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Conserved domains on  [gi|24762517|ref|NP_726406|]
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CCR4-NOT transcription complex subunit 11, isoform A [Drosophila melanogaster]

Protein Classification

CCR4-NOT transcription complex subunit 11( domain architecture ID 10562698)

CCR4-NOT transcription complex subunit 11 (CNOT11) is a DUF2363 domain-containing protein, a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation, and general transcription regulation

Gene Ontology:  GO:0031047|GO:0006402|GO:0017148
PubMed:  23303381

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CNOT11 pfam10155
CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in ...
 87-230 1.43e-59

CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in eukaryotes. Family members include CNOT 11 a subunit of the CCR4-NOT. CNOT11 was shown to interact with the first amino acids of CNOT1 and with CNOT10 and to be required for the association of CNOT10 with the CCR4-NOT complex.


:

Pssm-ID: 401964  Cd Length: 124  Bit Score: 183.96  E-value: 1.43e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762517    87 VESNPLISIEILLRLMTTSDITEYFNVLVNMDITLHSMEVVNRLTTSGPLPTEFIHLYISNCISTCETVKDKYMQSRLVR 166
Cdd:pfam10155   1 IENNPNIAIEILVKLLKSPQKPEYLDVLVSLPVTLHSLEVVNRLTKSVNLPREFLHLYISNCIKSCEEIKDKGSQNRLVR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24762517   167 LVCVFLQSLIRNKIVNVrvcattisstvlsdysivifQELFIEIEAFCVGFSKIKEAATLYRLI 230
Cdd:pfam10155  81 LVCVFLQSLIRNKIIDV--------------------KDLFVELQAFCLEFSRIKEASALFKLL 124
 
Name Accession Description Interval E-value
CNOT11 pfam10155
CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in ...
 87-230 1.43e-59

CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in eukaryotes. Family members include CNOT 11 a subunit of the CCR4-NOT. CNOT11 was shown to interact with the first amino acids of CNOT1 and with CNOT10 and to be required for the association of CNOT10 with the CCR4-NOT complex.


Pssm-ID: 401964  Cd Length: 124  Bit Score: 183.96  E-value: 1.43e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762517    87 VESNPLISIEILLRLMTTSDITEYFNVLVNMDITLHSMEVVNRLTTSGPLPTEFIHLYISNCISTCETVKDKYMQSRLVR 166
Cdd:pfam10155   1 IENNPNIAIEILVKLLKSPQKPEYLDVLVSLPVTLHSLEVVNRLTKSVNLPREFLHLYISNCIKSCEEIKDKGSQNRLVR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24762517   167 LVCVFLQSLIRNKIVNVrvcattisstvlsdysivifQELFIEIEAFCVGFSKIKEAATLYRLI 230
Cdd:pfam10155  81 LVCVFLQSLIRNKIIDV--------------------KDLFVELQAFCLEFSRIKEASALFKLL 124
 
Name Accession Description Interval E-value
CNOT11 pfam10155
CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in ...
 87-230 1.43e-59

CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in eukaryotes. Family members include CNOT 11 a subunit of the CCR4-NOT. CNOT11 was shown to interact with the first amino acids of CNOT1 and with CNOT10 and to be required for the association of CNOT10 with the CCR4-NOT complex.


Pssm-ID: 401964  Cd Length: 124  Bit Score: 183.96  E-value: 1.43e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762517    87 VESNPLISIEILLRLMTTSDITEYFNVLVNMDITLHSMEVVNRLTTSGPLPTEFIHLYISNCISTCETVKDKYMQSRLVR 166
Cdd:pfam10155   1 IENNPNIAIEILVKLLKSPQKPEYLDVLVSLPVTLHSLEVVNRLTKSVNLPREFLHLYISNCIKSCEEIKDKGSQNRLVR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24762517   167 LVCVFLQSLIRNKIVNVrvcattisstvlsdysivifQELFIEIEAFCVGFSKIKEAATLYRLI 230
Cdd:pfam10155  81 LVCVFLQSLIRNKIIDV--------------------KDLFVELQAFCLEFSRIKEASALFKLL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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