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Conserved domains on  [gi|24638820|ref|NP_726651|]
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pleiohomeotic, isoform B [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13416207)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
430-457 1.13e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|....*...
gi 24638820   430 NLRTHVRIHTGDRPFVCPFdaCNKKFAQ 457
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-426 2.31e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 24638820   401 LKRHQLVHTGEKPFQCTFegCGKRFS 426
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFK 25
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
386-515 8.10e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638820 386 HVCAECGKAFVESSKLKRHQ--LVHTGE--KPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNL 461
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN 369

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 24638820 462 KSHILTHAKAKRNTSISGksgcSNAESNSQSEDTSANYVKVELQDSVTENHVPF 515
Cdd:COG5048 370 EPPQSLQQYKDLKNDKKS----ETLSNSCIRNFKRDSNLSLHIITHLSFRPYNC 419
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
430-457 1.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|....*...
gi 24638820   430 NLRTHVRIHTGDRPFVCPFdaCNKKFAQ 457
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-426 2.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 24638820   401 LKRHQLVHTGEKPFQCTFegCGKRFS 426
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
386-515 8.10e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638820 386 HVCAECGKAFVESSKLKRHQ--LVHTGE--KPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNL 461
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN 369

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 24638820 462 KSHILTHAKAKRNTSISGksgcSNAESNSQSEDTSANYVKVELQDSVTENHVPF 515
Cdd:COG5048 370 EPPQSLQQYKDLKNDKKS----ETLSNSCIRNFKRDSNLSLHIITHLSFRPYNC 419
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 350-422 4.76e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 39.47  E-value: 4.76e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24638820  350 SYTNDKKIACPHKGCNKHFRDSSAmRKHLHthgprvhvCAECGKAFVESSKLKRHQLVHtgeKPFQCtfeGCG 422
Cdd:PLN03086 427 AYCSRHNVVCPHDGCGIVLRVEEA-KNHVH--------CEKCGQAFQQGEMEKHMKVFH---EPLQC---PCG 484
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 386-408 4.91e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.91e-03
                          10        20
                  ....*....|....*....|...
gi 24638820   386 HVCAECGKAFVESSKLKRHQLVH 408
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
430-457 1.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|....*...
gi 24638820   430 NLRTHVRIHTGDRPFVCPFdaCNKKFAQ 457
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-426 2.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 24638820   401 LKRHQLVHTGEKPFQCTFegCGKRFS 426
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
386-515 8.10e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638820 386 HVCAECGKAFVESSKLKRHQ--LVHTGE--KPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNL 461
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN 369

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 24638820 462 KSHILTHAKAKRNTSISGksgcSNAESNSQSEDTSANYVKVELQDSVTENHVPF 515
Cdd:COG5048 370 EPPQSLQQYKDLKNDKKS----ETLSNSCIRNFKRDSNLSLHIITHLSFRPYNC 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 406-465 1.46e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638820 406 LVHTGEKPFQCTFEGCGKRFSLDFNLRTHvRIH--------------------TGDRPFVCPFdaCNKKFAQSTNLKSHI 465
Cdd:COG5189 342 LKVKDGKPYKCPVEGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEV--CDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-464 2.40e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638820 383 PRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLK 462
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110


                ..
gi 24638820 463 SH 464
Cdd:COG5048 111 SS 112
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 350-422 4.76e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 39.47  E-value: 4.76e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24638820  350 SYTNDKKIACPHKGCNKHFRDSSAmRKHLHthgprvhvCAECGKAFVESSKLKRHQLVHtgeKPFQCtfeGCG 422
Cdd:PLN03086 427 AYCSRHNVVCPHDGCGIVLRVEEA-KNHVH--------CEKCGQAFQQGEMEKHMKVFH---EPLQC---PCG 484
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 386-408 4.91e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.91e-03
                          10        20
                  ....*....|....*....|...
gi 24638820   386 HVCAECGKAFVESSKLKRHQLVH 408
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 351-441 8.29e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 8.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24638820 351 YTNDKKI-ACPHKGCNKHFRDSSAMRKH-LHTHgprvhvcaeCGKAFVESSKLKRHQLVHTGEKPFQCTFegCGKRFSLD 428
Cdd:COG5189 343 KVKDGKPyKCPVEGCNKKYKNQNGLKYHmLHGH---------QNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNL 411

                        90
                ....*....|...
gi 24638820 429 FNLRTHvRIHTGD 441
Cdd:COG5189 412 NGLKYH-RKHSHD 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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