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Conserved domains on  [gi|24640368|ref|NP_727185|]
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uncharacterized protein Dmel_CG32727 [Drosophila melanogaster]

Protein Classification

J domain-containing protein( domain architecture ID 84)

J domain-containing protein similar to molecular chaperone DnaJ, a protein that plays crucial roles in protein translation, folding, unfolding, translocation, and degradation, primarily by stimulating the ATPase activity of Hsp70

CATH:  1.10.287.110
Gene Ontology:  GO:0006457
PubMed:  35729039|9644977|8016869|15170475
SCOP:  4000605

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaJ super family cl02542
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 34-115 3.50e-09

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


The actual alignment was detected with superfamily member PTZ00100:

Pssm-ID: 413365  Cd Length: 116  Bit Score: 50.62  E-value: 3.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640368   34 IFRSPNSTKTIGQLRLCFGNLGTGRFYSGcFQKRMSHREASKILSISPNAP--WIRRA----MLAKHPDRNGSPYLAGKI 107
Cdd:PTZ00100  29 IFGSNNMSFPLSGFNPSLGSLFLKNDLKG-FENPMSKSEAYKILNISPTASkeRIREAhkqlMLRNHPDNGGSTYIASKV 107


                 ....*...
gi 24640368  108 HKPKNGLL 115
Cdd:PTZ00100 108 NEAKDLLL 115
 
Name Accession Description Interval E-value
PTZ00100 PTZ00100
DnaJ chaperone protein; Provisional
 34-115 3.50e-09

DnaJ chaperone protein; Provisional


Pssm-ID: 240265  Cd Length: 116  Bit Score: 50.62  E-value: 3.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640368   34 IFRSPNSTKTIGQLRLCFGNLGTGRFYSGcFQKRMSHREASKILSISPNAP--WIRRA----MLAKHPDRNGSPYLAGKI 107
Cdd:PTZ00100  29 IFGSNNMSFPLSGFNPSLGSLFLKNDLKG-FENPMSKSEAYKILNISPTASkeRIREAhkqlMLRNHPDNGGSTYIASKV 107


                 ....*...
gi 24640368  108 HKPKNGLL 115
Cdd:PTZ00100 108 NEAKDLLL 115
 
Name Accession Description Interval E-value
PTZ00100 PTZ00100
DnaJ chaperone protein; Provisional
 34-115 3.50e-09

DnaJ chaperone protein; Provisional


Pssm-ID: 240265  Cd Length: 116  Bit Score: 50.62  E-value: 3.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640368   34 IFRSPNSTKTIGQLRLCFGNLGTGRFYSGcFQKRMSHREASKILSISPNAP--WIRRA----MLAKHPDRNGSPYLAGKI 107
Cdd:PTZ00100  29 IFGSNNMSFPLSGFNPSLGSLFLKNDLKG-FENPMSKSEAYKILNISPTASkeRIREAhkqlMLRNHPDNGGSTYIASKV 107


                 ....*...
gi 24640368  108 HKPKNGLL 115
Cdd:PTZ00100 108 NEAKDLLL 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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