NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24762439|ref|NP_726378|]
View 

kazachoc, isoform A [Drosophila melanogaster]

Protein Classification

APC family permease( domain architecture ID 1903533)

APC (amino acid/polyamine/organocation) family permease is involved in the uptake of a specific amino acid and/or polyamine substrate with the concomitant import of a proton

Gene Ontology:  GO:0055085|GO:0022857
TCDB:  2.A.3

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
AA_permease_2 super family cl45918
Amino acid permease;
64-1043 0e+00

Amino acid permease;


The actual alignment was detected with superfamily member TIGR00930:

Pssm-ID: 459263 [Multi-domain]  Cd Length: 953  Bit Score: 986.13  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439     64 NLYLYDDDLETRPHISTFISSIANYENTIPAATDPDA---------KPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTW 134
Cdd:TIGR00930   24 NRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEaedaegtkeKPPAGAVKFGWVMGVLVPCLLNIWGVILFLRLSW 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    135 VVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEI 214
Cdd:TIGR00930  104 IVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAET 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    215 VLTYMAPWASifgdftKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFdnihgnekl 294
Cdd:TIGR00930  184 VLDLLRENGS------KIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTI--------- 248
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    295 ymcvlgkrllkdIPLENctkedsflrdiycpdgkceeyylannvTKVKGIKGLASGVFYDNIFPSFlekgqfisygksai 374
Cdd:TIGR00930  249 ------------IPAFD---------------------------KPAKGFFGLGNEIFSENFIPGI-------------- 275
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    375 dientsgesynqimADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDN 454
Cdd:TIGR00930  276 --------------PGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVR 341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    455 LLLRDKFG---------------------QSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEI 513
Cdd:TIGR00930  342 DATGDKNDtlvtnctsaacfsecahntcsYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNI 421
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    514 IPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWS 592
Cdd:TIGR00930  422 YPFLQFFGKGyGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWW 501
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    593 LSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVL 672
Cdd:TIGR00930  502 LSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVL 581
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    673 SKLNdnllPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSV 752
Cdd:TIGR00930  582 TGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHL 657
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    753 IQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIG---------------- 816
Cdd:TIGR00930  658 IQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEGLPISVLQVQeelendcsedsielnd 737
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    817 -----------------------GNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLY 873
Cdd:TIGR00930  738 gkistqpdmhleastqfqkkqgkGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLY 817
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    874 HLRIEADVEVVEMnnsDISAytYERTLMMEQRNQMLRALGLNKkenskvdsqndekrNSIDLDGPEnadtPETTSNKDES 953
Cdd:TIGR00930  818 KFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLHK--------------TEKDREAKD----PKMTWTKPWK 874
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    954 TEKADgdfkssvkpDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREvrAERERNYMEFLEVLTEGLEKVLMVRG 1033
Cdd:TIGR00930  875 ITDAE---------LQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKG--SIPDELYMAWLEVLSEDLPPVLLVRG 943
                         1050
                   ....*....|
gi 24762439   1034 GGREVITIYS 1043
Cdd:TIGR00930  944 NHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
64-1043 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 986.13  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439     64 NLYLYDDDLETRPHISTFISSIANYENTIPAATDPDA---------KPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTW 134
Cdd:TIGR00930   24 NRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEaedaegtkeKPPAGAVKFGWVMGVLVPCLLNIWGVILFLRLSW 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    135 VVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEI 214
Cdd:TIGR00930  104 IVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAET 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    215 VLTYMAPWASifgdftKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFdnihgnekl 294
Cdd:TIGR00930  184 VLDLLRENGS------KIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTI--------- 248
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    295 ymcvlgkrllkdIPLENctkedsflrdiycpdgkceeyylannvTKVKGIKGLASGVFYDNIFPSFlekgqfisygksai 374
Cdd:TIGR00930  249 ------------IPAFD---------------------------KPAKGFFGLGNEIFSENFIPGI-------------- 275
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    375 dientsgesynqimADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDN 454
Cdd:TIGR00930  276 --------------PGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVR 341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    455 LLLRDKFG---------------------QSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEI 513
Cdd:TIGR00930  342 DATGDKNDtlvtnctsaacfsecahntcsYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNI 421
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    514 IPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWS 592
Cdd:TIGR00930  422 YPFLQFFGKGyGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWW 501
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    593 LSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVL 672
Cdd:TIGR00930  502 LSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVL 581
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    673 SKLNdnllPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSV 752
Cdd:TIGR00930  582 TGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHL 657
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    753 IQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIG---------------- 816
Cdd:TIGR00930  658 IQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEGLPISVLQVQeelendcsedsielnd 737
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    817 -----------------------GNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLY 873
Cdd:TIGR00930  738 gkistqpdmhleastqfqkkqgkGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLY 817
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    874 HLRIEADVEVVEMnnsDISAytYERTLMMEQRNQMLRALGLNKkenskvdsqndekrNSIDLDGPEnadtPETTSNKDES 953
Cdd:TIGR00930  818 KFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLHK--------------TEKDREAKD----PKMTWTKPWK 874
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    954 TEKADgdfkssvkpDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREvrAERERNYMEFLEVLTEGLEKVLMVRG 1033
Cdd:TIGR00930  875 ITDAE---------LQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKG--SIPDELYMAWLEVLSEDLPPVLLVRG 943
                         1050
                   ....*....|
gi 24762439   1034 GGREVITIYS 1043
Cdd:TIGR00930  944 NHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
114-670 1.97e-50

