIVGVPNVGKSTFFNVLTQ-SAAPAENFPF---------CTIKPNESRVPVPD----ERFDYLVEYHKPASVvpAYLN 88
Cdd:TIGR00231   3 KIVIVGHPNVGKSTLLNSLLGnKGSITEYYPGttrnyvttvIEEDGKTYKFNLLDtagqEDYDAIRRLYYPQVE--RSLR 80

                          90
                  ....*....|....
gi 24640875    89 VVDIAGLVKGAAEG 102
Cdd:TIGR00231  81 VFDIVILVLDVEEI 94
EngA2 cd01895
EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second ...
 21-42 2.40e-03

EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206682 [Multi-domain]  Cd Length: 174  Bit Score: 38.57  E-value: 2.40e-03
                        10        20
                ....*....|....*....|..
gi 24640875  21 NLRIGIVGVPNVGKSTFFNVLT 42
Cdd:cd01895   2 PIKIAIIGRPNVGKSSLLNALL 23
GTPase_YlqF TIGR03596
ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding ...
 16-41 2.41e-03

ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding proteins involved in ribosome biogenesis, including the essential YlqF protein of Bacillus subtilis, which is an essential protein. They are related to Era, EngA, and other GTPases of ribosome biogenesis, but are circularly permuted. This family is not universal, and is not present in Escherichia coli, and so is not as well studied as some other GTPases. This model is built for bacterial members. [Protein synthesis, Other]


Pssm-ID: 274669 [Multi-domain]  Cd Length: 276  Bit Score: 39.41  E-value: 2.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 24640875    16 GRIGTNLRIGIVGVPNVGKSTFFNVL 41
Cdd:TIGR03596 113 GLKNRPIRAMIVGIPNVGKSTLINRL 138
feoB TIGR00437
ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane ...
 28-70 2.82e-03

ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane protein required for iron(II) update, is encoded in an operon with FeoA (75 amino acids), which is also required, and is regulated by Fur. There appear to be two copies in Archaeoglobus fulgidus and Clostridium acetobutylicum. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273077 [Multi-domain]  Cd Length: 591  Bit Score: 39.72  E-value: 2.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 24640875    28 GVPNVGKSTFFNVLTQSAAPAENFPFCTIKPNESRVPVPDERF 70
Cdd:TIGR00437   1 GNPNVGKSTLFNALTGANQTVGNWPGVTVEKKEGKLGFQGEDI 43
NOG cd01897
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ...
 26-55 6.38e-03

Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.


Pssm-ID: 206684 [Multi-domain]  Cd Length: 167  Bit Score: 37.15  E-value: 6.38e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 24640875  26 IVGVPNVGKSTFFNVLTQSAAPAENFPFCT 55
Cdd:cd01897   5 IAGYPNVGKSSLVNKLTRAKPEVAPYPFTT 34
trmE cd04164
trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in ...
 22-43 7.22e-03

trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase domain that forms a canonical Ras-like fold. It functions a molecular switch GTPase, and apparently uses a conformational change associated with GTP hydrolysis to promote the tRNA modification reaction, in which the conserved cysteine in the C-terminal domain is thought to function as a catalytic residue. In bacteria that are able to survive in extremely low pH conditions, TrmE regulates glutamate-dependent acid resistance.


Pssm-ID: 206727 [Multi-domain]  Cd Length: 159  Bit Score: 37.09  E-value: 7.22e-03
                        10        20
                ....*....|....*....|..
gi 24640875  22 LRIGIVGVPNVGKSTFFNVLTQ 43
Cdd:cd04164   4 IKVVIAGKPNVGKSSLLNALAG 25
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
 3-52 7.69e-03

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 36.59  E-value: 7.69e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 24640875   3 PKKHDEPERKPLIGRIGTNLRIGIVGVPNVGKSTFFN-VLTQSAAPAENFP 52
Cdd:cd01849  73 LKLKAEITKQKLKLKYKKGIRVGVVGLPNVGKSSFINaLLNKFKLKVGSIP 123
YqeH cd01855
Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH ...
 12-41 8.04e-03

Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically present in bacteria with probable acquisition by plants from chloroplasts. Proteins of the YqeH family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases.


Pssm-ID: 206748 [Multi-domain]  Cd Length: 191  Bit Score: 37.24  E-value: 8.04e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 24640875  12 KPLIGRIGTNLRIG----IVGVPNVGKSTFFNVL 41
Cdd:cd01855 112 EELIEEIKKLAKYRgdvyVVGATNVGKSTLINAL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH