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Conserved domains on  [gi|24640769|ref|NP_727322|]
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Odorant-binding protein 8a [Drosophila melanogaster]

Protein Classification

pheromone/general odorant binding protein( domain architecture ID 10653825)

pheromone/general odorant binding protein (PBP/GOBP) is an olfaction-related protein characterized by six conserved cysteines that are paired in three disulfide bridges

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PhBP smart00708
Insect pheromone/odorant binding protein domains;
43-144 1.45e-15

Insect pheromone/odorant binding protein domains;


:

Pssm-ID: 214783  Cd Length: 103  Bit Score: 68.22  E-value: 1.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640769     43 ARDQCGRELTAAQRLQLDRMQFEDAAH----VRHYLHCFWSRLQLWLDETGFQAQRIVQSFGGeRRLNVEQALPAINGCN 118
Cdd:smart00708   1 TREECKKELGVSEADLADFVKFWREDYpdekVKCYIKCVLKKLGLMDDDGKFDAEKLLEQLKA-DDEMAEELEDIIEKCE 79

                           90       100
                   ....*....|....*....|....*.
gi 24640769    119 AKTSSRgsgaQTVVDWCFRAFVCVLA 144
Cdd:smart00708  80 KKKGTE----EDPCDTAYRVAKCFKK 101
 
Name Accession Description Interval E-value
PhBP smart00708
Insect pheromone/odorant binding protein domains;
43-144 1.45e-15

Insect pheromone/odorant binding protein domains;


Pssm-ID: 214783  Cd Length: 103  Bit Score: 68.22  E-value: 1.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640769     43 ARDQCGRELTAAQRLQLDRMQFEDAAH----VRHYLHCFWSRLQLWLDETGFQAQRIVQSFGGeRRLNVEQALPAINGCN 118
Cdd:smart00708   1 TREECKKELGVSEADLADFVKFWREDYpdekVKCYIKCVLKKLGLMDDDGKFDAEKLLEQLKA-DDEMAEELEDIIEKCE 79

                           90       100
                   ....*....|....*....|....*.
gi 24640769    119 AKTSSRgsgaQTVVDWCFRAFVCVLA 144
Cdd:smart00708  80 KKKGTE----EDPCDTAYRVAKCFKK 101
PBP_GOBP pfam01395
PBP/GOBP family; The olfactory receptors of terrestrial animals exist in an aqueous ...
 34-145 1.38e-07

PBP/GOBP family; The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is thought to be greatly enhanced via odorant binding proteins which exist in the extracellular fluid surrounding the odorant receptors. This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant binding proteins (GOBP).


Pssm-ID: 460193  Cd Length: 109  Bit Score: 47.48  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640769    34 SPQSLALLRARDQCGREL--TAAQRLQLDRMQFEDAAHVRHYLHCFWSRLQLWLDETGFQAQRIVQSFggERRLNVEQAL 111
Cdd:pfam01395   4 EEQKEKIKQARKECAKELgvSDEDVEKLKKGEFPDDDETKCYIRCVLKKLGLMDDDGGLNKDVLLEQL--EPVLDDEKAK 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 24640769   112 PAINGCNAKTSSrgsgaqTVVDWCFRAFVCVLAT 145
Cdd:pfam01395  82 EIIEKCQAGAVK------DPCETAYKLFKCFYKN 109
PBP_GOBP cd23992
pheromone binding protein/general-odorant binding protein (PBP/GOBP) family proteins; ...
 40-142 3.52e-04

pheromone binding protein/general-odorant binding protein (PBP/GOBP) family proteins; Arthropod Odorant Binding Proteins (OBPs) extract odorants at the air-lymph interface and carry them to the olfactory receptors. In insects, OBPs are located in the antennal sensillary lymph. OBPs that bind insects' specific pheromones are called Pheromone Binding Proteins (PBPs), and OBPs that bind general odorant molecules are sometimes called General OBPs (GOPBs). The family includes PBPs and GOBPs mainly from insects, which are distinct from the vertebrate OBPs. PBPs are male-specific and associate with pheromone-sensitive neurons and GOBPs. GOBPs share a high level of sequence similarity with the PBPs. They may carry odorants rather than pheromones.