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 185.60  E-value: 1.97e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    114 GVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVpAGGSYFMISRSLGPEFGGAVG 193
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    194 --MLFYTGTTLAAAmyiVGAVEIVLTYMAPWASIFGDFtkdadamynnfrVYGTLLLIFMGLIVFLGVKFVNKFATVALA 271
Cdd:pfam00324   80 wnYWLSWITVLALE---LTAASILIQFWELVPDIPYLW------------VWGAVFLVLLTIINLVGVKWYGEAEFWFAL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    272 CVILSIIAVYVGIFdnihgneklymcvlgkrllkdiplenctkedSFLRDIYCPDGKCEEYYLANnvtkvkgikglasgV 351
Cdd:pfam00324  145 IKIIAIIGFIIVGI-------------------------------ILLSGGNPNDGAIFRYLGDN--------------G 179
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    352 FYDNIFPSFlekgqfisygksaidientsgesynqimadiTTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTI 431
Cdd:pfam00324  180 GKNNFPPGF-------------------------------GKGFISVFVIAFFAFTGIELVGIAAGEVKNPEKSIPKAIL 228
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    432 CAILTTSTVY-LSSVMFFAGTVDNLLLRDKFGQSIGGKLVVA-----NIAWPNqwVILIGSFLSTLGAGLQSLTGAPRLL 505
Cdd:pfam00324  229 QVIWRITIFYiLSLLAIGLLVPWNDPGLLNDSASAASPFVIFfkflgISGLAP--LINAVILTAALSAANSSLYSGSRML 306
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    506 QAIARDEIIPFlaPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLlaPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPR 585
Cdd:pfam00324  307 YSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASLNP--AIVFNFLLAISGLSGLIVWGLISLSHLRFRKA 382
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    586 FKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNW 665
Cdd:pfam00324  383 FKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLLFLIILIGVKLHVKNW 462

                   ....*
gi 24762439    666 RPQIL 670
Cdd:pfam00324  463 KPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
111-630 3.26e-37

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 145.81  E-value: 3.26e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  111 TLIGVFLPCIQNIFGVILFIRLTWVVGTAG--AVCGFLIVLtccCVTMLTAISMSAIATNgvVP-AGGSYFMISRSLGPE 187
Cdd:COG0531   14 GLFDLVALGVGAIIGAGIFVLPGLAAGLAGpaAILAWLIAG---LLALLVALSYAELASA--FPrAGGAYTYARRALGPL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  188 FGGAVGMLFYTGTTLAAAMYIVGAVEiVLTYMAPWASIFgdftkdadamynnfrVYGTLLLIFMGLIVFLGVKFVNKFAT 267
Cdd:COG0531   89 LGFLAGWALLLSYVLAVAAVAVAFGG-YLSSLFPAGGSV---------------LIALVLILLLTLLNLRGVKESAKVNN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  268 VALACVILSIIAVYVGIFDNIHGneklymcvlgkrllkdiplenctkedsflrdiycpdgkceeyylannvtkvkgikgl 347
Cdd:COG0531  153 ILTVLKLLVLLLFIVVGLFAFDP--------------------------------------------------------- 175
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  348 asgvfyDNIFPsflekgqFISYGKSAIDIentsgesynqimadittsFTLLIGIFFpSVTGIMAGSNRSGDLADAQKSIP 427
Cdd:COG0531  176 ------ANFTP-------FLPAGGGLSGV------------------LAALALAFF-AFTGFEAIANLAEEAKNPKRNIP 223
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  428 IGTICAILTTSTVYLSSVMFFAGTVDNlllrDKFGQSIGGKLVVANIAWPN--QWVILIGSFLSTLGAGLQSLTGAPRLL 505
Cdd:COG0531  224 RAIILSLLIVGVLYILVSLALTGVVPY----DELAASGAPLADAAEAVFGPwgAILIALGALLSLLGALNASILGASRLL 299
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  506 QAIARDEIIPflAPFAK-SSKRGEPTRALLLTIVICQCGILLG--NVDLLAPLLSMFFLMCYGFVNLACAVQtLLRTPNW 582
Cdd:COG0531  300 YAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLGaaSFTALASLASVGVLLAYLLVALAVIVL-RRRRPDL 376
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 24762439  583 RPRFKFYHWSLSLIGLTLCISVMIMT---SWYFALIAMGMAIIIYKYIEYR 630
Cdd:COG0531  377 PRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
64-1043 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 986.13  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439     64 NLYLYDDDLETRPHISTFISSIANYENTIPAATDPDA---------KPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTW 134
Cdd:TIGR00930   24 NRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEaedaegtkeKPPAGAVKFGWVMGVLVPCLLNIWGVILFLRLSW 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    135 VVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEI 214
Cdd:TIGR00930  104 IVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAET 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    215 VLTYMAPWASifgdftKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFdnihgnekl 294
Cdd:TIGR00930  184 VLDLLRENGS------KIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTI--------- 248
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    295 ymcvlgkrllkdIPLENctkedsflrdiycpdgkceeyylannvTKVKGIKGLASGVFYDNIFPSFlekgqfisygksai 374
Cdd:TIGR00930  249 ------------IPAFD---------------------------KPAKGFFGLGNEIFSENFIPGI-------------- 275
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    375 dientsgesynqimADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDN 454
Cdd:TIGR00930  276 --------------PGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVR 341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    455 LLLRDKFG---------------------QSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEI 513
Cdd:TIGR00930  342 DATGDKNDtlvtnctsaacfsecahntcsYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNI 421
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    514 IPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWS 592
Cdd:TIGR00930  422 YPFLQFFGKGyGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWW 501
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    593 LSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVL 672
Cdd:TIGR00930  502 LSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVL 581
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    673 SKLNdnllPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSV 752
Cdd:TIGR00930  582 TGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHL 657
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    753 IQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIG---------------- 816
Cdd:TIGR00930  658 IQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEGLPISVLQVQeelendcsedsielnd 737
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    817 -----------------------GNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLY 873
Cdd:TIGR00930  738 gkistqpdmhleastqfqkkqgkGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLY 817
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    874 HLRIEADVEVVEMnnsDISAytYERTLMMEQRNQMLRALGLNKkenskvdsqndekrNSIDLDGPEnadtPETTSNKDES 953
Cdd:TIGR00930  818 KFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLHK--------------TEKDREAKD----PKMTWTKPWK 874
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    954 TEKADgdfkssvkpDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREvrAERERNYMEFLEVLTEGLEKVLMVRG 1033
Cdd:TIGR00930  875 ITDAE---------LQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKG--SIPDELYMAWLEVLSEDLPPVLLVRG 943
                         1050
                   ....*....|
gi 24762439   1034 GGREVITIYS 1043
Cdd:TIGR00930  944 NHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
114-670 1.97e-50

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 185.60  E-value: 1.97e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    114 GVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVpAGGSYFMISRSLGPEFGGAVG 193
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    194 --MLFYTGTTLAAAmyiVGAVEIVLTYMAPWASIFGDFtkdadamynnfrVYGTLLLIFMGLIVFLGVKFVNKFATVALA 271
Cdd:pfam00324   80 wnYWLSWITVLALE---LTAASILIQFWELVPDIPYLW------------VWGAVFLVLLTIINLVGVKWYGEAEFWFAL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    272 CVILSIIAVYVGIFdnihgneklymcvlgkrllkdiplenctkedSFLRDIYCPDGKCEEYYLANnvtkvkgikglasgV 351
Cdd:pfam00324  145 IKIIAIIGFIIVGI-------------------------------ILLSGGNPNDGAIFRYLGDN--------------G 179
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    352 FYDNIFPSFlekgqfisygksaidientsgesynqimadiTTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTI 431
Cdd:pfam00324  180 GKNNFPPGF-------------------------------GKGFISVFVIAFFAFTGIELVGIAAGEVKNPEKSIPKAIL 228
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    432 CAILTTSTVY-LSSVMFFAGTVDNLLLRDKFGQSIGGKLVVA-----NIAWPNqwVILIGSFLSTLGAGLQSLTGAPRLL 505
Cdd:pfam00324  229 QVIWRITIFYiLSLLAIGLLVPWNDPGLLNDSASAASPFVIFfkflgISGLAP--LINAVILTAALSAANSSLYSGSRML 306
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    506 QAIARDEIIPFlaPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLlaPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPR 585
Cdd:pfam00324  307 YSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASLNP--AIVFNFLLAISGLSGLIVWGLISLSHLRFRKA 382
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    586 FKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNW 665
Cdd:pfam00324  383 FKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLLFLIILIGVKLHVKNW 462

                   ....*
gi 24762439    666 RPQIL 670
Cdd:pfam00324  463 KPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
111-630 3.26e-37

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 145.81  E-value: 3.26e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  111 TLIGVFLPCIQNIFGVILFIRLTWVVGTAG--AVCGFLIVLtccCVTMLTAISMSAIATNgvVP-AGGSYFMISRSLGPE 187
Cdd:COG0531   14 GLFDLVALGVGAIIGAGIFVLPGLAAGLAGpaAILAWLIAG---LLALLVALSYAELASA--FPrAGGAYTYARRALGPL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  188 FGGAVGMLFYTGTTLAAAMYIVGAVEiVLTYMAPWASIFgdftkdadamynnfrVYGTLLLIFMGLIVFLGVKFVNKFAT 267
Cdd:COG0531   89 LGFLAGWALLLSYVLAVAAVAVAFGG-YLSSLFPAGGSV---------------LIALVLILLLTLLNLRGVKESAKVNN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  268 VALACVILSIIAVYVGIFDNIHGneklymcvlgkrllkdiplenctkedsflrdiycpdgkceeyylannvtkvkgikgl 347
Cdd:COG0531  153 ILTVLKLLVLLLFIVVGLFAFDP--------------------------------------------------------- 175
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  348 asgvfyDNIFPsflekgqFISYGKSAIDIentsgesynqimadittsFTLLIGIFFpSVTGIMAGSNRSGDLADAQKSIP 427
Cdd:COG0531  176 ------ANFTP-------FLPAGGGLSGV------------------LAALALAFF-AFTGFEAIANLAEEAKNPKRNIP 223
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  428 IGTICAILTTSTVYLSSVMFFAGTVDNlllrDKFGQSIGGKLVVANIAWPN--QWVILIGSFLSTLGAGLQSLTGAPRLL 505
Cdd:COG0531  224 RAIILSLLIVGVLYILVSLALTGVVPY----DELAASGAPLADAAEAVFGPwgAILIALGALLSLLGALNASILGASRLL 299
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439  506 QAIARDEIIPflAPFAK-SSKRGEPTRALLLTIVICQCGILLG--NVDLLAPLLSMFFLMCYGFVNLACAVQtLLRTPNW 582
Cdd:COG0531  300 YAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLGaaSFTALASLASVGVLLAYLLVALAVIVL-RRRRPDL 376
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 24762439  583 RPRFKFYHWSLSLIGLTLCISVMIMT---SWYFALIAMGMAIIIYKYIEYR 630
Cdd:COG0531  377 PRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
SLC12 pfam03522
Solute carrier family 12;
689-1043 2.13e-20

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 94.99  E-value: 2.13e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    689 FATQLKAGKGLTICVSVIKGDHTKITNKAVDAKAtlRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVII 768
Cdd:pfam03522    7 FAHLITKNVSLMICGHVVKGRLSQKLRSELQKKA--YRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLKPNILLM 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    769 GWPYSWRQEGRNSWKTFIQTVRTVAACHMA---LMVPKGINF-------------------------------------- 807
Cdd:pfam03522   85 GYKSDWRTCDKEELEEYFNVIHDAFDLQYAvaiLRLPEGLDVshllqdqdteelglgdetnssyaeqsseeqstsnskqd 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    808 -------YPESN-------------------------------------------------HKIG-GNIDIWWIVHDGGL 830
Cdd:pfam03522  165 ddksklsKKDSNlslspdkstknpsgkdssksdklkkkspsiilrtasnekeilnnitqfqKKQKkGTIDVWWLYDDGGL 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    831 LMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIE-ADVEVVemnnSDISAYTYERTLMMeqRNQML 909
Cdd:pfam03522  245 TLLLPYILSTRSKWSDCKLRVFALGNRKDELEEEQRNMASLLSKFRIDySDLTVI----PDITKKPKKETKKF--FDELI 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    910 RALGLNkkenskvDSQNDEkrnsidldgpenaDTPETTSNKDESTEKAdgdfKSsvkpdefnvRRMhtaIKLNEVIVEKS 989
Cdd:pfam03522  319 EPFRLH-------EDDKEE-------------ESAEKITDSELEALKE----KT---------NRQ---LRLRELLLEHS 362
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 24762439    990 QDAQLVIMNLPGPPRE-VRAERernYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1043
Cdd:pfam03522  363 SDANLIVMTLPMPRKGtVSAPL---YMAWLETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease_2 pfam13520
Amino acid permease;
385-616 2.02e-13