Pssm-ID: 467938  Cd Length: 99  Bit Score: 37.90  E-value: 3.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640769  40 LLRARDQCGRE--LTAAQRLQLDRMQFEDAAHVRHYLHCFWSRLQLWLDET-GFQAQRIVQSFGGErrlNVEQALPAING 116
Cdd:cd23992   2 LKEAHEECAKEtgVSEEDLEKLKKGEFPDDEKLKCFLACVLKKLGLMDDDGnKFNLEKLLEDFKKE---DKEKVKEIVEK 78

                        90       100
                ....*....|....*....|....*.
gi 24640769 117 CNAKTssrgsGAQTVVDWCFRAFVCV 142
Cdd:cd23992  79 CKKEV-----GKDDPCETAYKLAKCF 99
 
Name Accession Description Interval E-value
PhBP smart00708
Insect pheromone/odorant binding protein domains;
43-144 1.45e-15

Insect pheromone/odorant binding protein domains;


Pssm-ID: 214783  Cd Length: 103  Bit Score: 68.22  E-value: 1.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640769     43 ARDQCGRELTAAQRLQLDRMQFEDAAH----VRHYLHCFWSRLQLWLDETGFQAQRIVQSFGGeRRLNVEQALPAINGCN 118
Cdd:smart00708   1 TREECKKELGVSEADLADFVKFWREDYpdekVKCYIKCVLKKLGLMDDDGKFDAEKLLEQLKA-DDEMAEELEDIIEKCE 79

                           90       100
                   ....*....|....*....|....*.
gi 24640769    119 AKTSSRgsgaQTVVDWCFRAFVCVLA 144
Cdd:smart00708  80 KKKGTE----EDPCDTAYRVAKCFKK 101
PBP_GOBP pfam01395
PBP/GOBP family; The olfactory receptors of terrestrial animals exist in an aqueous ...
 34-145 1.38e-07

PBP/GOBP family; The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is thought to be greatly enhanced via odorant binding proteins which exist in the extracellular fluid surrounding the odorant receptors. This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant binding proteins (GOBP).


Pssm-ID: 460193  Cd Length: 109  Bit Score: 47.48  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640769    34 SPQSLALLRARDQCGREL--TAAQRLQLDRMQFEDAAHVRHYLHCFWSRLQLWLDETGFQAQRIVQSFggERRLNVEQAL 111
Cdd:pfam01395   4 EEQKEKIKQARKECAKELgvSDEDVEKLKKGEFPDDDETKCYIRCVLKKLGLMDDDGGLNKDVLLEQL--EPVLDDEKAK 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 24640769   112 PAINGCNAKTSSrgsgaqTVVDWCFRAFVCVLAT 145
Cdd:pfam01395  82 EIIEKCQAGAVK------DPCETAYKLFKCFYKN 109
PBP_GOBP cd23992
pheromone binding protein/general-odorant binding protein (PBP/GOBP) family proteins; ...
 40-142 3.52e-04

pheromone binding protein/general-odorant binding protein (PBP/GOBP) family proteins; Arthropod Odorant Binding Proteins (OBPs) extract odorants at the air-lymph interface and carry them to the olfactory receptors. In insects, OBPs are located in the antennal sensillary lymph. OBPs that bind insects' specific pheromones are called Pheromone Binding Proteins (PBPs), and OBPs that bind general odorant molecules are sometimes called General OBPs (GOPBs). The family includes PBPs and GOBPs mainly from insects, which are distinct from the vertebrate OBPs. PBPs are male-specific and associate with pheromone-sensitive neurons and GOBPs. GOBPs share a high level of sequence similarity with the PBPs. They may carry odorants rather than pheromones.


Pssm-ID: 467938  Cd Length: 99  Bit Score: 37.90  E-value: 3.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640769  40 LLRARDQCGRE--LTAAQRLQLDRMQFEDAAHVRHYLHCFWSRLQLWLDET-GFQAQRIVQSFGGErrlNVEQALPAING 116
Cdd:cd23992   2 LKEAHEECAKEtgVSEEDLEKLKKGEFPDDEKLKCFLACVLKKLGLMDDDGnKFNLEKLLEDFKKE---DKEKVKEIVEK 78

                        90       100
                ....*....|....*....|....*.
gi 24640769 117 CNAKTssrgsGAQTVVDWCFRAFVCV 142
Cdd:cd23992  79 CKKEV-----GKDDPCETAYKLAKCF 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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