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 73.50  E-value: 2.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    385 NQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDlaDAQKSIPIGTICAILTTSTVYLSSVMFFAGTV--DNLLLRD--- 459
Cdd:pfam13520  180 HTFFPDGWPGVFAGFLGVLWSFTGFESAANVSEE--VKKRNVPKAIFIGVIIVGVLYILVNIAFFGVVpdDEIALSSglg 257
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    460 ----KFGQSIGGKLVvaniawpnQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLL 535
Cdd:pfam13520  258 qvaaLLFQAVGGKWG--------AIIVVILLALSLLGAVNTAIVGASRLLYALARDGVLPFSRFFAKVNKFGSPIRAIIL 329
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    536 TIVICQ---CGILLGNVDLLAPL-LSMFFLMCYGFVNLACAVqtLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWY 611
Cdd:pfam13520  330 TAILSLillLLFLLSPAAYNALLsLSAYGYLLSYLLPIIGLL--ILRKKRPDLGRIPGRWPVAIFGILFSLFLIVALFFP 407

                   ....*
gi 24762439    612 FALIA 616
Cdd:pfam13520  408 PVGPA 412
2A0304 TIGR00907
amino acid permease (GABA permease); [Transport and binding proteins, Amino acids, peptides ...
395-547 2.31e-04

amino acid permease (GABA permease); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273331 [Multi-domain]  Cd Length: 482  Bit Score: 45.12  E-value: 2.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    395 FTLLIGIFFP--SVTGIMAGSNRSGDLADAQKSIP---IGTICAILTTSTVYLSsVMFFAGTVDNLLLRDKFGQSIggkL 469
Cdd:TIGR00907  217 FAFLLGLLNPawSMTGYDGTAHMAEEIENPEVVGPraiIGAVAIGIVTGFCFNI-VLFFSMGDIDSLISSTTGQPI---A 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    470 VVANIAWPNQ---WVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGE-PTRALLLTIVICQCGIL 545
Cdd:TIGR00907  293 QIFYNALGNKagaIFLLCLILVTSFFCAITCMTANSRMIYAFSRDGGLPFSPLWSRVNPRTQvPLNAVWLSAVWIILIGL 372

                   ..
gi 24762439    546 LG 547
Cdd:TIGR00907  373 LG 374
2A0303 TIGR00906
cationic amino acid transport permease; [Transport and binding proteins, Amino acids, peptides ...
423-573 3.82e-04

cationic amino acid transport permease; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273330 [Multi-domain]  Cd Length: 557  Bit Score: 44.42  E-value: 3.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    423 QKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAwpnQWVILIGSFLSTLGAGLQSLTGAP 502
Cdd:TIGR00906  261 QRAIPIGIVTSLLVCFVAYFLMSAALTLMMPYYLLDPDAPFPVAFEYVGWDPA---KYIVAVGALCGMSTSLLGGMFPLP 337
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24762439    503 RLLQAIARDEII-PFLAPFakSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAV 573
Cdd:TIGR00906  338 RVIYAMARDGLLfKWLAQI--NSKTKTPINATVVSGAIAALMAFLFDLKALVDLLSIGTLLAYSLVAACVLI 407
2A0308 TIGR00911
L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and ...
417-610 6.22e-04

L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273332 [Multi-domain]  Cd Length: 501  Bit Score: 43.58  E-value: 6.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    417 GDLADAQKSIPIGTICAILTTSTVY-LSSVMFFAG-TVDNLLLRDKFGQSIGGKLV-VANIAWPnqwvILIGsfLSTLGA 493
Cdd:TIGR00911  259 EEVKNPYRTLPIAIIISMPIVTFIYvLTNIAYFTVlSPEELLASLAVAVDFGERLLgVMSWAMP----ALVG--LSCFGS 332
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762439    494 GLQSLTGAPRLLQAIARDEIIPFLAPFAkSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGfvnLACAV 573
Cdd:TIGR00911  333 VNGSLFSSSRLFFVGGREGHLPSLLSMI-HVKRLTPLPSLLIVCTLTLLMLFSGDIYSLINLISFANWLFNA---LAVAG 408
                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 24762439    574 QTLLR--TPNWRPRFKFyHWSLSLIGLTLCISVMIMTSW 610
Cdd:TIGR00911  409 LLWLRykRPEMNRPIKV-PLFFPVFFLLSCLFLIILSLY 446
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH